GproteinDb

pramipexole

Agent/drug
Bioactivity

pramipexole

SMILES	CCCN[C@H]1CCc2nc(N)sc2C1
InChIKey	FASDKYOPVNHBLU-ZETCQYMHSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	3
Molecular weight (Da)	211.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7CMU
Ligand site mutations	D₃

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.12	7.12	7.12	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.77	6.45	7.12	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.17	7.17	7.17	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.20	6.69	7.17	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.28	7.28	7.28	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.00	6.14	7.28	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	4.00	4.00	4.00	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.40	8.40	8.40	Drug Central
δ	OPRD	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
μ	OPRM	Human	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.19	5.19	5.19	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central

Showing 1 to 20 of 72 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	5.75	5.75	5.75	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	5.93	5.93	5.93	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pEC50	8.23	8.23	8.23	Drug Central
D₂	DRD2	Rat	Dopamine	A	pEC50	7.67	8.06	8.77	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.33	5.84	6.35	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	6.60	7.67	8.30	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	8.18	8.18	8.18	Drug Central
D₃	DRD3	Rat	Dopamine	A	pEC50	9.68	9.68	9.68	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	8.11	8.11	8.11	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.27	8.74	9.09	ChEMBL
D₃	DRD3	Human	Dopamine	A	pEC50	8.06	8.06	8.06	Drug Central
D₄	DRD4	Human	Dopamine	A	pEC50	7.82	7.82	7.82	ChEMBL
H₂	HRH2	Human	Histamine	A	pEC50	6.78	6.78	6.78	ChEMBL

Showing 1 to 13 of 13 entries

pramipexole

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 6

Phase II 23

Phase III 15

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	7CMU
Ligand site mutations	D₃

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Alzheimer disease	8A20	N04B	0.408	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N04B	0.111	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N04B	0.660	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Chronic pain, unspecified	MG30.Z	N04B	0.019	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Chronic widespread pain	MG30.01	N04B	0.517	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	N04B	0.470	1	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N04B	0.655	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Essential tremor or related tremors	8A04.1	N04B	0.270	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Feeding or eating disorders, unspecified	6B8Z	N04B	0.514	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z	N04B	0.613	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Parkinson disease, unspecified	8A00.0Z	N04B	0.621	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Renal colic	MF56	N04B	0.037	2	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Restless legs syndrome	7A80	N04B	0.600	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z	N04B	0.606	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N04B	0.732	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Tourette syndrome	8A05.00	N04B	0.648	3	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Alzheimer disease	8A20	N04B	0.288	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Amyotrophic lateral sclerosis	8B60.0	N04B	0.106	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N04B	0.597	2	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Chronic pain, unspecified	MG30.Z	N04B	0.079	1	Yes

Showing 1 to 20 of 48 entries

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pramipexole

pramipexole

Chemical Properties

Database connections

Bioactivities

pramipexole

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information