ADOPRAZINE


SMILES Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1
InChIKey IUVSEUFHPNITEQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 405.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.9 7.9 7.9 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.0 8.0 8.0 ChEMBL
D2 DRD2 Rat Dopamine A pKi 8.4 8.4 8.4 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.64 8.64 8.64 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 9.1 9.1 9.1 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.4 8.4 8.4 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.4 8.4 8.4 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 8.23 8.23 8.23 ChEMBL