Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 4168101 | 20867 | 4 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 405 | 5 | 1 | 3 | 5.5 | O=C(OC(C(=O)Nc1cccc(C(F)(F)F)c1)c1ccccc1)C1CCCCC1 | nan | ||
| CHEMBL1310437 | 20867 | 4 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 405 | 5 | 1 | 3 | 5.5 | O=C(OC(C(=O)Nc1cccc(C(F)(F)F)c1)c1ccccc1)C1CCCCC1 | nan | ||
| 2794045 | 31569 | 9 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 279 | 4 | 1 | 1 | 4.6 | O=C(Nc1ccccc1)C(c1ccccc1)C1CCCC1 | nan | ||
| CHEMBL1404080 | 31569 | 9 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 279 | 4 | 1 | 1 | 4.6 | O=C(Nc1ccccc1)C(c1ccccc1)C1CCCC1 | nan | ||
| 2353214 | 29068 | 6 | None | 3 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 387 | 6 | 1 | 2 | 5.7 | O=C(Nc1ccc(OC(F)F)c(Cl)c1)C(c1ccccc1)c1ccccc1 | nan | ||
| CHEMBL1380914 | 29068 | 6 | None | 3 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 387 | 6 | 1 | 2 | 5.7 | O=C(Nc1ccc(OC(F)F)c(Cl)c1)C(c1ccccc1)c1ccccc1 | nan | ||
| 3893874 | 33957 | 4 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 397 | 5 | 1 | 4 | 5.4 | Cc1cc(C(=O)OC(C(=O)Nc2ccc(C)c(Cl)c2)c2ccccc2)c(C)o1 | nan | ||
| CHEMBL1424117 | 33957 | 4 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 397 | 5 | 1 | 4 | 5.4 | Cc1cc(C(=O)OC(C(=O)Nc2ccc(C)c(Cl)c2)c2ccccc2)c(C)o1 | nan | ||
| 5038554 | 46187 | 5 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 318 | 4 | 1 | 3 | 4.3 | Cc1ccc(NC(=O)C(C)c2ccc([N+](=O)[O-])cc2)cc1Cl | nan | ||
| CHEMBL1534431 | 46187 | 5 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 318 | 4 | 1 | 3 | 4.3 | Cc1ccc(NC(=O)C(C)c2ccc([N+](=O)[O-])cc2)cc1Cl | nan | ||
| 1090053 | 47750 | 15 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 443 | 4 | 1 | 5 | 3.9 | Cc1ccccc1C(=O)N1CCN(c2ccc(NC(=O)c3ccc4c(c3)OCO4)cc2)CC1 | nan | ||
| CHEMBL1548000 | 47750 | 15 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 443 | 4 | 1 | 5 | 3.9 | Cc1ccccc1C(=O)N1CCN(c2ccc(NC(=O)c3ccc4c(c3)OCO4)cc2)CC1 | nan | ||
| 5307823 | 26723 | 4 | None | 1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 332 | 5 | 1 | 3 | 4.6 | CCc1ccccc1NC1c2ccccc2C(=O)N1Cc1ccco1 | nan | ||
| CHEMBL1362304 | 26723 | 4 | None | 1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 332 | 5 | 1 | 3 | 4.6 | CCc1ccccc1NC1c2ccccc2C(=O)N1Cc1ccco1 | nan | ||
| 4841482 | 46080 | 5 | None | -2 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 397 | 5 | 1 | 3 | 5.3 | Cc1ccc(NC(=O)C(OC(=O)c2ccc(F)cc2)c2ccccc2)cc1Cl | nan | ||
| CHEMBL1533427 | 46080 | 5 | None | -2 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 397 | 5 | 1 | 3 | 5.3 | Cc1ccc(NC(=O)C(OC(=O)c2ccc(F)cc2)c2ccccc2)cc1Cl | nan | ||
| 2233014 | 38965 | 9 | None | 3 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 429 | 7 | 1 | 6 | 4.9 | COc1ccc(CC(=O)Nc2cccc(-c3nnc(-c4cccc(C)c4)o3)c2)cc1OC | nan | ||
| CHEMBL1467999 | 38965 | 9 | None | 3 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 429 | 7 | 1 | 6 | 4.9 | COc1ccc(CC(=O)Nc2cccc(-c3nnc(-c4cccc(C)c4)o3)c2)cc1OC | nan | ||
| 3827421 | 33447 | 7 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 329 | 4 | 1 | 1 | 5.8 | O=C(Nc1ccc2ccccc2c1)C(c1ccccc1)C1CCCC1 | nan | ||
| CHEMBL1419954 | 33447 | 7 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 329 | 4 | 1 | 1 | 5.8 | O=C(Nc1ccc2ccccc2c1)C(c1ccccc1)C1CCCC1 | nan | ||
| 6890484 | 72889 | 7 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 375 | 6 | 1 | 5 | 4.1 | O=C(N/N=C/c1ccc(-c2ccc([N+](=O)[O-])cc2)o1)[C@H]1C[C@@H]1c1ccccc1 | nan | ||
| CHEMBL2003667 | 72889 | 7 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 375 | 6 | 1 | 5 | 4.1 | O=C(N/N=C/c1ccc(-c2ccc([N+](=O)[O-])cc2)o1)[C@H]1C[C@@H]1c1ccccc1 | nan | ||
| 3247435 | 46143 | 3 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.7 | CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c1cccs1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1533923 | 46143 | 3 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 347 | 7 | 1 | 2 | 5.7 | CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c1cccs1)c1ccc(Cl)cc1 | nan | ||
| 564008 | 45247 | 13 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 333 | 4 | 0 | 5 | 4.5 | O=[N+]([O-])c1ccc(C2=NN(c3ccccc3)C(c3ccco3)C2)cc1 | nan | ||
| CHEMBL1526126 | 45247 | 13 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 333 | 4 | 0 | 5 | 4.5 | O=[N+]([O-])c1ccc(C2=NN(c3ccccc3)C(c3ccco3)C2)cc1 | nan | ||
| 2810094 | 29583 | 3 | None | 1 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 365 | 4 | 1 | 3 | 4.9 | Cc1cccc(Cn2nc(C(C)(C)C)cc2C(=O)Nc2ccc(F)cc2)c1 | nan | ||
| CHEMBL1385499 | 29583 | 3 | None | 1 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 365 | 4 | 1 | 3 | 4.9 | Cc1cccc(Cn2nc(C(C)(C)C)cc2C(=O)Nc2ccc(F)cc2)c1 | nan | ||
| 3513763 | 23133 | 5 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 413 | 5 | 1 | 3 | 5.8 | Cc1ccc(NC(=O)C(OC(=O)c2ccccc2Cl)c2ccccc2)cc1Cl | nan | ||
| CHEMBL1330917 | 23133 | 5 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 413 | 5 | 1 | 3 | 5.8 | Cc1ccc(NC(=O)C(OC(=O)c2ccccc2Cl)c2ccccc2)cc1Cl | nan | ||
| 3105194 | 38740 | 9 | None | 3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 402 | 5 | 2 | 4 | 4.9 | Cc1cccc(C2(c3cccc(C)c3)CC2C(=O)Nc2ccc([N+](=O)[O-])cc2O)c1 | nan | ||
| CHEMBL1466117 | 38740 | 9 | None | 3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 402 | 5 | 2 | 4 | 4.9 | Cc1cccc(C2(c3cccc(C)c3)CC2C(=O)Nc2ccc([N+](=O)[O-])cc2O)c1 | nan | ||
| 3730347 | 42941 | 7 | None | -2 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 293 | 4 | 1 | 1 | 4.9 | Cc1ccc(NC(=O)C(c2ccccc2)C2CCCC2)cc1 | nan | ||
| CHEMBL1503503 | 42941 | 7 | None | -2 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 293 | 4 | 1 | 1 | 4.9 | Cc1ccc(NC(=O)C(c2ccccc2)C2CCCC2)cc1 | nan | ||
| 969623 | 201404 | 10 | None | -1 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1ccc(NC(=O)C2(c3ccc([N+](=O)[O-])cc3)CCCC2)cc1 | nan | ||
| CHEMBL604664 | 201404 | 10 | None | -1 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 324 | 4 | 1 | 3 | 4.4 | Cc1ccc(NC(=O)C2(c3ccc([N+](=O)[O-])cc3)CCCC2)cc1 | nan | ||
| 1042 | 1581 | 23 | None | -2 | 13 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | ||
| 148 | 1581 | 23 | None | -2 | 13 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | ||
| 443884 | 1581 | 23 | None | -2 | 13 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | ||
| CHEMBL119443 | 1581 | 23 | None | -2 | 13 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | ||
| DB01253 | 1581 | 23 | None | -2 | 13 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 10009042 | 85810 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 620 | 15 | 6 | 4 | 6.9 | NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1 | 10.1016/0960-894X(94)00470-Z | |||
| CHEMBL22961 | 85810 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 620 | 15 | 6 | 4 | 6.9 | NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1 | 10.1016/0960-894X(94)00470-Z | |||
| 2543 | 3707 | 68 | None | -630 | 32 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 5358 | 3707 | 68 | None | -630 | 32 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 54 | 3707 | 68 | None | -630 | 32 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| CHEMBL128 | 3707 | 68 | None | -630 | 32 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| DB00669 | 3707 | 68 | None | -630 | 32 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm9704560 | |||
| 9851789 | 85522 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 606 | 14 | 6 | 4 | 6.5 | NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1 | 10.1021/jm7011722 | |||
| CHEMBL22744 | 85522 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 606 | 14 | 6 | 4 | 6.5 | NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1 | 10.1021/jm7011722 | |||
| 9851789 | 85522 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 606 | 14 | 6 | 4 | 6.5 | NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1 | 10.1016/0960-894X(94)00470-Z | |||
| CHEMBL22744 | 85522 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 606 | 14 | 6 | 4 | 6.5 | NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1 | 10.1016/0960-894X(94)00470-Z | |||
| 5 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| 5202 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL39 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| DB08839 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| 135398737 | 958 | 93 | None | -194 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| 38 | 958 | 93 | None | -194 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| 722 | 958 | 93 | None | -194 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| CHEMBL42 | 958 | 93 | None | -194 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| DB00363 | 958 | 93 | None | -194 | 89 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 10.1039/C2MD00311B | |||
| 9935387 | 99442 | 0 | None | -1258 | 14 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL282971 | 99442 | 0 | None | -1258 | 14 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 49783209 | 17609 | 0 | None | -5011 | 26 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| CHEMBL1258223 | 17609 | 0 | None | -5011 | 26 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 396 | 7 | 1 | 6 | 3.8 | CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 | 10.1021/jm100668r | |||
| 5 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| 5202 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL39 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| DB08839 | 139 | 72 | None | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1016/j.bmcl.2013.12.024 | |||
| 132060763 | 162861 | 0 | None | -4 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 405 | 5 | 0 | 4 | 4.1 | C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| CHEMBL4173095 | 162861 | 0 | None | -4 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 405 | 5 | 0 | 4 | 4.1 | C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| 67268994 | 163968 | 2 | None | -43 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| CHEMBL4207884 | 163968 | 2 | None | -43 | 7 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 247 | 1 | 2 | 2 | 2.4 | Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| 11121216 | 30139 | 0 | None | -70 | 14 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
| CHEMBL138989 | 30139 | 0 | None | -70 | 14 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
| 145972374 | 164674 | 0 | None | -4 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 388 | 6 | 3 | 7 | 1.3 | COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C | 10.1021/acs.jnatprod.7b00317 | |||
| CHEMBL4216860 | 164674 | 0 | None | -4 | 5 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 388 | 6 | 3 | 7 | 1.3 | COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C | 10.1021/acs.jnatprod.7b00317 | |||
| 168293874 | 192179 | 0 | None | -323 | 11 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 312 | 2 | 3 | 3 | 3.3 | COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5204071 | 192179 | 0 | None | -323 | 11 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 312 | 2 | 3 | 3 | 3.3 | COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| 6918647 | 100746 | 2 | None | -316 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL292759 | 100746 | 2 | None | -316 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 9913554 | 100992 | 0 | None | -1995 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29433 | 100992 | 0 | None | -1995 | 14 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 132060770 | 162639 | 0 | None | -26 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 3.5 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| CHEMBL4169689 | 162639 | 0 | None | -26 | 10 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 3.5 | CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| 168268877 | 189970 | 0 | None | -380 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5170784 | 189970 | 0 | None | -380 | 12 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 328 | 2 | 3 | 3 | 3.8 | COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1 | 10.1021/acsmedchemlett.1c00694 | |||
| 135367857 | 164604 | 0 | None | -109 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| CHEMBL4215875 | 164604 | 0 | None | -109 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 228 | 1 | 1 | 3 | 2.3 | Cc1ccc(-c2noc3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| CHEMBL5091373 | 215567 | 0 | None | -85 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5095981 | 215567 | 0 | None | -85 | 9 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | None | None | None | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 49756 | 204312 | 13 | None | -23 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 232 | 4 | 1 | 2 | 2.6 | COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 | 10.1021/jm990550b | |||
