substance P


SMILES None
InChIKey ADNPLDHMAVUMIW-CUZNLEPHSA-N
Sequence RPKPQQFFGLM

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Structure pdb 7VDM 7RMG 7P00 7P02 7RMI 7RMH 8U26

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK1 NK1R Human Tachykinin A pKi 8.5 9.4 10.3 Guide to Pharmacology
NK1 NK1R Human Tachykinin A pKd 8.6 8.6 8.6 Guide to Pharmacology
NK2 NK2R Human Tachykinin A pKi 5.9 6.4 6.9 Guide to Pharmacology
NK3 NK3R Human Tachykinin A pKi 5.0 5.5 6.0 Guide to Pharmacology
NK3 NK3R Mouse Tachykinin A pKi 5.3 5.3 5.3 Guide to Pharmacology
NK1 NK1R Guinea pig Tachykinin A pKi 7.3 7.3 7.3 ChEMBL
NK1 NK1R Rat Tachykinin A pKi 8.96 8.96 8.96 ChEMBL
NK2 NK2R Human Tachykinin A pKi 6.99 6.99 6.99 ChEMBL
NK1 NK1R Human Tachykinin A pKi 8.8 8.8 8.8 ChEMBL
NK1 NK1R Human Tachykinin A pKi 8.55 9.66 10.38 PDSP Ki database
NK2 NK2R Human Tachykinin A pKi 6.89 6.89 6.89 PDSP Ki database
NK3 NK3R Human Tachykinin A pKi 5.89 5.89 5.89 PDSP Ki database
NK1 NK1R Guinea pig Tachykinin A pKi 9.62 9.93 10.23 PDSP Ki database
NK1 NK1R Rat Tachykinin A pKi 8.99 9.63 10.27 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
MRGPRX2 MRGX2 Human A orphans A pEC50 5.97 5.97 5.97 Guide to Pharmacology
NK3 NK3R Guinea pig Tachykinin A pIC50 6.14 6.14 6.14 ChEMBL
NK2 NK2R Golden hamster Tachykinin A pIC50 6.83 6.83 6.83 ChEMBL
NK3 NK3R Rat Tachykinin A pIC50 6.89 6.89 6.89 ChEMBL
NK3 NK3R Rat Tachykinin A pEC50 5.12 5.12 5.12 ChEMBL
NK2 NK2R Rat Tachykinin A pEC50 6.78 7.52 9.0 ChEMBL
NK2 NK2R Rat Tachykinin A pIC50 6.7 6.7 6.7 ChEMBL
NK1 NK1R Guinea pig Tachykinin A pEC50 8.25 8.52 9.0 ChEMBL
NK1 NK1R Guinea pig Tachykinin A pIC50 10.15 10.15 10.15 ChEMBL
NK1 NK1R Rat Tachykinin A pIC50 8.82 9.5 9.92 ChEMBL
NK3 NK3R Human Tachykinin A pEC50 6.1 6.1 6.1 ChEMBL
NK3 NK3R Human Tachykinin A pIC50 6.9 6.9 6.9 ChEMBL
NK2 NK2R Human Tachykinin A pIC50 6.61 6.61 6.61 ChEMBL
NK1 NK1R Human Tachykinin A pIC50 8.77 9.16 9.92 ChEMBL
NK1 NK1R Human Tachykinin A pEC50 9.0 9.42 10.24 ChEMBL
ghrelin GHSR Human Ghrelin A pEC50 7.18 7.18 7.18 ChEMBL