Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL102250 5ht1f_human Human No 8.0 EC50 = 11 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1
CHEMBL105091 5ht1f_human Human No 8.0 EC50 = 11 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1
CHEMBL105958 5ht1f_human Human No 8.0 EC50 = 11 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1
CHEMBL3617557 5ht1f_human Human No 7.0 EC50 = 110 nM Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
341 4 1 4 3.0 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1
CHEMBL105955 5ht1f_human Human No 7.9 EC50 = 13 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
300 4 2 3 3.1 CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL187308 5ht1f_human Human No 6.9 EC50 = 140 nM Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
387 3 1 4 4.7 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1
CHEMBL321080 5ht1f_human Human No 7.8 EC50 = 15 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1
CHEMBL420475 5ht1f_human Human No 7.7 EC50 = 21 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
312 3 2 3 3.1 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1
CHEMBL105722 5ht1f_human Human No 7.6 EC50 = 25 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1
CHEMBL177238 5ht1f_human Human No 6.6 EC50 = 277 nM Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1
CHEMBL105261 5ht1f_human Human No 7.5 EC50 = 32 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL104720 5ht1f_human Human No 7.5 EC50 = 34 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
298 3 2 3 2.7 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1
CHEMBL128 5ht1f_human Human Yes 7.5 EC50 = 35 nM Funct
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL431041 5ht1f_human Human Yes 7.4 EC50 = 36 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptor
272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL186662 5ht1f_human Human No 6.3 EC50 = 470 nM Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
371 3 1 4 4.2 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1
CHEMBL187581 5ht1f_human Human No 7.3 EC50 = 50 nM Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
390 3 2 4 3.6 CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1
CHEMBL3617550 5ht1f_human Human No 7.3 EC50 = 55 nM Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
358 4 1 3 3.7 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1
CHEMBL339980 5ht1f_human Human No 8.2 EC50 = 6 nM Funct
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C
CHEMBL186951 5ht1f_human Human No 7.2 EC50 = 63 nM Funct
Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsStimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cells
388 3 2 4 4.0 CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1
CHEMBL177258 5ht1f_human Human No 7.2 EC50 = 66 nM Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
353 3 1 4 4.0 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL369705 5ht1f_human Human No 7.2 EC50 = 68.7 nM Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1
CHEMBL39 5ht1f_human Human Yes 8.1 EC50 = 7.9 nM Funct
In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL3617549 5ht1f_human Human No 7.1 EC50 = 87 nM Funct
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayAgonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
340 4 1 3 3.6 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1
CHEMBL104753 5ht1f_human Human No 8.0 EC50 = 9.4 nM Funct
In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptorIn vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F receptor
340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1
CHEMBL173949 5ht1f_human Human No 7.0 EC50 = 91.7 nM Funct
Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorConcentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor
389 3 1 4 4.3 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1
CHEMBL2110300 5ht1f_human Human No 6.4 IC50 = 363.1 nM Bind
Binding affinity towards human recombinant 5-hydroxytryptamine 1F receptorBinding affinity towards human recombinant 5-hydroxytryptamine 1F receptor
313 4 2 3 2.6 CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1
CHEMBL292779 5ht1f_human Human Yes 5.4 IC50 = 3800 nM Bind
Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorCompound was evaluated for the affinity at 5-hydroxytryptamine 1F receptor
432 8 1 5 3.7 Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL101690 5ht1f_human Human Yes 8.8 Ki = 1.6 nM Bind
Binding affinity at human 5HT1F receptorBinding affinity at human 5HT1F receptor
351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F
CHEMBL128636 5ht1f_human Human No 8.8 Ki = 1.6 nM Bind
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
351 3 2 2 4.4 CN1CCC(c2c[nH]c3cccc(NC(=O)c4ccc(F)cc4)c23)CC1
CHEMBL101690 5ht1f_human Human Yes 8.8 Ki = 1.6 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F
CHEMBL318105 5ht1f_human Human Yes 7.0 Ki = 100 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
