SB 277011-A


SMILES N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2
InChIKey OLWRVVHPJFLNPW-LSNLESRRSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 438.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pKi 7.97 8.08 8.2 ChEMBL
H1 HRH1 Human Histamine A pKi 6.2 6.2 6.2 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.95 8.22 8.4 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.29 6.18 6.4 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 8.0 8.0 8.0 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 5.55 5.55 5.55 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database