CHEMBL1774535


SMILES O=C(NCCC(F)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1
InChIKey VIHBCLOGDPFGGP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 7
Molecular weight (Da) 462.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 5.47 5.47 5.47 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.4 8.4 8.4 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.67 6.67 6.67 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.65 6.65 6.65 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.28 6.28 6.28 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 5.91 6.1 6.28 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 5.67 5.67 5.67 ChEMBL