Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL75642 5ht1d_cavpo Guinea pig No 10.4 EC50 = 0.0 Funct
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra
355 3 1 3 3.8 CN1CCCC1CC2=CNC3=C2C=C(C=C3)N4C=NC5=C4C=CC(=C5)C#N
CHEMBL65367 5ht1d_human Human No 10.0 EC50 = 0.1 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL65367 5ht1d_human Human No 10.0 EC50 = 0.1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL63167 5ht1d_human Human No 9.7 EC50 = 0.2 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
486 7 1 7 5.4 C1CN(CCC1(CC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL163462 5ht1d_human Human No 9.7 EC50 = 0.2 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
444 8 2 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(C5=CC=CC=C5)C(=O)N
CHEMBL161176 5ht1d_human Human No 9.7 EC50 = 0.2 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
458 8 2 5 2.3 CC(=O)NC1=CC=CC(=C1)CN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL65367 5ht1d_human Human No 9.7 EC50 = 0.2 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL357034 5ht1d_human Human Yes 9.7 EC50 = 0.2 Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
230 4 2 1 3.2 CC(C)(C)C1=CC2=C(C=C1)NC=C2CCNC
CHEMBL352234 5ht1d_human Human No 9.6 EC50 = 0.2 Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.24-0.55
409 7 2 5 2.4 COC1=CC=CC(=C1)N2CCN(CC2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN
CHEMBL138872 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor
304 4 1 3 2.1 CN(C)CCN1C=CC2=C1C=C(C=C2)C3(CCSCC3)O
CHEMBL164046 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
429 8 2 4 3.6 CC(C)(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161723 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
419 7 1 5 3.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)F
CHEMBL163573 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=N5
CHEMBL162722 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
429 8 1 4 4.0 CC(CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=CC=CC=C5
CHEMBL163386 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
431 8 2 5 2.5 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL164111 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
390 7 1 5 2.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=COC=C5
CHEMBL422366 5ht1d_human Human No 9.5 EC50 = 0.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CN=CC=C5
CHEMBL296161 5ht1d_human Human No 9.4 EC50 = 0.4 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL294732 5ht1d_human Human No 9.4 EC50 = 0.4 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL296161 5ht1d_human Human No 9.4 EC50 = 0.4 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL421064 5ht1d_human Human No 9.4 EC50 = 0.5 Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells
378 6 2 4 2.5 C1CN(CCN1C2=CC=CC=C2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN
CHEMBL296161 5ht1d_human Human No 9.4 EC50 = 0.5 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL294732 5ht1d_human Human No 9.3 EC50 = 0.5 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146285 5ht1d_human Human No 9.3 EC50 = 0.5 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
447 8 2 5 4.0 CC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL83426 5ht1d_human Human No 9.3 EC50 = 0.5 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
413 5 1 4 3.3 CN1C(CC2C1CN(C2)CC3=CC=CC=C3)CC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL160070 5ht1d_human Human No 9.3 EC50 = 0.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
447 9 3 4 4.0 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL162805 5ht1d_human Human No 9.3 EC50 = 0.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
390 7 1 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CO5
CHEMBL490417 5ht1d_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL490417 5ht1d_human Human No 9.3 EC50 = 0.5 Funct
Agonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assayAgonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL294547 5ht1d_human Human No 9.2 EC50 = 0.6 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL294547 5ht1d_human Human No 9.2 EC50 = 0.6 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL120055 5ht1d_human Human No 9.2 EC50 = 0.6 Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 0.6-2.0
393 6 2 4 2.8 CC1=CC=CC=C1N2CCN(CC2)C(=O)COC3=CC4=C(C=C3)NC=C4CCN
CHEMBL116153 5ht1d_human Human No 9.2 EC50 = 0.6 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC(=C5)F)F
CHEMBL159396 5ht1d_human Human No 9.2 EC50 = 0.6 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
388 6 1 6 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=NC=CC=N5
CHEMBL159759 5ht1d_human Human No 9.2 EC50 = 0.6 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
415 8 2 4 3.4 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL119668 5ht1d_human Human No 9.2 EC50 = 0.7 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=C(C=C5)F)F
CHEMBL420965 5ht1d_human Human Yes 9.1 EC50 = 0.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL313714 5ht1d_human Human Yes 9.1 EC50 = 0.8 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1d_human Human Yes 9.1 EC50 = 0.8 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1d_human Human Yes 9.1 EC50 = 0.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL164035 5ht1d_human Human No 9.1 EC50 = 0.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
472 8 1 5 2.9 CN(C)C(=O)C(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL145815 5ht1d_human Human No 9.1 EC50 = 0.9 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 10 2 5 3.4 COCC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL333341 5ht1d_human Human No 9.1 EC50 = 0.9 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
443 9 1 4 4.1 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL333341 5ht1d_human Human No 9.1 EC50 = 0.9 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
443 9 1 4 4.1 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL117633 5ht1d_human Human No 9.1 EC50 = 0.9 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
415 8 1 4 3.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL420965 5ht1d_human Human Yes 9.0 EC50 = 0.9 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1290716 5ht1d_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
413 4 0 4 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)N(C5=CC=C4)C
CHEMBL1290716 5ht1d_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
413 4 0 4 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)N(C5=CC=C4)C
CHEMBL143947 5ht1d_human Human No 9.0 EC50 = 1 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL292779 5ht1d_human Human No 9.0 EC50 = 1 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL162858 5ht1d_human Human No 9.0 EC50 = 1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=NC=C5
CHEMBL292779 5ht1d_human Human No 9.0 EC50 = 1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL313714 5ht1d_human Human Yes 9.0 EC50 = 1.1 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL313714 5ht1d_human Human Yes 9.0 EC50 = 1.1 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL313714 5ht1d_human Human Yes 9.0 EC50 = 1.1 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL347665 5ht1d_human Human No 9.0 EC50 = 1.1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
426 7 1 5 2.9 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)C#N
CHEMBL292779 5ht1d_human Human No 8.9 EC50 = 1.2 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL292779 5ht1d_human Human No 8.9 EC50 = 1.2 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL292779 5ht1d_human Human No 8.9 EC50 = 1.2 Funct
Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL85668 5ht1d_human Human No 8.9 EC50 = 1.2 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
412 5 1 3 3.9 CN1C(CC2C1CN(C2)CC3=CC=CC=C3)CC4=CNC5=C4C=C(C=C5)N6C=CN=C6
CHEMBL161696 5ht1d_human Human No 8.9 EC50 = 1.2 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
435 7 1 4 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)Cl
CHEMBL356808 5ht1d_human Human No 8.9 EC50 = 1.3 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
455 8 2 4 4.1 C1CC2=CC=CC=C2C1NCC3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL84107 5ht1d_rat Rat No 8.9 EC50 = 1.3 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
337 4 3 5 3.6 C1CC(NC1)CC2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL83597 5ht1d_rat Rat Yes 8.9 EC50 = 1.3 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
351 4 2 5 4.1 CN1CCCC1CC2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL349185 5ht1d_human Human No 8.9 EC50 = 1.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
390 8 2 5 2.0 C1CN(CC1CNCC2=COC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL116031 5ht1d_human Human No 8.9 EC50 = 1.4 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5F
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.5 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.5 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL331970 5ht1d_human Human No 8.8 EC50 = 1.5 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL115750 5ht1d_human Human No 8.8 EC50 = 1.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=C(C=C5)F
CHEMBL116031 5ht1d_human Human No 8.8 EC50 = 1.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5F
CHEMBL117579 5ht1d_human Human No 8.8 EC50 = 1.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
415 8 1 4 3.4 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL115750 5ht1d_human Human No 8.8 EC50 = 1.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=C(C=C5)F
CHEMBL1278 5ht1d_human Human Yes 8.8 EC50 = 1.6 Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
335 5 2 4 2.0 CNS(=O)(=O)CCC1=CC2=C(C=C1)NC=C2C3CCN(CC3)C
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.6 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL64004 5ht1d_human Human No 8.8 EC50 = 1.6 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=C(C=C5)F
CHEMBL304857 5ht1d_human Human No 8.8 EC50 = 1.6 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL117579 5ht1d_human Human No 8.8 EC50 = 1.6 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
415 8 1 4 3.4 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL333089 5ht1d_human Human No 8.8 EC50 = 1.6 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
472 9 2 5 2.8 CC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL88893 5ht1d_human Human No 8.8 EC50 = 1.7 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
481 9 3 7 3.0 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL118012 5ht1d_human Human No 8.8 EC50 = 1.7 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159483 5ht1d_human Human No 8.8 EC50 = 1.7 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
433 9 3 4 3.6 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL117633 5ht1d_human Human No 8.8 EC50 = 1.7 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
415 8 1 4 3.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL348962 5ht1d_human Human No 8.8 EC50 = 1.7 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
444 9 2 5 2.8 CNCC(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL148233 5ht1d_human Human No 8.8 EC50 = 1.8 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
407 8 1 4 4.0 CC(=CCN(C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C
CHEMBL118012 5ht1d_human Human No 8.8 EC50 = 1.8 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL351303 5ht1d_human Human No 8.8 EC50 = 1.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
431 9 3 5 2.3 C1CN(CC1CNC(CO)C2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL119785 5ht1d_human Human No 8.8 EC50 = 1.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
472 9 2 5 2.8 CC(=O)NC1=CC=C(C=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL65321 5ht1d_human Human No 8.7 EC50 = 1.9 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC(=CC=C5)F
CHEMBL84712 5ht1d_human Human No 8.7 EC50 = 1.9 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
445 6 1 5 3.9 CN1C(CC2C1CN(C2)CCC3=CC(=CC=C3)F)CC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL119785 5ht1d_human Human No 8.7 EC50 = 1.9 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
472 9 2 5 2.8 CC(=O)NC1=CC=C(C=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL119668 5ht1d_human Human No 8.7 EC50 = 1.9 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=C(C=C5)F)F
CHEMBL423749 5ht1d_human Human No 8.0 EC50 = 10 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 9 2 5 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL349390 5ht1d_human Human No 8.0 EC50 = 10 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
458 9 3 5 2.1 CC(=O)NC1=CC=C(C=C1)CNCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL324931 5ht1d_human Human No 7.0 EC50 = 105 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
310 4 1 4 0.5 CN1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL163376 5ht1d_human Human No 8.0 EC50 = 11 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
469 7 1 7 4.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL159733 5ht1d_human Human No 8.0 EC50 = 11 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
429 9 1 4 3.9 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)CN4C=NC=N4)CC5=CC=CC=C5
CHEMBL143952 5ht1d_human Human No 7.9 EC50 = 12 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
479 9 2 6 3.3 C1CN(CCC1CNS(=O)(=O)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL128 5ht1d_human Human Yes 7.9 EC50 = 12 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL148087 5ht1d_human Human No 7.9 EC50 = 12 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146729 5ht1d_human Human No 7.9 EC50 = 13 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
416 8 2 5 2.4 C1CN(CCC1NCC2=CC=NC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2112862 5ht1d_human Human No 7.9 EC50 = 13 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
457 7 3 5 2.9 C1CN(CCC1NC2C(CC3=CC=CC=C23)O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL331970 5ht1d_human Human No 7.9 EC50 = 13 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL308042 5ht1d_human Human No 6.9 EC50 = 138 Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
230 3 1 1 2.7 CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)C
CHEMBL128 5ht1d_human Human Yes 7.9 EC50 = 14 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL147853 5ht1d_human Human No 7.9 EC50 = 14 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 10 3 5 3.3 C1CN(CCC1NC(CC2=CC=CC=C2)CO)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL80189 5ht1d_cavpo Guinea pig No 7.9 EC50 = 14 Funct
Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraCompound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigra
