AZD8529


SMILES Cc1cc(cc2c1C(=O)N(C2)Cc1ccc(cc1)OC(F)(F)F)c1onc(n1)CN1CCNCC1
InChIKey IPCYZQQFECEHLI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 487.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 6.43 6.43 6.43 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKd 6.22 6.22 6.22 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 6.71 6.71 6.71 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 6.25 6.48 6.71 ChEMBL