GproteinDb

methoxamine

Agent/drug
Bioactivity

methoxamine

SMILES	COc1ccc(OC)c(C(O)C(C)N)c1
InChIKey	WJAJPNHVVFWKKL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	4
Molecular weight (Da)	211.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A α_1B

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	4.60	4.90	5.20	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	3.00	3.50	4.00	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.79	5.79	5.79	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.40	8.40	8.40	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	3.80	4.35	4.90	Guide to Pharmacology
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	4.50	4.50	4.50	Guide to Pharmacology
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	8.35	8.35	8.35	Drug Central

Showing 1 to 9 of 9 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	6.14	6.14	6.14	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	8.29	8.29	8.29	Drug Central
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	4.40	6.25	8.10	Guide to Pharmacology
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	4.00	5.30	6.60	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pEC50	5.10	5.25	5.40	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pEC50	8.31	8.31	8.31	Drug Central

Showing 1 to 6 of 6 entries

methoxamine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 3

Phase II 3

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A α_1B

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C01C	0.596	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Faecal incontinence, unspecified	ME07.Z	C01C	0.292	2	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Urinary incontinence, unspecified	MF50.2Z	C01C	0.468	1	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C01C	0.591	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Faecal incontinence, unspecified	ME07.Z	C01C	0.292	2	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Urinary incontinence, unspecified	MF50.2Z	C01C	0.466	1	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C01C	0.634	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Faecal incontinence, unspecified	ME07.Z	C01C	0.292	2	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Urinary incontinence, unspecified	MF50.2Z	C01C	0.466	1	Yes

Showing 1 to 9 of 9 entries