305 4 1 3 2.8 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NC4=C3N=CC=C4
CHEMBL128 5ht1d_human Human Yes 7.9 EC50 = 14 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL148110 5ht1d_human Human No 7.8 EC50 = 15 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
472 9 3 5 3.3 CC(C(=O)NC1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL423022 5ht1d_human Human No 7.8 EC50 = 15 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)O)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420874 5ht1d_human Human No 7.8 EC50 = 15 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420874 5ht1d_human Human No 7.8 EC50 = 15 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL72178 5ht1d_human Human Yes 6.8 EC50 = 150 Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
202 2 1 1 1.9 CC1=CC(=C(C(=C1)C)CC2=NCCN2)C
CHEMBL433108 5ht1d_human Human No 7.8 EC50 = 16 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
465 8 1 6 4.3 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)(F)F)C5=CC=CC=C5
CHEMBL128 5ht1d_human Human Yes 7.8 EC50 = 16 Funct
Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL128 5ht1d_human Human Yes 7.8 EC50 = 16 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL70409 5ht1d_human Human No 5.8 EC50 = 1670 Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
230 3 1 1 2.9 CC1=C(C=CC(=C1)C(C)(C)C)CC2=NCCN2
CHEMBL416688 5ht1d_human Human No 7.8 EC50 = 18 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL416688 5ht1d_human Human No 7.8 EC50 = 18 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL144002 5ht1d_human Human No 7.8 EC50 = 18 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
429 8 2 4 4.5 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NC=N5
CHEMBL416688 5ht1d_human Human No 7.8 EC50 = 18 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL314213 5ht1d_rat Rat No 8.7 EC50 = 2 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
325 5 2 5 3.5 CN(C)CCC1=CNC2=C1C=C(C=C2)NC3=C(C=CC=N3)[N+](=O)[O-]
CHEMBL84942 5ht1d_rat Rat No 8.7 EC50 = 2 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
337 3 2 5 3.5 CN1CCC(C1)C2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL164413 5ht1d_human Human No 8.7 EC50 = 2 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
390 7 2 5 1.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=NC=CN5
CHEMBL326371 5ht1d_human Human No 8.7 EC50 = 2.1 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
402 8 1 4 3.2 C1CN(CC1COCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161410 5ht1d_human Human No 8.7 EC50 = 2.1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
415 8 2 4 3.4 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL326371 5ht1d_human Human No 8.7 EC50 = 2.1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
402 8 1 4 3.2 C1CN(CC1COCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146991 5ht1d_human Human No 8.7 EC50 = 2.2 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
442 6 2 4 2.9 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL116092 5ht1d_human Human Yes 8.6 EC50 = 2.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1d_human Human Yes 8.6 EC50 = 2.3 Funct
Compound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorCompound was tested for measuring agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1d_human Human Yes 8.6 EC50 = 2.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL352159 5ht1d_human Human No 8.6 EC50 = 2.3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
431 7 1 4 3.3 C1CN(C(=S)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL146132 5ht1d_human Human No 8.6 EC50 = 2.6 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL67684 5ht1d_human Human No 8.6 EC50 = 2.6 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
446 8 1 4 5.2 CC(CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=CC=C5
CHEMBL116092 5ht1d_human Human Yes 8.6 EC50 = 2.6 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1d_human Human Yes 8.6 EC50 = 2.6 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL147660 5ht1d_human Human No 8.6 EC50 = 2.8 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
500 10 2 5 3.3 CC(=O)NC1=CC=C(C=C1)CN(C)CC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL160581 5ht1d_human Human No 8.6 EC50 = 2.8 Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 2.8-6.5
429 6 2 4 3.7 C1CN(CCN1C2=CC=CC3=CC=CC=C32)C(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL349041 5ht1d_human Human No 8.6 EC50 = 2.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
390 8 2 5 2.1 C1CN(CC1CNCC2=CC=CO2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL82204 5ht1d_human Human No 8.5 EC50 = 2.9 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMeasurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
431 5 1 5 3.4 CN1C(CC2C1CN(C2)CC3=CC=C(C=C3)F)CC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL128 5ht1d_human Human Yes 6.7 EC50 = 220 Funct
Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL148095 5ht1d_human Human No 7.6 EC50 = 25 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
441 7 2 4 3.9 C1CC2=CC=CC=C2C1NC3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL905 5ht1d_human Human Yes 8.5 EC50 = 3 Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
269 5 1 3 1.7 CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3
CHEMBL146483 5ht1d_human Human No 8.5 EC50 = 3 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
500 10 3 5 3.3 CC(C1=CC=C(C=C1)NC(=O)C)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159683 5ht1d_human Human No 8.5 EC50 = 3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
415 8 1 4 3.6 CN(CC1CCCN1CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL424154 5ht1d_human Human No 8.5 EC50 = 3 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
429 9 2 4 3.9 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL350153 5ht1d_human Human No 8.5 EC50 = 3.2 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
461 9 1 4 4.3 CN1C(COC1=O)CC2=CC3=C(C=C2)NC=C3CCN4CCC(C4)CN(C)CC5=CC=CC=C5
CHEMBL148194 5ht1d_human Human No 8.5 EC50 = 3.4 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 9 3 5 3.0 CC(CO)(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL423212 5ht1d_human Human No 8.5 EC50 = 3.5 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
435 8 1 5 3.7 CN(CC1=CC=CS1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161780 5ht1d_human Human No 8.5 EC50 = 3.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
441 10 3 5 2.4 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN3CCC(C3)CNCC4=CC=CC=C4
CHEMBL146131 5ht1d_human Human No 8.4 EC50 = 3.6 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 10 3 5 3.3 C1CN(CCC1NC(CC2=CC=CC=C2)CO)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63432 5ht1d_human Human No 8.4 EC50 = 3.8 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL163462 5ht1d_human Human No 8.4 EC50 = 3.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
444 8 2 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(C5=CC=CC=C5)C(=O)N
CHEMBL356315 5ht1d_human Human No 7.5 EC50 = 30 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL128 5ht1d_human Human Yes 7.5 EC50 = 30 Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta in CHO-K1 cells; value ranges from 30-70
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL435060 5ht1d_human Human No 7.5 EC50 = 31 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1084132 5ht1d_human Human No 5.5 EC50 = 3162.3 Funct
Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor
245 3 1 3 2.4 C1CCNC(C1)CN2CCN(C2)C3=CC=CC=C3
CHEMBL1084132 5ht1d_human Human No 5.5 EC50 = 3162.3 Funct
Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor
245 3 1 3 2.4 C1CCNC(C1)CN2CCN(C2)C3=CC=CC=C3
CHEMBL341854 5ht1d_human Human No 7.5 EC50 = 32 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 10 3 5 3.3 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL63258 5ht1d_human Human No 7.5 EC50 = 34 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
452 8 1 6 4.1 C1CN(CCC1OCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL305301 5ht1d_human Human No 7.5 EC50 = 35 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
469 8 1 7 4.0 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL312448 5ht1d_human Human Yes 6.4 EC50 = 369 Funct
Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)
244 3 1 1 3.2 CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C
CHEMBL352123 5ht1d_human Human No 8.4 EC50 = 4 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
429 9 1 4 4.0 C1CN(CCN1CCCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159819 5ht1d_human Human No 8.4 EC50 = 4.1 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159819 5ht1d_human Human No 8.4 EC50 = 4.1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146024 5ht1d_human Human No 8.4 EC50 = 4.2 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
435 8 1 5 3.6 CN(CC1=CSC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL128 5ht1d_human Human Yes 8.4 EC50 = 4.3 Funct
Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL63432 5ht1d_human Human No 8.4 EC50 = 4.4 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL348864 5ht1d_human Human No 8.4 EC50 = 4.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
443 9 1 4 4.3 CC(C1=CC=CC=C1)N(C)CC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL147838 5ht1d_human Human No 8.3 EC50 = 4.7 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
469 7 1 4 4.8 C1CCN(C(C1)C2=CC=CC=C2)C3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL161192 5ht1d_human Human No 8.3 EC50 = 4.9 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
415 9 2 4 3.5 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL137485 5ht1d_cavpo Guinea pig No 7.4 EC50 = 43 Funct
Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.Effect on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.
244 3 1 2 2.9 CN1CCCC1CC2=CNC3=C2C=C(C=C3)OC
CHEMBL146335 5ht1d_human Human No 8.3 EC50 = 5 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
472 9 3 5 2.7 CC(=O)NC1=CC=C(C=C1)CNC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63799 5ht1d_human Human No 8.3 EC50 = 5 Funct
Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorAgonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1290596 5ht1d_human Human No 8.3 EC50 = 5.0 Funct
Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
415 4 1 4 4.0 CC1=C(C2=C(C=C1)NC(=O)CC2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL1290596 5ht1d_human Human No 8.3 EC50 = 5.0 Funct
Agonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assayAgonist activity at human 5-HT1D receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay
415 4 1 4 4.0 CC1=C(C2=C(C=C1)NC(=O)CC2)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL63799 5ht1d_human Human No 8.3 EC50 = 5.1 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63799 5ht1d_human Human No 8.3 EC50 = 5.1 Funct
Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorAgonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146628 5ht1d_human Human No 8.3 EC50 = 5.1 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
459 10 3 5 3.7 C1CN(CCC1NC(CCO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL128 5ht1d_human Human Yes 8.3 EC50 = 5.3 Funct
Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptorAbility to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL143893 5ht1d_human Human No 8.3 EC50 = 5.6 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
429 9 2 4 3.7 C1CN(CCC1CNCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL1085672 5ht1d_human Human No 6.3 EC50 = 501.2 Funct
Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor
294 3 1 2 2.2 C1CCNC(C1)CN2CCN(C2=O)C3=CC(=CC=C3)Cl
CHEMBL1085672 5ht1d_human Human No 6.3 EC50 = 501.2 Funct
Binding affinity to 5HT1D receptorBinding affinity to 5HT1D receptor
294 3 1 2 2.2 C1CCNC(C1)CN2CCN(C2=O)C3=CC(=CC=C3)Cl
CHEMBL117249 5ht1d_human Human No 7.3 EC50 = 53 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
324 5 1 4 1.7 CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL117249 5ht1d_human Human No 7.3 EC50 = 54 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
324 5 1 4 1.7 CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL146129 5ht1d_human Human No 8.2 EC50 = 6 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
477 10 4 5 3.5 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL163127 5ht1d_human Human No 8.2 EC50 = 6.1 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
458 8 2 5 2.3 CC(=O)NC1=CC=C(C=C1)CN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147907 5ht1d_human Human No 8.2 EC50 = 6.2 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
428 8 2 3 4.5 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=CN=C5
CHEMBL348815 5ht1d_human Human No 8.2 EC50 = 6.2 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
415 9 2 4 3.4 C1CN(CC1CNCCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146502 5ht1d_human Human No 8.2 EC50 = 6.8 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
443 9 2 4 4.4 CC(CC1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL97450 5ht1d_human Human Yes 7.2 EC50 = 68 Funct
Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cellsCompound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1D-beta receptor in CHO-K1 cells
302 11 2 2 4.5 CCCCCCCCCOC1=CC2=C(C=C1)NC=C2CCN
CHEMBL357408 5ht1d_human Human No 8.2 EC50 = 7.1 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
405 8 2 5 2.6 C1CN(CCC1NCC2=COC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147961 5ht1d_human Human No 8.1 EC50 = 7.4 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
445 9 3 5 3.4 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NC=N5
CHEMBL162899 5ht1d_human Human No 8.1 EC50 = 7.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
415 7 1 4 2.7 C1CN(C(=O)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL117046 5ht1d_human Human No 8.1 EC50 = 7.6 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
415 8 2 4 3.5 C1CN(CCC1NCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL349528 5ht1d_human Human No 8.1 EC50 = 7.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
297 4 2 4 1.0 C1CN(CC1O)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL351311 5ht1d_human Human No 8.1 EC50 = 7.8 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.
416 8 1 5 2.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CN=CC=C5
CHEMBL117046 5ht1d_human Human No 8.1 EC50 = 8 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
415 8 2 4 3.5 C1CN(CCC1NCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL905 5ht1d_human Human Yes 8.1 EC50 = 8.4 Funct
Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.
