BENZAMIL


SMILES N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1
InChIKey KXDROGADUISDGY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 3
Molecular weight (Da) 319.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pKi 5.96 5.96 5.96 PDSP Ki database
A1 AA1R Rat Adenosine A pKi 6.01 6.01 6.01 PDSP Ki database
CCK2 GASR Rat Cholecystokinin A pKi 5.0 5.0 5.0 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 5.24 5.24 5.24 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.72 5.72 5.72 PDSP Ki database
κ OPRK Rat Opioid A pKi 5.0 5.0 5.0 PDSP Ki database
A1 AA1R Bovine Adenosine A pKi 6.19 6.19 6.19 PDSP Ki database
H1 HRH1 Rat Histamine A pKi 5.49 5.49 5.49 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.12 5.12 5.12 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 5.54 5.54 5.54 PDSP Ki database
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 5.55 5.55 5.55 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 4.82 4.85 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL