Vorapaxar
Chemical Properties
| SMILES | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@@H]1[C@H]([C@H]2/C=C/c2ccc(cn2)c2cccc(c2)F)[C@H](OC1=O)C |
| Hydrogen bond acceptors | 5 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 5 |
| Molecular weight | 492.2 |
Drug Properties
| Type | Small molecule |
| Endogenous | No |
| Approved | Yes |
| InChIKey | ZBGXUVOIWDMMJE-QHNZEKIYSA-N |
Bioactivity
| Receptor | Experimental Data | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| PAR1 | PAR1 | Human | Proteinase-activated | A | pKi | 8.09 | 8.09 | 8.09 | Guide to Pharmacology |
| PAR1 | PAR1 | Human | Proteinase-activated | A | pKi | 7.89 | 8.22 | 8.96 | ChEMBL |
| PAR1 | PAR1 | Human | Proteinase-activated | A | pIC50 | 6.6 | 7.56 | 8.96 | ChEMBL |