terazosin
| SMILES | COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 |
| InChIKey | VCKUSRYTPJJLNI-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 7 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 387.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 7.9 | 8.3 | 8.7 | Guide to Pharmacology |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.0 | 8.3 | 8.6 | Guide to Pharmacology |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 7.7 | 8.4 | 9.1 | Guide to Pharmacology |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 8.11 | 8.11 | 8.11 | ChEMBL |
| α1B | ADA1B | Golden hamster | Adrenoceptors | A | pKi | 9.16 | 9.16 | 9.16 | ChEMBL |
| α1A | ADA1A | Rabbit | Adrenoceptors | A | pKd | 7.7 | 7.7 | 7.7 | ChEMBL |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 7.58 | 8.09 | 8.6 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKd | 8.59 | 8.6 | 8.6 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.48 | 8.6 | 8.72 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 7.52 | 8.59 | 8.92 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 8.02 | 8.51 | 9.09 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKd | 7.9 | 7.98 | 8.04 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.08 | 8.52 | 9.07 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.38 | 7.04 | 7.58 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.06 | 6.65 | 7.11 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKd | 7.44 | 7.44 | 7.44 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 7.4 | 8.24 | 8.7 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 5.29 | 5.81 | 6.26 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.7 | 8.82 | 8.94 | PDSP Ki database |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.2 | 8.71 | 9.18 | PDSP Ki database |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.26 | 8.26 | 8.26 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.2 | 8.2 | 8.2 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| α1B | ADA1B | Golden hamster | Adrenoceptors | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| α2B | ADA2B | Rat | Adrenoceptors | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 8.22 | 8.22 | 8.22 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pEC50 | 8.76 | 9.03 | 9.3 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 7.62 | 7.62 | 7.62 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 7.77 | 7.77 | 7.77 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 6.37 | 6.37 | 6.37 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 5.22 | 5.22 | 5.22 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pEC50 | 7.29 | 7.29 | 7.29 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 4.86 | 4.86 | 4.86 | ChEMBL |