MGS0039


SMILES OC(=O)[C@]1(N)[C@H](OCc2ccc(c(c2)Cl)Cl)C[C@@H]2[C@H]1[C@@]2(F)C(=O)O
InChIKey LFAGGDAZZKUVKO-JAGWWQSPSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 5
Molecular weight (Da) 377.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 8.3 8.35 8.4 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 8.6 8.65 8.7 Guide to Pharmacology
mGlu7 GRM7 Rat Metabotropic glutamate C pKi 6.18 6.18 6.18 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.35 8.35 8.35 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 8.35 8.35 8.35 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 8.62 8.62 8.62 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.66 8.66 8.66 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu6 GRM6 Rat Metabotropic glutamate C pIC50 5.69 5.69 5.69 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pIC50 5.76 5.76 5.76 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 7.62 7.62 7.62 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pIC50 7.62 7.62 7.62 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 4.03 4.03 4.03 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pIC50 7.7 7.7 7.7 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 7.7 7.7 7.7 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 4.93 4.93 4.93 ChEMBL