CHEMBL273921


SMILES O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1
InChIKey KOTITFQGTVUMBT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 422.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.65 8.65 8.65 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.83 5.83 5.83 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.62 5.62 5.62 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.65 8.65 8.65 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.91 5.91 5.91 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.63 6.63 6.63 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.32 6.32 6.32 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.48 5.48 5.48 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.32 6.32 6.32 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.52 6.52 6.52 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.77 5.77 5.77 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.63 6.63 6.63 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database