GproteinDb

spiperone

Agent/drug
Bioactivity

spiperone

SMILES	O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1
InChIKey	DKGZKTPJOSAWFA-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	395.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central Guide To Pharmacology GPCRdb
Structure pdb	7DFP
Ligand site mutations	α_1A α_1B 5-HT_1A D₁ D₂ D₃

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	Guide to Pharmacology
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	7.87	7.87	7.87	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.42	7.78	8.14	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	7.20	7.80	8.30	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	9.20	9.20	9.20	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.89	8.89	8.89	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	ChEMBL
α_1B	A0A4X1U0M4	Pig	Adrenoceptors	A	pKi	8.30	8.30	8.30	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.51	8.51	8.51	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.04	8.04	8.04	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.69	7.88	8.08	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.70	7.75	8.80	Guide to Pharmacology

Showing 1 to 20 of 130 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.91	6.91	6.91	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	6.00	6.00	6.00	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.25	8.25	8.25	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pIC50	6.51	6.51	6.51	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	10.22	10.22	10.22	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	8.59	9.05	9.60	ChEMBL
D₂	DRD2	Human	Dopamine	A	pEC50	8.85	8.85	8.85	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	7.01	7.83	9.44	ChEMBL
D₄	DRD4	Human	Dopamine	A	pIC50	8.31	8.90	9.30	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.00	5.22	5.45	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.00	5.00	5.00	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.60	5.60	5.60	ChEMBL

Showing 1 to 12 of 12 entries

spiperone

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central Guide To Pharmacology GPCRdb
Structure pdb	7DFP
Ligand site mutations	α_1A α_1B 5-HT_1A D₁ D₂ D₃

Compound is not listed as a drug.