| CHEMBL7143 | 204312 | 13 | None | -23 | 8 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 232 | 4 | 1 | 2 | 2.6 | COc1ccc2[nH]c(C)c(CCN(C)C)c2c1 | 10.1021/jm990550b | |||
| 1534 | 103040 | 53 | None | -18 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 9287 | 103040 | 53 | None | -18 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL30713 | 103040 | 53 | None | -18 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 1534 | 103040 | 53 | None | -18 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 9287 | 103040 | 53 | None | -18 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL30713 | 103040 | 53 | None | -18 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 174 | 2 | 2 | 1 | 2.1 | CC(N)Cc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 10947658 | 28702 | 0 | None | -181 | 16 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
| CHEMBL137781 | 28702 | 0 | None | -181 | 16 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
| CHEMBL5074190 | 214314 | 0 | None | -870 | 9 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | None | None | None | COc1ccccc1-c1cc(CCN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
| 92042876 | 151336 | 0 | None | -457 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
| CHEMBL3961059 | 151336 | 0 | None | -457 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 261 | 4 | 1 | 2 | 3.7 | CNCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||
| 145963830 | 164123 | 0 | None | -23 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 4 | 2 | 4 | 4.0 | Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1 | 10.1021/acs.jnatprod.7b00317 | |||
| CHEMBL4209942 | 164123 | 0 | None | -23 | 7 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 335 | 4 | 2 | 4 | 4.0 | Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1 | 10.1021/acs.jnatprod.7b00317 | |||
| 75306277 | 109254 | 0 | None | -1258 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | |||
| CHEMBL3217984 | 109254 | 0 | None | -1258 | 23 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 308 | 0 | 0 | 3 | 4.2 | CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 | 10.1039/C2MD00311B | |||
| 10835110 | 114588 | 0 | None | -630 | 8 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 404 | 5 | 0 | 3 | 4.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm991151j | |||
| CHEMBL333784 | 114588 | 0 | None | -630 | 8 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 404 | 5 | 0 | 3 | 4.3 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm991151j | |||
| 6918648 | 101559 | 1 | None | -4073 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL29846 | 101559 | 1 | None | -4073 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 24865725 | 188084 | 0 | None | -5011 | 12 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL497963 | 188084 | 0 | None | -5011 | 12 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 6918648 | 101559 | 1 | None | -4073 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29846 | 101559 | 1 | None | -4073 | 14 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL5094234 | 215573 | 0 | None | -1258 | 8 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5096019 | 215573 | 0 | None | -1258 | 8 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | None | None | None | CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| 10472143 | 119277 | 0 | None | -630 | 16 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
| CHEMBL343755 | 119277 | 0 | None | -630 | 16 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 335 | 1 | 1 | 2 | 3.0 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | 10.1021/jm020153s | |||
| 46915370 | 54967 | 0 | None | -5 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 195 | 0 | 3 | 5 | -1.6 | Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N | 10.1021/jm100490m | |||
| CHEMBL1241328 | 54967 | 0 | None | -5 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 195 | 0 | 3 | 5 | -1.6 | Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N | 10.1021/jm100490m | |||
| CHEMBL1615596 | 54967 | 0 | None | -5 | 6 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 195 | 0 | 3 | 5 | -1.6 | Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N | 10.1021/jm100490m | |||
| CHEMBL4576555 | 214017 | 5 | None | -3 | 19 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 | 10.6019/CHEMBL4507307 | |||||
| 127036932 | 137348 | 0 | None | -11 | 22 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 274 | 7 | 1 | 1 | 4.0 | C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3752900 | 137348 | 0 | None | -11 | 22 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 274 | 7 | 1 | 1 | 4.0 | C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL4576555 | 214017 | 5 | None | -3 | 19 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 | 10.6019/CHEMBL5212743 | |||||
| CHEMBL4576555 | 214017 | 5 | None | -3 | 19 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 | 10.6019/CHEMBL4507307 | |||||
| 24839550 | 137315 | 14 | None | -6 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 240 | 7 | 1 | 1 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3752576 | 137315 | 14 | None | -6 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 240 | 7 | 1 | 1 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccccc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 155770281 | 177747 | 0 | None | -4 | 9 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 517 | 4 | 1 | 2 | 7.6 | CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 | 10.1021/acs.jmedchem.1c00164 | |||
| CHEMBL4642592 | 177747 | 0 | None | -4 | 9 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 517 | 4 | 1 | 2 | 7.6 | CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1 | 10.1021/acs.jmedchem.1c00164 | |||
| 5 | 139 | 72 | None | -14 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| 5202 | 139 | 72 | None | -14 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| CHEMBL39 | 139 | 72 | None | -14 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| DB08839 | 139 | 72 | None | -14 | 54 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm00164a046 | |||
| 145977799 | 163643 | 0 | None | -5 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 257 | 3 | 1 | 3 | 2.9 | C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1 | 10.1021/acs.jnatprod.7b00317 | |||
| CHEMBL4204036 | 163643 | 0 | None | -5 | 6 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 257 | 3 | 1 | 3 | 2.9 | C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1 | 10.1021/acs.jnatprod.7b00317 | |||
| 132060743 | 162236 | 0 | None | -1 | 13 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| CHEMBL4163428 | 162236 | 0 | None | -1 | 13 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 351 | 3 | 0 | 4 | 3.1 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | 10.1016/j.ejmech.2018.02.024 | |||
| 21509921 | 104458 | 0 | None | -398 | 24 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104091 | 104458 | 0 | None | -398 | 24 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 21509921 | 104458 | 0 | None | -398 | 24 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| CHEMBL3104091 | 104458 | 0 | None | -398 | 24 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 288 | 0 | 0 | 2 | 3.7 | CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 | 10.1016/j.bmcl.2013.12.024 | |||
| 134138168 | 147691 | 0 | None | -371 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
| CHEMBL3931889 | 147691 | 0 | None | -371 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 275 | 4 | 0 | 2 | 4.1 | COc1ccccc1-c1cc(CN(C)C)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||
| CHEMBL5083607 | 214873 | 0 | None | -338 | 9 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
| 50878551 | 90745 | 61 | None | -11 | 18 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL2391541 | 90745 | 61 | None | -11 | 18 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 50878551 | 90745 | 61 | None | -11 | 18 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| CHEMBL2391541 | 90745 | 61 | None | -11 | 18 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2013.03.066 | |||
| 6918542 | 204924 | 24 | None | -2089 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00453-4 | |||
| CHEMBL76237 | 204924 | 24 | None | -2089 | 10 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00453-4 | |||
| 145975226 | 163933 | 0 | None | -8 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 388 | 6 | 3 | 7 | 1.3 | COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C | 10.1021/acs.jnatprod.7b00317 | |||
| CHEMBL4207529 | 163933 | 0 | None | -8 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 388 | 6 | 3 | 7 | 1.3 | COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C | 10.1021/acs.jnatprod.7b00317 | |||
| 127026052 | 137553 | 0 | None | -28 | 19 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 258 | 7 | 1 | 1 | 3.5 | C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3754496 | 137553 | 0 | None | -28 | 19 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 258 | 7 | 1 | 1 | 3.5 | C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 127036186 | 137414 | 0 | None | -15 | 19 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3753318 | 137414 | 0 | None | -15 | 19 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 254 | 7 | 1 | 1 | 3.7 | C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 50878551 | 90745 | 61 | None | -11 | 18 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL2391541 | 90745 | 61 | None | -11 | 18 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 270 | 8 | 1 | 2 | 3.4 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 127036953 | 137515 | 0 | None | -51 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 7 | 1 | 1 | 4.1 | C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| CHEMBL3754166 | 137515 | 0 | None | -51 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 318 | 7 | 1 | 1 | 4.1 | C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 | 10.1016/j.bmcl.2015.12.053 | |||
| 12 | 1553 | 17 | None | -21 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1021/jm990550b | |||
| 6918513 | 1553 | 17 | None | -21 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1021/jm990550b | |||
| CHEMBL267615 | 1553 | 17 | None | -21 | 7 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10.1021/jm990550b | |||
| 10436045 | 3516 | 4 | None | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| 782 | 3516 | 4 | None | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| CHEMBL432713 | 3516 | 4 | None | -1 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| 10020895 | 4705 | 0 | None | -87 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103479 | 4705 | 0 | None | -87 | 8 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 4376990 | 193009 | 5 | None | -263 | 11 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 372 | 4 | 2 | 4 | 4.1 | COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5207529 | 193009 | 5 | None | -263 | 11 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 372 | 4 | 2 | 4 | 4.1 | COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5222754 | 193009 | 5 | None | -263 | 11 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 372 | 4 | 2 | 4 | 4.1 | COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC | 10.1021/acsmedchemlett.1c00694 | |||
| CHEMBL5084249 | 214905 | 0 | None | -812 | 8 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | None | None | None | CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1 | 10.1021/acs.jmedchem.1c00110 | |||||
| CHEMBL5077293 | 214491 | 0 | None | -275 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | None | None | None | COc1ccccc1-c1cc(C2CCNC2)ccc1Cl | 10.1021/acs.jmedchem.1c00110 | |||||
| 9947817 | 5047 | 0 | None | -141 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL105261 | 5047 | 0 | None | -141 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 146025727 | 171685 | 0 | None | -288 | 27 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4466483 | 171685 | 0 | None | -288 | 27 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 411 | 3 | 0 | 5 | 6.4 | FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 124247485 | 164069 | 8 | None | -8 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| CHEMBL4209274 | 164069 | 8 | None | -8 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 231 | 1 | 2 | 2 | 1.9 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| 135367405 | 164196 | 0 | None | -19 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| CHEMBL4210782 | 164196 | 0 | None | -19 | 7 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 227 | 1 | 2 | 2 | 2.1 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | 10.1021/acs.jmedchem.8b00642 | |||
| 130442480 | 175270 | 0 | None | -109 | 24 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4572614 | 175270 | 0 | None | -109 | 24 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 410 | 3 | 0 | 6 | 5.7 | Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F | 10.1021/acs.jmedchem.9b00351 | |||
| 1621 | 2429 | 17 | None | -83 | 45 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
| 17 | 2429 | 17 | None | -83 | 45 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
| 5761 | 2429 | 17 | None | -83 | 45 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
| CHEMBL263881 | 2429 | 17 | None | -83 | 45 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
| DB04829 | 2429 | 17 | None | -83 | 45 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | 10.1021/jm020153s | |||
| 75201901 | 166425 | 19 | None | -724 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4277264 | 166425 | 19 | None | -724 | 24 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 356 | 3 | 0 | 6 | 4.9 | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 130442572 | 171908 | 0 | None | -213 | 24 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| CHEMBL4469848 | 171908 | 0 | None | -213 | 24 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 395 | 3 | 0 | 5 | 6.0 | FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12 | 10.1021/acs.jmedchem.9b00351 | |||
| 2543 | 3707 | 68 | None | -630 | 32 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | None | -630 | 32 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | None | -630 | 32 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | None | -630 | 32 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | None | -630 | 32 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 28 | 3496 | 46 | 3H-5HT | -602 | 10 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3292447 | 3496 | 46 | 3H-5HT | -602 | 10 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL20963 | 3496 | 46 | 3H-5HT | -602 | 10 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 179 | 400 | 115 | 3H-5HT | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 2159 | 400 | 115 | 3H-5HT | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 963 | 400 | 115 | 3H-5HT | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| CHEMBL243712 | 400 | 115 | 3H-5HT | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| DB06288 | 400 | 115 | 3H-5HT | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 242 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 34 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 60795 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| CHEMBL1112 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| DB01238 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 135398737 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 1353 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 1524 | 2181 | 96 | 3H-5HT | -7585 | 52 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 2181 | 96 | 3H-5HT | -7585 | 52 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 2181 | 96 | 3H-5HT | -7585 | 52 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 2181 | 96 | 3H-5HT | -7585 | 52 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 2181 | 96 | 3H-5HT | -7585 | 52 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 2181 | 96 | 3H-5HT | -7585 | 52 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 15897 | 2862 | 0 | 3H-5HT | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 215 | 2862 | 0 | 3H-5HT | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| CHEMBL1979333 | 2862 | 0 | 3H-5HT | -354 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 203 | 2 | 1 | 1 | 2.6 | CC(Cc1cccc(c1)C(F)(F)F)N | None | |||
| 2176 | 3127 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 3127 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 3127 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 3127 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 3127 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 119570 | 3159 | 96 | 3H-5HT | -7585 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 2233 | 3159 | 96 | 3H-5HT | -7585 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 953 | 3159 | 96 | 3H-5HT | -7585 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| CHEMBL301265 | 3159 | 96 | 3H-5HT | -7585 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| DB00413 | 3159 | 96 | 3H-5HT | -7585 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 211 | 3 | 2 | 4 | 1.6 | CCCN[C@H]1CCc2c(C1)sc(n2)N | None | |||
| 243 | 3202 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3052762 | 3202 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3502 | 3202 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| CHEMBL117287 | 3202 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| DB06480 | 3202 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 2389 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 128563 | 3464 | 33 | 3H-5-HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 128563 | 3464 | 33 | 3H-5HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 1666 | 3464 | 33 | 3H-5-HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 1666 | 3464 | 33 | 3H-5HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| CHEMBL445332 | 3464 | 33 | 3H-5-HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| CHEMBL445332 | 3464 | 33 | 3H-5HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| DB12327 | 3464 | 33 | 3H-5-HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| DB12327 | 3464 | 33 | 3H-5HT | -2398 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 432 | 3 | 0 | 8 | 3.0 | COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 | None | |||
| 121881 | 3490 | 27 | 3H-5HT | -199526 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 256 | 3490 | 27 | 3H-5HT | -199526 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| CHEMBL68131 | 3490 | 27 | 3H-5HT | -199526 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 6 | 1 | 6 | 3.4 | CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N | None | |||
| 221 | 3491 | 71 | UNDEFINED | -478 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | |||
| 3277600 | 3491 | 71 | UNDEFINED | -478 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | |||
| CHEMBL323356 | 3491 | 71 | UNDEFINED | -478 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 286 | 2 | 2 | 4 | 3.6 | O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C | None | |||
| 130 | 3500 | 47 | 35S-GTPGammaS | -2754 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3378093 | 3500 | 47 | 35S-GTPGammaS | -2754 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL281350 | 3500 | 47 | 35S-GTPGammaS | -2754 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 2435 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 6917970 | 3691 | 61 | 3H-5HT | -2290 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
| 8370 | 3691 | 61 | 3H-5HT | -2290 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
| CHEMBL487387 | 3691 | 61 | 3H-5HT | -2290 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 327 | 2 | 2 | 5 | 2.8 | COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O | None | |||
| 213 | 3853 | 55 | 3H-5HT | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 2717 | 3853 | 55 | 3H-5HT | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 5533 | 3853 | 55 | 3H-5HT | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| CHEMBL621 | 3853 | 55 | 3H-5HT | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| DB00656 | 3853 | 55 | 3H-5HT | -912 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 371 | 5 | 0 | 6 | 2.4 | Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 | None | |||
| 185 | 4006 | 60 | 3H-5HT | -30902 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| 5311271 | 4006 | 60 | 3H-5HT | -30902 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| CHEMBL74355 | 4006 | 60 | 3H-5HT | -30902 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| DB16351 | 4006 | 60 | 3H-5HT | -30902 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 1 | 4 | 3.8 | COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O | None | |||
| 108182 | 4131 | 22 | 3H-5HT | -32 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 4131 | 22 | 3H-5HT | -32 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 4131 | 22 | 3H-5HT | -32 | 16 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 103 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2662 | 11384 | 131 | 3H-5HT | -41 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | |||
| CHEMBL118 | 11384 | 131 | 3H-5HT | -41 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 381 | 3 | 1 | 4 | 3.5 | Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 | None | |||
| 5090 | 15561 | 106 | 3H-5HT | -1348 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 0 | 4 | 2.6 | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 | None | |||
| CHEMBL122 | 15561 | 106 | 3H-5HT | -1348 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 0 | 4 | 2.6 | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 | None | |||
| 10297 | 27112 | 30 | 3H-5HT | -38 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | |||
| CHEMBL136560 | 27112 | 30 | 3H-5HT | -38 | 42 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | C[C@H](N)[C@H](O)c1ccccc1 | None | |||
| 156391 | 46800 | 99 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
| CHEMBL1200806 | 46800 | 99 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
| CHEMBL154 | 46800 | 99 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 | None | |||
| 115237 | 55585 | 119 | 3H-5HT | -1698 | 54 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | 3H-5HT | -1698 | 54 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 21830793 | 91835 | 10 | 3H-8-OH-DPAT | -66069 | 45 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | |||
| CHEMBL2413154 | 91835 | 10 | 3H-8-OH-DPAT | -66069 | 45 | Bovine | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 373 | 7 | 0 | 8 | 0.6 | COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 | None | |||
| 446220 | 133521 | 14 | 3H-5HT | -1778 | 45 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
| CHEMBL370805 | 133521 | 14 | 3H-5HT | -1778 | 45 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 303 | 3 | 0 | 5 | 1.9 | COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C | None | |||
| 1615 | 167791 | 24 | 3H-5HT | -26 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | |||
| CHEMBL43048 | 167791 | 24 | 3H-5HT | -26 | 44 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 193 | 3 | 1 | 3 | 1.6 | CNC(C)Cc1ccc2c(c1)OCO2 | None | |||
| 3672 | 192533 | 136 | 3H-5HT | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)Cc1ccc(C(C)C(=O)O)cc1 | None | |||
| CHEMBL521 | 192533 | 136 | 3H-5HT | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 206 | 4 | 1 | 1 | 3.1 | CC(C)Cc1ccc(C(C)C(=O)O)cc1 | None | |||
| 54676228 | 193615 | 112 | 3H-5HT | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | |||
| CHEMBL527 | 193615 | 112 | 3H-5HT | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 331 | 2 | 2 | 5 | 1.6 | CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O | None | |||
| 4495 | 196535 | 92 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | |||
| CHEMBL56367 | 196535 | 92 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | None | |||
| 54677470 | 200551 | 115 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
| CHEMBL1256873 | 200551 | 115 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
| CHEMBL599 | 200551 | 115 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 351 | 2 | 2 | 6 | 2.0 | Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 | None | |||
| 162265 | 202274 | 22 | 3H-5HT | -239 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
| 4786 | 202274 | 22 | 3H-5HT | -239 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
| CHEMBL61006 | 202274 | 22 | 3H-5HT | -239 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 151 | 2 | 2 | 2 | 1.1 | CC(N)C(O)c1ccccc1 | None | |||
| 5281600 | 203025 | 92 | 3H-5HT | -275 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
| CHEMBL63354 | 203025 | 92 | 3H-5HT | -275 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 538 | 3 | 6 | 10 | 5.1 | O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 | None | |||
| 5656 | 203066 | 87 | 3H-5HT | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| CHEMBL637 | 203066 | 87 | 3H-5HT | -79 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| 202478 | 204687 | 20 | 3H-5HT | -97 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | |||
| CHEMBL7393 | 204687 | 20 | 3H-5HT | -97 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@H](c2cccc(O)c2)C1 | None | |||
| 3821 | 204718 | 17 | 3H-5HT | -1 | 18 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(c2ccccc2Cl)CCCCC1=O | None | |||
| CHEMBL742 | 204718 | 17 | 3H-5HT | -1 | 18 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 237 | 2 | 1 | 2 | 2.9 | CNC1(c2ccccc2Cl)CCCCC1=O | None | |||