269 5 1 3 1.7 CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3
CHEMBL441296 5ht1d_human Human No 8.1 EC50 = 8.7 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
431 9 3 5 2.3 C1CN(CC1CNC(CO)C2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL148085 5ht1d_human Human No 8.1 EC50 = 8.9 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
419 8 1 5 3.0 CN(CC1=COC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL344537 5ht1d_human Human No 8.1 EC50 = 8.9 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
491 11 2 6 4.0 COCC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL324931 5ht1d_human Human No 7.1 EC50 = 80 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor
310 4 1 4 0.5 CN1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL342805 5ht1d_human Human No 8.0 EC50 = 9.3 Funct
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorAgonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor
488 11 3 6 2.8 C1CN(CCC1NC(COC(=O)N)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161066 5ht1d_human Human No 8.0 EC50 = 9.5 Funct
Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorStimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor
402 8 2 5 1.9 C1CN(CC1CNCC2=CC=NC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL128 5ht1d_rat Rat Yes 7.0 EC50 = 97 Funct
Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorInhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL22744 5ht1d_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
607 14 6 4 4.9 C1CC(=CCC1NCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL22744 5ht1d_human Human No 10.3 IC50 = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
607 14 6 4 4.9 C1CC(=CCC1NCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL22744 5ht1d_human Human No 10.3 IC50 = 0.1 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
607 14 6 4 4.9 C1CC(=CCC1NCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL112507 5ht1d_human Human No 10.0 IC50 = 0.1 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
416 7 2 4 3.5 C1CN(CCC1(CC2=CC=CC=C2)O)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161723 5ht1d_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
419 7 1 5 3.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)F
CHEMBL65367 5ht1d_human Human No 10.0 IC50 = 0.1 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL65824 5ht1d_human Human No 10.0 IC50 = 0.1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
436 7 1 5 4.6 C1CN(CCC1(CC2=CC=CC=C2F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL22961 5ht1d_human Human No 10.0 IC50 = 0.1 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
621 15 6 4 5.4 C1CC(=CCC1NCCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL65367 5ht1d_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL65367 5ht1d_human Human No 9.9 IC50 = 0.1 Funct
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL65367 5ht1d_human Human No 9.9 IC50 = 0.1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL65367 5ht1d_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL163462 5ht1d_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
444 8 2 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(C5=CC=CC=C5)C(=O)N
CHEMBL161176 5ht1d_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 8 2 5 2.3 CC(=O)NC1=CC=CC(=C1)CN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL65367 5ht1d_human Human No 9.7 IC50 = 0.2 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
401 7 1 4 3.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL160070 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
447 9 3 4 4.0 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL296161 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL296161 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL160070 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
447 9 3 4 4.0 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL296161 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
255 4 1 3 0.7 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
CHEMBL422366 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CN=CC=C5
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63167 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
486 7 1 7 5.4 C1CN(CCC1(CC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL89878 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
330 8 3 3 2.8 CCC1=CC2=C(CCC(O2)CNCCCNC3=NCCCN3)C=C1
CHEMBL22960 5ht1d_human Human No 9.5 IC50 = 0.3 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
677 19 6 4 7.6 C1CC(=CCC1NCCCCCCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL159483 5ht1d_human Human No 9.5 IC50 = 0.4 Funct
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
433 9 3 4 3.6 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL331970 5ht1d_human Human No 9.5 IC50 = 0.4 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159483 5ht1d_human Human No 9.5 IC50 = 0.4 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
433 9 3 4 3.6 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL294547 5ht1d_human Human No 9.5 IC50 = 0.4 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
400 7 1 3 4.6 C1CN(CCC1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL331970 5ht1d_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL163573 5ht1d_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=N5
CHEMBL162805 5ht1d_human Human No 9.4 IC50 = 0.4 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 7 1 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CO5
CHEMBL65765 5ht1d_human Human No 9.4 IC50 = 0.4 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
436 7 1 5 4.6 C1CN(CCC1(CC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL326125 5ht1d_human Human No 9.4 IC50 = 0.5 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
445 9 3 5 2.6 C1CN(CCC1(CNCC2=CC=CC=C2)O)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL349185 5ht1d_human Human No 9.4 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 8 2 5 2.0 C1CN(CC1CNCC2=COC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159759 5ht1d_human Human No 9.4 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 2 4 3.4 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1d_human Human Yes 9.3 IC50 = 0.5 Funct
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1d_human Human Yes 9.3 IC50 = 0.5 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420965 5ht1d_human Human Yes 9.3 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL148233 5ht1d_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
407 8 1 4 4.0 CC(=CCN(C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C
CHEMBL116031 5ht1d_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5F
CHEMBL161696 5ht1d_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
435 7 1 4 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)Cl
CHEMBL292779 5ht1d_human Human No 9.3 IC50 = 0.5 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL292779 5ht1d_human Human No 9.3 IC50 = 0.5 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL292779 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL292779 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL420965 5ht1d_human Human Yes 9.2 IC50 = 0.6 Funct
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL148087 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
429 8 2 4 3.9 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL292779 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL420965 5ht1d_human Human Yes 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147660 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
500 10 2 5 3.3 CC(=O)NC1=CC=C(C=C1)CN(C)CC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146483 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
500 10 3 5 3.3 CC(C1=CC=C(C=C1)NC(=O)C)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL162858 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 7 1 5 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=NC=C5
CHEMBL159396 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
388 6 1 6 2.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=NC=CC=N5
CHEMBL116031 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5F
CHEMBL292779 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL292779 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F
CHEMBL67684 5ht1d_human Human No 9.2 IC50 = 0.6 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
446 8 1 4 5.2 CC(CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=CC=C5
CHEMBL116161 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
451 7 2 5 3.3 CC1(CCCN(C1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O)C
CHEMBL331819 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
425 9 2 5 2.9 CC(C)CN(C)CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL85668 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
412 5 1 3 3.9 CN1C(CC2C1CN(C2)CC3=CC=CC=C3)CC4=CNC5=C4C=C(C=C5)N6C=CN=C6
CHEMBL117579 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
415 8 1 4 3.4 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL117579 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 1 4 3.4 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL348864 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 9 1 4 4.3 CC(C1=CC=CC=C1)N(C)CC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL163386 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
431 8 2 5 2.5 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL347665 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
426 7 1 5 2.9 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)C#N
CHEMBL116153 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC(=C5)F)F
CHEMBL63799 5ht1d_human Human No 9.2 IC50 = 0.7 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161410 5ht1d_human Human No 9.1 IC50 = 0.7 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 2 4 3.4 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63799 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63799 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC(=CC=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL88283 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
332 8 3 4 2.0 COC1=CC=CC2=C1OC(CC2)CNCCCNC3=NCCCN3
CHEMBL82204 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
431 5 1 5 3.4 CN1C(CC2C1CN(C2)CC3=CC=C(C=C3)F)CC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL159683 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 1 4 3.6 CN(CC1CCCN1CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL115750 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=C(C=C5)F
CHEMBL162722 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 8 1 4 4.0 CC(CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=CC=CC=C5
CHEMBL352159 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
431 7 1 4 3.3 C1CN(C(=S)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL115750 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=C(C=C5)F
CHEMBL67460 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC=CC=C2F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL348304 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 8 1 4 3.4 C1CC(N(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)COCC5=CC=CC=C5
CHEMBL21862 5ht1d_human Human No 9.1 IC50 = 0.8 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
593 13 6 4 4.3 C1CC(=CCC1NCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL294732 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL313714 5ht1d_human Human Yes 9.1 IC50 = 0.9 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL84070 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
414 7 1 3 4.1 CN1CC(CC1CC2=CNC3=C2C=C(C=C3)N4C=CN=C4)CN(C)CC5=CC=CC=C5
CHEMBL83426 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
413 5 1 4 3.3 CN1C(CC2C1CN(C2)CC3=CC=CC=C3)CC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL313714 5ht1d_human Human Yes 9.1 IC50 = 0.9 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL294732 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsDisplacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cells
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL143947 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL313714 5ht1d_human Human Yes 9.1 IC50 = 0.9 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL333341 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 9 1 4 4.1 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL119668 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=C(C=C5)F)F
CHEMBL348962 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
444 9 2 5 2.8 CNCC(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL313714 5ht1d_human Human Yes 9.1 IC50 = 0.9 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL294732 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL65321 5ht1d_human Human No 9.1 IC50 = 0.9 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC(=CC=C5)F
CHEMBL333341 5ht1d_human Human No 9.0 IC50 = 1.0 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
443 9 1 4 4.1 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL164046 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 8 2 4 3.6 CC(C)(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL164035 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
472 8 1 5 2.9 CN(C)C(=O)C(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL351346 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 7 1 4 3.6 CC(C1=CC=CC=C1)N2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL294732 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
418 7 1 4 4.5 C1CN(CCC1(CC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL119668 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=C(C=C5)F)F
CHEMBL293614 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 5.0 C1CN(CCC1(CCC2=CC=C(C=C2)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304833 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=CC=C5F
CHEMBL64004 5ht1d_human Human No 9.0 IC50 = 1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
465 8 1 6 4.1 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)F)C5=CC=C(C=C5)F
CHEMBL161780 5ht1d_human Human No 9.0 IC50 = 1.1 Funct
Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueAffinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding technique
441 10 3 5 2.4 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN3CCC(C3)CNCC4=CC=CC=C4
CHEMBL161780 5ht1d_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
441 10 3 5 2.4 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN3CCC(C3)CNCC4=CC=CC=C4
CHEMBL161045 5ht1d_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
267 4 1 3 0.8 C1CN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL423599 5ht1d_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 8 1 4 2.9 CC(=O)N(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL356808 5ht1d_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
455 8 2 4 4.1 C1CC2=CC=CC=C2C1NCC3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL164111 5ht1d_human Human No 9.0 IC50 = 1.1 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
390 7 1 5 2.2 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=COC=C5
CHEMBL84712 5ht1d_human Human No 8.9 IC50 = 1.2 Funct
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
445 6 1 5 3.9 CN1C(CC2C1CN(C2)CCC3=CC(=CC=C3)F)CC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL111899 5ht1d_human Human No 8.9 IC50 = 1.2 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
465 9 2 5 4.0 CN(CC1CCCCC1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL114877 5ht1d_human Human No 8.9 IC50 = 1.2 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
459 9 2 5 3.1 CN(CC1=CC=CC=C1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL146991 5ht1d_human Human No 8.9 IC50 = 1.2 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
442 6 2 4 2.9 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL114303 5ht1d_human Human No 8.9 IC50 = 1.3 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
473 9 2 5 3.5 CC1=CC=CC=C1CN(C)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL118012 5ht1d_human Human No 8.9 IC50 = 1.3 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL118012 5ht1d_human Human No 8.9 IC50 = 1.3 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL119785 5ht1d_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
472 9 2 5 2.8 CC(=O)NC1=CC=C(C=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL119785 5ht1d_human Human No 8.9 IC50 = 1.3 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
472 9 2 5 2.8 CC(=O)NC1=CC=C(C=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL75642 5ht1d_human Human No 8.9 IC50 = 1.3 Funct
Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand
355 3 1 3 3.8 CN1CCCC1CC2=CNC3=C2C=C(C=C3)N4C=NC5=C4C=CC(=C5)C#N
CHEMBL115989 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
423 9 2 5 2.3 CN(CC1CC1)CC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL351303 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
431 9 3 5 2.3 C1CN(CC1CNC(CO)C2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL343217 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
477 10 2 6 3.5 COCC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL343648 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 9 2 4 4.1 CC(C1=CC=CC=C1)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL162463 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
387 6 1 4 3.5 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C5=CC=CC=C5
CHEMBL117633 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 1 4 3.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL117633 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
415 8 1 4 3.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL88893 5ht1d_human Human No 8.9 IC50 = 1.4 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
481 9 3 7 3.0 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL349041 5ht1d_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 8 2 5 2.1 C1CN(CC1CNCC2=CC=CO2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147818 5ht1d_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
472 10 2 5 3.6 CN(C)CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL357634 5ht1d_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
479 8 1 6 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)S(=O)(=O)C5=CC=CC=C5
CHEMBL146338 5ht1d_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
500 10 3 5 3.3 CC(C1=CC=C(C=C1)NC(=O)C)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146024 5ht1d_human Human No 8.8 IC50 = 1.5 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
435 8 1 5 3.6 CN(CC1=CSC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL422243 5ht1d_human Human No 8.8 IC50 = 1.6 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
298 7 2 5 3.1 C1CC2=CC=CC=C2OC1CNCCCNC3=NC=CC=N3
CHEMBL159819 5ht1d_human Human No 8.8 IC50 = 1.6 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL159819 5ht1d_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 8 2 4 3.0 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL145982 5ht1d_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
493 9 1 6 3.5 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)S(=O)(=O)C5=CC=CC=C5
CHEMBL143893 5ht1d_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 9 2 4 3.7 C1CN(CCC1CNCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL164413 5ht1d_human Human No 8.8 IC50 = 1.6 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
390 7 2 5 1.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=NC=CN5
CHEMBL350153 5ht1d_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
461 9 1 4 4.3 CN1C(COC1=O)CC2=CC3=C(C=C2)NC=C3CCN4CCC(C4)CN(C)CC5=CC=CC=C5
CHEMBL358072 5ht1d_human Human No 8.8 IC50 = 1.7 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
416 8 2 5 3.6 C1CN(CCC1CNC2=CC=CC=N2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL115352 5ht1d_human Human No 8.8 IC50 = 1.8 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
439 9 2 5 3.3 CC(C)(C)CN(C)CC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL333089 5ht1d_human Human No 8.8 IC50 = 1.8 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
472 9 2 5 2.8 CC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL65215 5ht1d_human Human No 8.8 IC50 = 1.8 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
483 8 1 7 4.4 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)(F)F)C5=CC=C(C=C5)F
CHEMBL304197 5ht1d_human Human No 8.8 IC50 = 1.8 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
417 7 2 5 2.2 C1CN(CCN1CC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL146285 5ht1d_human Human No 8.7 IC50 = 1.9 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
447 8 2 5 4.0 CC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147838 5ht1d_human Human No 8.7 IC50 = 1.9 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
469 7 1 4 4.8 C1CCN(C(C1)C2=CC=CC=C2)C3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL417650 5ht1d_human Human No 8.7 IC50 = 2.0 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
354 9 3 2 4.4 CCCCCCCNC1CCC(=CC1)C2=CNC3=C2C=C(C=C3)C(=O)N
CHEMBL89007 5ht1d_human Human No 8.7 IC50 = 2.0 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
333 7 2 5 3.7 C1CC2=CC=CC=C2OC1CNCCCNC3=NN=C(C=C3)Cl
CHEMBL88784 5ht1d_human Human No 8.0 IC50 = 10 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
330 9 3 3 2.2 C1CNC(=NC1)NCCCCCNCC2CCC3=CC=CC=C3O2
CHEMBL88152 5ht1d_human Human No 8.0 IC50 = 10 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
298 7 2 5 2.7 C1CC2=CC=CC=C2OC1CNCCCNC3=NC=CN=C3
CHEMBL329207 5ht1d_human Human No 8.0 IC50 = 10 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
298 7 2 5 3.1 C1CC2=CC=CC=C2OC1CNCCCNC3=NC=NC=C3
CHEMBL314213 5ht1d_rat Rat No 8.0 IC50 = 10 Funct
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
325 5 2 5 3.5 CN(C)CCC1=CNC2=C1C=C(C=C2)NC3=C(C=CC=N3)[N+](=O)[O-]
CHEMBL147071 5ht1d_human Human Yes 8.0 IC50 = 10 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
459 6 2 5 3.5 CC1=C(C=CC(=C1)C(=O)N)C2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)OC)N4CCN(CC4)C
CHEMBL128 5ht1d_human Human Yes 7.0 IC50 = 100 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL274922 5ht1d_rat Rat No 7.0 IC50 = 100 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
491 5 3 5 2.3 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=C(C=C5)C(=O)N)OC
CHEMBL326723 5ht1d_human Human No 8.0 IC50 = 11 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
502 10 4 6 1.8 CC(=O)NC1=CC=C(C=C1)CNCC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL423022 5ht1d_human Human No 8.0 IC50 = 11 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)O)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL905 5ht1d_human Human Yes 8.0 IC50 = 11 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
269 5 1 3 1.7 CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3
CHEMBL80189 5ht1d_human Human No 8.0 IC50 = 11 Funct
Tested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligandTested in vitro for receptor binding affinity to 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT radioligand
305 4 1 3 2.8 CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NC4=C3N=CC=C4
CHEMBL27173 5ht1d_human Human No 7.0 IC50 = 110 Funct
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
216 2 2 2 1.7 C1CC2=C(C=CC3=C2C(=CN3)CCN)OC1
CHEMBL143723 5ht1d_human Human No 7.0 IC50 = 110 Funct
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
322 8 1 2 3.7 CCN(CC)CCC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3
CHEMBL143723 5ht1d_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
322 8 1 2 3.7 CCN(CC)CCC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3
CHEMBL143890 5ht1d_human Human No 7.9 IC50 = 12 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)O)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL349390 5ht1d_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 9 3 5 2.1 CC(=O)NC1=CC=C(C=C1)CNCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL143951 5ht1d_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
324 5 2 4 1.5 C1CN(CCC1N)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL146023 5ht1d_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
486 10 3 5 3.1 CC(=O)NC1=CC=C(C=C1)CCNC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL91534 5ht1d_human Human No 7.9 IC50 = 12 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL431211 5ht1d_human Human No 7.9 IC50 = 12.6 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
316 8 3 3 1.8 C1CNC(=NC1)NCCCCNCC2CCC3=CC=CC=C3O2
CHEMBL122860 5ht1d_human Human No 5.9 IC50 = 1200 Funct
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
244 3 1 2 2.7 CN(C)CCC1=CNC2=CC3=C(C=C21)OCCC3
CHEMBL91154 5ht1d_human Human No 6.9 IC50 = 125.9 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
288 7 3 3 1.7 C1CNC(=NC1)NCCCNCC2CC3=CC=CC=C3O2
CHEMBL92207 5ht1d_human Human No 7.9 IC50 = 13 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2114039 5ht1d_human Human No 7.9 IC50 = 13 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
515 8 1 8 4.9 CN(CC1=CC=CC=C1C(F)(F)F)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2115111 5ht1d_human Human No 7.9 IC50 = 13 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
501 8 2 8 4.4 C1CN(CC(C1NCC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL100875 5ht1d_human Human No 4.9 IC50 = 13000 Funct
Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT
395 4 1 5 3.3 C1CC(CCC1N2CCN(CC2)CC3=CC=CC=C3)(C4=CC5=C(C=C4)OCO5)O
CHEMBL324931 5ht1d_human Human No 6.9 IC50 = 134 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
310 4 1 4 0.5 CN1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL315772 5ht1d_human Human No 6.9 IC50 = 134.9 Funct
Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor
329 2 0 3 4.5 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)Cl
CHEMBL315772 5ht1d_human Human No 6.9 IC50 = 134.9 Funct
Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor
329 2 0 3 4.5 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)Cl
CHEMBL145997 5ht1d_human Human No 7.9 IC50 = 14 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
416 8 2 5 2.5 C1CN(CCC1NCC2=CC=CC=N2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2368254 5ht1d_human Human No 7.8 IC50 = 14.5 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
278 3 2 2 3.2 C1C(CC1N)C2=CNC3=C2C=C(C=C3)OC4=CC=CC=C4
CHEMBL158638 5ht1d_human Human No 7.8 IC50 = 14.8 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
257 3 2 2 1.6 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)C(=O)N
CHEMBL324931 5ht1d_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
310 4 1 4 0.5 CN1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL267615 5ht1d_human Human Yes 5.9 IC50 = 1400 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor in calfInhibitory activity against 5-hydroxytryptamine 1D receptor in calf
246 5 1 2 3.2 CCC1=C(C2=C(N1)C=CC(=C2)OC)CCN(C)C
CHEMBL267615 5ht1d_human Human Yes 5.9 IC50 = 1400 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor in calfInhibitory activity against 5-hydroxytryptamine 1D receptor in calf
246 5 1 2 3.2 CCC1=C(C2=C(N1)C=CC(=C2)OC)CCN(C)C
CHEMBL159470 5ht1d_human Human No 6.9 IC50 = 141.3 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
347 5 2 2 3.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)C(=O)NCC4=CC=CC=C4
CHEMBL2368262 5ht1d_human Human No 5.8 IC50 = 1479.1 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
368 5 2 3 2.5 CC1(C(=O)N(C(=O)N1)CCC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C)C
CHEMBL148071 5ht1d_human Human No 7.8 IC50 = 15 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
522 11 3 7 2.6 CS(=O)(=O)NCC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL84942 5ht1d_rat Rat No 7.8 IC50 = 15 Funct
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
337 3 2 5 3.5 CN1CCC(C1)C2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL305301 5ht1d_human Human No 7.8 IC50 = 15 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
469 8 1 7 4.0 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL88212 5ht1d_human Human No 7.8 IC50 = 15.9 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
302 7 3 3 2.0 C1CNC(=NC1)NCCCNCC2CCC3=CC=CC=C3O2
CHEMBL18710 5ht1d_human Human No 6.8 IC50 = 151.4 Funct
In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate
232 4 1 3 1.5 CN(C)CCC1=COC2=C1C=C(C=C2)C(=O)N
CHEMBL90981 5ht1d_human Human No 6.8 IC50 = 158.5 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
330 7 3 4 1.7 C1CC(=O)NC(=NC1)NCCCNCC2CCC3=CC=CC=C3O2
CHEMBL16035 5ht1d_rat Rat No 6.8 IC50 = 167 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
426 6 3 5 3.0 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)NCCC3=CNC4=C3C=C(C=C4)F)OC
CHEMBL2110300 5ht1d_human Human No 6.8 IC50 = 169.8 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
313 4 2 3 2.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL162296 5ht1d_human Human No 7.8 IC50 = 17 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
350 8 2 4 2.1 C=CCNCC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL347570 5ht1d_human Human No 7.8 IC50 = 17 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
514 9 2 5 2.9 CC(=O)NC1=CC=C(C=C1)C(=O)N(C)CC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL143967 5ht1d_human Human No 6.8 IC50 = 170 Funct
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.
