GproteinDb

ZD-7155

Agent/drug
Bioactivity

ZD-7155

SMILES	CCc1cc2c(c(CC)n1)CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
InChIKey	BFVNEYDCFJNLGN-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	438.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4YAY

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

μ	OPRM	Human	Opioid	A	pKi	5.20	5.20	5.20	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pKi	9.30	9.30	9.30	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	6.57	6.57	6.57	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	6.26	6.26	6.26	ChEMBL

Showing 1 to 4 of 4 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

AT₁	AGTR1	Guinea pig	Angiotensin	A	pIC50	8.42	8.42	8.42	Guide to Pharmacology
AT₁	AGTR1	Guinea pig	Angiotensin	A	pIC50	8.42	8.42	8.42	ChEMBL
AT₁	AGTR1	Human	Angiotensin	A	pIC50	9.22	9.22	9.22	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.70	4.70	4.70	ChEMBL

Showing 1 to 4 of 4 entries

ZD-7155

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Structure pdb	4YAY

Compound is not listed as a drug.