GproteinDb

cetirizine

Agent/drug
Bioactivity

cetirizine

SMILES	O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
InChIKey	ZKLPARSLTMPFCP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	8
Molecular weight (Da)	388.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

No bioactivity data available.

cetirizine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 1

Phase II 2

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	H₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	R06A, S01G	0.589	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A, S01G	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A, S01G	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z	R06A, S01G	0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Alopecia, unspecified	ED70.Z	R06A, S01G	0.195	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Atopic eczema, unspecified	EA80.Z	R06A, S01G	0.474	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	COVID-19	RA01	R06A, S01G	0.486	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Chronic rhinitis	CA09.0	R06A, S01G	0.571	2	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Dermatitis or eczema, unspecified	EA8Z	R06A, S01G	0.375	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Neuromyelitis optica, unspecified	8A43.Z	R06A, S01G	0.037	1	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Other allergic rhinitis	CA08.03	R06A, S01G	0.602	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Pruritus, unspecified	EC90.Z	R06A, S01G	0.602	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05	R06A, S01G	0.606	4	Yes

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