| 5311189 | 204841 | 11 | 3H-5HT | -194 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | |||
| CHEMBL7549 | 204841 | 11 | 3H-5HT | -194 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 219 | 3 | 1 | 2 | 3.0 | CCCN1CCC[C@@H](c2cccc(O)c2)C1 | None | |||
| 4158 | 205341 | 21 | 3H-5HT | -141 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 233 | 3 | 1 | 3 | 2.1 | COC(=O)C(c1ccccc1)C1CCCCN1 | None | |||
| CHEMBL1722 | 205341 | 21 | 3H-5HT | -141 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 233 | 3 | 1 | 3 | 2.1 | COC(=O)C(c1ccccc1)C1CCCCN1 | None | |||
| CHEMBL796 | 205341 | 21 | 3H-5HT | -141 | 21 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 233 | 3 | 1 | 3 | 2.1 | COC(=O)C(c1ccccc1)C1CCCCN1 | None | |||
| 4054 | 205501 | 72 | 3H-5HT | -1 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
| CHEMBL1699 | 205501 | 72 | 3H-5HT | -1 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
| CHEMBL807 | 205501 | 72 | 3H-5HT | -1 | 36 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 179 | 0 | 1 | 1 | 2.7 | CC12CC3CC(C)(C1)CC(N)(C3)C2 | None | |||
| 119607 | 206203 | 113 | 3H-5HT | -97 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 1 | 4 | 3.0 | Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 | None | |||
| CHEMBL865 | 206203 | 113 | 3H-5HT | -97 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 314 | 3 | 1 | 4 | 3.0 | Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 | None | |||
| 3337 | 206367 | 27 | 3H-5HT | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 65801 | 206367 | 27 | 3H-5HT | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 66264 | 206367 | 27 | 3H-5HT | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 91452 | 206367 | 27 | 3H-5HT | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| CHEMBL87493 | 206367 | 27 | 3H-5HT | -1513 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 231 | 4 | 1 | 1 | 3.2 | CCNC(C)Cc1cccc(C(F)(F)F)c1 | None | |||
| 57174031 | 215940 | 0 | 3H-5HT | -1778 | 19 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 284 | 2 | 1 | 3 | 3.0 | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 | None | |||
| None | 215956 | 0 | 3H-5HT | -1318 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.9 | CCC(=O)C1=CC=C(C=C1)N | None | |||
| 11954259 | 215979 | 0 | 3H-5HT | -33113 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 443 | 5 | 0 | 5 | 3.5 | CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C | None | |||
| None | 215993 | 0 | 3H-5-HT | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 329 | 2 | 0 | 4 | 3.6 | CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl | None | |||
| 104911 | 216019 | 0 | 3H-5HT | -41686 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 530 | 7 | 0 | 5 | 5.1 | COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl | None | |||
| 25137849 | 216179 | 0 | 3H-5HT | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | |||
| 71290 | 216179 | 0 | 3H-5HT | -4 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 165 | 3 | 2 | 2 | 1.3 | CC(C(C1=CC=CC=C1)O)NC | None | |||
| None | 216214 | 0 | 3H-5HT | -933 | 14 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 438 | 5 | 1 | 4 | 4.8 | C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45 | None | |||
| None | 216239 | 0 | 3H-5HT | -95499 | 30 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 316 | 7 | 3 | 3 | 3.0 | CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O | None | |||
| None | 216325 | 0 | 3H-5HT | -13 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 149 | 2 | 1 | 2 | 1.2 | CC(C(=O)C1=CC=CC=C1)N | None | |||
| 1576 | 216326 | 0 | 3H-5HT | -16 | 40 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 163 | 3 | 1 | 2 | 1.5 | CC(C(=O)C1=CC=CC=C1)NC | None | |||
| 135269 | 216389 | 0 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 222 | 5 | 1 | 3 | 2.5 | CCCCC(=O)OC1=CC=CC=C1C(=O)O | None | |||
| 23681059 | 216390 | 0 | 3H-5HT | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 230 | 3 | 1 | 2 | 3.0 | CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O | None | |||
| 5018304 | 216391 | 0 | 3H-5HT | -1 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 317 | 4 | 1 | 3 | 0.0 | C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] | None | |||
| 84003 | 216392 | 0 | 3H-5HT | -1 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 376 | 6 | 5 | 7 | -0.0 | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O | None | |||
| 123619 | 216393 | 0 | 3H-5HT | -1412 | 26 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 358 | 3 | 0 | 4 | 4.2 | CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl | None | |||
| 119828 | 216394 | 0 | 3H-5HT | -1 | 29 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 370 | 5 | 1 | 5 | 3.5 | CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C | None | |||
| None | 216395 | 0 | 3H-5HT | -7 | 28 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 517 | 8 | 2 | 5 | 5.2 | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C | None | |||
| None | 216489 | 0 | 3H-5HT | -4570 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 347 | 6 | 0 | 3 | 5.0 | CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3 | None | |||
| 115237 | 55585 | 119 | 3H-5HT | -1698 | 54 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | 3H-5HT | -1698 | 54 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 103 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 46780481 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 133 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 2435 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 4.9 | pKi | = | 4.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 4.9 | pKi | = | 4.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 4.9 | pKi | = | 4.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 4.9 | pKi | = | 4.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 4.9 | pKi | = | 4.9 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 152 | 364 | 29 | 3H-5HT | -15 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2107 | 364 | 29 | 3H-5HT | -15 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| CHEMBL275854 | 364 | 29 | 3H-5HT | -15 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 152 | 364 | 29 | 3H-5HT | -15 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2107 | 364 | 29 | 3H-5HT | -15 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| CHEMBL275854 | 364 | 29 | 3H-5HT | -15 | 18 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2337 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 102 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 102 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | 3H-5HT | -524 | 49 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 2865 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 124936 | 217692 | 0 | 3H-5HT | -6 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 268 | 3 | 1 | 5 | 4.8 | CNC1=CC=C(C=C1)N=NC2=CC3=C(C=C2)N=CS3 | None | |||
| 2389 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | 3H-5HT | -1513 | 67 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 1613 | 2348 | 53 | 3H-5HT | -25 | 44 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 205 | 2348 | 53 | 3H-5HT | -25 | 44 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 3964 | 2348 | 53 | 3H-5HT | -25 | 44 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| CHEMBL831 | 2348 | 53 | 3H-5HT | -25 | 44 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| DB00408 | 2348 | 53 | 3H-5HT | -25 | 44 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 18971832 | 2418 | 0 | 3H-5HT | -245 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| 21 | 2418 | 0 | 3H-5HT | -245 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| CHEMBL3186179 | 2418 | 0 | 3H-5HT | -245 | 13 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| 11954224 | 215953 | 0 | 3H-5HT | -1737 | 58 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 11954224 | 215953 | 0 | 3H-5-HT | -1737 | 58 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 11954224 | 215953 | 0 | 3H-5HT | -1737 | 58 | Human | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 100 | 3805 | 58 | 3H-5HT | -17 | 55 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 2637 | 3805 | 58 | 3H-5HT | -17 | 55 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 5452 | 3805 | 58 | 3H-5HT | -17 | 55 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| CHEMBL479 | 3805 | 58 | 3H-5HT | -17 | 55 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| DB00679 | 3805 | 58 | 3H-5HT | -17 | 55 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 10624 | 70300 | 19 | 3H-5HT | -15 | 33 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
| 138543650 | 70300 | 19 | 3H-5HT | -15 | 33 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
| CHEMBL194378 | 70300 | 19 | 3H-5HT | -15 | 33 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 284 | 5 | 3 | 3 | 1.7 | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 135398745 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 1342 | 35 | 49 | 3H-5HT | -72 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 3H-5HT | -72 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 3H-5HT | -72 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 1342 | 35 | 49 | 3H-5HT | -72 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 35 | 49 | 3H-5HT | -72 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 35 | 49 | 3H-5HT | -72 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 4106 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 2502 | 22 | 3H-5HT | -407 | 34 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1222 | 1664 | 49 | 3H-5HT | -524 | 33 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3396 | 1664 | 49 | 3H-5HT | -524 | 33 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 85 | 1664 | 49 | 3H-5HT | -524 | 33 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL46516 | 1664 | 49 | 3H-5HT | -524 | 33 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| DB04842 | 1664 | 49 | 3H-5HT | -524 | 33 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 134 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 134 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2337 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | 3H-5HT | -43 | 62 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 135398745 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | 3H-5HT | -245 | 65 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 3652 | 4097 | 79 | 3H-5HT | -47 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 57 | 4097 | 79 | 3H-5HT | -47 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 60809 | 4097 | 79 | 3H-5HT | -47 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| CHEMBL21536 | 4097 | 79 | 3H-5HT | -47 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| DB15357 | 4097 | 79 | 3H-5HT | -47 | 18 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 2543 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 3707 | 68 | 3H-5HT | -630 | 32 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1150 | 3878 | 121 | 3H-5HT | -66 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 125 | 3878 | 121 | 3H-5HT | -66 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| CHEMBL6640 | 3878 | 121 | 3H-5HT | -66 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| DB08653 | 3878 | 121 | 3H-5HT | -66 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 11957541 | 1459 | 40 | 3H-5HT | -588 | 16 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 1229 | 1459 | 40 | 3H-5HT | -588 | 16 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 147 | 1459 | 40 | 3H-5HT | -588 | 16 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 170617 | 1459 | 40 | 3H-5HT | -588 | 16 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| CHEMBL6616 | 1459 | 40 | 3H-5HT | -588 | 16 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 5 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 107 | 141 | 121 | 3H-5HT | -3162 | 30 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 141 | 121 | 3H-5HT | -3162 | 30 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 141 | 121 | 3H-5HT | -3162 | 30 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| None | 216450 | 0 | UNDEFINED | -208 | 28 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | |||
| 103 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | 3H-5HT | -309 | 53 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 134 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1809 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1220 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 138107169 | 215952 | 0 | 3H-5HT | -9332 | 22 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 22831402 | 215952 | 0 | 3H-5HT | -9332 | 22 | Human | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O | None | |||
| 2726 | 919 | 68 | 3H-5HT | -28 | 72 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 621 | 919 | 68 | 3H-5HT | -28 | 72 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 83 | 919 | 68 | 3H-5HT | -28 | 72 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL71 | 919 | 68 | 3H-5HT | -28 | 72 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB00477 | 919 | 68 | 3H-5HT | -28 | 72 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2865 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | 3H-5HT | -380 | 53 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 145 | 140 | 49 | 3H-5-HT | -95 | 30 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 140 | 49 | 3H-5-HT | -95 | 30 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 140 | 49 | 3H-5-HT | -95 | 30 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 140 | 49 | 3H-5-HT | -95 | 30 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 46780481 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | 3H-5HT | -87 | 53 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 202 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 60835 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 972 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| CHEMBL1175 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| DB00476 | 1508 | 77 | 3H-5HT | -1 | 30 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 135409468 | 2035 | 69 | 3H-5HT | -138 | 39 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
| 333 | 2035 | 69 | 3H-5HT | -138 | 39 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
| CHEMBL845 | 2035 | 69 | 3H-5HT | -138 | 39 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 312 | 1 | 2 | 4 | 1.7 | Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 | None | |||
| 107780 | 1844 | 54 | 3H-5HT | -4265 | 17 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 1844 | 54 | 3H-5HT | -4265 | 17 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 1844 | 54 | 3H-5HT | -4265 | 17 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 124 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 124 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | 3H-5HT | -74 | 33 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 12312583 | 216017 | 0 | 3H-5HT | -48 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 254 | 1 | 2 | 2 | 2.0 | CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)CO | None | |||
| 12312583 | 216017 | 0 | 3H-5HT | -48 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 254 | 1 | 2 | 2 | 2.0 | CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)CO | None | |||
| 135398737 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 2435 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 1588 | 2325 | 27 | 3H-5-HT | -128 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 28864 | 2325 | 27 | 3H-5-HT | -128 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 43 | 2325 | 27 | 3H-5-HT | -128 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL157138 | 2325 | 27 | 3H-5-HT | -128 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB00589 | 2325 | 27 | 3H-5-HT | -128 | 44 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 338 | 3 | 2 | 2 | 2.8 | CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 141 | 1427 | 35 | 3H-5-HT | -5 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| 6089 | 1427 | 35 | 3H-5-HT | -5 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| CHEMBL12420 | 1427 | 35 | 3H-5-HT | -5 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| DB01488 | 1427 | 35 | 3H-5-HT | -5 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 188 | 3 | 1 | 1 | 2.3 | CN(CCc1c[nH]c2c1cccc2)C | None | |||
| 242 | 470 | 124 | None | -537 | 51 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 34 | 470 | 124 | None | -537 | 51 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 60795 | 470 | 124 | None | -537 | 51 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| CHEMBL1112 | 470 | 124 | None | -537 | 51 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| DB01238 | 470 | 124 | None | -537 | 51 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 2470 | 3653 | 50 | None | -4897 | 59 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | None | -4897 | 59 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | None | -4897 | 59 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | None | -4897 | 59 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | None | -4897 | 59 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 10531 | 1420 | 21 | None | -316 | 23 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 121 | 1420 | 21 | None | -316 | 23 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 888 | 1420 | 21 | None | -316 | 23 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| CHEMBL1732 | 1420 | 21 | None | -316 | 23 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| DB00320 | 1420 | 21 | None | -316 | 23 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 1222 | 1664 | 49 | None | -524 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3396 | 1664 | 49 | None | -524 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 85 | 1664 | 49 | None | -524 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL46516 | 1664 | 49 | None | -524 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| DB04842 | 1664 | 49 | None | -524 | 33 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3652 | 4097 | 79 | None | -47 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 57 | 4097 | 79 | None | -47 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 60809 | 4097 | 79 | None | -47 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| CHEMBL21536 | 4097 | 79 | None | -47 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| DB15357 | 4097 | 79 | None | -47 | 18 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 135398745 | 2914 | 112 | None | -245 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 2914 | 112 | None | -245 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 2914 | 112 | None | -245 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 2914 | 112 | None | -245 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 1613 | 2348 | 53 | None | -25 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 205 | 2348 | 53 | None | -25 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 3964 | 2348 | 53 | None | -25 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| CHEMBL831 | 2348 | 53 | None | -25 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| DB00408 | 2348 | 53 | None | -25 | 44 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 327 | 0 | 0 | 4 | 3.8 | CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 | None | |||
| 2337 | 3256 | 77 | None | -43 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 3256 | 77 | None | -43 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 3256 | 77 | None | -43 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 3256 | 77 | None | -43 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 3256 | 77 | None | -43 | 62 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 2389 | 3331 | 118 | None | -1513 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 3331 | 118 | None | -1513 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 3331 | 118 | None | -1513 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 3331 | 118 | None | -1513 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 3331 | 118 | None | -1513 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 102 | 4127 | 48 | None | -524 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 4127 | 48 | None | -524 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 4127 | 48 | None | -524 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 4127 | 48 | None | -524 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 4127 | 48 | None | -524 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 115237 | 55585 | 119 | None | -1698 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| CHEMBL1621 | 55585 | 119 | None | -1698 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 426 | 4 | 1 | 7 | 3.1 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O | None | |||
| 1353 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-5HT | -446 | 83 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 2181 | 3128 | 46 | 3H-5HT | -134 | 35 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4830 | 3128 | 46 | 3H-5HT | -134 | 35 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 92 | 3128 | 46 | 3H-5HT | -134 | 35 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| CHEMBL440294 | 3128 | 46 | 3H-5HT | -134 | 35 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| DB09286 | 3128 | 46 | 3H-5HT | -134 | 35 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 189 | 3492 | 39 | 3H-5HT | -2089 | 17 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | |||
| 5163 | 3492 | 39 | 3H-5HT | -2089 | 17 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | |||
| CHEMBL297784 | 3492 | 39 | 3H-5HT | -2089 | 17 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | |||
| 2470 | 3653 | 50 | 3H-5HT | -4897 | 59 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 3653 | 50 | 3H-5HT | -4897 | 59 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 3653 | 50 | 3H-5HT | -4897 | 59 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 3653 | 50 | 3H-5HT | -4897 | 59 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 3653 | 50 | 3H-5HT | -4897 | 59 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 145 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 145 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 140 | 49 | 3H-5HT | -95 | 30 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 11954224 | 215953 | 0 | 3H-5HT | -1737 | 58 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 1212 | 1662 | 50 | 3H-5HT | -117 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 204 | 1662 | 50 | 3H-5HT | -117 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 3372 | 1662 | 50 | 3H-5HT | -117 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| CHEMBL726 | 1662 | 50 | 3H-5HT | -117 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| DB00623 | 1662 | 50 | 3H-5HT | -117 | 65 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 155 | 728 | 25 | 3H-5HT | -177 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| 163 | 728 | 25 | 3H-5HT | -177 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| 62065 | 728 | 25 | 3H-5HT | -177 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| CHEMBL6607 | 728 | 25 | 3H-5HT | -177 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| DB01484 | 728 | 25 | 3H-5HT | -177 | 13 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 273 | 4 | 1 | 3 | 2.4 | COc1cc(Br)c(cc1CC(N)C)OC | None | |||
| 115 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 11954224 | 215953 | 0 | 3H-5HT | -1737 | 58 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 134 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | 3H-5HT | -102 | 67 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 11954224 | 215953 | 0 | 3H-5HT | -1737 | 58 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 133 | 2496 | 52 | None | -549 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | None | -549 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | None | -549 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | None | -549 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | None | -549 | 42 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 5 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 1212 | 1662 | 50 | None | -117 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 204 | 1662 | 50 | None | -117 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 3372 | 1662 | 50 | None | -117 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| CHEMBL726 | 1662 | 50 | None | -117 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| DB00623 | 1662 | 50 | None | -117 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 437 | 6 | 1 | 5 | 4.3 | OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F | None | |||
| 3389 | 217711 | 0 | None | -1 | 26 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 549 | 12 | 0 | 6 | 6.8 | CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 | None | |||
| 11954224 | 215953 | 0 | None | -1737 | 58 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 124 | 2981 | 47 | None | -74 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 2032 | 2981 | 47 | None | -74 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 4636 | 2981 | 47 | None | -74 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| CHEMBL762 | 2981 | 47 | None | -74 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| DB00935 | 2981 | 47 | None | -74 | 33 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 260 | 2 | 2 | 3 | 2.9 | Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C | None | |||
| 135398737 | 958 | 93 | None | -194 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | None | -194 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | None | -194 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | None | -194 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | None | -194 | 89 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 2435 | 3590 | 83 | None | -1949 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | None | -1949 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | None | -1949 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | None | -1949 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | None | -1949 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 2865 | 4143 | 73 | None | -380 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 59 | 4143 | 73 | None | -380 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 60854 | 4143 | 73 | None | -380 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| CHEMBL708 | 4143 | 73 | None | -380 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| DB00246 | 4143 | 73 | None | -380 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | None | |||
| 2726 | 919 | 68 | None | -28 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 621 | 919 | 68 | None | -28 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 83 | 919 | 68 | None | -28 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL71 | 919 | 68 | None | -28 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB00477 | 919 | 68 | None | -28 | 72 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 318 | 4 | 0 | 3 | 4.9 | CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 103 | 4153 | 61 | None | -309 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 2875 | 4153 | 61 | None | -309 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 5736 | 4153 | 61 | None | -309 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| CHEMBL285802 | 4153 | 61 | None | -309 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| DB09225 | 4153 | 61 | None | -309 | 53 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | None | |||
| 100 | 3805 | 58 | None | -17 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 2637 | 3805 | 58 | None | -17 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 5452 | 3805 | 58 | None | -17 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| CHEMBL479 | 3805 | 58 | None | -17 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| DB00679 | 3805 | 58 | None | -17 | 55 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 370 | 4 | 0 | 4 | 5.9 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 | None | |||
| 134 | 2514 | 24 | None | -102 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 2514 | 24 | None | -102 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 2514 | 24 | None | -102 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 2514 | 24 | None | -102 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 2514 | 24 | None | -102 | 67 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2393 | 3334 | 82 | None | -2 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 5078 | 3334 | 82 | None | -2 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 51 | 3334 | 82 | None | -2 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| CHEMBL905 | 3334 | 82 | None | -2 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| DB00953 | 3334 | 82 | None | -2 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 11954224 | 215953 | 0 | 3H-5HT | -1737 | 58 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 115 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 115 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 3791 | 80 | 3H-5HT | -64 | 27 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 1621 | 2429 | 17 | None | -83 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 17 | 2429 | 17 | None | -83 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 5761 | 2429 | 17 | None | -83 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| CHEMBL263881 | 2429 | 17 | None | -83 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| DB04829 | 2429 | 17 | None | -83 | 45 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 323 | 3 | 1 | 2 | 2.9 | CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC | None | |||
| 40 | 1547 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 77993 | 1547 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 995 | 1547 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| CHEMBL1510 | 1547 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| DB00216 | 1547 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 150 | 2509 | 21 | None | -17 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 1764 | 2509 | 21 | None | -17 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 8226 | 2509 | 21 | None | -17 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| CHEMBL1201356 | 2509 | 21 | None | -17 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| DB00353 | 2509 | 21 | None | -17 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 5 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 139 | 72 | 3H-5HT | -14 | 54 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 1884 | 2735 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 4440 | 2735 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 45 | 2735 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| CHEMBL1278 | 2735 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| DB00952 | 2735 | 58 | None | -6 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 2869 | 4152 | 89 | None | -19 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 60 | 4152 | 89 | None | -19 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 60857 | 4152 | 89 | None | -19 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| CHEMBL1185 | 4152 | 89 | None | -19 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| DB00315 | 4152 | 89 | None | -19 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 1809 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 2435 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 3590 | 83 | 3H-5HT | -1949 | 48 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 133 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 2496 | 52 | 3H-5HT | -549 | 42 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1809 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 46780481 | 107531 | 20 | None | -87 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 9903970 | 107531 | 20 | None | -87 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3187365 | 107531 | 20 | None | -87 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| CHEMBL3544974 | 107531 | 20 | None | -87 | 53 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 285 | 0 | 0 | 2 | 4.3 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | None | |||
| 242 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 34 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 60795 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| CHEMBL1112 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| DB01238 | 470 | 124 | 3H-5HT | -537 | 51 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | None | |||
| 1574 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 1574 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 81 | 60 | 3H-5HT | -8 | 21 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 1220 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 187 | 55 | 3H-5HT | -1621 | 44 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 1042 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 148 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 443884 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| CHEMBL119443 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| DB01253 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 1042 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 148 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| 443884 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| CHEMBL119443 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| DB01253 | 1581 | 23 | 3H-5HT | -104 | 17 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | None | |||
| None | 216052 | 0 | 3H-5HT | -251 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 339 | 4 | 3 | 3 | 1.9 | CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C | None | |||
| None | 216052 | 0 | 3H-5HT | -251 | 8 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 339 | 4 | 3 | 3 | 1.9 | CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C | None | |||
| 1809 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 134 | 32 | 3H-5HT | -42657 | 36 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 6971132 | 216009 | 0 | 3H-5-HT | -23 | 14 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 268 | 1 | 2 | 2 | 2.1 | CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O | None | |||
| 135398737 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-5HT | -194 | 89 | Human | 6.0 | pKi | = | 6.0 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 1150 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 14744596 | |||
| 1150 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 15110837 | |||
| 1150 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| 125 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 14744596 | |||
| 125 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 15110837 | |||
| 125 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| CHEMBL6640 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 14744596 | |||
| CHEMBL6640 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 15110837 | |||
| CHEMBL6640 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| DB08653 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 14744596 | |||
| DB08653 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 15110837 | |||
| DB08653 | 3878 | 121 | None | -66 | 25 | Human | 6.1 | pKi | = | 6.1 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| 8422 | 129 | 0 | None | -66 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 272 | 7 | 1 | 2 | 3.2 | CCCC(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 21422162 | |||
| 91827360 | 129 | 0 | None | -66 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | Guide to Pharmacology | 272 | 7 | 1 | 2 | 3.2 | CCCC(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 21422162 | |||
| 2438 | 727 | 92 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 230 | 1 | 2 | 2 | 2.7 | CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | None | |||
| 3927 | 727 | 92 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 230 | 1 | 2 | 2 | 2.7 | CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL1371156 | 727 | 92 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 230 | 1 | 2 | 2 | 2.7 | CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | None | |||
| 1353 | 1911 | 93 | None | -446 | 83 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | None | -446 | 83 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | None | -446 | 83 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | None | -446 | 83 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | None | -446 | 83 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 2181 | 3128 | 46 | None | -134 | 35 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4830 | 3128 | 46 | None | -134 | 35 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 92 | 3128 | 46 | None | -134 | 35 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| CHEMBL440294 | 3128 | 46 | None | -134 | 35 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| DB09286 | 3128 | 46 | None | -134 | 35 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 202 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 60835 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 972 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| CHEMBL1175 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| DB00476 | 1508 | 77 | None | -1 | 30 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 10 | 723 | 28 | None | -501 | 9 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| 3654103 | 723 | 28 | None | -501 | 9 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| CHEMBL534232 | 723 | 28 | None | -501 | 9 | Human | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| 1809 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 14744596 | |||
| 1809 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1608964 | |||
| 1809 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| 1809 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8863519 | |||
| 4 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 14744596 | |||
| 4 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1608964 | |||
| 4 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| 4 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8863519 | |||
| CHEMBL18840 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 14744596 | |||
| CHEMBL18840 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 1608964 | |||
| CHEMBL18840 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| CHEMBL18840 | 134 | 32 | None | -42657 | 36 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8863519 | |||
| 115 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 14744596 | |||
| 115 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8380639 | |||
| 115 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8863519 | |||
| 4296 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 14744596 | |||
| 4296 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8380639 | |||
| 4296 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8863519 | |||
| CHEMBL274866 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 14744596 | |||
| CHEMBL274866 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8380639 | |||
| CHEMBL274866 | 3791 | 80 | None | -64 | 27 | Human | 5.3 | pKi | None | 5.3 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8863519 | |||
| 107780 | 1844 | 54 | None | -4265 | 17 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 14 | 1844 | 54 | None | -4265 | 17 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| CHEMBL15928 | 1844 | 54 | None | -4265 | 17 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 1355 | 2011 | 88 | None | -251 | 16 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 14744596 | |||
| 142 | 2011 | 88 | None | -251 | 16 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 14744596 | |||
| CHEMBL478 | 2011 | 88 | None | -251 | 16 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 14744596 | |||
| DB12110 | 2011 | 88 | None | -251 | 16 | Human | 5.4 | pKi | None | 5.4 | Binding | Guide to Pharmacology | 196 | 1 | 1 | 2 | 1.8 | Clc1cccc(c1)N1CCNCC1 | 14744596 | |||
| 136 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 14744596 | |||
| 136 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| 223 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 14744596 | |||
| 223 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| 643606 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 14744596 | |||
| 643606 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| CHEMBL10347 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 14744596 | |||
| CHEMBL10347 | 3292 | 32 | None | -5623 | 15 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8863519 | |||
| 1220 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 14744596 | |||
| 1220 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| 31 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 14744596 | |||
| 31 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| 7 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 14744596 | |||
| 7 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| CHEMBL56 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 14744596 | |||
| CHEMBL56 | 187 | 55 | None | -1621 | 44 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| 10531 | 1420 | 21 | None | -316 | 23 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| 121 | 1420 | 21 | None | -316 | 23 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| 888 | 1420 | 21 | None | -316 | 23 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| CHEMBL1732 | 1420 | 21 | None | -316 | 23 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| DB00320 | 1420 | 21 | None | -316 | 23 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8863519 | |||
| 1222 | 1664 | 49 | None | -524 | 33 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | |||
| 3396 | 1664 | 49 | None | -524 | 33 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | |||
| 85 | 1664 | 49 | None | -524 | 33 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | |||
| CHEMBL46516 | 1664 | 49 | None | -524 | 33 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | |||
| DB04842 | 1664 | 49 | None | -524 | 33 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 475 | 7 | 1 | 3 | 5.3 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | 8935801 | |||
| 3652 | 4097 | 79 | None | -47 | 18 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 57 | 4097 | 79 | None | -47 | 18 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 60809 | 4097 | 79 | None | -47 | 18 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| CHEMBL21536 | 4097 | 79 | None | -47 | 18 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| DB15357 | 4097 | 79 | None | -47 | 18 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 11957541 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 14744596 | |||
| 11957541 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 1229 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 14744596 | |||
| 1229 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 147 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 14744596 | |||
| 147 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 170617 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 14744596 | |||
| 170617 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| CHEMBL6616 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 14744596 | |||
| CHEMBL6616 | 1459 | 40 | None | -588 | 16 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 2543 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 2543 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 14744596 | |||
| 2543 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1608964 | |||
| 2543 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 2543 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| 5358 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 5358 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 14744596 | |||
| 5358 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1608964 | |||
| 5358 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 5358 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| 54 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 54 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 14744596 | |||
| 54 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1608964 | |||
| 54 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 54 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| CHEMBL128 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| CHEMBL128 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 14744596 | |||
| CHEMBL128 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1608964 | |||
| CHEMBL128 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| CHEMBL128 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| DB00669 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| DB00669 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 14744596 | |||
| DB00669 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 1608964 | |||
| DB00669 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| DB00669 | 3707 | 68 | None | -630 | 32 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8863519 | |||
| 135398745 | 2914 | 112 | None | -245 | 65 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| 47 | 2914 | 112 | None | -245 | 65 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| CHEMBL715 | 2914 | 112 | None | -245 | 65 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| DB00334 | 2914 | 112 | None | -245 | 65 | Human | 5.7 | pKi | None | 5.7 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| 18971832 | 2418 | 0 | None | -245 | 13 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| 21 | 2418 | 0 | None | -245 | 13 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| CHEMBL3186179 | 2418 | 0 | None | -245 | 13 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| 107 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 14744596 | |||
| 107 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 15110837 | |||
| 107 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8380639 | |||
| 107 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8863519 | |||
| 1833 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 14744596 | |||
| 1833 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 15110837 | |||
| 1833 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8380639 | |||
| 1833 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8863519 | |||
| CHEMBL8165 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 14744596 | |||
| CHEMBL8165 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 15110837 | |||
| CHEMBL8165 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8380639 | |||
| CHEMBL8165 | 141 | 121 | None | -3162 | 30 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8863519 | |||
| 133 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 14744596 | |||
| 133 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 1608964 | |||
| 133 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| 1723 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 14744596 | |||
| 1723 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 1608964 | |||
| 1723 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| 28693 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 14744596 | |||
| 28693 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 1608964 | |||
| 28693 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| CHEMBL19215 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 14744596 | |||
| CHEMBL19215 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 1608964 | |||
| CHEMBL19215 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| DB13520 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 14744596 | |||
| DB13520 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 1608964 | |||
| DB13520 | 2496 | 52 | None | -549 | 42 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8863519 | |||
| 197706 | 1464 | 0 | None | -6309 | 10 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| 39 | 1464 | 0 | None | -6309 | 10 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| CHEMBL1742428 | 1464 | 0 | None | -6309 | 10 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| 2337 | 3256 | 77 | None | -43 | 62 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| 50 | 3256 | 77 | None | -43 | 62 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| 5002 | 3256 | 77 | None | -43 | 62 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| CHEMBL716 | 3256 | 77 | None | -43 | 62 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| DB01224 | 3256 | 77 | None | -43 | 62 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| 2389 | 3331 | 118 | None | -1513 | 67 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 5073 | 3331 | 118 | None | -1513 | 67 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 96 | 3331 | 118 | None | -1513 | 67 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| CHEMBL85 | 3331 | 118 | None | -1513 | 67 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| DB00734 | 3331 | 118 | None | -1513 | 67 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 102 | 4127 | 48 | None | -524 | 49 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| 3659 | 4127 | 48 | None | -524 | 49 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| 8969 | 4127 | 48 | None | -524 | 49 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| CHEMBL15245 | 4127 | 48 | None | -524 | 49 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| DB01392 | 4127 | 48 | None | -524 | 49 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| 475100 | 189 | 0 | None | -1000 | 6 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | |||
| 67 | 189 | 0 | None | -1000 | 6 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | |||
| CHEMBL3542429 | 189 | 0 | None | -1000 | 6 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 426 | 4 | 1 | 7 | 2.6 | OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F | 8935801 | |||
| 1574 | 81 | 60 | None | -8 | 21 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 8380639 | |||
| 218 | 81 | 60 | None | -8 | 21 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 8380639 | |||
| CHEMBL266591 | 81 | 60 | None | -8 | 21 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 8380639 | |||
| 145 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15110837 | |||
| 145 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 1832 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15110837 | |||
| 1832 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| CHEMBL7257 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15110837 | |||
| CHEMBL7257 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| DB14010 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15110837 | |||
| DB14010 | 140 | 49 | None | -95 | 30 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 1043 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 1608964 | |||