392 9 1 7 4.1 CCCN(CCC)CCC1=CNC2=C1C=C(C=C2)OS(=O)(=O)C(F)(F)F
CHEMBL161969 5ht1d_human Human No 6.8 IC50 = 173 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 7 1 4 2.7 C1CN(C(=O)CN1CC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL144002 5ht1d_human Human No 7.8 IC50 = 18 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 8 2 4 4.5 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NC=N5
CHEMBL148325 5ht1d_human Human No 7.8 IC50 = 18 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 7 2 4 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(=O)NC5=CC=CC=C5
CHEMBL147555 5ht1d_human Human No 7.8 IC50 = 18 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
507 9 1 6 3.2 CN(CC1=CC=C(C=C1)S(=O)(=O)C)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL149488 5ht1d_human Human No 7.7 IC50 = 19 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
486 9 2 5 3.1 CC(=O)NC1=CC=C(C=C1)CN(C)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL28178 5ht1d_human Human No 6.7 IC50 = 190 Funct
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
320 1 1 6 3.5 C1CN(CCN1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4
CHEMBL2368259 5ht1d_human Human No 6.7 IC50 = 190.6 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
321 5 2 4 1.3 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2C3CC(C3)N(C)C
CHEMBL2368261 5ht1d_human Human No 6.7 IC50 = 195.0 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
387 5 1 3 3.6 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CCN4C(=O)C5=CC=CC=C5C4=O
CHEMBL293678 5ht1d_human Human No 8.7 IC50 = 2 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
432 8 1 4 4.9 C1CN(CCC1(CCC2=CC=CC=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146131 5ht1d_human Human No 8.7 IC50 = 2.1 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 3 5 3.3 C1CN(CCC1NC(CC2=CC=CC=C2)CO)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161735 5ht1d_human Human No 8.7 IC50 = 2.1 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
416 9 1 4 3.6 C1CN(CC1COCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.1 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2114040 5ht1d_human Human No 8.7 IC50 = 2.1 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL91534 5ht1d_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.2 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL304857 5ht1d_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
429 8 1 4 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL91534 5ht1d_human Human No 8.7 IC50 = 2.2 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL326371 5ht1d_human Human No 8.6 IC50 = 2.3 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
402 8 1 4 3.2 C1CN(CC1COCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL163462 5ht1d_human Human No 8.6 IC50 = 2.3 Funct
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
444 8 2 5 2.3 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(C5=CC=CC=C5)C(=O)N
CHEMBL326371 5ht1d_human Human No 8.6 IC50 = 2.3 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 8 1 4 3.2 C1CN(CC1COCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL424154 5ht1d_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 9 2 4 3.9 CC(C1=CC=CC=C1)NCC2CCN(C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL163127 5ht1d_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
458 8 2 5 2.3 CC(=O)NC1=CC=C(C=C1)CN2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL88240 5ht1d_human Human Yes 8.6 IC50 = 2.5 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
302 7 3 3 2.0 C1CNC(=NC1)NCCCNCC2CCC3=CC=CC=C3O2
CHEMBL348815 5ht1d_human Human No 8.6 IC50 = 2.6 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 9 2 4 3.4 C1CN(CC1CNCCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL357007 5ht1d_human Human No 8.6 IC50 = 2.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
421 9 1 4 4.4 CC(=CCCN(C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C
CHEMBL281575 5ht1d_human Human No 8.6 IC50 = 2.6 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
649 17 6 4 6.5 C1CC(=CCC1NCCCCCCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL1185 5ht1d_human Human Yes 8.6 IC50 = 2.8 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
287 5 2 3 2.2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
CHEMBL128 5ht1d_human Human Yes 8.5 IC50 = 3.0 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL435060 5ht1d_human Human No 7.7 IC50 = 20 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL148286 5ht1d_human Human No 7.7 IC50 = 20 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
379 8 1 4 3.1 CN(CC=C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL277452 5ht1d_human Human No 7.7 IC50 = 20.3 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
565 11 6 4 3.6 C1CC(=CCC1NCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL330803 5ht1d_human Human No 6.7 IC50 = 200 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
295 4 1 3 1.6 C1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL278917 5ht1d_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
466 4 2 5 3.5 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=CC(=C5)F)OC
CHEMBL15139 5ht1d_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
424 6 4 5 2.6 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)NCCC3=CNC4=C3C=C(C=C4)O)OC
CHEMBL15965 5ht1d_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
509 7 3 6 3.3 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)NCCN3CCC(CC3)C4=CNC5=C4C=CC(=C5)F)OC
CHEMBL280000 5ht1d_rat Rat No 6.7 IC50 = 200 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
476 6 2 4 4.4 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)CCC4=CNC5=CC=CC=C54)OC
CHEMBL330803 5ht1d_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
295 4 1 3 1.6 C1CCN(CC1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL159536 5ht1d_human Human No 5.7 IC50 = 2041.7 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
309 4 2 3 3.1 CC1=NC(=NN1)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL115496 5ht1d_human Human No 7.7 IC50 = 21 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
455 9 3 6 2.3 CC(C)(C)OC(=O)NCC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL143510 5ht1d_human Human No 7.7 IC50 = 21 Funct
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.
364 7 1 7 3.0 CCN(CC)CCC1=CNC2=C1C=C(C=C2)OS(=O)(=O)C(F)(F)F
CHEMBL422191 5ht1d_human Human No 6.7 IC50 = 210 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
338 6 1 4 2.0 CN1CCN(CC1)CCCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL147786 5ht1d_human Human No 7.7 IC50 = 22 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
393 8 1 4 3.2 CN(CC1CC1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL412876 5ht1d_human Human Yes 6.7 IC50 = 220 Funct
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
244 3 1 2 2.7 CN(C)CCC1=CNC2=C1C3=C(C=C2)OCCC3
CHEMBL341854 5ht1d_human Human No 7.6 IC50 = 23 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
459 10 3 5 3.3 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL15855 5ht1d_rat Rat No 6.6 IC50 = 233 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
448 4 2 4 3.4 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=CC=CC=C54)OC
CHEMBL2079627 5ht1d_rat Rat No 6.6 IC50 = 233 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
466 4 2 5 3.5 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=C(C=C5)F)OC
CHEMBL279646 5ht1d_rat Rat No 6.6 IC50 = 233 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
452 4 2 5 3.1 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(C3)C4=CNC5=C4C=C(C=C5)F)OC
CHEMBL137485 5ht1d_cavpo Guinea pig No 7.6 IC50 = 24 Funct
Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor
244 3 1 2 2.9 CN1CCCC1CC2=CNC3=C2C=C(C=C3)OC
CHEMBL331612 5ht1d_human Human No 7.6 IC50 = 24 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
309 5 1 3 2.7 C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL146729 5ht1d_human Human No 7.6 IC50 = 24 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
416 8 2 5 2.4 C1CN(CCC1NCC2=CC=NC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL331612 5ht1d_human Human No 7.6 IC50 = 24 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
309 5 1 3 2.7 C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL128 5ht1d_human Human Yes 5.6 IC50 = 2400 Funct
Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL2368258 5ht1d_human Human No 5.6 IC50 = 2454.7 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
326 4 2 3 1.4 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CN4C(=O)CNC4=O
CHEMBL357130 5ht1d_human Human Yes 7.6 IC50 = 25 Funct
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
294 6 1 2 3.0 CN(C)CCC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3
CHEMBL89448 5ht1d_human Human No 7.6 IC50 = 25.1 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
304 7 3 4 1.4 C1CNC(=NC1)NCCCNCC2COC3=CC=CC=C3O2
CHEMBL159627 5ht1d_human Human No 7.6 IC50 = 26 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
311 5 2 4 1.2 C1CN(CC1CO)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL278610 5ht1d_human Human No 7.6 IC50 = 27.3 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
551 10 6 4 3.2 C1CC(=CCC1NCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL3084967 5ht1d_human Human No 7.5 IC50 = 28.8 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
327 5 2 3 3.0 CN(C)C1CC(C1)CC2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL303997 5ht1d_human Human No 6.6 IC50 = 280 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
452 8 1 6 4.6 C1CN(CCC1COC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL146150 5ht1d_human Human No 7.5 IC50 = 29 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
486 9 3 5 3.1 CC(C1=CC=C(C=C1)NC(=O)C)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL145815 5ht1d_human Human No 8.5 IC50 = 3 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 2 5 3.4 COCC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146335 5ht1d_human Human No 8.5 IC50 = 3 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
472 9 3 5 2.7 CC(=O)NC1=CC=C(C=C1)CNC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL147503 5ht1d_human Human Yes 8.5 IC50 = 3 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
458 6 3 5 3.6 CC1=C(C=CC(=C1)C(=N)N)C2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)OC)N4CCN(CC4)C
CHEMBL83597 5ht1d_rat Rat Yes 8.5 IC50 = 3.1 Funct
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
351 4 2 5 4.1 CN1CCCC1CC2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL116092 5ht1d_human Human Yes 8.5 IC50 = 3.1 Funct
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1d_human Human Yes 8.5 IC50 = 3.1 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL116092 5ht1d_human Human Yes 8.5 IC50 = 3.1 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL88676 5ht1d_human Human Yes 8.5 IC50 = 3.2 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
302 7 3 3 2.0 C1CNC(=NC1)NCCCNCC2CCC3=CC=CC=C3O2
CHEMBL90443 5ht1d_human Human No 8.5 IC50 = 3.2 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
319 9 4 4 1.7 CC(C)N=C(N)NNCCCNCC1CCC2=CC=CC=C2O1
CHEMBL91596 5ht1d_human Human No 8.5 IC50 = 3.2 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
332 8 3 4 2.0 COC1=CC2=C(CCC(O2)CNCCCNC3=NCCCN3)C=C1
CHEMBL112558 5ht1d_human Human No 8.5 IC50 = 3.2 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
446 9 3 6 1.6 C1CN(CCC1(CNCC2=CC=CC=N2)O)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL161192 5ht1d_human Human No 8.5 IC50 = 3.2 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 9 2 4 3.5 C1CN(CC1CNCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL310061 5ht1d_human Human No 8.5 IC50 = 3.3 Funct
Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)Ability to displace [3H]- -5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in chinese hamster cells (CHO cells)
425 7 1 4 4.4 CN1CC(CC1CC2=CNC3=C2C=C(C=C3)N4C=CN=C4)CN(CC5=CC=CC=C5)C#N
CHEMBL17828 5ht1d_human Human No 8.5 IC50 = 3.4 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
579 12 6 4 4.0 C1CC(=CCC1NCCCCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL116092 5ht1d_human Human Yes 8.5 IC50 = 3.4 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL146265 5ht1d_human Human No 8.5 IC50 = 3.4 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
459 10 3 5 3.0 C1CN(CCC1CNC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL116092 5ht1d_human Human Yes 8.5 IC50 = 3.4 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
281 4 1 3 1.2 C1CCN(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL146132 5ht1d_human Human No 8.5 IC50 = 3.5 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
445 9 3 5 2.8 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63432 5ht1d_human Human No 8.5 IC50 = 3.5 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL349893 5ht1d_human Human No 8.4 IC50 = 3.6 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 8 2 5 1.9 C1CN(CC1CNCC2=CC=CC=N2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2110299 5ht1d_human Human No 8.4 IC50 = 3.6 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
