GproteinDb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

α-ergocryptine	358	None	18	Rat	Binding	Ki	=	5.02	8.30	-5	21	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)	ChEMBL	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-ergocryptine	358	None	18	Rat	Binding	pKi	=	8.30	8.08	-5	21	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)	Drug Central	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-ergocryptine	358	None	18	Rat	Binding	IC50	=	8.20	8.09	-5	21	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)	ChEMBL	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-methyl-5-HT	364	None	24	Human	Binding	Ki	=	250.00	6.60	-33	19	Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor beta	ChEMBL	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://dx.doi.org/10.1021/jm950498t
α-methyl-5-HT	364	None	24	Rat	Binding	Ki	=	1000.00	6.00	-57	19	Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand.	ChEMBL	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://dx.doi.org/10.1021/jm00384a001
α-methyl-5-HT	364	None	24	Rat	Binding	Ki	=	85.00	7.07	-57	19	Binding affinity was determined against 5-hydroxytryptamine 1B receptor was determined in male Sprague-Dawley rat brain.	ChEMBL	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	https://dx.doi.org/10.1021/jm00164a046
α-methyl-5-HT	364	125I-CYP	24	Rat	Binding	pKi	=	1000.00	6.00	-57	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
α-methyl-5-HT	364	125I-CYP	24	Rat	Binding	pKi	=	1000.00	6.00	-57	19	-	PDSP KiDatabase	190.1	2	3	2	1.76	CC(N)Cc1c[nH]c2ccc(O)cc12	-
(+)-WAY 100135	4070	None	6	Human	Binding	pKi	None	-	5.80	-1258	5	Unclassified	Guide to Pharmacology	395.3	6	1	4	3.52	COc1ccccc1N1CCN(C[C@@H](C(=O)NC(C)(C)C)c2ccccc2)CC1	https://pubmed.ncbi.nlm.nih.gov/9208142
(-)-pindolol	3126	3H-5HT	37	Rat	Binding	pKi	=	77.60	7.11	-95	15	-	PDSP KiDatabase	248.2	6	3	3	1.91	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12	-
(-)-pindolol	3126	125I-CYP	37	Rat	Binding	pKi	=	64.60	7.19	-95	15	-	PDSP KiDatabase	248.2	6	3	3	1.91	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12	-
(-)-pindolol	3126	125I-ICYP	37	Rat	Binding	pKi	=	24.00	7.62	-95	15	-	PDSP KiDatabase	248.2	6	3	3	1.91	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12	-
(-)-pindolol	3126	3H-GR-125743	37	Rat	Binding	pKi	=	25.12	7.60	-95	15	-	PDSP KiDatabase	248.2	6	3	3	1.91	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12	-
(-)-pindolol	3126	None	37	Mouse	Binding	pKi	None	-	8.10	-18	15	Unclassified	Guide to Pharmacology	248.2	6	3	3	1.91	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12	https://pubmed.ncbi.nlm.nih.gov/1557407
(-)-pindolol	3126	3H-GR-125743	37	Guinea pig	Binding	pKi	=	1479.11	5.83	-3388	15	-	PDSP KiDatabase	248.2	6	3	3	1.91	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12	-
(-)-propranolol	3187	3H-5HT	44	Human	Binding	pKi	=	2691.53	5.57	-1174	34	-	PDSP KiDatabase	259.2	6	2	3	2.58	CC(C)NC[C@H](O)COc1cccc2ccccc12	-
(-)-propranolol	3187	3H-5HT	44	Human	Binding	pKi	=	10000.00	5.00	-1174	34	-	PDSP KiDatabase	259.2	6	2	3	2.58	CC(C)NC[C@H](O)COc1cccc2ccccc12	-
(-)-propranolol	3187	3H-5HT	44	Human	Binding	pKi	=	630.95	6.20	-1174	34	-	PDSP KiDatabase	259.2	6	2	3	2.58	CC(C)NC[C@H](O)COc1cccc2ccccc12	-
(-)-propranolol	3187	3H-5HT	44	Human	Binding	pKi	=	10000.00	5.00	-1174	34	-	PDSP KiDatabase	259.2	6	2	3	2.58	CC(C)NC[C@H](O)COc1cccc2ccccc12	-
(-)-propranolol	3187	None	44	Human	Binding	pKi	=	6.20	8.21	-1174	34	None	Drug Central	259.2	6	2	3	2.58	CC(C)NC[C@H](O)COc1cccc2ccccc12	-

Showing 1 to 20 of 2,728 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)