BMS-182874


SMILES Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C
InChIKey MJRGSRRZKSJHOE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 345.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETA EDNRA Rat Endothelin A pKi 7.26 7.26 7.26 ChEMBL
ETA EDNRA Human Endothelin A pKi 7.26 7.29 7.32 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETA EDNRA Rat Endothelin A pIC50 7.82 7.82 7.82 ChEMBL
ETB EDNRB Human Endothelin A pIC50 4.85 4.85 4.85 ChEMBL
ETA EDNRA Human Endothelin A pIC50 6.24 7.08 8.24 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.8 4.8 ChEMBL