230 1 2 3 2.0 CN1CCC(c2c[nH]c3ccc(N)nc23)CC1
CHEMBL318110 5ht1f_human Human No 7.0 Ki = 100 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
231 1 2 3 2.1 CN1CCC(c2c[nH]c3ccc(O)nc23)CC1
CHEMBL522708 5ht1f_human Human No 6.0 Ki = 1000 nM Bind
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
479 7 0 5 4.4 Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1
CHEMBL103550 5ht1f_human Human No 8.0 Ki = 11 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1
CHEMBL105369 5ht1f_human Human No 8.0 Ki = 11 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
367 3 3 3 4.2 CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1
CHEMBL321967 5ht1f_human Human No 8.0 Ki = 11 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
326 3 2 3 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1
CHEMBL419547 5ht1f_human Human No 8.0 Ki = 11 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
359 3 2 4 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(C#N)c4)nc23)CC1
CHEMBL3617556 5ht1f_human Human No 6.0 Ki = 1100 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
356 4 2 4 3.3 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2O)CC1
CHEMBL186662 5ht1f_human Human No 7.9 Ki = 12 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
371 3 1 4 4.2 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1
CHEMBL105025 5ht1f_human Human No 7.9 Ki = 12 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
348 3 2 3 3.9 Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL420101 5ht1f_human Human No 7.9 Ki = 12 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
348 3 2 3 3.9 Cc1ccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)cc1
CHEMBL609742 5ht1f_human Human No 7.9 Ki = 12.3 nM Bind
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
389 5 3 3 3.9 O=S(=O)(Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1Cl
CHEMBL186951 5ht1f_human Human No 7.9 Ki = 13 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
388 3 2 4 4.0 CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1
CHEMBL102344 5ht1f_human Human No 7.9 Ki = 13 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
328 6 2 3 3.9 CCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL103503 5ht1f_human Human No 7.9 Ki = 13 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 3 3.8 CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1
CHEMBL105091 5ht1f_human Human No 7.9 Ki = 13 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1
CHEMBL369391 5ht1f_human Human No 7.9 Ki = 13.5 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
341 5 1 4 3.6 Cc1oc2ccc(NC(=O)c3ccc(F)cc3)nc2c1CCN(C)C
CHEMBL3617551 5ht1f_human Human No 5.9 Ki = 1300 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 3 3.7 CN1CCC(C(=O)c2cc(NC(=O)c3ccc(F)cc3)ccc2F)CC1
CHEMBL105850 5ht1f_human Human No 7.9 Ki = 14 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
394 6 2 3 4.9 CCCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL319857 5ht1f_human Human No 7.9 Ki = 14 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
314 5 2 3 3.5 CCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL321133 5ht1f_human Human No 7.8 Ki = 16 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
364 4 2 4 3.6 COc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1
CHEMBL606547 5ht1f_human Human No 7.8 Ki = 16 nM Bind
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12
CHEMBL187581 5ht1f_human Human No 7.8 Ki = 17 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
390 3 2 4 3.6 CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1
CHEMBL445651 5ht1f_human Human No 7.8 Ki = 17 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 4 4.0 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1
CHEMBL2113386 5ht1f_human Human No 7.8 Ki = 17.8 nM Bind
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
495 6 3 3 4.0 O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1
CHEMBL104953 5ht1f_human Human No 6.8 Ki = 170 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
366 4 2 3 4.2 CCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL3617554 5ht1f_human Human No 5.8 Ki = 1700 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
374 4 1 3 4.3 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2Cl)CC1
CHEMBL105478 5ht1f_human Human No 7.8 Ki = 18 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
380 5 2 3 4.5 CCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL104384 5ht1f_human Human No 7.7 Ki = 19 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4F)nc23)CC1
CHEMBL105327 5ht1f_human Human No 7.7 Ki = 19 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
308 3 2 4 1.7 CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1
CHEMBL321343 5ht1f_human Human No 7.7 Ki = 19 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4[N+](=O)[O-])nc23)CC1
CHEMBL282971 5ht1f_human Human No 6.7 Ki = 199.5 nM Bind
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1
