SKF-38393


SMILES Oc1cc2CCNCC(c2cc1O)c1ccccc1
InChIKey JUDKOGFHZYMDMF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 1
Molecular weight (Da) 255.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 6.2 6.5 6.8 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 6.91 6.91 6.91 ChEMBL
D1 DRD1 Rat Dopamine A pKi 7.19 7.19 7.19 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.08 7.08 7.08 ChEMBL
D2 DRD2 Rat Dopamine A pKd 4.34 4.5 4.75 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.16 5.16 5.16 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.41 7.14 8.96 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.06 5.93 6.8 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.01 6.69 7.25 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.0 5.17 5.33 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.51 5.51 5.51 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 5.11 5.21 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.0 5.15 5.79 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.87 6.7 7.52 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 7.0 7.0 7.0 PDSP Ki database
D3 DRD3 Rat Dopamine A pKi 5.3 5.3 5.3 PDSP Ki database
D2 DRD2 Dog Dopamine A pKi 6.8 6.8 6.8 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 7.19 7.86 9.52 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 5.03 5.03 5.03 PDSP Ki database
D1 DRD1 Mouse Dopamine A pKi 7.74 7.74 7.74 PDSP Ki database
D1 DRD1 Rhesus macaque Dopamine A pKi 6.97 6.97 6.97 PDSP Ki database
D5 DRD5 Rat Dopamine A pKi 7.1 7.1 7.1 PDSP Ki database
H1 HRH1 Human Histamine A pKi 5.6 5.6 5.6 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pIC50 6.72 6.72 6.72 ChEMBL
α2C ADA2C Human Adrenoceptors A pEC50 5.86 5.86 5.86 ChEMBL
D1 DRD1 Human Dopamine A pEC50 6.18 6.83 8.96 ChEMBL