285 3 3 3 1.5 C1C(CC1N)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL63432 5ht1d_human Human No 8.4 IC50 = 3.7 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL345657 5ht1d_human Human No 8.4 IC50 = 3.8 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 8 2 5 1.9 C1CN(CC1CNCC2=CN=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL91123 5ht1d_human Human No 8.4 IC50 = 4.0 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
301 7 2 3 2.5 C1CCN=C(C1)NCCCNCC2CCC3=CC=CC=C3O2
CHEMBL305062 5ht1d_human Human No 7.5 IC50 = 30 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
434 8 1 5 3.8 C1CN(CCC1OCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL15961 5ht1d_rat Rat No 6.5 IC50 = 300 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
466 4 2 5 3.5 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C(=CC=C5)F)OC
CHEMBL84931 5ht1d_human Human No 6.5 IC50 = 302 Funct
Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor
312 2 0 4 4.0 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)F
CHEMBL2368260 5ht1d_human Human No 5.5 IC50 = 3090.3 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
354 4 2 3 2.0 CC1(C(=O)N(C(=O)N1)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C)C
CHEMBL274001 5ht1d_human Human No 7.5 IC50 = 31 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
310 5 2 4 1.2 C1CN(CCN1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL313490 5ht1d_human Human No 7.5 IC50 = 31.6 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
284 6 2 5 2.2 C1CC2=CC=CC=C2OC1CNCCNC3=NC=CC=N3
CHEMBL117249 5ht1d_human Human No 7.5 IC50 = 33 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
324 5 1 4 1.7 CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL350277 5ht1d_human Human No 6.5 IC50 = 338.8 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
361 6 2 2 3.4 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC(=O)NCC4=CC=CC=C4
CHEMBL27403 5ht1d_human Human Yes 7.5 IC50 = 35 Funct
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
334 1 0 6 4.0 CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4
CHEMBL146891 5ht1d_human Human No 7.5 IC50 = 35 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
416 8 2 5 2.4 C1CN(CCC1NCC2=CN=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL117249 5ht1d_human Human No 7.5 IC50 = 35 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
324 5 1 4 1.7 CN1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL67367 5ht1d_human Human No 7.5 IC50 = 35 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
465 8 1 6 4.3 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL15837 5ht1d_rat Rat No 6.4 IC50 = 367 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
523 8 2 6 3.7 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCN(CC3)CCCCC4=CNC5=C4C=C(C=C5)F)OC
CHEMBL324287 5ht1d_human Human No 7.4 IC50 = 37 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
401 7 1 4 3.2 CN(CC1=CC=CC=C1)C2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL143894 5ht1d_human Human No 7.4 IC50 = 37 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
457 7 3 5 2.9 C1CN(CCC1NC2C(CC3=CC=CC=C23)O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL146735 5ht1d_human Human Yes 7.4 IC50 = 37 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
498 6 1 7 4.5 CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL324287 5ht1d_human Human No 7.4 IC50 = 38 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
401 7 1 4 3.2 CN(CC1=CC=CC=C1)C2CCN(C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL18785 5ht1d_human Human Yes 7.4 IC50 = 39 Funct
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligandCompound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]5-HT as the radioligand
228 2 2 2 1.8 COC1=CC2=C(C=C1)NC=C2C3=CCNCC3
CHEMBL314738 5ht1d_human Human No 7.4 IC50 = 39.8 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
300 7 3 2 2.5 C1CNC(=NC1)NCCCNCC2CCC3=CC=CC=C3C2
CHEMBL128 5ht1d_human Human Yes 7.4 IC50 = 39.8 Funct
Binding activity radioligand.Binding activity radioligand.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL324751 5ht1d_human Human No 8.4 IC50 = 4 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
459 9 3 5 3.0 CC1=CC=CC=C1CNCC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL147961 5ht1d_human Human No 8.4 IC50 = 4.1 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
445 9 3 5 3.4 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NC=N5
CHEMBL159650 5ht1d_human Human No 8.4 IC50 = 4.2 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 9 1 4 3.8 CN(CC1CCN(C1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL147907 5ht1d_human Human No 8.4 IC50 = 4.2 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
428 8 2 3 4.5 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=CN=C5
CHEMBL147940 5ht1d_human Human No 8.4 IC50 = 4.2 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
486 10 3 5 2.9 CC(=O)NC1=CC=C(C=C1)CNCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL342330 5ht1d_human Human No 8.4 IC50 = 4.3 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 2 5 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL423212 5ht1d_human Human No 8.4 IC50 = 4.3 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
435 8 1 5 3.7 CN(CC1=CC=CS1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146391 5ht1d_human Human No 8.4 IC50 = 4.4 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
443 9 2 4 4.1 CC(C1=CC=CC=C1)NCC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL331143 5ht1d_human Human No 8.4 IC50 = 4.5 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
409 9 3 5 1.9 C1CC1CNCC2(CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL423749 5ht1d_human Human No 8.4 IC50 = 4.5 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 2 5 3.3 CN(C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL357408 5ht1d_human Human No 8.4 IC50 = 4.5 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
405 8 2 5 2.6 C1CN(CCC1NCC2=COC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL117046 5ht1d_human Human No 8.3 IC50 = 4.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 8 2 4 3.5 C1CN(CCC1NCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL342805 5ht1d_human Human No 8.3 IC50 = 4.7 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
488 11 3 6 2.8 C1CN(CCC1NC(COC(=O)N)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL292262 5ht1d_human Human No 8.3 IC50 = 4.7 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC=CC=C2F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL117046 5ht1d_human Human No 8.3 IC50 = 4.8 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
415 8 2 4 3.5 C1CN(CCC1NCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL351311 5ht1d_human Human No 8.3 IC50 = 4.9 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
416 8 1 5 2.6 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CN=CC=C5
CHEMBL352123 5ht1d_human Human No 8.3 IC50 = 4.9 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 9 1 4 4.0 C1CN(CCN1CCCC2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL430122 5ht1d_rat Rat No 6.4 IC50 = 400 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
473 4 2 5 3.1 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)C4=CNC5=C4C=C(C=C5)C#N)OC
CHEMBL359447 5ht1d_human Human Yes 6.4 IC50 = 400 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
484 5 2 7 4.2 CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)O)N5CCN(CC5)C
CHEMBL439849 5ht1d_rat Rat Yes 5.4 IC50 = 4000 Funct
Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL439849 5ht1d_rat Rat Yes 5.4 IC50 = 4000 Funct
Inhibition of rat hydroxytryptamine 1D receptorInhibition of rat hydroxytryptamine 1D receptor
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL19114 5ht1d_human Human No 7.4 IC50 = 42.7 Funct
In Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudateIn Vitro Binding affinity againist 5-hydroxytryptamine 1D receptor by displacing [125I]GTI from pig caudate
204 3 2 3 0.5 C1=CC2=C(C=C1C(=O)N)C(=CO2)CCN
CHEMBL133939 5ht1d_cavpo Guinea pig No 6.4 IC50 = 420 Funct
Binding affinity against 5-hydroxytryptamine 1D receptorBinding affinity against 5-hydroxytryptamine 1D receptor
244 3 1 2 2.9 CN1CCCC1CC2=CNC3=C2C=C(C=C3)OC
CHEMBL25800 5ht1d_human Human Yes 5.4 IC50 = 4200 Funct
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
230 2 1 2 1.7 CN1C=C(C2=C1C=CC3=C2CCCO3)CCN
CHEMBL341897 5ht1d_human Human No 7.4 IC50 = 43 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
469 10 3 5 3.3 CC(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)CS(=O)(=O)NC
CHEMBL279320 5ht1d_rat Rat No 6.4 IC50 = 433 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
498 10 3 6 3.4 CN(C)CCOC1=C(C=CC(=C1)NC(=O)NCCN2CCC(CC2)C3=CNC4=C3C=CC(=C4)F)OC
CHEMBL470432 5ht1d_rat Rat No 5.3 IC50 = 4570.9 Funct
Displacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptorDisplacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL470432 5ht1d_rat Rat No 5.3 IC50 = 4570.9 Funct
Displacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptorDisplacement of [3H]5OH-tryptamine rat recombinant 5HT1D receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL422504 5ht1d_human Human No 6.3 IC50 = 467 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
484 5 2 7 4.6 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)O)N5CCN(CC5)C
CHEMBL143745 5ht1d_human Human No 6.3 IC50 = 470 Funct
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
351 10 1 2 4.8 CCCN(CCC)CCC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3
CHEMBL143745 5ht1d_human Human No 6.3 IC50 = 470 Funct
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
351 10 1 2 4.8 CCCN(CCC)CCC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3
CHEMBL334923 5ht1d_human Human No 6.3 IC50 = 478.6 Funct
Compound was tested for binding affinity against 5-hydroxytryptamine 1D receptorCompound was tested for binding affinity against 5-hydroxytryptamine 1D receptor
275 4 0 4 3.2 CC1=CSC2=C1N3C=CC=C3C2=NOCCN(C)C
CHEMBL128 5ht1d_human Human Yes 8.3 IC50 = 5 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL344537 5ht1d_human Human No 8.3 IC50 = 5 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
491 11 2 6 4.0 COCC(C1=CC=C(C=C1)F)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)CN5C=NC=N5
CHEMBL128 5ht1d_human Human Yes 8.3 IC50 = 5 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL2114038 5ht1d_human Human No 8.3 IC50 = 5 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
501 8 2 8 4.4 C1CN(CC(C1NCC2=CC=CC=C2C(F)(F)F)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL88207 5ht1d_human Human No 8.3 IC50 = 5.0 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
297 7 2 4 3.8 C1CC2=CC=CC=C2OC1CNCCCNC3=CC=CC=N3
CHEMBL148194 5ht1d_human Human No 8.3 IC50 = 5.2 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 9 3 5 3.0 CC(CO)(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL163376 5ht1d_human Human No 8.3 IC50 = 5.2 Funct
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
469 7 1 7 4.1 C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)C(F)(F)F
CHEMBL161970 5ht1d_human Human No 8.3 IC50 = 5.2 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 8 1 4 3.1 C1CN(C(=O)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC=CC=C5
CHEMBL416688 5ht1d_human Human No 8.3 IC50 = 5.4 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL416688 5ht1d_human Human No 8.3 IC50 = 5.4 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL416688 5ht1d_human Human No 8.3 IC50 = 5.4 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
447 8 1 5 4.0 CN(CC1=CC=CC=C1)C2CCN(CC2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL146502 5ht1d_human Human No 8.3 IC50 = 5.5 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
443 9 2 4 4.4 CC(CC1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146628 5ht1d_human Human No 8.3 IC50 = 5.5 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 3 5 3.7 C1CN(CCC1NC(CCO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL303514 5ht1d_human Human No 8.3 IC50 = 5.5 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC=C(C=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL147546 5ht1d_human Human No 8.2 IC50 = 5.7 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
500 10 2 5 3.6 CC(=O)NC1=CC=C(C=C1)CCN(C)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2114036 5ht1d_human Human No 8.2 IC50 = 5.8 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
451 8 1 6 3.8 C1CN(CCN1CCC2=CC(=CC=C2)F)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL147148 5ht1d_human Human No 8.2 IC50 = 5.9 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
472 8 2 4 3.5 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(=O)NC5=CC=CC=C5
CHEMBL147979 5ht1d_human Human No 8.2 IC50 = 5.9 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
459 10 3 5 3.0 C1CN(CCC1CNC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL312845 5ht1d_human Human No 7.3 IC50 = 50.1 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
329 9 3 4 2.4 CC(C)NC(=NCCCNCC1CCC2=CC=CC=C2O1)NC#N
CHEMBL2368255 5ht1d_human Human No 6.3 IC50 = 501.2 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
340 4 3 3 1.5 CC1(C(=O)N(C(=O)N1)CCC2=CC3=C(C=C2)NC=C3C4CC(C4)N)C