CHEMBL425190 5ht1f_human Human Yes 5.7 Ki = 1995.3 nM Bind
Binding affinity for human 5-hydroxytryptamine 1F receptor Binding affinity for human 5-hydroxytryptamine 1F receptor
412 6 0 5 4.3 Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F
CHEMBL101690 5ht1f_human Human Yes 8.7 Ki = 2.1 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
351 3 2 2 4.4 CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F
CHEMBL361303 5ht1f_human Human Yes 8.7 Ki = 2.2 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
351 3 1 3 4.3 CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1
CHEMBL173949 5ht1f_human Human No 8.6 Ki = 2.3 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
389 3 1 4 4.3 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1
CHEMBL323264 5ht1f_human Human No 8.6 Ki = 2.5 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
287 2 3 3 2.1 CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL606556 5ht1f_human Human No 8.6 Ki = 2.7 nM Bind
Inhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cellsInhibition of [3H]8-OH-DPAT binding to human 5-hydroxytryptamine 1F receptor expressed in CHO cells
403 5 2 3 4.3 CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12
CHEMBL369705 5ht1f_human Human No 8.5 Ki = 2.9 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1
CHEMBL101686 5ht1f_human Human No 7.7 Ki = 20 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
356 8 2 3 4.7 CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL321562 5ht1f_human Human No 7.7 Ki = 20 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
364 4 2 4 3.6 COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL418806 5ht1f_human Human No 7.7 Ki = 20 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
340 3 2 3 3.9 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCCC4)nc23)CC1
CHEMBL317535 5ht1f_human Human No 5.7 Ki = 2000 nM Bind
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
260 5 1 3 2.4 CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C
CHEMBL103058 5ht1f_human Human No 7.7 Ki = 21 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
284 3 2 3 2.6 CCN1CC=C(c2c[nH]c3ccc(NC(C)=O)nc23)CC1
CHEMBL104026 5ht1f_human Human No 6.7 Ki = 210 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
272 2 2 3 2.3 CC(=O)Nc1cc2c(C3CCN(C)CC3)c[nH]c2cn1
CHEMBL104158 5ht1f_human Human No 6.7 Ki = 220 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
273 2 2 4 1.7 CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL104374 5ht1f_human Human No 7.6 Ki = 23 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
245 2 1 3 2.4 COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL3617560 5ht1f_human Human No 5.6 Ki = 2400 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 4 3.0 CN1CCC(C(=O)c2ccnc(NC(=O)c3ccc(F)cc3)c2)CC1
CHEMBL316979 5ht1f_human Human No 7.6 Ki = 25 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
364 4 2 3 4.1 CCN1CC=C(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL128 5ht1f_human Human Yes 7.6 Ki = 25.7 nM Bind
Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedBinding affinity towards human 5-hydroxytryptamine 1F receptor was determined
295 6 2 3 1.3 CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL76237 5ht1f_human Human Yes 5.6 Ki = 2500 nM Bind
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
358 6 0 5 3.0 COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1
CHEMBL29846 5ht1f_human Human Yes 6.6 Ki = 251.2 nM Bind
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1
CHEMBL29846 5ht1f_human Human Yes 6.6 Ki = 251.2 nM Bind
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
465 5 1 6 4.4 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1
CHEMBL104968 5ht1f_human Human No 7.6 Ki = 27 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
388 4 2 4 3.3 CN1CCC(c2c[nH]c3ccc(NS(=O)(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL263700 5ht1f_human Human No 7.5 Ki = 29 nM Bind
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO using [3H]5-HT radioligand
308 4 1 4 3.1 CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12
CHEMBL177238 5ht1f_human Human No 8.5 Ki = 3 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
387 3 1 4 4.7 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1
CHEMBL177258 5ht1f_human Human No 8.5 Ki = 3.1 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 4 4.0 CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL432713 5ht1f_human Human Yes 8.5 Ki = 3.2 nM Bind
Binding affinity for 5-hydroxytryptamine 1F receptor was determinedBinding affinity for 5-hydroxytryptamine 1F receptor was determined
499 9 3 3 6.4 O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2
CHEMBL187308 5ht1f_human Human No 8.4 Ki = 3.6 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
387 3 1 4 4.7 CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1
CHEMBL421287 5ht1f_human Human No 8.4 Ki = 3.8 nM Bind
