GproteinDb

biphenylindanone A

Agent/drug
Bioactivity

biphenylindanone A

SMILES	Cc1c(OCc2cccc(-c3ccc(C(=O)O)cc3)c2)cc2c(c1C)C(=O)C(C1CCCC1)C2
InChIKey	KMKBEESNZAPKMP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	6
Molecular weight (Da)	454.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	mGlu₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₃	ADRB3	Human	Adrenoceptors	A	pKi	5.30	5.30	5.30	ChEMBL
mGlu₂	GRM2	Human	Metabotropic glutamate	C	pKi	7.22	7.22	7.22	ChEMBL
mGlu₂	GRM2	Human	Metabotropic glutamate	C	pKd	6.72	6.72	6.72	ChEMBL

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

GPR183	GP183	Human	A orphans	A	pIC50	5.35	5.35	5.35	ChEMBL
mGlu₂	GRM2	Human	Metabotropic glutamate	C	pEC50	7.00	7.00	7.00	Guide to Pharmacology
mGlu₂	GRM2	Human	Metabotropic glutamate	C	pEC50	7.03	7.29	7.56	ChEMBL
mGlu₂	GRM2	Rat	Metabotropic glutamate	C	pEC50	6.36	6.40	6.42	ChEMBL

Showing 1 to 4 of 4 entries

biphenylindanone A

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Distribution across phases (no. indications)

Phase I 0

Phase II 0

Phase III 0

Phase IV

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids GPCRdb
Ligand site mutations	mGlu₂

Compound is not listed as a drug.