GproteinDb

phenylephrine

Agent/drug
Bioactivity

phenylephrine

SMILES	CNC[C@H](O)c1cccc(O)c1
InChIKey	SONNWYBIRXJNDC-VIFPVBQESA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	3
Rotatable bonds	3
Molecular weight (Da)	167.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A α_1B α_2A β₂

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	4.90	5.15	5.40	Guide to Pharmacology
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	6.03	6.03	6.03	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.01	6.01	6.01	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	3.90	3.90	3.90	Guide to Pharmacology
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	5.90	5.90	5.90	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_1B	ADA1B	Golden hamster	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	4.70	4.70	4.70	Guide to Pharmacology
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	5.90	5.90	5.90	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.49	5.49	5.49	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	4.89	4.89	4.89	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	8.31	8.31	8.31	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.96	5.96	5.96	ChEMBL

Showing 1 to 16 of 16 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	4.90	6.60	8.30	Guide to Pharmacology
α_1A	ADA1A	Bovine	Adrenoceptors	A	pEC50	8.05	8.05	8.05	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pEC50	5.78	5.78	5.78	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pEC50	5.53	6.68	7.26	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	6.10	7.22	9.00	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pEC50	4.96	4.96	4.96	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pEC50	8.23	8.65	9.07	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pEC50	6.20	6.70	7.20	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	8.23	8.23	8.23	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	6.32	6.42	6.51	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	6.47	6.47	6.47	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.70	4.70	4.70	ChEMBL

Showing 1 to 12 of 12 entries

phenylephrine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 3

Phase II 6

Phase III 15

Phase IV 27

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A α_1B α_2A β₂

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Acute bronchiolitis, unspecified	2	CA41.Z		0.547
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Acute nasopharyngitis	4	CA00		0.322
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Acute upper respiratory infection, site unspecified	3	CA07.0		0.379
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Allergic rhinitis due to other seasonal allergens	4	CA08.01		0.606
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Anomalies of pupillary function	4	LA11.62		0.542
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Cerebral ischaemic stroke, unspecified	3	8B11.5Z		0.453
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Chronic rhinosinusitis, unspecified	4	CA0A.Z		0.599
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Disorder of oral mucosa, unspecified	1	DA01.Z		0.037
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Faecal incontinence, unspecified	3	ME07.Z		0.292
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Haemorrhoids, unspecified	4	DB60.Z		0.599
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Hypotension, unspecified	4	BA2Z		0.603
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Influenza, virus not identified	4	1E32		0.352
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Injury of lung, unspecified	2	NB32.3Z		0.297
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Nasal congestion	4	MD11.9		0.607
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Sepsis with septic shock	4	1G41		0.590
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Stroke not known if ischaemic or haemorrhagic	3	8B20		0.363
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Vasomotor rhinitis	3	CA08.3		0.323
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Acute bronchiolitis, unspecified	2	CA41.Z		0.547
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Acute nasopharyngitis	4	CA00		0.322
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Acute upper respiratory infection, site unspecified	3	CA07.0		0.379

Showing 1 to 20 of 51 entries

Join us

Cite us

Main reference

phenylephrine

phenylephrine

Chemical Properties

Database connections

Bioactivities

phenylephrine

Drug properties

Distribution across phases (no. indications)

Database connections

Sankey plot

Drug Information