GproteinDb

rizatriptan

Agent/drug
Bioactivity

rizatriptan

SMILES	CN(C)CCc1c[nH]c2ccc(Cn3cncn3)cc12
InChIKey	ULFRLSNUDGIQQP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	269.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.53	6.69	6.85	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.00	8.26	8.52	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.90	7.90	7.90	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.40	8.04	8.52	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.10	8.10	8.10	Drug Central
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	6.80	6.80	6.80	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	6.40	6.60	6.80	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central

Showing 1 to 13 of 13 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	6.40	6.45	6.50	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pIC50	7.39	7.39	7.39	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pIC50	7.10	7.53	7.96	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pEC50	8.08	8.30	8.52	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.10	5.10	5.10	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.29	8.29	8.29	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.10	5.10	5.10	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	8.29	8.29	8.29	Drug Central

Showing 1 to 8 of 8 entries

rizatriptan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 6

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine with aura, unspecified	8A80.1Z	N02C	0.501	3	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine without aura	8A80.0	N02C	0.497	3	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	N02C	0.611	4	Yes
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine with aura, unspecified	8A80.1Z	N02C	0.513	3	Yes
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine without aura	8A80.0	N02C	0.510	3	Yes
5HT1D	5-HT_1D receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	N02C	0.609	4	Yes
5HT1F	5-HT_1F receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine with aura, unspecified	8A80.1Z	N02C	0.434	3	Yes
5HT1F	5-HT_1F receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine without aura	8A80.0	N02C	0.434	3	Yes
5HT1F	5-HT_1F receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	N02C	0.599	4	Yes

Showing 1 to 9 of 9 entries