GproteinDb

DANAZOL

Agent/drug
Bioactivity

DANAZOL

SMILES	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C
InChIKey	POZRVZJJTULAOH-LHZXLZLDSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	0
Molecular weight (Da)	337.2

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.16	5.16	5.16	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.29	8.29	8.29	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	4.98	4.98	4.98	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.30	8.30	8.30	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	5.46	5.46	5.46	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.26	8.26	8.26	Drug Central
β₃	ADRB3	Human	Adrenoceptors	A	pKi	4.89	4.89	4.89	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	8.31	8.31	8.31	Drug Central
κ	OPRK	Human	Opioid	A	pKi	5.21	5.21	5.21	ChEMBL
κ	OPRK	Human	Opioid	A	pKi	8.28	8.28	8.28	Drug Central
μ	OPRM	Human	Opioid	A	pKi	5.24	5.24	5.24	ChEMBL
μ	OPRM	Human	Opioid	A	pKi	8.28	8.28	8.28	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.60	5.60	5.60	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.25	8.25	8.25	Drug Central
A₃	AA3R	Human	Adenosine	A	pKi	5.20	5.20	5.20	ChEMBL
A₃	AA3R	Human	Adenosine	A	pKi	8.28	8.28	8.28	Drug Central
D₁	DRD1	Human	Dopamine	A	pKi	4.99	4.99	4.99	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	8.30	8.30	8.30	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	5.01	5.01	5.01	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.30	8.30	8.30	Drug Central

Showing 1 to 20 of 24 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	4.74	4.74	4.74	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	4.63	4.63	4.63	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	4.62	4.62	4.62	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pIC50	4.77	4.77	4.77	ChEMBL
κ	OPRK	Human	Opioid	A	pIC50	4.81	4.81	4.81	ChEMBL
μ	OPRM	Human	Opioid	A	pIC50	4.85	4.85	4.85	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.05	5.05	5.05	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	4.95	4.95	4.95	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	4.69	4.69	4.69	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	4.54	4.54	4.54	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	4.75	4.75	4.75	ChEMBL
NK₂	NK2R	Human	Tachykinin	A	pIC50	4.58	4.58	4.58	ChEMBL

Showing 1 to 12 of 12 entries

DANAZOL

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 6

Phase III 2

Approved Yes

Database connections

ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

GNRHR	GnRH₁ receptor	Gonadotrophin-releasing hormone receptors	Peptide receptors	Class A	Endometriosis of unspecified site	GA10.Z		0.601	4	Yes
GNRHR	GnRH₁ receptor	Gonadotrophin-releasing hormone receptors	Peptide receptors	Class A	Malignant neoplasms of corpus uteri, unspecified	2C76.Z		0.259	2	Yes
GNRHR	GnRH₁ receptor	Gonadotrophin-releasing hormone receptors	Peptide receptors	Class A	Other specified diseases of the genitourinary system	GC8Y		0.688	3	Yes

Showing 1 to 3 of 3 entries