Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL350221 5ht2b_human Human Yes 9.0 EC50 = 1 Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 4 -1.2 C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
CHEMBL201930 5ht2b_human Human Yes 9.0 EC50 = 1.1 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)N
CHEMBL201930 5ht2b_human Human Yes 9.0 EC50 = 1.1 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)N
CHEMBL350221 5ht2b_human Human Yes 8.9 EC50 = 1.3 Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 4 -1.2 C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
CHEMBL350221 5ht2b_human Human Yes 8.9 EC50 = 1.3 Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 4 -1.2 C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
CHEMBL76781 5ht2b_human Human Yes 8.8 EC50 = 1.6 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL76781 5ht2b_human Human Yes 8.8 EC50 = 1.6 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL451543 5ht2b_human Human No 8.0 EC50 = 10 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
222 3 1 3 2.1 CC(CN1CCC2=C1C=C(C=C2)SC)N
CHEMBL376676 5ht2b_human Human No 7.0 EC50 = 100 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL376676 5ht2b_human Human No 7.0 EC50 = 100 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL180815 5ht2b_human Human No 7.0 EC50 = 100 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
270 1 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL180668 5ht2b_human Human Yes 6.0 EC50 = 1000 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
182 0 1 1 2.4 C1CNCCC2=C1C=CC(=C2)Cl
CHEMBL181172 5ht2b_human Human Yes 6.0 EC50 = 1000 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL3286565 5ht2b_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.7 CC(C1=CC=CC=C1)C2=NC3=C(CCNCC3)C(=N2)NC
CHEMBL180668 5ht2b_human Human Yes 6.0 EC50 = 1000 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
182 0 1 1 2.4 C1CNCCC2=C1C=CC(=C2)Cl
CHEMBL181172 5ht2b_human Human Yes 6.0 EC50 = 1000 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL3286565 5ht2b_human Human No 6.0 EC50 = 1000 Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.7 CC(C1=CC=CC=C1)C2=NC3=C(CCNCC3)C(=N2)NC
CHEMBL360328 5ht2b_human Human Yes 6.0 EC50 = 1000 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL179329 5ht2b_human Human No 6.0 EC50 = 1000 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
298 2 1 2 3.6 CC(C)C1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL180668 5ht2b_human Human Yes 6.0 EC50 = 1000 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
182 0 1 1 2.4 C1CNCCC2=C1C=CC(=C2)Cl
CHEMBL590816 5ht2b_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 C1CNCCN2C1NC(=O)C3=CC=CC=C32
CHEMBL590816 5ht2b_human Human No 7.0 EC50 = 101 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 1.0 C1CNCCN2C1NC(=O)C3=CC=CC=C32
CHEMBL511044 5ht2b_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
280 4 2 4 1.5 C1CC1CNS(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL511044 5ht2b_human Human No 7.0 EC50 = 103 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
280 4 2 4 1.5 C1CC1CNS(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL209106 5ht2b_human Human Yes 7.0 EC50 = 108 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
206 1 1 3 1.9 C1CN(C2C1CNC2)C3=CC(=CC=C3)F
CHEMBL209106 5ht2b_human Human Yes 7.0 EC50 = 108 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
206 1 1 3 1.9 C1CN(C2C1CNC2)C3=CC(=CC=C3)F
CHEMBL309760 5ht2b_human Human Yes 8.0 EC50 = 11 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
255 2 1 2 2.3 CC(CN1CCC2=C1C=C(C=C2)Br)N
CHEMBL134519 5ht2b_rat Rat Yes 7.9 EC50 = 11.9 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL134519 5ht2b_rat Rat Yes 7.9 EC50 = 11.9 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL134519 5ht2b_rat Rat Yes 7.9 EC50 = 11.9 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL134519 5ht2b_rat Rat Yes 7.9 EC50 = 11.9 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
321 4 1 3 2.5 CC(CC1=CC(=C(C=C1OC)I)OC)N
CHEMBL181172 5ht2b_human Human Yes 6.0 EC50 = 1100 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL1643857 5ht2b_human Human No 5.9 EC50 = 1158 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=NC=C5
CHEMBL1643857 5ht2b_human Human No 5.9 EC50 = 1158 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=NC=C5
CHEMBL197646 5ht2b_human Human No 5.9 EC50 = 1180 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay
206 3 1 2 2.6 CN(C)CCC1=CNC2=C1C(=CC=C2)F
CHEMBL197646 5ht2b_human Human No 5.9 EC50 = 1180 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay
206 3 1 2 2.6 CN(C)CCC1=CNC2=C1C(=CC=C2)F
CHEMBL1643858 5ht2b_human Human No 5.9 EC50 = 1184 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
406 4 1 6 1.5 CC(=O)N(C)C1=CC=C(C=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL1643858 5ht2b_human Human No 5.9 EC50 = 1184 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
406 4 1 6 1.5 CC(=O)N(C)C1=CC=C(C=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL2397896 5ht2b_human Human No 7.9 EC50 = 12 Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 CC1=CC2=C(CC3CNCCN3C2=O)C=C1
CHEMBL1770378 5ht2b_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=CC=C1CC2=NC=C3CCNCCC3=N2
