Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL1310437 5ht1e_human Human Yes 5.0 IC50 = 11190 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
405 5 1 3 5.5 O=C(OC(C(=O)Nc1cccc(C(F)(F)F)c1)c1ccccc1)C1CCCCC1
CHEMBL1404080 5ht1e_human Human Yes 4.9 IC50 = 12070 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
279 4 1 1 4.6 O=C(Nc1ccccc1)C(c1ccccc1)C1CCCC1
CHEMBL1380914 5ht1e_human Human Yes 5.9 IC50 = 1253 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
387 6 1 2 5.7 O=C(Nc1ccc(OC(F)F)c(Cl)c1)C(c1ccccc1)c1ccccc1
CHEMBL1424117 5ht1e_human Human Yes 4.9 IC50 = 13370 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
397 5 1 4 5.4 Cc1cc(C(=O)OC(C(=O)Nc2ccc(C)c(Cl)c2)c2ccccc2)c(C)o1
CHEMBL1534431 5ht1e_human Human Yes 4.9 IC50 = 13380 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
318 4 1 3 4.3 Cc1ccc(NC(=O)C(C)c2ccc([N+](=O)[O-])cc2)cc1Cl
CHEMBL1548000 5ht1e_human Human Yes 4.9 IC50 = 13740 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
443 4 1 5 3.9 Cc1ccccc1C(=O)N1CCN(c2ccc(NC(=O)c3ccc4c(c3)OCO4)cc2)CC1
CHEMBL1362304 5ht1e_human Human Yes 4.8 IC50 = 15650 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
332 5 1 3 4.6 CCc1ccccc1NC1c2ccccc2C(=O)N1Cc1ccco1
CHEMBL1533427 5ht1e_human Human Yes 4.8 IC50 = 15650 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
397 5 1 3 5.3 Cc1ccc(NC(=O)C(OC(=O)c2ccc(F)cc2)c2ccccc2)cc1Cl
CHEMBL1467999 5ht1e_human Human Yes 5.8 IC50 = 1755 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
429 7 1 6 4.9 COc1ccc(CC(=O)Nc2cccc(-c3nnc(-c4cccc(C)c4)o3)c2)cc1OC
CHEMBL1419954 5ht1e_human Human Yes 5.7 IC50 = 1852 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
329 4 1 1 5.8 O=C(Nc1ccc2ccccc2c1)C(c1ccccc1)C1CCCC1
CHEMBL2003667 5ht1e_human Human Yes 5.7 IC50 = 1963 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
375 6 1 5 4.1 O=C(N/N=C/c1ccc(-c2ccc([N+](=O)[O-])cc2)o1)[C@H]1C[C@@H]1c1ccccc1
CHEMBL1533923 5ht1e_human Human Yes 5.6 IC50 = 2468 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
347 7 1 2 5.7 CCCC[C@@H]1C[C@H]1[C@@H](NC(=O)c1cccs1)c1ccc(Cl)cc1
CHEMBL1526126 5ht1e_human Human Yes 5.6 IC50 = 2488 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
333 4 0 5 4.5 O=[N+]([O-])c1ccc(C2=NN(c3ccccc3)C(c3ccco3)C2)cc1
CHEMBL1385499 5ht1e_human Human Yes 5.4 IC50 = 3864 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
365 4 1 3 4.9 Cc1cccc(Cn2nc(C(C)(C)C)cc2C(=O)Nc2ccc(F)cc2)c1
CHEMBL22961 5ht1e_human Human No 6.4 IC50 = 392 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1E receptor subtypeInhibitory activity against 5-hydroxytryptamine 1E receptor subtype
620 15 6 4 6.9 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL1330917 5ht1e_human Human Yes 5.3 IC50 = 5284 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
413 5 1 3 5.8 Cc1ccc(NC(=O)C(OC(=O)c2ccccc2Cl)c2ccccc2)cc1Cl
CHEMBL1466117 5ht1e_human Human Yes 5.3 IC50 = 5463 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
402 5 2 4 4.9 Cc1cccc(C2(c3cccc(C)c3)CC2C(=O)Nc2ccc([N+](=O)[O-])cc2O)c1
CHEMBL128 5ht1e_human Human Yes 5.3 IC50 = 5500 nM Bind
Compound was evaluated for the affinity at 5-hydroxytryptamine 1E receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1E receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL1503503 5ht1e_human Human Yes 5.2 IC50 = 7062 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
293 4 1 1 4.9 Cc1ccc(NC(=O)C(c2ccccc2)C2CCCC2)cc1
CHEMBL604664 5ht1e_human Human Yes 5.0 IC50 = 9477 nM Funct
PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]PUBCHEM_BIOASSAY: Counterscreen assay for S1P3 antagonists: Dose response cell-based high throughput screening assay to identify antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E). (Class of assay: confirmatory) [Related pubchem assays: 1429, 485 ]
324 4 1 3 4.4 Cc1ccc(NC(=O)C2(c3ccc([N+](=O)[O-])cc3)CCCC2)cc1
CHEMBL22744 5ht1e_human Human No 7.0 IC50 = 99 nM Bind
