Initializing potency table...
Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
α-ergocryptine | 358 | None | 18 | Rat | Binding | Ki | = | 5.02 | 8.30 | -5 | 21 | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL | 575.3 | 5 | 3 | 6 | 2.43 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | - | |
α-ergocryptine | 358 | None | 18 | Rat | Binding | pKi | = | 8.30 | 8.08 | -5 | 21 | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) | Drug Central | 575.3 | 5 | 3 | 6 | 2.43 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | - | |
α-ergocryptine | 358 | None | 18 | Rat | Binding | IC50 | = | 8.20 | 8.09 | -5 | 21 | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL | 575.3 | 5 | 3 | 6 | 2.43 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | - | |
α-methyl-5-HT | 364 | None | 24 | Human | Binding | Ki | = | 250.00 | 6.60 | -33 | 19 | Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor beta | ChEMBL | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | https://dx.doi.org/10.1021/jm950498t | |
α-methyl-5-HT | 364 | None | 24 | Rat | Binding | Ki | = | 1000.00 | 6.00 | -57 | 19 | Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. | ChEMBL | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | https://dx.doi.org/10.1021/jm00384a001 | |
α-methyl-5-HT | 364 | None | 24 | Rat | Binding | Ki | = | 85.00 | 7.07 | -57 | 19 | Binding affinity was determined against 5-hydroxytryptamine 1B receptor was determined in male Sprague-Dawley rat brain. | ChEMBL | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | https://dx.doi.org/10.1021/jm00164a046 | |
α-methyl-5-HT | 364 | 125I-CYP | 24 | Rat | Binding | pKi | = | 1000.00 | 6.00 | -57 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
α-methyl-5-HT | 364 | 125I-CYP | 24 | Rat | Binding | pKi | = | 1000.00 | 6.00 | -57 | 19 | - | PDSP KiDatabase | 190.1 | 2 | 3 | 2 | 1.76 | CC(N)Cc1c[nH]c2ccc(O)cc12 | - | |
(+)-WAY 100135 | 4070 | None | 6 | Human | Binding | pKi | None | - | 5.80 | -1258 | 5 | Unclassified | Guide to Pharmacology | 395.3 | 6 | 1 | 4 | 3.52 | COc1ccccc1N1CCN(C[C@@H](C(=O)NC(C)(C)C)c2ccccc2)CC1 | https://pubmed.ncbi.nlm.nih.gov/9208142 | |
(-)-pindolol | 3126 | 3H-5HT | 37 | Rat | Binding | pKi | = | 77.60 | 7.11 | -95 | 15 | - | PDSP KiDatabase | 248.2 | 6 | 3 | 3 | 1.91 | CC(C)NC[C@H](O)COc1cccc2[nH]ccc12 | - | |
(-)-pindolol | 3126 | 125I-CYP | 37 | Rat | Binding | pKi | = | 64.60 | 7.19 | -95 | 15 | - | PDSP KiDatabase | 248.2 | 6 | 3 | 3 | 1.91 | CC(C)NC[C@H](O)COc1cccc2[nH]ccc12 | - | |
(-)-pindolol | 3126 | 125I-ICYP | 37 | Rat | Binding | pKi | = | 24.00 | 7.62 | -95 | 15 | - | PDSP KiDatabase | 248.2 | 6 | 3 | 3 | 1.91 | CC(C)NC[C@H](O)COc1cccc2[nH]ccc12 | - | |
(-)-pindolol | 3126 | 3H-GR-125743 | 37 | Rat | Binding | pKi | = | 25.12 | 7.60 | -95 | 15 | - | PDSP KiDatabase | 248.2 | 6 | 3 | 3 | 1.91 | CC(C)NC[C@H](O)COc1cccc2[nH]ccc12 | - | |
(-)-pindolol | 3126 | None | 37 | Mouse | Binding | pKi | None | - | 8.10 | -18 | 15 | Unclassified | Guide to Pharmacology | 248.2 | 6 | 3 | 3 | 1.91 | CC(C)NC[C@H](O)COc1cccc2[nH]ccc12 | https://pubmed.ncbi.nlm.nih.gov/1557407 | |
(-)-pindolol | 3126 | 3H-GR-125743 | 37 | Guinea pig | Binding | pKi | = | 1479.11 | 5.83 | -3388 | 15 | - | PDSP KiDatabase | 248.2 | 6 | 3 | 3 | 1.91 | CC(C)NC[C@H](O)COc1cccc2[nH]ccc12 | - | |
(-)-propranolol | 3187 | 3H-5HT | 44 | Human | Binding | pKi | = | 2691.53 | 5.57 | -1174 | 34 | - | PDSP KiDatabase | 259.2 | 6 | 2 | 3 | 2.58 | CC(C)NC[C@H](O)COc1cccc2ccccc12 | - | |
(-)-propranolol | 3187 | 3H-5HT | 44 | Human | Binding | pKi | = | 10000.00 | 5.00 | -1174 | 34 | - | PDSP KiDatabase | 259.2 | 6 | 2 | 3 | 2.58 | CC(C)NC[C@H](O)COc1cccc2ccccc12 | - | |
(-)-propranolol | 3187 | 3H-5HT | 44 | Human | Binding | pKi | = | 630.95 | 6.20 | -1174 | 34 | - | PDSP KiDatabase | 259.2 | 6 | 2 | 3 | 2.58 | CC(C)NC[C@H](O)COc1cccc2ccccc12 | - | |
(-)-propranolol | 3187 | 3H-5HT | 44 | Human | Binding | pKi | = | 10000.00 | 5.00 | -1174 | 34 | - | PDSP KiDatabase | 259.2 | 6 | 2 | 3 | 2.58 | CC(C)NC[C@H](O)COc1cccc2ccccc12 | - | |
(-)-propranolol | 3187 | None | 44 | Human | Binding | pKi | = | 6.20 | 8.21 | -1174 | 34 | None | Drug Central | 259.2 | 6 | 2 | 3 | 2.58 | CC(C)NC[C@H](O)COc1cccc2ccccc12 | - |
Showing 1 to 20 of 2,728 entries
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name |
GPCRdb ID |
Reference ligand |
Vendors | Species | Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI | |