GproteinDb

mavorixafor

Agent/drug
Bioactivity

mavorixafor

SMILES	NCCCCN(Cc1nc2ccccc2[nH]1)[C@H]1CCCc2cccnc21
InChIKey	WVLHHLRVNDMIAR-IBGZPJMESA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	349.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb
Ligand site mutations	CXCR4

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

CXCR4	CXCR4	Human	Chemokine	A	pKi	7.64	7.64	7.64	ChEMBL
CXCR4	CXCR4	Human	Chemokine	A	pKi	7.96	7.96	7.96	Guide to Pharmacology

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

μ	OPRM	Human	Opioid	A	pIC50	4.92	4.92	4.92	ChEMBL
CXCR4	CXCR4	Human	Chemokine	A	pIC50	7.52	8.00	8.30	ChEMBL
CXCR4	CXCR4	Human	Chemokine	A	pIC50	7.89	7.89	7.89	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pIC50	5.39	5.39	5.39	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.12	5.12	5.12	ChEMBL

Showing 1 to 5 of 5 entries

mavorixafor

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 7

Phase II 1

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb
Ligand site mutations	CXCR4

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

CXCR4	CXCR4	Chemokine receptors	Protein receptors	Class A	Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecified	1C62.Z		0.224	1	Yes
CXCR4	CXCR4	Chemokine receptors	Protein receptors	Class A	Lymphoplasmacytic lymphoma	2A85.4		0.058	1	Yes
CXCR4	CXCR4	Chemokine receptors	Protein receptors	Class A	Malignant neoplasms of breast, unspecified	2C6Z		0.174	1	Yes
CXCR4	CXCR4	Chemokine receptors	Protein receptors	Class A	Melanoma of skin, unspecified	2C30.Z		0.293	1	Yes
CXCR4	CXCR4	Chemokine receptors	Protein receptors	Class A	Neutropaenia, unspecified	4B00.0Z		0.276	2	Yes
CXCR4	CXCR4	Chemokine receptors	Protein receptors	Class A	Other specified primary immunodeficiencies due to disorders of innate immunity	4A00.Y		0.792	4	Yes
CXCR4	CXCR4	Chemokine receptors	Protein receptors	Class A	Renal cell carcinoma of kidney, except renal pelvis	2C90.0		0.219	1	Yes

Showing 1 to 7 of 7 entries