Binding affinity to 5HT1E receptorBinding affinity to 5HT1E receptor
606 14 6 4 6.5 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL22744 5ht1e_human Human No 7.0 IC50 = 99 nM Bind
Inhibitory activity against 5-hydroxytryptamine 1E receptor subtypeInhibitory activity against 5-hydroxytryptamine 1E receptor subtype
606 14 6 4 6.5 NC(=O)c1ccc2[nH]cc(C3=CCC(NCCCCCCCNC4CC=C(c5c[nH]c6ccc(C(N)=O)cc56)CC4)CC3)c2c1
CHEMBL39 5ht1e_human Human Yes 8.0 Ki = 10.7 nM Bind
Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL42 5ht1e_human Human Yes 6.0 Ki = 1000 nM Bind
Binding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assay
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL282971 5ht1e_human Human No 6.0 Ki = 1000 nM Bind
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligand
491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1
CHEMBL1258223 5ht1e_human Human No 5.0 Ki = 10000 nM Bind
Binding affinity to human 5-HT1E receptorBinding affinity to human 5-HT1E receptor
396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1
CHEMBL39 5ht1e_human Human Yes 8.0 Ki = 11 nM Bind
Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4173095 5ht1e_human Human No 5.9 Ki = 1242 nM Bind
Displacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
405 5 0 4 4.1 C=C(C)CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1
CHEMBL4207884 5ht1e_human Human Yes 5.9 Ki = 1366 nM Bind
Displacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
247 1 2 2 2.4 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)Cl
CHEMBL138989 5ht1e_human Human No 6.9 Ki = 140 nM Bind
Binding affinity towards 5-hydroxytryptamine 1E receptorBinding affinity towards 5-hydroxytryptamine 1E receptor
335 1 1 2 3.0 C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1
CHEMBL4216860 5ht1e_human Human No 5.9 Ki = 1400 nM Bind
Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
388 6 3 7 1.3 COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C
CHEMBL292759 5ht1e_human Human Yes 5.8 Ki = 1584.9 nM Bind
Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HT
439 5 1 5 3.0 COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1
CHEMBL29433 5ht1e_human Human No 5.8 Ki = 1584.9 nM Bind
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligand
491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1
CHEMBL4169689 5ht1e_human Human No 5.8 Ki = 1666 nM Bind
Displacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
451 7 0 6 3.5 CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1
CHEMBL4215875 5ht1e_human Human No 5.8 Ki = 1787 nM Bind
Displacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
228 1 1 3 2.3 CC1=CC=C(C=C1)C2=NOC3=C2CCNCC3
CHEMBL7143 5ht1e_human Human Yes 5.8 Ki = 1800 nM Bind
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor
232 4 1 2 2.6 COc1ccc2[nH]c(C)c(CCN(C)C)c2c1
CHEMBL30713 5ht1e_human Human Yes 5.7 Ki = 1905.5 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12
CHEMBL30713 5ht1e_human Human Yes 5.7 Ki = 1919 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12
CHEMBL137781 5ht1e_human Human No 6.7 Ki = 200 nM Bind
Binding affinity towards 5-hydroxytryptamine 1E receptorBinding affinity towards 5-hydroxytryptamine 1E receptor
335 1 1 2 3.0 C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1
CHEMBL4209942 5ht1e_human Human No 5.6 Ki = 2400 nM Bind
Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
335 4 2 4 4.0 Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1
CHEMBL3217984 5ht1e_human Human No 5.6 Ki = 2511.9 nM Bind
Binding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT1E receptor (unknown origin) by PDSP assay
308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3
CHEMBL333784 5ht1e_human Human No 5.6 Ki = 2511.9 nM Bind
Binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells using [3H]5-HT as radioligand.Binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells using [3H]5-HT as radioligand.
