GproteinDb

atenolol

Agent/drug
Bioactivity

atenolol

SMILES	CC(C)NCC(O)COc1ccc(CC(N)=O)cc1
InChIKey	METKIMKYRPQLGS-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	3
Rotatable bonds	8
Molecular weight (Da)	266.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.70	7.15	7.60	Guide to Pharmacology
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.82	6.38	6.82	ChEMBL
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	7.01	7.01	7.01	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pKd	8.12	8.12	8.12	Drug Central
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.41	6.41	6.41	PDSP Ki database
β₁	B0FL73	Guinea pig	Adrenoceptors	A	pKd	6.80	7.35	7.62	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.60	5.80	6.00	Guide to Pharmacology
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.01	5.02	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKd	5.92	6.25	6.58	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.09	5.09	5.09	PDSP Ki database
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.55	5.55	5.55	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKd	8.24	8.24	8.24	Drug Central
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKd	8.23	8.23	8.23	Drug Central
β₂	ADRB2	Guinea pig	Adrenoceptors	A	pKd	5.90	5.92	5.93	ChEMBL
β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.30	8.30	8.30	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 21 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Rat	Adrenoceptors	A	pA2	6.80	6.80	6.80	Guide to Pharmacology
β₁	ADRB1	Human	Adrenoceptors	A	pIC50	5.76	6.54	8.75	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pIC50	4.83	4.83	4.83	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	8.06	8.06	8.06	Drug Central

Showing 1 to 4 of 4 entries

atenolol

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 1

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	β₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute myocardial infarction, unspecified	BA41.Z	C07C, C07F, C07A, C07B, C07D	0.601	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Angina pectoris, unspecified	BA40.Z	C07C, C07F, C07A, C07B, C07D	0.605	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Coronary atherosclerosis, unspecified site	BA52.Z	C07C, C07F, C07A, C07B, C07D	0.541	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	C07C, C07F, C07A, C07B, C07D	0.665	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Marfan syndrome	LD28.01	C07C, C07F, C07A, C07B, C07D	0.503	4	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neoplastic haemangioma, unspecified site	2E81.0Z	C07C, C07F, C07A, C07B, C07D	0.584	3	Yes
ADRB1	β₁-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Stroke not known if ischaemic or haemorrhagic	8B20	C07C, C07F, C07A, C07B, C07D	0.588	4	Yes

Showing 1 to 7 of 7 entries