S-15535


SMILES C1COc2c(O1)cccc2N1CCN(CC1)C1Cc2c(C1)cccc2
InChIKey QJPPEMXOOWNICQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Molecular weight (Da) 336.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.2 9.2 9.2 Guide to Pharmacology
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 5.8 5.85 5.9 Guide to Pharmacology
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.46 6.46 6.46 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.75 8.75 8.75 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.1 9.1 9.1 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.75 8.75 8.75 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.76 5.76 5.76 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 6.27 6.27 6.27 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.72 8.91 9.1 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.88 6.88 6.88 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.1 5.38 5.65 ChEMBL