404 5 0 3 4.3 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc(Cl)c(Cl)c2)CC1
CHEMBL29846 5ht1e_human Human Yes 5.6 Ki = 2511.9 nM Bind
Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 1E receptor in CHO cells using [3H]-5-HT
465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1
CHEMBL497963 5ht1e_human Human No 5.6 Ki = 2511.9 nM Bind
Displacement of radioligand from human cloned 5HT1E receptorDisplacement of radioligand from human cloned 5HT1E receptor
453 8 1 5 4.2 Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
CHEMBL29846 5ht1e_human Human Yes 5.6 Ki = 2511.9 nM Bind
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1E receptor in CHO cells, using [3H]5-HT as radioligand
465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1
CHEMBL343755 5ht1e_human Human No 6.6 Ki = 280 nM Bind
Binding affinity towards 5-hydroxytryptamine 1E receptorBinding affinity towards 5-hydroxytryptamine 1E receptor
335 1 1 2 3.0 C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1
CHEMBL1241328 5ht1e_human Human No 5.5 Ki = 2900 nM Bind
Binding affinity to 5HT1E receptorBinding affinity to 5HT1E receptor
195 0 3 5 -1.6 Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N
CHEMBL1615596 5ht1e_human Human No 5.5 Ki = 2900 nM Bind
Binding affinity to 5HT1E receptorBinding affinity to 5HT1E receptor
195 0 3 5 -1.6 Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N
CHEMBL3752900 5ht1e_human Human No 6.5 Ki = 354.8 nM Bind
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
274 7 1 1 4.0 C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12
CHEMBL3752576 5ht1e_human Human Yes 6.4 Ki = 380.2 nM Bind
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
240 7 1 1 3.4 C=CCN(CC=C)CCc1c[nH]c2ccccc12
CHEMBL39 5ht1e_human Human Yes 8.4 Ki = 4 nM Bind
Binding affinity was determined against 5-hydroxytryptamine 1E receptor in human cortical homogenateBinding affinity was determined against 5-hydroxytryptamine 1E receptor in human cortical homogenate
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4204036 5ht1e_human Human No 5.4 Ki = 4000 nM Bind
Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
257 3 1 3 2.9 C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1
CHEMBL4163428 5ht1e_human Human No 6.4 Ki = 403 nM Bind
Displacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method
351 3 0 4 3.1 CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1
CHEMBL3104091 5ht1e_human Human No 5.4 Ki = 4045 nM Bind
Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)
288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1
CHEMBL3104091 5ht1e_human Human No 5.4 Ki = 4073.8 nM Bind
Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)Displacement of [3H]5HT from 5-HT1E receptor (unknown origin)
288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1
CHEMBL2391541 5ht1e_human Human Yes 6.4 Ki = 413 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12
CHEMBL2391541 5ht1e_human Human Yes 6.4 Ki = 416.9 nM Bind
Displacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]5-HT from human recombinant 5-HT1E receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis
270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12
CHEMBL76237 5ht1e_human Human Yes 5.4 Ki = 4220 nM Bind
Compound was evaluated for its binding affinity for human 5-hydroxytryptamine 1E receptorCompound was evaluated for its binding affinity for human 5-hydroxytryptamine 1E receptor
358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1
CHEMBL4207529 5ht1e_human Human No 5.3 Ki = 4600 nM Bind
Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis
388 6 3 7 1.3 COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C
CHEMBL3754496 5ht1e_human Human No 6.3 Ki = 478.6 nM Bind
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
258 7 1 1 3.5 C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12
CHEMBL3753318 5ht1e_human Human No 6.3 Ki = 489.8 nM Bind
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
254 7 1 1 3.7 C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12
CHEMBL2391541 5ht1e_human Human Yes 6.3 Ki = 501.2 nM Bind
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12
CHEMBL3754166 5ht1e_human Human No 6.3 Ki = 512.9 nM Bind
Binding affinity to 5-HT 1E (unknown origin) by competition binding assayBinding affinity to 5-HT 1E (unknown origin) by competition binding assay
318 7 1 1 4.1 C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12
CHEMBL267615 5ht1e_human Human Yes 6.3 Ki = 520 nM Bind
Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptorCompound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor
246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC
CHEMBL432713 5ht1e_human Human Yes 8.2 Ki = 6.3 nM Bind
Binding affinity for 5-hydroxytryptamine 1E receptor was determinedBinding affinity for 5-hydroxytryptamine 1E receptor was determined
499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2
CHEMBL103479 5ht1e_human Human No 6.2 Ki = 660 nM Bind
In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptor
352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL105261 5ht1e_human Human No 6.1 Ki = 770 nM Bind
In vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptorIn vitro binding affinity by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1E receptor
286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL4466483 5ht1e_human Human No 5.1 Ki = 7800 nM Bind
Displacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
411 3 0 5 6.4 C1=CC2=NC=CN2C(=C1)C3=C(C=C(C=C3)OC4=NC=CC5=C4SC=C5)C(F)(F)F
CHEMBL4209274 5ht1e_human Human Yes 6.1 Ki = 793 nM Bind
Displacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
231 1 2 2 1.9 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)F
CHEMBL4210782 5ht1e_human Human No 6.1 Ki = 890 nM Bind
Displacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT1E receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
227 1 2 2 2.1 CC1=CC=C(C=C1)C2=NNC3=C2CCNCC3
CHEMBL4572614 5ht1e_human Human No 5.1 Ki = 8900 nM Bind
Displacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
410 3 0 6 5.7 CC1=C(N2C=CN=C2C=N1)C3=C(C=C(C=C3)OC4=NC=CC5=C4C=CO5)C(F)(F)F
CHEMBL263881 5ht1e_human Human Yes 7.0 Ki = 93 nM Bind
Binding affinity towards 5-hydroxytryptamine 1E receptorBinding affinity towards 5-hydroxytryptamine 1E receptor
323 3 1 2 2.9 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
CHEMBL4277264 5ht1e_human Human Yes 5.0 Ki = 9800 nM Bind
Displacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
356 3 0 6 4.9 CC1=C(C=CC(=C1)OC2=NC=CC3=C2C=CO3)C4=C(N=CC5=NC=CN54)C
CHEMBL4469848 5ht1e_human Human No 5.0 Ki = 9900 nM Bind
Displacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]5-HT from recombinant human 5HT1E receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method
395 3 0 5 6.0 C1=CC2=NC=CN2C(=C1)C3=C(C=C(C=C3)OC4=NC=CC5=C4C=CO5)C(F)(F)F