GproteinDb

nefazodone

Agent/drug
Bioactivity

nefazodone

SMILES	CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1
InChIKey	VRBKIVRKKCLPHA-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	0
Rotatable bonds	10
Molecular weight (Da)	469.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.86	6.86	6.86	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.24	6.24	6.24	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.35	6.35	6.35	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.32	7.32	7.32	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.86	5.86	5.86	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.72	6.72	6.72	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.18	8.18	8.18	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.45	6.45	6.45	ChEMBL
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	7.28	7.28	7.28	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	6.80	6.80	6.80	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.64	7.28	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.10	7.10	7.10	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.15	8.15	8.15	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.58	6.58	6.58	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.92	6.92	6.92	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.81	8.03	8.24	ChEMBL

Showing 1 to 20 of 41 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.43	5.43	5.43	ChEMBL
GPR35	GPR35	Human	A orphans	A	pIC50	5.46	5.46	5.46	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.47	5.47	5.47	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.18	5.18	5.18	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	4.90	4.90	ChEMBL

Showing 1 to 5 of 5 entries

nefazodone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.