ENPROFYLLINE


SMILES CCCn1c(=O)[nH]c(=O)c2[nH]cnc21
InChIKey SIQPXVQCUCHWDI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 194.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A2A AA2AR Guinea pig Adenosine A pKi 4.04 4.04 4.04 ChEMBL
A1 AA1R Guinea pig Adenosine A pKi 4.22 4.22 4.22 ChEMBL
A3 AA3R Rat Adenosine A pKi 4.19 4.19 4.19 ChEMBL
A2A AA2AR Rat Adenosine A pKi 4.5 4.5 4.5 ChEMBL
A1 AA1R Rat Adenosine A pKi 4.09 4.28 4.5 ChEMBL
A2B AA2BR Human Adenosine A pKi 5.19 5.3 5.33 ChEMBL
A3 AA3R Human Adenosine A pKi 4.03 4.03 4.03 ChEMBL
A2A AA2AR Human Adenosine A pKi 4.09 4.64 5.33 ChEMBL
A1 AA1R Human Adenosine A pKi 4.36 4.37 4.38 ChEMBL
A1 AA1R Rat Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
A1 AA1R Human Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
A2A AA2AR Human Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
A2B AA2BR Human Adenosine A pKi 5.19 5.19 5.2 PDSP Ki database
A3 AA3R Human Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
A1 AA1R Bovine Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
A3 AA3R Rat Adenosine A pKi 5.0 5.0 5.0 PDSP Ki database
A2A AA2AR Human Adenosine A pKi 8.35 8.35 8.35 Drug Central
A2B AA2BR Human Adenosine A pKi 8.27 8.27 8.27 Drug Central
A3 AA3R Human Adenosine A pKi 8.39 8.39 8.39 Drug Central
A1 AA1R Rat Adenosine A pKi 8.35 8.35 8.35 Drug Central
A1 AA1R Guinea pig Adenosine A pKi 8.37 8.37 8.37 Drug Central
A3 AA3R Rat Adenosine A pKi 8.38 8.38 8.38 Drug Central
A2A AA2AR Guinea pig Adenosine A pKi 8.39 8.39 8.39 Drug Central
A2A AA2AR Rat Adenosine A pKi 8.35 8.35 8.35 Drug Central
A1 AA1R Human Adenosine A pKi 8.36 8.36 8.36 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
A2A AA2AR Human Adenosine A pEC50 5.14 5.14 5.14 ChEMBL