GproteinDb

valsartan

Agent/drug
Bioactivity

valsartan

SMILES	CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C
InChIKey	ACWBQPMHZXGDFX-QFIPXVFZSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	10
Molecular weight (Da)	435.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pKi	5.33	6.92	8.52	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKi	8.27	8.27	8.27	Drug Central

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.80	8.75	9.00	Guide to Pharmacology
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	8.72	8.72	8.72	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	8.13	8.35	8.57	ChEMBL
AT₁	AGTRB	Rat	Angiotensin	A	pIC50	8.06	8.06	8.06	Drug Central
AT₁	AGTRA	Rat	Angiotensin	A	pIC50	8.07	8.07	8.07	Drug Central
AT₁	AGTRA	Rat	Angiotensin	A	pIC50	8.47	8.47	8.47	ChEMBL
BLT₂	LT4R2	Human	Leukotriene	A	pEC50	4.80	4.80	4.80	ChEMBL

Showing 1 to 7 of 7 entries

valsartan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 4

Phase III 10

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Acute ST elevation myocardial infarction	BA41.0	C09D, C09C, C10B	0.324	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Acute ischaemic heart disease, unspecified	BA4Z	C09D, C09C, C10B	0.081	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	C09D, C09C, C10B	0.474	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Aortic valve insufficiency, unspecified	BB71.Z	C09D, C09C, C10B	0.092	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Atrial fibrillation, unspecified	BC81.3Z	C09D, C09C, C10B	0.587	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Congestive heart failure	BD10	C09D, C09C, C10B	0.599	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Diseases of arteries or arterioles, unspecified	BD5Z	C09D, C09C, C10B	0.049	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Diseases of the urinary system, unspecified	GC2Z	C09D, C09C, C10B	0.317	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Essential hypertension, unspecified	BA00.Z	C09D, C09C, C10B	0.708	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Heart failure, unspecified	BD1Z	C09D, C09C, C10B	0.611	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Hypercholesterolaemia, unspecified	5C80.0Z	C09D, C09C, C10B	0.391	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Hypertrophic cardiomyopathy, unspecified	BC43.1Z	C09D, C09C, C10B	0.132	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Inborn errors of lipid metabolism, unspecified	5C52.Z	C09D, C09C, C10B	0.353	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Infectious myocarditis	BC42.1	C09D, C09C, C10B	0.259	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Other specified syndromic genetic deafness	LD2H.Y	C09D, C09C, C10B	0.074	2	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Pulmonary hypertension, unspecified	BB01.Z	C09D, C09C, C10B	0.329	3	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20	C09D, C09C, C10B	0.605	4	Yes
AGTR1	AT₁ receptor	Angiotensin receptors	Peptide receptors	Class A	Type 2 diabetes mellitus	5A11	C09D, C09C, C10B	0.592	3	Yes

Showing 1 to 18 of 18 entries

Join us

Cite us

Main reference

valsartan

valsartan

Chemical Properties

Database connections

Bioactivities

valsartan

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information