GproteinDb

afamelanotide

Agent/drug
Bioactivity

afamelanotide

SMILES	None
InChIKey	UAHFGYDRQSXQEB-LEBBXHLNSA-N
Sequence	SYSXEHFRWGKPV

Chemical Properties

Hydrogen bond acceptors	None
Hydrogen bond donors	None
Rotatable bonds	None
Molecular weight (Da)

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem PubChem PubChem PubChem PubChem GPCRdb
Structure pdb	7PIV 7F54
Ligand site mutations	MC₄

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

MC₁	MSHR	Human	Melanocortin	A	pKi	8.74	9.46	10.34	ChEMBL
MC₃	MC3R	Human	Melanocortin	A	pKi	8.90	8.90	8.90	Guide to Pharmacology
MC₃	MC3R	Human	Melanocortin	A	pKi	9.11	9.14	9.17	ChEMBL
MC₄	MC4R	Human	Melanocortin	A	pKi	8.50	8.65	8.80	Guide to Pharmacology
MC₄	MC4R	Human	Melanocortin	A	pKi	7.72	9.00	9.52	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pKi	8.00	8.66	9.32	ChEMBL

Showing 1 to 6 of 6 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

MC₁	MSHR	Human	Melanocortin	A	pIC50	10.00	10.00	10.00	Guide to Pharmacology
MC₁	MSHR	Mouse	Melanocortin	A	pEC50	7.92	10.40	11.00	ChEMBL
MC₁	MSHR	Mouse	Melanocortin	A	pIC50	9.51	9.52	9.54	ChEMBL
MC₁	MSHR	Human	Melanocortin	A	pEC50	9.30	9.95	10.64	ChEMBL
MC₁	MSHR	Human	Melanocortin	A	pIC50	9.29	9.29	9.29	ChEMBL
MC₃	MC3R	Human	Melanocortin	A	pEC50	8.17	9.15	9.89	ChEMBL
MC₃	MC3R	Human	Melanocortin	A	pIC50	8.42	8.63	8.93	ChEMBL
MC₃	MC3R	Rat	Melanocortin	A	pEC50	10.00	10.00	10.00	ChEMBL
MC₄	MC4R	Human	Melanocortin	A	pIC50	7.85	8.96	9.82	ChEMBL
MC₄	MC4R	Human	Melanocortin	A	pEC50	8.05	9.27	10.77	ChEMBL
MC₄	MC4R	Mouse	Melanocortin	A	pEC50	6.92	9.41	10.01	ChEMBL
MC₄	MC4R	Mouse	Melanocortin	A	pIC50	8.38	8.73	8.96	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pIC50	9.00	9.00	9.00	Guide to Pharmacology
MC₅	MC5R	Human	Melanocortin	A	pIC50	8.66	8.90	9.07	ChEMBL
MC₅	MC5R	Human	Melanocortin	A	pEC50	8.96	9.21	9.64	ChEMBL
MC₅	MC5R	Mouse	Melanocortin	A	pEC50	6.77	9.71	10.52	ChEMBL
MC₅	MC5R	Mouse	Melanocortin	A	pIC50	6.85	6.85	6.85	ChEMBL

Showing 1 to 17 of 17 entries

afamelanotide

Drug properties

Molecular type	Peptide
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 5

Phase III 0

Phase IV 1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem PubChem PubChem PubChem PubChem GPCRdb
Structure pdb	7PIV 7F54
Ligand site mutations	MC₄

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

MSHR	MC₁ receptor	Melanocortin receptors	Peptide receptors	A	Acne, unspecified	2	ED80.Z	D02B	0.078
MSHR	MC₁ receptor	Melanocortin receptors	Peptide receptors	A	Cerebral ischaemic stroke, unspecified	2	8B11.5Z	D02B	0.039
MSHR	MC₁ receptor	Melanocortin receptors	Peptide receptors	A	Erythropoietic porphyrias	4	5C58.12	D02B	0.533
MSHR	MC₁ receptor	Melanocortin receptors	Peptide receptors	A	Urticaria of unspecified type	2	EB05	D02B	0.074
MSHR	MC₁ receptor	Melanocortin receptors	Peptide receptors	A	Vitiligo	2	ED63.0	D02B	0.121
MSHR	MC₁ receptor	Melanocortin receptors	Peptide receptors	A	Xeroderma pigmentosum	2	LD27.1	D02B	0.094

Showing 1 to 6 of 6 entries