GproteinDb

clonidine

Agent/drug
Bioactivity

clonidine

SMILES	Clc1cccc(Cl)c1NC1=NCCN1
InChIKey	GJSURZIOUXUGAL-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	2
Rotatable bonds	1
Molecular weight (Da)	229.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A α_1B α_2A α_2B

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pKd	6.59	6.59	6.59	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	6.82	6.82	6.82	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	6.01	6.18	6.29	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKd	8.18	8.18	8.18	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.99	5.99	5.99	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	6.50	6.50	6.50	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.19	8.19	8.19	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	5.58	5.58	5.58	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	6.50	6.50	6.50	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.60	5.60	5.60	Guide to Pharmacology
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	6.90	6.90	6.90	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	5.70	5.96	6.22	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	6.50	6.70	6.90	PDSP Ki database
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	7.00	7.00	7.00	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.70	7.95	9.20	Guide to Pharmacology
α_2A	ADA2A	Rat	Adrenoceptors	A	pKi	6.07	8.30	9.41	ChEMBL

Showing 1 to 20 of 47 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	6.43	6.43	6.43	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pEC50	8.15	8.15	8.15	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pEC50	7.05	7.05	7.05	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.73	5.73	5.73	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	5.92	5.92	5.92	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	7.67	7.67	7.67	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.20	8.20	8.20	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pEC50	7.52	7.86	8.28	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	6.55	6.55	6.55	ChEMBL
α_2A	ADA2A	Bovine	Adrenoceptors	A	pIC50	8.70	8.70	8.70	ChEMBL
α_2A	ADA2A	Bovine	Adrenoceptors	A	pIC50	8.06	8.06	8.06	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	8.60	8.60	8.60	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	7.70	7.70	7.70	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	5.93	6.36	6.78	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.08	7.08	7.08	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	4.64	6.75	6.74	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	7.50	7.60	7.70	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	7.24	7.25	7.26	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pEC50	8.17	8.17	8.17	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.27	5.27	5.27	ChEMBL

Showing 1 to 20 of 23 entries

clonidine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 12

Phase II 18

Phase III 24

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	α_1A α_1B α_2A α_2B

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Anxiety	MB24.3	S01E, C02A, N02C, C02L	0.550	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Atopic eczema, unspecified	EA80.Z	S01E, C02A, N02C, C02L	0.037	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	S01E, C02A, N02C, C02L	0.609	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cannabis dependence, unspecified	6C41.2Z	S01E, C02A, N02C, C02L	0.107	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cerebral ischaemia, unspecified	8B1Z	S01E, C02A, N02C, C02L	0.042	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Cocaine dependence, unspecified	6C45.2Z	S01E, C02A, N02C, C02L	0.107	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Delirium, unspecified or unknown cause	6D70.Z	S01E, C02A, N02C, C02L	0.599	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Diabetic polyneuropathy	8C03.0	S01E, C02A, N02C, C02L	0.101	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Essential hypertension, unspecified	BA00.Z	S01E, C02A, N02C, C02L	0.600	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Faecal incontinence, unspecified	ME07.Z	S01E, C02A, N02C, C02L	0.281	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Glaucoma, unspecified	9C61.Z	S01E, C02A, N02C, C02L	0.597	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Haemorrhage, not elsewhere classified	MG27	S01E, C02A, N02C, C02L	0.549	1	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Injury or harm arising from surgical or medical care, not elsewhere classified, unspecified	NE8Z	S01E, C02A, N02C, C02L	0.549	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Intracranial injury, unspecified	NA07.Z	S01E, C02A, N02C, C02L	0.504	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Low back pain, unspecified	ME84.2Z	S01E, C02A, N02C, C02L	0.468	2	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Malignant neoplasms of male genital organs, unspecified	2C8Z	S01E, C02A, N02C, C02L	0.323	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	S01E, C02A, N02C, C02L	0.586	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Mild hyperemesis gravidarum	JA60.0	S01E, C02A, N02C, C02L	0.259	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neonatal withdrawal syndrome from maternal use of drugs of addiction	KD35	S01E, C02A, N02C, C02L	0.526	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Neuropathic pain, unspecified	8E43.0Z	S01E, C02A, N02C, C02L	0.374	4	Yes

Showing 1 to 20 of 72 entries

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clonidine

clonidine

Chemical Properties

Database connections

Bioactivities

clonidine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information