compound 23 [PMID: 17590335]


SMILES N#Cc1cc(F)cc(c1)c1ccc2c(c1)nc(cc2)C
InChIKey SDOLISUYGVMVBK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Molecular weight (Da) 262.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.66 7.66 7.66 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pKi 7.66 7.66 7.66 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 9.1 9.1 9.1 Guide to Pharmacology
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 9.1 9.1 9.1 ChEMBL