GproteinDb

clozapine

Agent/drug
Bioactivity

clozapine

SMILES	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1
InChIKey	QZUDBNBUXVUHMW-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	0
Molecular weight (Da)	326.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8JXV
Ligand site mutations	5-HT_2C 5-HT₆ 5-HT₇ D₁ D₂ D₄ H₄ M₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.10	8.20	8.30	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.66	7.74	7.82	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKd	7.43	7.43	7.43	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.72	7.81	8.00	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	6.20	7.63	8.50	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.09	8.09	8.09	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.40	7.80	8.20	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.54	7.88	8.45	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.00	8.00	8.00	ChEMBL
α_1B	A0A4X1U0M4	Pig	Adrenoceptors	A	pKi	7.40	7.40	7.40	PDSP Ki database
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.51	8.51	8.51	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.70	7.70	7.70	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.77	7.77	7.77	ChEMBL
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	8.11	8.11	8.11	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.72	8.58	8.80	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central

Showing 1 to 20 of 222 entries

…

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.42	7.42	7.42	ChEMBL
α_1A	ADA1A	Bovine	Adrenoceptors	A	pIC50	8.17	8.17	8.17	Drug Central
α_1A	ADA1A	Bovine	Adrenoceptors	A	pIC50	6.80	6.80	6.80	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	8.19	8.19	8.19	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	7.46	7.46	7.46	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	7.05	7.05	7.05	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.64	7.64	7.64	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	8.10	8.10	8.10	ChEMBL
5-HT_1A	5HT1A	Mouse	5-Hydroxytryptamine	A	pIC50	5.70	5.70	5.70	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	5.70	6.05	6.57	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pIC50	6.82	6.82	6.82	ChEMBL
5-HT_1A	5HT1A	Mouse	5-Hydroxytryptamine	A	pIC50	8.24	8.24	8.24	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	5.60	5.64	5.68	ChEMBL
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pIC50	8.25	8.25	8.25	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.92	8.15	8.38	ChEMBL
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pIC50	8.07	8.07	8.07	Drug Central
5-HT_2A	5HT2A	Bovine	5-Hydroxytryptamine	A	pIC50	8.52	8.52	8.52	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.96	7.96	7.96	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pEC50	7.70	7.70	7.70	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pIC50	7.96	7.96	7.96	ChEMBL

Showing 1 to 20 of 48 entries

clozapine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8JXV
Ligand site mutations	5-HT_2C 5-HT₆ 5-HT₇ D₁ D₂ D₄ H₄ M₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.609	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Disorders of intellectual development, unspecified	6A00.Z	N05A	0.360	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z	N05A	0.606	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.660	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Disorders of intellectual development, unspecified	6A00.Z	N05A	0.363	3	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizoaffective disorder, unspecified	6A21.Z	N05A	0.606	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.615	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.732	4	Yes

Showing 1 to 10 of 10 entries