CHEMBL1770378 5ht2b_human Human No 5.9 EC50 = 1200 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=CC=C1CC2=NC=C3CCNCCC3=N2
CHEMBL492949 5ht2b_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
254 2 1 4 0.9 CN(C)S(=O)(=O)C1=CC2=C(CCNCC2)C=C1
CHEMBL492949 5ht2b_human Human No 6.9 EC50 = 125 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
254 2 1 4 0.9 CN(C)S(=O)(=O)C1=CC2=C(CCNCC2)C=C1
CHEMBL178365 5ht2b_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL181076 5ht2b_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL178365 5ht2b_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL181076 5ht2b_human Human Yes 5.9 EC50 = 1258.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL201117 5ht2b_human Human No 6.9 EC50 = 128 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
321 5 1 2 4.6 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4CCCCC4
CHEMBL379223 5ht2b_human Human No 6.9 EC50 = 128 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
329 5 1 2 4.1 CC1=CC=CC=C1CNC(C)CN2C=CC3=C2C4=C(C=C3)N=CC=C4
CHEMBL201117 5ht2b_human Human No 6.9 EC50 = 128 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
321 5 1 2 4.6 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4CCCCC4
CHEMBL379223 5ht2b_human Human No 6.9 EC50 = 128 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
329 5 1 2 4.1 CC1=CC=CC=C1CNC(C)CN2C=CC3=C2C4=C(C=C3)N=CC=C4
CHEMBL1643677 5ht2b_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC(=CC=C5)F
CHEMBL1643677 5ht2b_human Human No 7.9 EC50 = 13 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC(=CC=C5)F
CHEMBL234837 5ht2b_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
315 4 1 6 2.3 CC1=NOC(=N1)CC2=C3CCOC3=C(C4=C2OCC4)CC(C)N
CHEMBL234837 5ht2b_rat Rat No 6.9 EC50 = 130 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
315 4 1 6 2.3 CC1=NOC(=N1)CC2=C3CCOC3=C(C4=C2OCC4)CC(C)N
CHEMBL179915 5ht2b_human Human No 6.9 EC50 = 130 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
259 1 1 5 3.0 CC1CNCCC2=CC(=C(C=C12)C(F)(F)F)OC
CHEMBL2113264 5ht2b_human Human No 7.9 EC50 = 14 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 5 2.6 CC(C)C1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL2113264 5ht2b_human Human No 7.9 EC50 = 14 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 5 2.6 CC(C)C1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL181787 5ht2b_human Human No 6.9 EC50 = 140 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL178365 5ht2b_human Human Yes 5.9 EC50 = 1400 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL577410 5ht2b_human Human No 6.9 EC50 = 142 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
339 3 1 7 2.0 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3OC(F)(F)F
CHEMBL577410 5ht2b_human Human No 6.9 EC50 = 142 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
339 3 1 7 2.0 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3OC(F)(F)F
CHEMBL1643856 5ht2b_human Human No 5.8 EC50 = 1478 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CN=CC=C5
CHEMBL1643856 5ht2b_human Human No 5.8 EC50 = 1478 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.1 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CN=CC=C5
CHEMBL3425755 5ht2b_human Human No 5.8 EC50 = 1484 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
267 3 2 3 3.0 CNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL3425755 5ht2b_human Human No 5.8 EC50 = 1484 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
267 3 2 3 3.0 CNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL492911 5ht2b_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=C(C=C3)F
CHEMBL492911 5ht2b_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=C(C=C3)F
CHEMBL253811 5ht2b_human Human Yes 7.8 EC50 = 15.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
203 2 1 4 2.5 CC(CC1=CC(=CC=C1)C(F)(F)F)N
CHEMBL253811 5ht2b_human Human Yes 7.8 EC50 = 15.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
203 2 1 4 2.5 CC(CC1=CC(=CC=C1)C(F)(F)F)N
CHEMBL440752 5ht2b_human Human Yes 5.8 EC50 = 1500 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
240 0 1 1 2.8 CC1CNCCC2=C1C=C(C=C2)Br
CHEMBL210215 5ht2b_human Human No 6.8 EC50 = 151 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL210215 5ht2b_human Human No 6.8 EC50 = 151 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL202656 5ht2b_human Human No 6.8 EC50 = 152 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=NC=C3)N
CHEMBL202656 5ht2b_human Human No 6.8 EC50 = 152 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=NC=C3)N
CHEMBL178231 5ht2b_human Human Yes 5.8 EC50 = 1584.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL178231 5ht2b_human Human Yes 5.8 EC50 = 1584.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL1770385 5ht2b_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
307 2 1 6 2.9 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)C(F)(F)F
CHEMBL1770385 5ht2b_human Human No 6.8 EC50 = 160 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
307 2 1 6 2.9 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)C(F)(F)F
CHEMBL222566 5ht2b_human Human No 5.8 EC50 = 1610 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
282 1 1 5 2.0 C=CC1=CC2=C(C(=C1)C(F)(F)F)C(=O)N3C2CNCC3
CHEMBL222566 5ht2b_human Human No 5.8 EC50 = 1610 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
282 1 1 5 2.0 C=CC1=CC2=C(C(=C1)C(F)(F)F)C(=O)N3C2CNCC3
CHEMBL1643678 5ht2b_human Human No 6.8 EC50 = 163 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=C(C=C5)F
CHEMBL1643678 5ht2b_human Human No 6.8 EC50 = 163 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=C(C=C5)F
CHEMBL1770380 5ht2b_human Human No 6.8 EC50 = 164 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=C(C=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL1770380 5ht2b_human Human No 6.8 EC50 = 164 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC=C(C=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL493951 5ht2b_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
294 4 1 4 1.7 CN(CC1CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL493951 5ht2b_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
294 4 1 4 1.7 CN(CC1CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL220211 5ht2b_human Human No 6.8 EC50 = 175 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
286 1 1 6 1.2 COC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL220211 5ht2b_human Human No 6.8 EC50 = 175 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
286 1 1 6 1.2 COC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL1770381 5ht2b_human Human No 6.8 EC50 = 178 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3Cl
CHEMBL1770381 5ht2b_human Human No 6.8 EC50 = 178 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3Cl
CHEMBL3425756 5ht2b_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
281 4 2 3 3.4 CCNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL449999 5ht2b_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3F
CHEMBL521805 5ht2b_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
287 2 1 3 2.6 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3
CHEMBL3425756 5ht2b_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
281 4 2 3 3.4 CCNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL449999 5ht2b_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3F
CHEMBL521805 5ht2b_human Human No 7.8 EC50 = 18 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
287 2 1 3 2.6 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC=C3
CHEMBL222514 5ht2b_human Human No 6.8 EC50 = 180 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL222514 5ht2b_human Human No 6.8 EC50 = 180 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL360968 5ht2b_human Human No 6.8 EC50 = 180 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
284 2 1 2 3.1 CCOC1=C(C=C2C(CNCCC2=C1)C)Br
CHEMBL178231 5ht2b_human Human Yes 5.8 EC50 = 1800 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=C1C(=C(C=C2)Cl)Cl
CHEMBL1770376 5ht2b_human Human No 6.7 EC50 = 183 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)F
CHEMBL1770376 5ht2b_human Human No 6.7 EC50 = 183 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)F
CHEMBL595195 5ht2b_human Human No 6.7 EC50 = 187 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL572228 5ht2b_human Human No 6.7 EC50 = 187 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay
319 5 1 5 2.5 C1CN(CCN1)C2=CN=CC(=N2)OCCC3=CC=CC=C3Cl
CHEMBL209155 5ht2b_human Human No 6.7 EC50 = 187 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
255 1 1 4 3.4 C1CC(C2C1CNC2)C3=CC(=CC=C3)C(F)(F)F
CHEMBL595195 5ht2b_human Human No 6.7 EC50 = 187 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL572228 5ht2b_human Human No 6.7 EC50 = 187 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay
319 5 1 5 2.5 C1CN(CCN1)C2=CN=CC(=N2)OCCC3=CC=CC=C3Cl
CHEMBL209155 5ht2b_human Human No 6.7 EC50 = 187 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
255 1 1 4 3.4 C1CC(C2C1CNC2)C3=CC(=CC=C3)C(F)(F)F
CHEMBL178313 5ht2b_human Human No 6.7 EC50 = 190 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
256 0 2 2 2.5 CC1CNCCC2=CC(=C(C=C12)Br)O
CHEMBL220274 5ht2b_human Human No 6.7 EC50 = 192 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL220274 5ht2b_human Human No 6.7 EC50 = 192 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 5 1.2 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL493151 5ht2b_human Human No 6.7 EC50 = 197 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
268 4 2 4 1.6 CCCNS(=O)(=O)C1=CC2=C(CCNCC2)C=C1
CHEMBL493151 5ht2b_human Human No 6.7 EC50 = 197 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
268 4 2 4 1.6 CCCNS(=O)(=O)C1=CC2=C(CCNCC2)C=C1
CHEMBL399750 5ht2b_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)OC)Cl
CHEMBL399750 5ht2b_human Human No 6.7 EC50 = 199.5 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)OC)Cl
CHEMBL440752 5ht2b_human Human Yes 5.7 EC50 = 1995.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
240 0 1 1 2.8 CC1CNCCC2=C1C=C(C=C2)Br
CHEMBL440752 5ht2b_human Human Yes 5.7 EC50 = 1995.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
240 0 1 1 2.8 CC1CNCCC2=C1C=C(C=C2)Br
CHEMBL371300 5ht2b_rat Rat Yes 8.7 EC50 = 2 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL371300 5ht2b_rat Rat Yes 8.7 EC50 = 2 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL201454 5ht2b_human Human No 8.7 EC50 = 2.1 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
