GproteinDb

tolvaptan

Agent/drug
Bioactivity

tolvaptan

SMILES	Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc32)c(C)c1
InChIKey	GYHCTFXIZSNGJT-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	3
Molecular weight (Da)	448.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem PubChem PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

μ	OPRM	Human	Opioid	A	pKi	6.39	6.39	6.39	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.31	5.31	5.31	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.17	5.17	5.17	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	7.90	7.90	7.90	Guide to Pharmacology
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	6.50	6.50	6.50	Guide to Pharmacology
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	6.53	7.02	7.50	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	7.91	7.91	7.91	PDSP Ki database
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	6.49	6.49	6.49	PDSP Ki database
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pKi	8.10	8.10	8.10	Drug Central
V_1A	V1AR	Rat	Vasopressin and oxytocin	A	pKi	8.19	8.19	8.19	Drug Central
V_1B	V1BR	Human	Vasopressin and oxytocin	A	pKi	5.00	5.00	5.00	PDSP Ki database
V₂	V2R	Human	Vasopressin and oxytocin	A	pKi	9.37	9.37	9.37	Guide to Pharmacology
V₂	V2R	Rat	Vasopressin and oxytocin	A	pKi	8.90	8.90	8.90	Guide to Pharmacology
V₂	V2R	Human	Vasopressin and oxytocin	A	pKi	8.62	8.94	9.37	ChEMBL
V₂	V2R	Human	Vasopressin and oxytocin	A	pKi	9.37	9.45	9.52	PDSP Ki database
V₂	V2R	Rat	Vasopressin and oxytocin	A	pKi	8.88	8.88	8.88	PDSP Ki database
V₂	V2R	Human	Vasopressin and oxytocin	A	pKi	8.05	8.05	8.05	Drug Central
V₂	V2R	Rat	Vasopressin and oxytocin	A	pKi	8.05	8.05	8.05	Drug Central

Showing 1 to 18 of 18 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₂	ADRB2	Human	Adrenoceptors	A	pEC50	5.47	5.47	5.47	ChEMBL
FFA4	FFAR4	Human	Free fatty acid	A	pEC50	5.29	5.29	5.29	ChEMBL
GLP-1	GLP1R	Human	Glucagon	B1	pEC50	5.33	5.33	5.33	ChEMBL
GPR119	GP119	Human	GPR18, GPR55 and GPR119	A	pEC50	5.40	5.40	5.40	ChEMBL
V_1A	V1AR	Human	Vasopressin and oxytocin	A	pIC50	6.33	6.33	6.33	ChEMBL
V₂	V2R	Human	Vasopressin and oxytocin	A	pIC50	7.95	8.15	8.35	ChEMBL

Showing 1 to 6 of 6 entries

tolvaptan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 0

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem PubChem PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Autosomal dominant polycystic kidney disease	GB81	C03X	0.566	3	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Calculus of kidney, unspecified	GB70.0Z	C03X	0.037	1	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Chronic kidney disease, stage unspecified	GB61.Z	C03X	0.028	3	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Congestive heart failure	BD10	C03X	0.487	4	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Diseases of the circulatory system, unspecified	BE2Z	C03X	0.503	4	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Diseases of the urinary system, unspecified	GC2Z	C03X	0.238	3	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Heart failure, unspecified	BD1Z	C03X	0.580	4	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Hypo-osmolality or hyponatraemia	5C72	C03X	0.586	4	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Other specified cystic or dysplastic kidney disease	GB8Y	C03X	0.482	4	Yes
V2R	V₂ receptor	Vasopressin and oxytocin receptors	Peptide receptors	Class A	Syndrome of inappropriate secretion of antidiuretic hormone, unspecified	5A60.2Z	C03X	0.391	3	Yes

Showing 1 to 10 of 10 entries