CHEMBL15928 5ht1d_human Human Yes 7.3 IC50 = 52 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL15928 5ht1d_rat Rat Yes 7.3 IC50 = 53 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL68019 5ht1d_human Human No 7.3 IC50 = 56 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
450 8 1 5 5.4 C1CN(CCC1CCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL350637 5ht1d_human Human No 6.3 IC50 = 562.3 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
296 3 1 4 3.0 CC1=NOC(=N1)C2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL2368257 5ht1d_human Human No 7.2 IC50 = 57.5 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
327 4 1 3 2.7 CN1C(COC1=O)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL145849 5ht1d_human Human No 8.2 IC50 = 6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
473 10 2 5 3.5 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)C(CO)C5=CC=CC=C5
CHEMBL84107 5ht1d_rat Rat No 8.2 IC50 = 6.2 Funct
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
337 4 3 5 3.6 C1CC(NC1)CC2=CNC3=C2C=C(C=C3)NC4=C(C=CC=N4)[N+](=O)[O-]
CHEMBL143952 5ht1d_human Human No 8.2 IC50 = 6.2 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
479 9 2 6 3.3 C1CN(CCC1CNS(=O)(=O)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL433108 5ht1d_human Human No 8.2 IC50 = 6.2 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
465 8 1 6 4.3 CC(CN1CCN(CC1)CC(CC2=CNC3=C2C=C(C=C3)N4C=NN=C4)(F)F)C5=CC=CC=C5
CHEMBL420874 5ht1d_human Human No 8.2 IC50 = 6.3 Funct
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL420874 5ht1d_human Human No 8.2 IC50 = 6.3 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
387 7 1 4 3.1 C1CN(CC1OCC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146129 5ht1d_human Human No 8.2 IC50 = 6.3 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
477 10 4 5 3.5 C1CN(CCC1NC(CO)C2=CC=CC=C2)CCCC3=CNC4=C3C=C(C=C4)CC5COC(=O)N5
CHEMBL88208 5ht1d_human Human No 8.2 IC50 = 6.3 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
288 7 3 3 1.7 C1CC2=CC=CC=C2OC1CNCCCNC3=NCCN3
CHEMBL2112862 5ht1d_human Human No 8.2 IC50 = 6.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
457 7 3 5 2.9 C1CN(CCC1NC2C(CC3=CC=CC=C23)O)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL162899 5ht1d_human Human No 8.2 IC50 = 6.6 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
415 7 1 4 2.7 C1CN(C(=O)CN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=CC=C5
CHEMBL128 5ht1d_human Human Yes 8.2 IC50 = 6.7 Funct
Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL128 5ht1d_human Human Yes 8.2 IC50 = 6.7 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL128 5ht1d_human Human Yes 8.2 IC50 = 6.8 Funct
Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL304993 5ht1d_human Human No 8.2 IC50 = 6.8 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
433 8 1 5 3.7 C1CN(CCN1CCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)F
CHEMBL163114 5ht1d_human Human No 8.2 IC50 = 6.9 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
497 9 1 7 3.9 CC1=NOC(=N1)C2=CC=C(C=C2)CCN3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL159174 5ht1d_cavpo Guinea pig Yes 7.2 IC50 = 60 Funct
Binding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determinedBinding affinity towards guinea pig 5-hydroxytryptamine 1D receptor was determined
453 11 6 6 0.6 C1=CC(=CC=C1CC(C(=O)N)NC(=O)CNC(=O)COC2=CC3=C(C=C2)NC=C3CCN)O
CHEMBL151420 5ht1d_human Human No 6.2 IC50 = 600 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
530 8 1 8 5.3 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OCCF)N5CCN(CC5)C
CHEMBL128 5ht1d_rat Rat Yes 7.2 IC50 = 61 Funct
Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorBinding affinity was measured against serotonin 5-hydroxytryptamine 1D receptor
295 6 2 4 0.9 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
CHEMBL88783 5ht1d_human Human No 7.2 IC50 = 63.1 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
288 6 3 3 1.1 C1CNC(=NC1)NCCNCC2CCC3=CC=CC=C3O2
CHEMBL2368253 5ht1d_human Human No 7.2 IC50 = 64.6 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
306 4 1 2 4.2 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)OC4=CC=CC=C4
CHEMBL83658 5ht1d_human Human No 6.2 IC50 = 660.7 Funct
Binding affinity against 5-HT1D receptorBinding affinity against 5-HT1D receptor
294 2 0 3 3.9 CN(C)CC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL83658 5ht1d_human Human No 6.2 IC50 = 660.7 Funct
Binding affinity for human cloned 5-hydroxytryptamine 1D receptorBinding affinity for human cloned 5-hydroxytryptamine 1D receptor
294 2 0 3 3.9 CN(C)CC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL15808 5ht1d_rat Rat No 6.2 IC50 = 667 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
438 3 2 5 2.8 CN1CCN(CC1)C2=C(C=CC(=C2)NC(=O)N3CCC4=C(C3)C5=C(N4)C=CC(=C5)F)OC
CHEMBL2368256 5ht1d_human Human No 8.2 IC50 = 7.1 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
299 4 3 3 2.0 CNC1CC(C1)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL159332 5ht1d_human Human Yes 8.1 IC50 = 7.2 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
321 5 2 4 1.5 CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CC3CCCN3C
CHEMBL113831 5ht1d_human Human No 8.1 IC50 = 7.3 Funct
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroAbility to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro
425 9 3 5 2.9 CC(C)(C)CNCC1(CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)O
CHEMBL148110 5ht1d_human Human No 8.1 IC50 = 7.6 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
472 9 3 5 3.3 CC(C(=O)NC1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL356315 5ht1d_human Human No 8.1 IC50 = 7.6 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
459 9 3 5 3.3 CC(C(C1=CC=CC=C1)NC2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5)O
CHEMBL159733 5ht1d_human Human No 8.1 IC50 = 7.7 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
429 9 1 4 3.9 CN(CC1CCN(C1)CCC2=CNC3=C2C=C(C=C3)CN4C=NC=N4)CC5=CC=CC=C5
CHEMBL90405 5ht1d_human Human No 8.1 IC50 = 7.9 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
320 7 3 4 2.1 C1CNC(=NC1)NCCCNCC2CCC3=C(O2)C=CC(=C3)F
CHEMBL89427 5ht1d_human Human No 8.1 IC50 = 7.9 Funct
Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraAbility to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigra
303 7 2 5 3.9 C1CC2=CC=CC=C2OC1CNCCCNC3=NC=CS3
CHEMBL151894 5ht1d_human Human No 6.2 IC50 = 700 Funct
Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayInhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assay
534 7 1 9 4.2 CC1=C(C=CC(=C1)C2=NN=C(O2)C)C3=CC=C(C=C3)S(=O)(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL100086 5ht1d_human Human No 6.2 IC50 = 700 Funct
Inhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HTInhibitory concentration required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]5-HT
425 5 1 6 3.3 COC1=CC=CC(=C1)CN2CCN(CC2)C3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O
CHEMBL348811 5ht1d_human Human No 6.1 IC50 = 724.4 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
271 4 2 2 1.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC(=O)N
CHEMBL357130 5ht1d_human Human Yes 7.1 IC50 = 76 Funct
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
294 6 1 2 3.0 CN(C)CCC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3
CHEMBL142629 5ht1d_human Human Yes 7.1 IC50 = 77 Funct
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
232 5 2 2 1.9 CCN(CC)CCC1=CNC2=C1C=C(C=C2)O
CHEMBL142629 5ht1d_human Human Yes 7.1 IC50 = 77 Funct
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
232 5 2 2 1.9 CCN(CC)CCC1=CNC2=C1C=C(C=C2)O
CHEMBL64003 5ht1d_human Human No 7.1 IC50 = 78 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
436 7 1 5 4.9 C1CN(CCC1CC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL905 5ht1d_human Human Yes 7.1 IC50 = 79.4 Funct
Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.
269 5 1 3 1.7 CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3
CHEMBL22553 5ht1d_human Human No 8.1 IC50 = 8 Funct
Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeInhibitory activity against 5-hydroxytryptamine 1D receptor subtype
537 9 6 4 2.9 C1CC(=CCC1NCCNC2CCC(=CC2)C3=CNC4=C3C=C(C=C4)C(=O)N)C5=CNC6=C5C=C(C=C6)C(=O)N
CHEMBL148085 5ht1d_human Human No 8.1 IC50 = 8.1 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
419 8 1 5 3.0 CN(CC1=COC=C1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL343667 5ht1d_human Human No 8.1 IC50 = 8.1 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
521 10 1 6 3.4 CN(CC1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CC5=CC=C(C=C5)S(=O)(=O)C
CHEMBL147853 5ht1d_human Human No 8.1 IC50 = 8.3 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
459 10 3 5 3.3 C1CN(CCC1NC(CC2=CC=CC=C2)CO)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL441296 5ht1d_human Human No 8.1 IC50 = 8.3 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
431 9 3 5 2.3 C1CN(CC1CNC(CO)C2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL143767 5ht1d_human Human No 8.1 IC50 = 8.4 Funct
Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.Compound was tested for binding affinity against human 5-hydroxytryptamine 1D receptor alpha clones expressed in human embryonic kidney (HEK 293) cells line.
336 5 1 7 2.3 CN(C)CCC1=CNC2=C1C=C(C=C2)OS(=O)(=O)C(F)(F)F
CHEMBL161066 5ht1d_human Human No 8.1 IC50 = 8.5 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 8 2 5 1.9 C1CN(CC1CNCC2=CC=NC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL63258 5ht1d_human Human No 8.1 IC50 = 8.5 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
452 8 1 6 4.1 C1CN(CCC1OCC2=CC=CC=C2)CC(CC3=CNC4=C3C=C(C=C4)N5C=NN=C5)(F)F
CHEMBL162930 5ht1d_human Human No 8.1 IC50 = 8.8 Funct
Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
311 5 1 4 1.5 C1COCCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL148095 5ht1d_human Human No 8.1 IC50 = 8.9 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
441 7 2 4 3.9 C1CC2=CC=CC=C2C1NC3CCN(CC3)CCCC4=CNC5=C4C=C(C=C5)N6C=NN=C6
CHEMBL141706 5ht1d_human Human Yes 6.1 IC50 = 820 Funct
Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells.
260 7 2 2 3.0 CCCN(CCC)CCC1=CNC2=C1C=C(C=C2)O
CHEMBL141706 5ht1d_human Human Yes 6.1 IC50 = 820 Funct
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cellsDisplacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
260 7 2 2 3.0 CCCN(CCC)CCC1=CNC2=C1C=C(C=C2)O
CHEMBL2110300 5ht1d_human Human No 7.1 IC50 = 89.1 Funct
Binding affinity against calf caudate 5-hydroxytryptamine 1D receptorBinding affinity against calf caudate 5-hydroxytryptamine 1D receptor
313 4 2 3 2.5 CN(C)C1CC(C1)C2=CNC3=C2C=C(C=C3)CC4COC(=O)N4
CHEMBL349528 5ht1d_human Human No 8.1 IC50 = 9 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
297 4 2 4 1.0 C1CN(CC1O)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL159493 5ht1d_human Human No 8.0 IC50 = 9.1 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
387 7 2 4 3.6 C1CN(CC1CNC2=CC=CC=C2)CCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL434315 5ht1d_human Human No 8.0 IC50 = 9.3 Funct
Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
419 8 1 5 3.1 CN(CC1=CC=CO1)C2CCN(CC2)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL2115112 5ht1d_human Human No 8.0 IC50 = 9.3 Funct
Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells
515 8 1 8 4.9 CN(CC1=CC=CC=C1C(F)(F)F)C2CCN(CC2F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL146396 5ht1d_human Human No 8.0 IC50 = 9.8 Funct
Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.Binding affinity at human cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells by [3H]5-HT displacement.
391 7 1 4 3.1 CC#CCN(C)C1CCN(CC1)CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4
CHEMBL15909 5ht1d_rat Rat No 6.1 IC50 = 900 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
506 5 3 5 3.8 CN1CCC2(CC1)COC3=C2C=C(C=C3)NC(=O)NCCN4CCC(CC4)C5=CNC6=C5C=CC(=C6)F
CHEMBL276928 5ht1d_rat Rat No 6.1 IC50 = 900 Funct
Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.Binding affinity towards 5-hydroxytryptamine 1D receptor in rat frontal cortex using [125I]iodocyanopindolol as radio-ligand.
463 2 2 4 3.9 CN1CCC2(CC1)COC3=C2C=C(C=C3)NC(=O)N4CCC(CC4)C5=CNC6=C5C=C(C=C6)F
CHEMBL26427 5ht1d_human Human No 5.0 IC50 = 9300 Funct
Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligandCompound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
258 3 0 2 2.7 CN1C=C(C2=C1C=CC3=C2CCCO3)CCN(C)C
CHEMBL161694 5ht1d_human Human No 6.0 IC50 = 933.3 Funct
Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptorBinding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor
310 4 1 4 3.3 CC1=NOC(=N1)CC2=CC3=C(C=C2)NC=C3C4CC(C4)N(C)C
CHEMBL159381 5ht1d_human Human No 7.0 IC50 = 95 Funct
Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsDisplacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells
402 8 1 4 3.4 C1CC(N(C1)CCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)COCC5=CC=CC=C5
CHEMBL1241913 5ht1d_human Human No 9.8 Kd = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL1185 5ht1d_human Human Yes 8.8 Kd = 1.5 Funct
Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.Binding affinity against 5-hydroxytryptamine 1D receptor beta using rabbit saphenous vein assay.