260 2 1 2 2.3 CC(CN1C=CC2=CC(=C3C(=C21)C=CC=N3)Cl)N
CHEMBL201454 5ht2b_human Human No 8.7 EC50 = 2.1 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
260 2 1 2 2.3 CC(CN1C=CC2=CC(=C3C(=C21)C=CC=N3)Cl)N
CHEMBL76781 5ht2b_human Human Yes 8.6 EC50 = 2.4 Funct
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL76781 5ht2b_human Human Yes 8.6 EC50 = 2.4 Funct
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL31115 5ht2b_rat Rat Yes 8.6 EC50 = 2.7 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
204 3 2 2 1.0 CC(CC1=CNC2=C1C=C(C=C2)OC)N
CHEMBL31115 5ht2b_rat Rat Yes 8.6 EC50 = 2.7 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
204 3 2 2 1.0 CC(CC1=CNC2=C1C=C(C=C2)OC)N
CHEMBL202458 5ht2b_human Human No 7.7 EC50 = 20 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
359 5 1 4 3.5 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=C(C=C4)OCO5
CHEMBL42 5ht2b_human Human Yes 7.7 EC50 = 20 Funct
Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL202458 5ht2b_human Human No 7.7 EC50 = 20 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
359 5 1 4 3.5 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=C(C=C4)OCO5
CHEMBL376456 5ht2b_human Human No 6.7 EC50 = 207 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
218 1 1 3 0.3 COC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL376456 5ht2b_human Human No 6.7 EC50 = 207 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
218 1 1 3 0.3 COC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL1201356 5ht2b_human Human Yes 7.7 EC50 = 21.4 Funct
Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay
339 4 3 3 2.3 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
CHEMBL1201356 5ht2b_human Human Yes 7.7 EC50 = 21.4 Funct
Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay
339 4 3 3 2.3 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
CHEMBL1643853 5ht2b_human Human No 6.7 EC50 = 215 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC(=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL1643853 5ht2b_human Human No 6.7 EC50 = 215 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC(=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL1643675 5ht2b_human Human No 6.7 EC50 = 218 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
335 3 1 5 2.2 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5
CHEMBL1643675 5ht2b_human Human No 6.7 EC50 = 218 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
335 3 1 5 2.2 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5
CHEMBL360328 5ht2b_human Human Yes 6.7 EC50 = 219 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2b_human Human Yes 6.7 EC50 = 219 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL219837 5ht2b_human Human No 7.7 EC50 = 22 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL3425758 5ht2b_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
307 5 2 3 3.7 C1CC1CNC2=C3CCNCCC3=CC(=N2)CC4=CC=CC=C4
CHEMBL219837 5ht2b_human Human No 7.7 EC50 = 22 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL3425758 5ht2b_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
307 5 2 3 3.7 C1CC1CNC2=C3CCNCCC3=CC(=N2)CC4=CC=CC=C4
CHEMBL76301 5ht2b_human Human No 7.7 EC50 = 22 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
320 2 1 3 2.3 CC(CN1CCC2=CC(=C(C=C21)I)F)N
CHEMBL1770375 5ht2b_human Human No 6.7 EC50 = 220 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3F
CHEMBL1770375 5ht2b_human Human No 6.7 EC50 = 220 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3F
CHEMBL180867 5ht2b_human Human No 6.7 EC50 = 220 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
270 1 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL1643671 5ht2b_human Human No 5.7 EC50 = 2242 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
257 1 1 4 1.2 C1CCN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL1643671 5ht2b_human Human No 5.7 EC50 = 2242 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
257 1 1 4 1.2 C1CCN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL234682 5ht2b_rat Rat No 7.6 EC50 = 23 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
311 4 1 6 3.1 CC1=NOC(=N1)CC2=C3C=COC3=C(C4=C2OC=C4)CC(C)N
CHEMBL203013 5ht2b_human Human No 7.6 EC50 = 23 Funct
Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR
273 4 1 4 1.6 CC1CNCC2N1C3=C(C2)C=CC(=N3)COCC4CC4
CHEMBL234682 5ht2b_rat Rat No 7.6 EC50 = 23 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
311 4 1 6 3.1 CC1=NOC(=N1)CC2=C3C=COC3=C(C4=C2OC=C4)CC(C)N
CHEMBL203013 5ht2b_human Human No 7.6 EC50 = 23 Funct
Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR
273 4 1 4 1.6 CC1CNCC2N1C3=C(C2)C=CC(=N3)COCC4CC4
CHEMBL415029 5ht2b_human Human No 6.6 EC50 = 230 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
298 2 1 2 3.6 CC1CNCCC2=CC(=C(C=C12)Br)OC(C)C
CHEMBL2397911 5ht2b_human Human No 5.6 EC50 = 2366 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
244 1 1 2 2.0 CCC1=CC(=C2C(=C1)CC3CNCCN3C2=O)C
CHEMBL3286564 5ht2b_human Human No 6.6 EC50 = 247 Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
324 3 1 5 2.1 C1CNCCC2=C1C(=NC(=N2)CC3=CC=CC=C3)N4CCOCC4
CHEMBL3286564 5ht2b_human Human No 6.6 EC50 = 247 Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
