CHEMBL2376804


SMILES CNC1CN(c2nc(N)nc3cc(C4CC4)cnc23)C1
InChIKey KICLSPYVVBSUFF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 270.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pKi 7.82 7.82 7.82 ChEMBL
H4 HRH4 Rat Histamine A pKi 7.53 7.53 7.53 ChEMBL
H4 HRH4 Human Histamine A pKd 7.87 7.87 7.87 ChEMBL
H4 HRH4 Human Histamine A pKi 8.28 8.28 8.28 ChEMBL
H1 HRH1 Human Histamine A pKi 4.68 4.68 4.68 ChEMBL
H3 HRH3 Human Histamine A pKi 6.2 6.2 6.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pIC50 7.15 7.15 7.15 ChEMBL