287 5 2 3 2.2 CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
CHEMBL251541 5ht1d_human Human No 7.0 Kd = 112.2 Funct
Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor
465 3 0 6 3.6 CN1CC(CC2C1CC3=C(C2)C(=CC=C3)OC)C(=O)N4CCN(CC4)C5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL251541 5ht1d_human Human No 7.0 Kd = 112.2 Funct
Binding affinity to human 5HT1D receptorBinding affinity to human 5HT1D receptor
465 3 0 6 3.6 CN1CC(CC2C1CC3=C(C2)C(=CC=C3)OC)C(=O)N4CCN(CC4)C5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL1242345 5ht1d_human Human No 10.7 Ki = 0.0 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 7 1 6 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NCC7CC7
CHEMBL1242345 5ht1d_human Human No 10.7 Ki = 0.0 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 7 1 6 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NCC7CC7
CHEMBL1242081 5ht1d_human Human No 10.4 Ki = 0.0 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
509 6 1 6 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CC7
CHEMBL1242081 5ht1d_human Human No 10.4 Ki = 0.0 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
509 6 1 6 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CC7
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL513715 5ht1d_human Human No 10.3 Ki = 0.1 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)NC(=O)CO5
CHEMBL1290487 5ht1d_human Human No 10.1 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
415 4 0 4 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)N(C5=CC=C4)C
CHEMBL469374 5ht1d_human Human No 10.1 Ki = 0.1 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
435 4 0 6 3.7 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C)F
CHEMBL1290487 5ht1d_human Human No 10.1 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
415 4 0 4 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)N(C5=CC=C4)C
CHEMBL469374 5ht1d_human Human No 10.1 Ki = 0.1 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
435 4 0 6 3.7 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C)F
CHEMBL357478 5ht1d_human Human No 10.1 Ki = 0.1 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
610 12 5 7 2.8 C1CN(CCN1C2=CC=C(C=C2)NC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=O)COC5=CC6=C(C=C5)NC=C6CCN
CHEMBL1242904 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
426 4 0 5 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=CN=C6CO5
CHEMBL522257 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5C
CHEMBL1242167 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 6 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CCC7
CHEMBL1241736 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
468 5 0 6 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)C
CHEMBL469345 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C
CHEMBL1290486 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
401 4 1 4 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)NC5=CC=C4
CHEMBL522257 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5C
CHEMBL1241913 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation countingDisplacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation counting
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL1242904 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
426 4 0 5 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=CN=C6CO5
CHEMBL522257 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5C
CHEMBL1242167 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 6 1 6 4.3 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CCC7
CHEMBL1241736 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
468 5 0 6 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)C
CHEMBL469345 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C
CHEMBL1290486 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
401 4 1 4 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5CCC(=O)NC5=CC=C4
CHEMBL522257 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
417 4 0 5 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5C
CHEMBL1241913 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation countingDisplacement of [3H]-5-HT from human recombinant 5HT1D receptor expressed in CHO cells after 45 mins by scintillation counting
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL144030 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
455 10 4 4 3.7 C1=CC(=CC=C1COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL144030 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
455 10 4 4 3.7 C1=CC(=CC=C1COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL356277 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
541 12 6 6 2.6 C1=CC(=CC=C1NC(=O)COC2=CC3=C(C=C2)NC=C3CCN)NC(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL144030 5ht1d_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingDisplacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation counting
455 10 4 4 3.7 C1=CC(=CC=C1COC2=CC3=C(C=C2)NC=C3CCN)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL1241912 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
483 5 1 6 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC
CHEMBL1241547 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
440 4 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=C(N=C6CO5)C
CHEMBL1241639 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
428 4 0 7 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=NN=N6)CO5
CHEMBL1241642 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
426 4 0 5 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC=C6CO5
CHEMBL1241641 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
494 4 0 8 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=C(N=C6CO5)C(F)(F)F
CHEMBL1241546 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
441 4 0 6 3.9 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=C(N=N6)C)CO5
CHEMBL1290715 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
399 4 1 4 3.9 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)NC5=CC=C4
CHEMBL1289394 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
445 4 0 5 4.6 CC1CN(CCN1CCC2=C3C=CC(=O)N(C3=CC=C2)C)C4=C5C=CC(=NC5=CC(=C4)F)C
CHEMBL1631538 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
419 7 1 5 4.4 CCOC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL1631535 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
425 6 1 6 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL1241912 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
483 5 1 6 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC
CHEMBL1241547 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
440 4 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=C(N=C6CO5)C
CHEMBL1241639 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
428 4 0 7 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=NN=N6)CO5
CHEMBL1241642 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
426 4 0 5 3.8 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC=C6CO5
CHEMBL1241641 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
494 4 0 8 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=C(N=C6CO5)C(F)(F)F
CHEMBL1241546 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
441 4 0 6 3.9 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=C(N=N6)C)CO5
CHEMBL1290715 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
399 4 1 4 3.9 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C=CC(=O)NC5=CC=C4
CHEMBL1289394 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayAntagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay
445 4 0 5 4.6 CC1CN(CCN1CCC2=C3C=CC(=O)N(C3=CC=C2)C)C4=C5C=CC(=NC5=CC(=C4)F)C
CHEMBL15928 5ht1d_human Human Yes 9.9 Ki = 0.1 Funct
Binding affinity against 5-hydroxytryptamine 1D receptor betaBinding affinity against 5-hydroxytryptamine 1D receptor beta
498 6 1 7 4.9 CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C
CHEMBL1631538 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
419 7 1 5 4.4 CCOC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL1631535 5ht1d_human Human No 9.9 Ki = 0.1 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
425 6 1 6 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NS(=O)(=O)C
CHEMBL1241998 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
511 6 1 6 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC(C)C
CHEMBL1242533 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 5 0 6 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCCC7
CHEMBL1242257 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
537 6 1 6 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CCCC7
CHEMBL1241738 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
441 4 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=NN=C6CO5)C
CHEMBL1242717 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
539 5 0 7 3.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCOCC7
CHEMBL1241824 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
497 5 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N(C)C
CHEMBL1242623 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
537 5 0 6 4.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCCCC7
CHEMBL1241548 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
454 4 0 5 4.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=C(N=C6CO5)C)C
CHEMBL1241913 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL469568 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
443 5 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C6CC6
CHEMBL1631542 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
417 5 0 5 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCOC5=O
CHEMBL490417 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL1632220 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
418 6 2 4 3.9 CCNC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL1632215 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
481 7 1 5 5.3 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=CC(=CC=C5)OC
CHEMBL1631545 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
398 5 0 4 4.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5C=CC=N5
CHEMBL1632208 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
417 6 1 4 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C(C)C
CHEMBL1632221 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
432 7 2 4 4.4 CCCNC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL490417 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL491839 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
408 4 1 5 3.4 CC1(CC2=C(O1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)C
CHEMBL521506 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL1241998 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
511 6 1 6 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC(C)C
CHEMBL1242533 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
523 5 0 6 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCCC7
CHEMBL1242257 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
537 6 1 6 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)NC7CCCC7
CHEMBL1241738 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
441 4 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=NN=C6CO5)C
CHEMBL1242717 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
539 5 0 7 3.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCOCC7
CHEMBL1241824 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
497 5 0 6 3.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N(C)C
CHEMBL1242623 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
537 5 0 6 4.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCCCC7
CHEMBL1241548 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
454 4 0 5 4.6 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C(=C(N=C6CO5)C)C
CHEMBL1241913 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
469 5 1 6 3.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N
CHEMBL469568 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
443 5 0 5 4.2 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C6CC6
CHEMBL1631542 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
417 5 0 5 4.0 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCOC5=O
CHEMBL490417 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL1632220 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
418 6 2 4 3.9 CCNC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL1632215 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
481 7 1 5 5.3 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=CC(=CC=C5)OC
CHEMBL1631545 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
398 5 0 4 4.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5C=CC=N5
CHEMBL1632208 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
417 6 1 4 4.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C(C)C
CHEMBL1632221 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
432 7 2 4 4.4 CCCNC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL490417 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL491839 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
408 4 1 5 3.4 CC1(CC2=C(O1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)C
CHEMBL521506 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL147851 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
505 11 4 6 1.8 C1CN(CCN1CCOC2=CC3=C(C=C2)NC=C3CCN)C(=O)COC4=CC5=C(C=C4)NC=C5CCN
CHEMBL147901 5ht1d_human Human No 9.8 Ki = 0.2 Funct
Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsAbility to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cells
436 11 5 5 1.8 C1=CC2=C(C=C1OCCNC(=O)COC3=CC4=C(C=C3)NC=C4CCN)C(=CN2)CCN
CHEMBL1242436 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
509 5 0 6 3.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCC7
CHEMBL472290 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
431 5 0 5 4.0 CCN1C(=O)COC2=C(C=CC=C21)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL459282 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells
458 7 0 4 5.9 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC=CC(=C4)C5CCN(CC5)C
CHEMBL1632217 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
453 6 1 6 3.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=NC=CN=C5
CHEMBL1631533 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
484 6 2 5 5.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)NC5=CC=CC=C5F
CHEMBL1631540 5ht1d_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
416 5 1 4 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCNC5=O
CHEMBL1632207 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
403 6 1 4 4.1 CCC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL489394 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 6 3.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C(=C4)F)OCC(=O)N5
CHEMBL444398 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
390 4 2 4 3.3 CC1=CC2=C(N1)C=CC=C2N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL485491 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 6 3.5 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)F
CHEMBL497980 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=C(C=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL490417 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL1242436 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Antagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity against human recombinant 5HT1D receptor expressed in CHO cells assessed as inhibition of 5HT-induced [35S]GTPgammaS binding by scintillation proximity assay
509 5 0 6 3.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N6C=NC(=C6CO5)C(=O)N7CCC7
CHEMBL472290 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
431 5 0 5 4.0 CCN1C(=O)COC2=C(C=CC=C21)CCN3CCN(CC3)C4=CC=CC5=C4C=CC(=N5)C
CHEMBL459282 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of 3H]5HT from human 5HT1D receptor expressed in CHO cells
458 7 0 4 5.9 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCC(CC3)CC4=CC=CC(=C4)C5CCN(CC5)C
CHEMBL1632217 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
453 6 1 6 3.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=NC=CN=C5
CHEMBL1631533 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
484 6 2 5 5.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)NC5=CC=CC=C5F
CHEMBL1631540 5ht1d_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
416 5 1 4 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCNC5=O
CHEMBL1632207 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
403 6 1 4 4.1 CCC(=O)NC1=CC=CC(=C1)CCN2CCN(CC2)C3=CC=CC4=C3C=CC(=N4)C
CHEMBL489394 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 6 3.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C(=C4)F)OCC(=O)N5
CHEMBL444398 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
390 4 2 4 3.3 CC1=CC2=C(N1)C=CC=C2N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL485491 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 6 3.5 CC1=NC2=CC(=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)F
CHEMBL497980 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
437 4 1 5 4.1 CC1=NC2=C(C=CC(=C2C=C1)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5)Cl
CHEMBL490417 5ht1d_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cells
402 4 1 5 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4)OCC(=O)N5
CHEMBL49826 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Binding affinity for human 5-hydroxytryptamine 1D receptorBinding affinity for human 5-hydroxytryptamine 1D receptor
270 3 1 1 4.6 CC(C)(C)C1=CC2=C(C=C1)NC=C2CC3CCCN3C
CHEMBL469567 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
445 5 0 5 4.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C(C)C
CHEMBL190298 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
402 6 1 5 3.5 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=C5C(=CC=C4)NC=N5
CHEMBL1631532 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
405 6 1 5 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)OC
CHEMBL1632219 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
472 6 1 6 5.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=C(N=CS5)C
CHEMBL1632211 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
469 6 1 5 5.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=CC=CC=C5F
CHEMBL1632222 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
446 6 2 4 4.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)NC(C)(C)C
CHEMBL1632206 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
389 5 1 4 3.7 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C
CHEMBL1631543 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
431 5 0 5 4.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCCOC5=O
CHEMBL490211 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
388 4 1 5 3.3 C1CN(CCN1CCC2=CC3=C(C=C2)OCC(=O)N3)C4=NC=CC5=CC=CC=C54
CHEMBL496317 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
420 4 1 6 3.5 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC5=C(C=C4F)OCC(=O)N5
CHEMBL523095 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsDisplacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells
388 4 1 5 3.0 C1CN(CCN1CCC2=CC3=C(C=C2)OCC(=O)N3)C4=CC=CC5=C4N=CC=C5
CHEMBL525362 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5HT from human recombinant 5HT1D receptorDisplacement of [3H]5HT from human recombinant 5HT1D receptor
447 8 2 4 4.7 CCNC(=O)NC1=CC=CC(=C1)CC2CCN(CC2)CCOC3=CC=CC4=C3C=CC(=N4)C
CHEMBL469567 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTAntagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HT
445 5 0 5 4.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=C5C(=CC=C4)N(C(=O)CO5)C(C)C
CHEMBL190298 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells
402 6 1 5 3.5 CC1=NC2=C(C=C1)C(=CC=C2)OCCN3CCN(CC3)CC4=C5C(=CC=C4)NC=N5
CHEMBL1631532 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
405 6 1 5 4.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)OC
CHEMBL1632219 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
472 6 1 6 5.1 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=C(N=CS5)C
CHEMBL1632211 5ht1d_human Human No 9.6 Ki = 0.3 Funct
Displacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cellsDisplacement of [3H]5-HT from human recombinant 5-HT1D receptor expressed in CHO cells
469 6 1 5 5.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)NC(=O)C5=CC=CC=C5F
CHEMBL1632222 5ht1d_human Human No 9.6 Ki =