324 3 1 5 2.1 C1CNCCC2=C1C(=NC(=N2)CC3=CC=CC=C3)N4CCOCC4
CHEMBL253805 5ht2b_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL253809 5ht2b_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL253805 5ht2b_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL253809 5ht2b_human Human No 6.6 EC50 = 251.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL368016 5ht2b_human Human Yes 5.6 EC50 = 2511.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=C1C(=C(C=C2)Cl)F
CHEMBL368016 5ht2b_human Human Yes 5.6 EC50 = 2511.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=C1C(=C(C=C2)Cl)F
CHEMBL585012 5ht2b_human Human No 6.6 EC50 = 267 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)Cl
CHEMBL585012 5ht2b_human Human No 6.6 EC50 = 267 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)Cl
CHEMBL3425763 5ht2b_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
238 2 1 2 2.7 C1CNCCC2=CN=C(C=C21)CC3=CC=CC=C3
CHEMBL3425759 5ht2b_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
295 5 2 3 3.9 CCCNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL202616 5ht2b_human Human No 7.6 EC50 = 27 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
365 5 1 2 4.9 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=CC=CC=C5C=C4
CHEMBL3425763 5ht2b_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
238 2 1 2 2.7 C1CNCCC2=CN=C(C=C21)CC3=CC=CC=C3
CHEMBL3425759 5ht2b_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
295 5 2 3 3.9 CCCNC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL202616 5ht2b_human Human No 7.6 EC50 = 27 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
365 5 1 2 4.9 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC5=CC=CC=C5C=C4
CHEMBL594469 5ht2b_human Human No 5.6 EC50 = 2700 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
345 4 1 6 2.5 C1CC2=C(C1OCC3=C(C=CC(=C3)F)F)N=C(C=C2)N4CCNCC4
CHEMBL594469 5ht2b_human Human No 5.6 EC50 = 2700 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
345 4 1 6 2.5 C1CC2=C(C1OCC3=C(C=CC(=C3)F)F)N=C(C=C2)N4CCNCC4
CHEMBL2397888 5ht2b_human Human No 6.6 EC50 = 271 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 CC1C2CNCCN2C(=O)C3=CC=CC=C13
CHEMBL223466 5ht2b_human Human No 6.6 EC50 = 274 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
251 1 1 2 1.8 CCC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL223466 5ht2b_human Human No 6.6 EC50 = 274 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
251 1 1 2 1.8 CCC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL385577 5ht2b_human Human No 7.6 EC50 = 28 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C(C=CC2=C1C(=O)N3C2CNCC3)Cl
CHEMBL385577 5ht2b_human Human No 7.6 EC50 = 28 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
253 1 1 3 0.9 COC1=C(C=CC2=C1C(=O)N3C2CNCC3)Cl
CHEMBL2397897 5ht2b_human Human No 7.6 EC50 = 28 Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 1 1 2 1.6 CCC1=CC2=C(CC3CNCCN3C2=O)C=C1
CHEMBL374562 5ht2b_human Human No 6.6 EC50 = 282 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.6 CC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL374562 5ht2b_human Human No 6.6 EC50 = 282 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.6 CC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL1643672 5ht2b_human Human No 5.5 EC50 = 2848 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
271 1 1 4 1.5 C1CCN(CC1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL1643672 5ht2b_human Human No 5.6 EC50 = 2848 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
271 1 1 4 1.5 C1CCN(CC1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL2023357 5ht2b_human Human No 6.5 EC50 = 289 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL2023357 5ht2b_human Human No 6.5 EC50 = 289 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL2023357 5ht2b_human Human No 6.5 EC50 = 289 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL2023357 5ht2b_human Human No 6.5 EC50 = 289 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization
235 5 1 3 2.2 C1CC1COC2=C(C=C(C=C2)F)C3CC3CN
CHEMBL223292 5ht2b_human Human No 6.5 EC50 = 290 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
237 0 1 2 1.3 CC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL223292 5ht2b_human Human No 6.5 EC50 = 290 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
237 0 1 2 1.3 CC1=C2C3CNCCN3C(=O)C2=C(C=C1)Cl
CHEMBL375302 5ht2b_human Human No 6.5 EC50 = 293 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.2 CCC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL375302 5ht2b_human Human No 6.5 EC50 = 293 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.2 CCC1C2C3=C(C(=CC=C3)C(F)(F)F)C(=O)N2CCN1
CHEMBL375170 5ht2b_human Human No 5.5 EC50 = 2980 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
296 1 1 5 2.1 C1CC1C2=CC3=C(C(=C2)C(F)(F)F)C(=O)N4C3CNCC4
CHEMBL375170 5ht2b_human Human No 5.5 EC50 = 2980 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
296 1 1 5 2.1 C1CC1C2=CC3=C(C(=C2)C(F)(F)F)C(=O)N4C3CNCC4
CHEMBL77880 5ht2b_human Human Yes 8.5 EC50 = 3 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
218 2 1 3 1.6 CC(CN1CCC2=C1C3=C(C=C2)OCC3)N
CHEMBL407909 5ht2b_human Human Yes 8.5 EC50 = 3.2 Funct
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