Binding affinity towards human 5-hydroxytryptamine 1F receptorBinding affinity towards human 5-hydroxytryptamine 1F receptor
325 5 2 2 3.7 CN(C)CCc1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12
CHEMBL102292 5ht1f_human Human No 8.4 Ki = 3.8 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
301 3 3 3 2.5 CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL92139 5ht1f_human Human No 8.4 Ki = 3.9 nM Bind
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
328 5 0 4 3.0 CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1
CHEMBL184597 5ht1f_human Human No 8.4 Ki = 3.9 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 2 3 3.8 CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1
CHEMBL105240 5ht1f_human Human No 7.5 Ki = 30 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
380 4 2 3 4.5 CC(C)N1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL292759 5ht1f_human Human Yes 6.5 Ki = 316.2 nM Bind
Compound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HTCompound was tested for its binding affinity against 5-hydroxytryptamine 1F receptor in human cloned receptors in CHO cells using [3H]5-HT
439 5 1 5 3.0 COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1
CHEMBL29433 5ht1f_human Human No 6.5 Ki = 316.2 nM Bind
The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1F receptor in CHO cells, using [3H]5-HT as radioligand
491 5 1 6 5.0 COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1
CHEMBL3617559 5ht1f_human Human No 5.5 Ki = 3200 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 4 3.0 CN1CCC(C(=O)c2cncc(NC(=O)c3ccc(F)cc3)c2)CC1
CHEMBL40650 5ht1f_rat Rat No 5.5 Ki = 3380 nM Bind
Binding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligandBinding affinity against 5-hydroxytryptamine 1 receptor using [3H]5-HT as radioligand
448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21
CHEMBL104946 5ht1f_human Human No 7.5 Ki = 35 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
272 3 3 3 2.4 CCC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1
CHEMBL365405 5ht1f_human Human Yes 8.4 Ki = 4.1 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 1 4 3.7 CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1
CHEMBL104496 5ht1f_human Human No 8.4 Ki = 4.1 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
402 3 2 3 4.9 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1
CHEMBL102250 5ht1f_human Human No 8.3 Ki = 4.6 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
324 3 2 4 3.2 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1
CHEMBL105556 5ht1f_human Human No 8.3 Ki = 4.7 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
309 3 1 5 1.7 CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1
CHEMBL361061 5ht1f_human Human No 8.3 Ki = 4.8 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 1 3 3.5 CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1
CHEMBL3617552 5ht1f_human Human No 7.4 Ki = 41 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 3 3.7 CN1CCC(C(=O)c2cc(F)cc(NC(=O)c3ccc(F)cc3)c2)CC1
CHEMBL105118 5ht1f_human Human No 7.4 Ki = 42 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1
CHEMBL322018 5ht1f_human Human No 7.4 Ki = 45 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
258 2 3 3 2.0 CC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1
CHEMBL125745 5ht1f_human Human No 7.3 Ki = 47 nM Bind
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
300 4 1 4 2.4 NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1
CHEMBL431041 5ht1f_human Human Yes 8.3 Ki = 5 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
272 2 2 3 2.3 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL3617549 5ht1f_human Human No 8.3 Ki = 5.1 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
340 4 1 3 3.6 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1
CHEMBL105261 5ht1f_human Human No 8.3 Ki = 5.5 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
286 3 2 3 2.7 CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL449406 5ht1f_human Human No 8.2 Ki = 5.8 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
348 3 2 3 3.9 Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1
CHEMBL497963 5ht1f_human Human No 6.3 Ki = 501.2 nM Bind
Displacement of radioligand from human cloned 5HT1F receptorDisplacement of radioligand from human cloned 5HT1F receptor
453 8 1 5 4.2 Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
CHEMBL184994 5ht1f_human Human No 6.3 Ki = 520 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
369 3 1 4 3.4 CN1CCC(N2CCOc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1
CHEMBL3617553 5ht1f_human Human No 6.3 Ki = 530 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 3 3.7 CN1CCC(C(=O)c2ccc(F)c(NC(=O)c3ccc(F)cc3)c2)CC1
CHEMBL126340 5ht1f_human Human No 6.2 Ki = 570 nM Bind
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
432 7 0 5 4.2 CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1
CHEMBL105722 5ht1f_human Human No 8.2 Ki = 6.3 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1