| 1043 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| 149 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 1608964 | |||
| 149 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| 8223 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 1608964 | |||
| 8223 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| CHEMBL442 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 1608964 | |||
| CHEMBL442 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| DB00696 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 1608964 | |||
| DB00696 | 1582 | 14 | None | -6165 | 28 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| 146 | 135 | 85 | None | -89 | 3 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 178 | 2 | 2 | 1 | 1.8 | NCCc1c[nH]c2c1cc(F)cc2 | 14744596 | |||
| 164682 | 135 | 85 | None | -89 | 3 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 178 | 2 | 2 | 1 | 1.8 | NCCc1c[nH]c2c1cc(F)cc2 | 14744596 | |||
| CHEMBL275628 | 135 | 85 | None | -89 | 3 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 178 | 2 | 2 | 1 | 1.8 | NCCc1c[nH]c2c1cc(F)cc2 | 14744596 | |||
| 12 | 1553 | 17 | None | -21 | 7 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10715164 | |||
| 6918513 | 1553 | 17 | None | -21 | 7 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10715164 | |||
| CHEMBL267615 | 1553 | 17 | None | -21 | 7 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 246 | 5 | 1 | 2 | 2.8 | CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC | 10715164 | |||
| 135398737 | 958 | 93 | None | -194 | 89 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 38 | 958 | 93 | None | -194 | 89 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 722 | 958 | 93 | None | -194 | 89 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| CHEMBL42 | 958 | 93 | None | -194 | 89 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| DB00363 | 958 | 93 | None | -194 | 89 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 2435 | 3590 | 83 | None | -1949 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 60149 | 3590 | 83 | None | -1949 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 98 | 3590 | 83 | None | -1949 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| CHEMBL12713 | 3590 | 83 | None | -1949 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| DB06144 | 3590 | 83 | None | -1949 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 2865 | 4143 | 73 | None | -380 | 53 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| 59 | 4143 | 73 | None | -380 | 53 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| 60854 | 4143 | 73 | None | -380 | 53 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| CHEMBL708 | 4143 | 73 | None | -380 | 53 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| DB00246 | 4143 | 73 | None | -380 | 53 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 412 | 4 | 1 | 5 | 3.8 | O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 | 8935801 | |||
| 103 | 4153 | 61 | None | -309 | 53 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| 2875 | 4153 | 61 | None | -309 | 53 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| 5736 | 4153 | 61 | None | -309 | 53 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| CHEMBL285802 | 4153 | 61 | None | -309 | 53 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| DB09225 | 4153 | 61 | None | -309 | 53 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 331 | 4 | 0 | 3 | 4.9 | CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C | 8935801 | |||
| 134 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 14744596 | |||
| 134 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15110837 | |||
| 134 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1608964 | |||
| 134 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| 134 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| 1775 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 14744596 | |||
| 1775 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15110837 | |||
| 1775 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1608964 | |||
| 1775 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| 1775 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| 9681 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 14744596 | |||
| 9681 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15110837 | |||
| 9681 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1608964 | |||
| 9681 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| 9681 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| CHEMBL1065 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 14744596 | |||
| CHEMBL1065 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15110837 | |||
| CHEMBL1065 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1608964 | |||
| CHEMBL1065 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| CHEMBL1065 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| DB00247 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 14744596 | |||
| DB00247 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15110837 | |||
| DB00247 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 1608964 | |||
| DB00247 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| DB00247 | 2514 | 24 | None | -102 | 67 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8863519 | |||
| 2393 | 3334 | 82 | None | -2 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 5078 | 3334 | 82 | None | -2 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 51 | 3334 | 82 | None | -2 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| CHEMBL905 | 3334 | 82 | None | -2 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| DB00953 | 3334 | 82 | None | -2 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 1342 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 14744596 | |||
| 1342 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8380639 | |||
| 1342 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8863519 | |||
| 3 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 14744596 | |||
| 3 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8380639 | |||
| 3 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8863519 | |||
| CHEMBL277120 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 14744596 | |||
| CHEMBL277120 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8380639 | |||
| CHEMBL277120 | 35 | 49 | None | -72 | 19 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8863519 | |||
| 4106 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 14744596 | |||
| 4106 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 1608964 | |||
| 4106 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| 4106 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| 5358812 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 14744596 | |||
| 5358812 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 1608964 | |||
| 5358812 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| 5358812 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| 89 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 14744596 | |||
| 89 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 1608964 | |||
| 89 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| 89 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| CHEMBL93240 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 14744596 | |||
| CHEMBL93240 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 1608964 | |||
| CHEMBL93240 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| CHEMBL93240 | 2502 | 22 | None | -407 | 34 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8863519 | |||
| 152 | 364 | 29 | None | -15 | 18 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 14744596 | |||
| 152 | 364 | 29 | None | -15 | 18 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8380639 | |||
| 2107 | 364 | 29 | None | -15 | 18 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 14744596 | |||
| 2107 | 364 | 29 | None | -15 | 18 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8380639 | |||
| CHEMBL275854 | 364 | 29 | None | -15 | 18 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 14744596 | |||
| CHEMBL275854 | 364 | 29 | None | -15 | 18 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8380639 | |||
| 150 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 15110837 | |||
| 150 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| 1764 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 15110837 | |||
| 1764 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| 8226 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 15110837 | |||
| 8226 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| CHEMBL1201356 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 15110837 | |||
| CHEMBL1201356 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| DB00353 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 15110837 | |||
| DB00353 | 2509 | 21 | None | -17 | 16 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| 40 | 1547 | 58 | None | -6 | 5 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 77993 | 1547 | 58 | None | -6 | 5 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 995 | 1547 | 58 | None | -6 | 5 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| CHEMBL1510 | 1547 | 58 | None | -6 | 5 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| DB00216 | 1547 | 58 | None | -6 | 5 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 1042 | 1581 | 23 | None | -104 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | 14744596 | |||
| 148 | 1581 | 23 | None | -104 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | 14744596 | |||
| 443884 | 1581 | 23 | None | -104 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | 14744596 | |||
| CHEMBL119443 | 1581 | 23 | None | -104 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | 14744596 | |||
| DB01253 | 1581 | 23 | None | -104 | 17 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 325 | 3 | 3 | 3 | 1.5 | OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C | 14744596 | |||
| 123 | 2430 | 41 | None | -63 | 3 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 8863519 | |||
| 14987 | 2430 | 41 | None | -63 | 3 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 8863519 | |||
| CHEMBL39947 | 2430 | 41 | None | -63 | 3 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 254 | 1 | 2 | 2 | 2.0 | OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3 | 8863519 | |||
| 1884 | 2735 | 58 | None | -6 | 5 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 4440 | 2735 | 58 | None | -6 | 5 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 45 | 2735 | 58 | None | -6 | 5 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| CHEMBL1278 | 2735 | 58 | None | -6 | 5 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| DB00952 | 2735 | 58 | None | -6 | 5 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 2869 | 4152 | 89 | None | -19 | 7 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 60 | 4152 | 89 | None | -19 | 7 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 60857 | 4152 | 89 | None | -19 | 7 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| CHEMBL1185 | 4152 | 89 | None | -19 | 7 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| DB00315 | 4152 | 89 | None | -19 | 7 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 163091 | 494 | 34 | None | -165 | 10 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | |||
| 22 | 494 | 34 | None | -165 | 10 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | |||
| CHEMBL504548 | 494 | 34 | None | -165 | 10 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 285 | 0 | 0 | 2 | 4.3 | Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C | 8935801 | |||
| 5 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 14744596 | |||
| 5 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15110837 | |||
| 5 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1608964 | |||
| 5 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| 5202 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 14744596 | |||
| 5202 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15110837 | |||
| 5202 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1608964 | |||
| 5202 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| CHEMBL39 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 14744596 | |||
| CHEMBL39 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15110837 | |||
| CHEMBL39 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1608964 | |||
| CHEMBL39 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| DB08839 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 14744596 | |||
| DB08839 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15110837 | |||
| DB08839 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 1608964 | |||
| DB08839 | 139 | 72 | None | -14 | 54 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||