243 3 1 3 2.2 CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N
CHEMBL407909 5ht2b_human Human Yes 8.5 EC50 = 3.2 Funct
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
243 3 1 3 2.2 CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N
CHEMBL1224034 5ht2b_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay
336 1 1 4 3.4 C1CCC(CC1)NC(=O)N2C3C(CO2)CSC4=C3C=C(C=C4)F
CHEMBL1224034 5ht2b_human Human No 8.4 EC50 = 4.0 Funct
Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay
336 1 1 4 3.4 C1CCC(CC1)NC(=O)N2C3C(CO2)CSC4=C3C=C(C=C4)F
CHEMBL1770382 5ht2b_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)Cl
CHEMBL3425762 5ht2b_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
281 3 1 3 3.1 CN(C)C1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL1770382 5ht2b_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC(=CC=C3)Cl
CHEMBL3425762 5ht2b_human Human No 7.5 EC50 = 30 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
281 3 1 3 3.1 CN(C)C1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL182184 5ht2b_human Human No 7.5 EC50 = 30 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
270 1 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL609306 5ht2b_human Human No 6.5 EC50 = 300 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL609306 5ht2b_human Human No 6.5 EC50 = 300 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL80731 5ht2b_human Human No 7.5 EC50 = 31 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
254 4 1 4 2.5 CCSC1=C(C=C2CCN(C2=C1)CC(C)N)F
CHEMBL360492 5ht2b_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Cl)F
CHEMBL360492 5ht2b_human Human No 6.5 EC50 = 316.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
214 0 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Cl)F
CHEMBL208936 5ht2b_human Human No 6.5 EC50 = 320 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL208936 5ht2b_human Human No 6.5 EC50 = 320 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL360328 5ht2b_human Human Yes 6.5 EC50 = 328 Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL374436 5ht2b_human Human No 7.5 EC50 = 33 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C=C2C(=C1)C3CNCCN3C2=O)OC
CHEMBL3425760 5ht2b_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
295 4 2 3 3.8 CC(C)NC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL492910 5ht2b_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC(=C3)F
CHEMBL374436 5ht2b_human Human No 7.5 EC50 = 33 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C=C2C(=C1)C3CNCCN3C2=O)OC
CHEMBL3425760 5ht2b_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
295 4 2 3 3.8 CC(C)NC1=C2CCNCCC2=CC(=N1)CC3=CC=CC=C3
CHEMBL492910 5ht2b_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 4 2.7 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)C3=CC=CC(=C3)F
CHEMBL455039 5ht2b_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
294 2 1 4 1.8 C1CCN(CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL455039 5ht2b_human Human No 7.5 EC50 = 34 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
294 2 1 4 1.8 C1CCN(CC1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL577903 5ht2b_human Human No 6.5 EC50 = 353 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
243 3 2 3 1.9 C1CNCCC2=C1C(=NN2)OCC3=CC=CC=C3
CHEMBL577903 5ht2b_human Human No 6.5 EC50 = 353 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
243 3 2 3 1.9 C1CNCCC2=C1C(=NN2)OCC3=CC=CC=C3
CHEMBL522514 5ht2b_human Human No 6.5 EC50 = 357 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
280 2 1 4 1.4 C1CCN(C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL522514 5ht2b_human Human No 6.5 EC50 = 357 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
280 2 1 4 1.4 C1CCN(C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL524778 5ht2b_human Human No 6.5 EC50 = 358 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
255 2 1 3 0.8 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3
CHEMBL524778 5ht2b_human Human No 6.5 EC50 = 358 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
255 2 1 3 0.8 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3
CHEMBL80482 5ht2b_human Human No 7.4 EC50 = 36 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
232 2 1 3 1.9 CC(CN1CCC2=C1C3=C(C=C2)OCCC3)N
CHEMBL360492 5ht2b_human Human No 6.4 EC50 = 360 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
214 0 1 2 2.8 CC1CNCCC2=CC(=C(C=C12)Cl)F
CHEMBL2397887 5ht2b_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.3 CC1CNCC2N1C(=O)C3=CC=CC=C3C2
CHEMBL1643679 5ht2b_human Human No 6.4 EC50 = 379 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC=C1OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL1643679 5ht2b_human Human No 6.4 EC50 = 379 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=CC=C1OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL178124 5ht2b_human Human No 6.4 EC50 = 380 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL253591 5ht2b_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL400600 5ht2b_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL253591 5ht2b_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL400600 5ht2b_human Human No 7.4 EC50 = 39.8 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL595194 5ht2b_human Human No 6.4 EC50 = 397 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL595194 5ht2b_human Human No 6.4 EC50 = 397 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL253806 5ht2b_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL253806 5ht2b_human Human No 6.4 EC50 = 398.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL367796 5ht2b_human Human Yes 5.4 EC50 = 3981.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
