LY379268


SMILES OC(=O)[C@H]1[C@H]2[C@@H]1[C@](CO2)(N)C(=O)O
InChIKey YASVRZWVUGJELU-MDASVERJSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 2
Molecular weight (Da) 187.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 8TQB

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu3 GRM3 Human Metabotropic glutamate C pKi 5.98 7.73 8.34 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 5.7 7.48 8.57 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.9 7.9 7.9 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 4.8 4.8 4.8 Guide to Pharmacology
mGlu4 GRM4 Human Metabotropic glutamate C pKi 4.68 4.68 4.68 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pKi 6.4 6.4 6.4 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pKi 5.77 5.77 5.77 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu3 GRM3 Human Metabotropic glutamate C pEC50 8.34 8.34 8.34 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 8.57 8.57 8.57 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 4.68 4.68 4.68 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 6.4 6.4 6.4 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pIC50 6.4 6.4 6.4 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 5.77 5.77 5.77 ChEMBL