CHEMBL2312640


SMILES O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12
InChIKey HNYKNGYYMXLUFG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 492.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.68 7.68 7.68 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.66 6.66 6.66 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.23 7.23 7.23 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.05 7.05 7.05 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.1 8.1 8.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 6.09 6.09 6.09 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 4.82 4.82 4.82 ChEMBL