CHEMBL105955 5ht1f_human Human No 8.2 Ki = 6.9 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
300 4 2 3 3.1 CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1
CHEMBL3616488 5ht1f_human Human No 6.2 Ki = 610 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
370 5 1 4 3.6 COc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1
CHEMBL321578 5ht1f_human Human No 7.2 Ki = 62 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
314 2 2 3 3.4 CN1CCC(c2c[nH]c3ccc(NC(=O)C(C)(C)C)nc23)CC1
CHEMBL320198 5ht1f_human Human No 7.2 Ki = 67 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
353 3 2 4 3.2 CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL321080 5ht1f_human Human No 8.2 Ki = 7.1 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1
CHEMBL104484 5ht1f_human Human No 8.1 Ki = 7.2 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
359 3 2 4 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1
CHEMBL105743 5ht1f_human Human No 8.1 Ki = 7.3 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
334 3 2 3 3.6 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1
CHEMBL104753 5ht1f_human Human No 8.1 Ki = 7.4 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
340 3 2 4 3.7 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1
CHEMBL319920 5ht1f_human Human No 8.1 Ki = 7.5 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
389 4 1 5 3.3 CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL103479 5ht1f_human Human No 8.1 Ki = 7.6 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL103479 5ht1f_human Human No 8.1 Ki = 7.6 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
352 3 2 3 3.8 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1
CHEMBL104692 5ht1f_human Human No 8.1 Ki = 7.7 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
379 4 2 5 3.5 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1
CHEMBL495075 5ht1f_human Human Yes 5.1 Ki = 7200 nM Bind
Binding affinity to 5HT1F receptorBinding affinity to 5HT1F receptor
525 6 2 4 4.9 Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl
CHEMBL102182 5ht1f_human Human No 7.1 Ki = 75 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
442 6 2 3 5.4 O=C(Nc1ccc2[nH]cc(C3CCN(CCc4ccccc4)CC3)c2n1)c1ccc(F)cc1
CHEMBL93868 5ht1f_human Human No 6.1 Ki = 770 nM Bind
Binding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligandBinding affinity against 5-hydroxytryptamine 1F receptor in CHO cells using [3H]5-HT radioligand
328 5 0 4 3.0 CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12
CHEMBL339980 5ht1f_human Human No 8.1 Ki = 8.2 nM Bind
Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligandBinding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligand
339 5 2 2 4.0 Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C
CHEMBL178066 5ht1f_human Human Yes 8.1 Ki = 8.2 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
339 5 2 2 4.0 Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C
CHEMBL3617550 5ht1f_human Human No 8.1 Ki = 8.3 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
358 4 1 3 3.7 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1
CHEMBL105958 5ht1f_human Human No 8.1 Ki = 8.4 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
335 3 2 4 3.0 CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1
CHEMBL187952 5ht1f_human Human No 8.1 Ki = 8.6 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1
CHEMBL420475 5ht1f_human Human No 8.1 Ki = 8.7 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
312 3 2 3 3.1 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1
CHEMBL3617555 5ht1f_human Human No 6.1 Ki = 870 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
354 4 1 3 3.9 Cc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1
CHEMBL187952 5ht1f_human Human No 8.1 Ki = 9 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1
CHEMBL3617557 5ht1f_human Human No 8.0 Ki = 9.5 nM Bind
Binding affinity to human 5HT1F receptor by radioligand binding assayBinding affinity to human 5HT1F receptor by radioligand binding assay
341 4 1 4 3.0 CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1
CHEMBL102335 5ht1f_human Human No 8.0 Ki = 9.5 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
338 3 3 3 3.4 O=C(Nc1ccc2[nH]cc(C3CCNCC3)c2n1)c1ccc(F)cc1
CHEMBL187952 5ht1f_human Human No 8.0 Ki = 9.6 nM Bind
In vitro binding affinity for human 5-hydroxytryptamine 1F receptorIn vitro binding affinity for human 5-hydroxytryptamine 1F receptor
353 3 2 3 3.9 CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1
CHEMBL103424 5ht1f_human Human Yes 8.0 Ki = 9.7 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
271 2 2 2 2.9 CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1
CHEMBL104720 5ht1f_human Human No 8.0 Ki = 9.8 nM Bind
In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptorIn vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor
298 3 2 3 2.7 CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1