CHEMBL140612


SMILES COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1
InChIKey OLKYYLJXZLWORJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 393.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D2 D3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 7.25 7.65 7.85 ChEMBL
D1 DRD1 Human Dopamine A pKi 5.66 5.66 5.66 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.99 6.74 7.8 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.08 7.86 8.41 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database