GproteinDb

WAY-181187

Agent/drug
Bioactivity

WAY-181187

SMILES	NCCc1cn(S(=O)(=O)c2c(Cl)nc3sccn23)c2ccccc12
InChIKey	RYBOXBBYCVOYNO-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	7
Hydrogen bond donors	1
Rotatable bonds	4
Molecular weight (Da)	380.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	5.96	5.96	5.96	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.31	5.31	5.31	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.82	6.82	6.82	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.25	6.25	6.25	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.67	6.67	6.67	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.96	6.96	6.96	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.34	6.34	6.34	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.75	6.83	6.91	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.70	8.70	8.70	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.66	8.71	8.85	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	5.84	6.00	6.17	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.78	5.78	5.78	ChEMBL
H₃	HRH3	Human	Histamine	A	pKi	5.70	5.70	5.70	ChEMBL

Showing 1 to 13 of 13 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.00	5.00	5.00	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	5.53	5.53	5.53	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pEC50	8.19	8.19	8.19	ChEMBL
ADGRF1	AGRF1	Human	ADGRF	B2	pIC50	5.39	5.39	5.39	ChEMBL
apelin	APJ	Human	Apelin	A	pIC50	5.41	5.41	5.41	ChEMBL
C5a₁	C5AR1	Human	Complement peptide	A	pIC50	5.27	5.27	5.27	ChEMBL
CX₃CR1	CX3C1	Human	Chemokine	A	pIC50	5.53	5.53	5.53	ChEMBL
FPR3	FPR3	Human	Formylpeptide	A	pIC50	5.46	5.46	5.46	ChEMBL
GLP-1	GLP1R	Human	Glucagon	B1	pIC50	5.52	5.52	5.52	ChEMBL
GPR119	GP119	Human	GPR18, GPR55 and GPR119	A	pIC50	5.29	5.29	5.29	ChEMBL
GPR183	GP183	Human	A orphans	A	pIC50	5.37	5.37	5.37	ChEMBL
GPR35	GPR35	Human	A orphans	A	pIC50	5.28	5.28	5.28	ChEMBL
GPR65	PSYR	Human	A orphans	A	pIC50	5.53	5.53	5.53	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	5.37	5.37	5.37	ChEMBL
S1P₁	S1PR1	Human	Lysophospholipid (S1P)	A	pIC50	5.40	5.40	5.40	ChEMBL

Showing 1 to 15 of 15 entries

WAY-181187

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb

Compound is not listed as a drug.