SB 204070


SMILES CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N
InChIKey AOOSJYIINXVNHV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 382.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 9.8 10.11 10.41 Guide to Pharmacology
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 10.8 10.8 10.8 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.9 7.0 7.1 ChEMBL
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 8.9 9.27 9.51 PDSP Ki database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 10.0 10.0 10.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 6.0 6.0 6.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 6.0 6.0 6.0 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 6.0 6.0 6.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 6.0 6.0 6.0 PDSP Ki database
5-HT1D 5HT1D Guinea pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
A1 AA1R Rat Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 PDSP Ki database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 8.9 9.2 9.5 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.85 5.05 5.25 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 7.6 7.6 7.6 ChEMBL