161 0 1 1 2.1 CC1CNCCC2=CC=CC=C12
CHEMBL367796 5ht2b_human Human Yes 5.4 EC50 = 3981.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
161 0 1 1 2.1 CC1CNCCC2=CC=CC=C12
CHEMBL76474 5ht2b_human Human Yes 8.4 EC50 = 4.1 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
240 3 1 4 2.2 CC(CN1CCC2=CC(=C(C=C21)SC)F)N
CHEMBL199775 5ht2b_rat Rat Yes 8.4 EC50 = 4.2 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
205 3 1 3 1.0 CC(CN1C2=C(C=CC(=C2)OC)C=N1)N
CHEMBL199775 5ht2b_rat Rat Yes 8.4 EC50 = 4.2 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
205 3 1 3 1.0 CC(CN1C2=C(C=CC(=C2)OC)C=N1)N
CHEMBL76781 5ht2b_human Human Yes 8.4 EC50 = 4.3 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL76781 5ht2b_human Human Yes 8.4 EC50 = 4.3 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL76781 5ht2b_human Human Yes 8.4 EC50 = 4.3 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
227 2 1 2 2.2 CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N
CHEMBL223272 5ht2b_human Human No 7.4 EC50 = 40 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL223272 5ht2b_human Human No 7.4 EC50 = 40 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 5 1.7 CC1CNCC2N1C(=O)C3=C2C=CC=C3C(F)(F)F
CHEMBL426235 5ht2b_human Human No 7.4 EC50 = 40 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
284 2 1 2 3.1 CCC1CNCCC2=CC(=C(C=C12)Br)OC
CHEMBL180166 5ht2b_human Human No 6.4 EC50 = 400 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
256 1 1 2 2.4 COC1=C(C=C2CCNCCC2=C1)Br
CHEMBL1093699 5ht2b_human Human No 5.4 EC50 = 4027 Funct
Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor
364 7 2 5 3.6 COC1=CC(=C(C=C1CNC(=O)C2CCCN2)F)OCC3CCCCC3
CHEMBL1093699 5ht2b_human Human No 5.4 EC50 = 4027 Funct
Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor
364 7 2 5 3.6 COC1=CC(=C(C=C1CNC(=O)C2CCCN2)F)OCC3CCCCC3
CHEMBL1770379 5ht2b_human Human No 6.4 EC50 = 410 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC(=CC=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL1770379 5ht2b_human Human No 6.4 EC50 = 410 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.4 CC1=CC(=CC=C1)CC2=NC=C3CCNCCC3=N2
CHEMBL375642 5ht2b_human Human No 6.4 EC50 = 417 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 0 5 1.7 CN1CCN2C(C1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL375642 5ht2b_human Human No 6.4 EC50 = 417 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 0 5 1.7 CN1CCN2C(C1)C3=C(C2=O)C(=CC=C3)C(F)(F)F
CHEMBL202538 5ht2b_human Human No 7.4 EC50 = 44 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
350 5 1 2 4.3 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4Cl
CHEMBL202538 5ht2b_human Human No 7.4 EC50 = 44 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
350 5 1 2 4.3 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4Cl
CHEMBL201062 5ht2b_human Human No 7.4 EC50 = 45 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.7 CC(CN1C=CC2=C1C3=C(C=CC=N3)C=C2)N
CHEMBL201062 5ht2b_human Human No 7.4 EC50 = 45 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.7 CC(CN1C=CC2=C1C3=C(C=CC=N3)C=C2)N
CHEMBL590483 5ht2b_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
252 0 2 3 1.6 C1CNCCN2C1NC(=O)C3=C2C=CC=C3Cl
CHEMBL590483 5ht2b_human Human No 7.3 EC50 = 46 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
252 0 2 3 1.6 C1CNCCN2C1NC(=O)C3=C2C=CC=C3Cl
CHEMBL383042 5ht2b_human Human No 6.3 EC50 = 462 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
345 6 1 3 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4OC
CHEMBL383042 5ht2b_human Human No 6.3 EC50 = 462 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
345 6 1 3 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4OC
CHEMBL576651 5ht2b_human Human No 6.3 EC50 = 473 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
323 2 1 6 1.7 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL576651 5ht2b_human Human No 6.3 EC50 = 473 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
323 2 1 6 1.7 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=C(C=C3)C(F)(F)F
CHEMBL360328 5ht2b_human Human Yes 6.3 EC50 = 478 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL492348 5ht2b_human Human No 6.3 EC50 = 478 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
337 3 2 4 2.5 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3Cl
CHEMBL492950 5ht2b_human Human No 6.3 EC50 = 478 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
316 3 1 4 2.5 CN(C1=CC=CC=C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL360328 5ht2b_human Human Yes 6.3 EC50 = 478 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL492348 5ht2b_human Human No 6.3 EC50 = 478 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
337 3 2 4 2.5 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3Cl
