fluperlapine


SMILES CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2
InChIKey OBWGMKKHCLHVIE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 309.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.3 7.4 7.5 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.8 7.8 7.8 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Guide to Pharmacology
D1 DRD1 Rat Dopamine A pKi 6.85 6.85 6.85 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.88 6.88 6.88 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.78 7.78 7.78 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.34 8.34 8.34 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.54 7.54 7.54 PDSP Ki database
D4 DRD4 Rat Dopamine A pKi 6.89 6.89 6.89 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 6.5 6.5 6.5 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.7 7.73 7.74 PDSP Ki database
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.39 7.39 7.39 PDSP Ki database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.06 8.06 8.06 PDSP Ki database
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.15 7.15 7.15 PDSP Ki database
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 7.77 7.77 7.77 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 7.68 7.68 7.68 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 6.61 6.61 6.61 PDSP Ki database
D1 DRD1 Mouse Dopamine A pKi 7.07 7.07 7.07 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 7.85 7.85 7.85 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database