CHEMBL492950 5ht2b_human Human No 6.3 EC50 = 478 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
316 3 1 4 2.5 CN(C1=CC=CC=C1)S(=O)(=O)C2=CC3=C(CCNCC3)C=C2
CHEMBL210484 5ht2b_human Human No 7.3 EC50 = 48 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL210484 5ht2b_human Human No 7.3 EC50 = 48 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
272 1 1 7 1.8 CC1CC2CNCC2N1C3=NC=CC(=N3)C(F)(F)F
CHEMBL80246 5ht2b_human Human No 7.3 EC50 = 49 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
262 2 1 6 2.6 CC(CN1CCC2=CC(=C(C=C21)C(F)(F)F)F)N
CHEMBL221113 5ht2b_human Human No 5.3 EC50 = 4926 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.0 CCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL221113 5ht2b_human Human No 5.3 EC50 = 4926 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 5 2.0 CCC1=CC(=C2C(=C1)C3CNCCN3C2=O)C(F)(F)F
CHEMBL219734 5ht2b_human Human No 6.3 EC50 = 498 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
272 1 1 6 1.5 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)OC(F)(F)F
CHEMBL219734 5ht2b_human Human No 6.3 EC50 = 498 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
272 1 1 6 1.5 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)OC(F)(F)F
CHEMBL2391541 5ht2b_human Human Yes 8.3 EC50 = 5.5 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
270 8 1 2 2.8 COC1=CC2=C(C=C1)NC=C2CCN(CC=C)CC=C
CHEMBL397321 5ht2b_rat Rat No 8.2 EC50 = 5.8 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
307 7 1 5 1.2 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCCOC)N
CHEMBL397321 5ht2b_rat Rat No 8.2 EC50 = 5.8 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
307 7 1 5 1.2 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCCOC)N
CHEMBL373245 5ht2b_rat Rat Yes 8.2 EC50 = 5.9 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
226 2 2 4 1.0 CC(CN1C2=C(C(=O)C=CC2=CN1)Cl)N
CHEMBL373245 5ht2b_rat Rat Yes 8.2 EC50 = 5.9 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
226 2 2 4 1.0 CC(CN1C2=C(C(=O)C=CC2=CN1)Cl)N
CHEMBL178366 5ht2b_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL178366 5ht2b_human Human No 7.3 EC50 = 50.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL223896 5ht2b_human Human No 6.3 EC50 = 501 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
223 0 1 2 1.0 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)Cl
CHEMBL223896 5ht2b_human Human No 6.3 EC50 = 501 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
223 0 1 2 1.0 C1CN2C(CN1)C3=C(C2=O)C(=CC=C3)Cl
CHEMBL181672 5ht2b_human Human Yes 6.3 EC50 = 501.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=CC(=C2)Cl
CHEMBL254009 5ht2b_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL181672 5ht2b_human Human Yes 6.3 EC50 = 501.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=CC(=C2)Cl
CHEMBL254009 5ht2b_human Human No 6.3 EC50 = 501.2 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL361742 5ht2b_human Human Yes 5.3 EC50 = 5011.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 2.1 CC1CNCCC2=C1C=C(C=C2)OC
CHEMBL361742 5ht2b_human Human Yes 5.3 EC50 = 5011.9 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 2.1 CC1CNCCC2=C1C=C(C=C2)OC
CHEMBL1643854 5ht2b_human Human No 6.3 EC50 = 503 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=C(C=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL1643854 5ht2b_human Human No 6.3 EC50 = 503 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 6 2.2 COC1=CC=C(C=C1)OC2CN(C2)C3=C4CCNCCC4=NC5=CC=NN53
CHEMBL572252 5ht2b_human Human No 6.3 EC50 = 506 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(COC1=CC=CC=C1Cl)N2C(=O)C=CC(=N2)N3CCNCC3
CHEMBL572252 5ht2b_human Human No 6.3 EC50 = 506 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay
349 5 1 4 1.5 CC(COC1=CC=CC=C1Cl)N2C(=O)C=CC(=N2)N3CCNCC3
CHEMBL360328 5ht2b_human Human Yes 6.3 EC50 = 512.9 Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2b_human Human Yes 6.3 EC50 = 512.9 Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL181672 5ht2b_human Human Yes 6.3 EC50 = 530 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
196 0 1 1 2.7 CC1CNCCC2=C1C=CC(=C2)Cl
CHEMBL2397878 5ht2b_human Human No 7.3 EC50 = 56 Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.8 COC1=CC2=C(CC3CNCCN3C2=O)C=C1
CHEMBL594717 5ht2b_human Human No 6.3 EC50 = 566 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
355 4 1 5 3.2 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)C)C=C2
CHEMBL594717 5ht2b_human Human No 6.3 EC50 = 566 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
355 4 1 5 3.2 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)C)C=C2
CHEMBL220900 5ht2b_human Human No 7.2 EC50 = 57 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
257 0 1 2 1.6 C1CN2C(CN1)C3=C(C2=O)C(=C(C=C3)Cl)Cl
CHEMBL220900 5ht2b_human Human No 7.2 EC50 = 57 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
257 0 1 2 1.6 C1CN2C(CN1)C3=C(C2=O)C(=C(C=C3)Cl)Cl
CHEMBL232995 5ht2b_rat Rat No 7.2 EC50 = 59 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
383 8 1 6 2.8 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCC(=O)OC4=CC=CC=C4)N
CHEMBL209254 5ht2b_human Human No 7.2 EC50 = 59 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
223 1 1 2 2.5 C1CN(C2C1CNC2)C3=CC(=CC=C3)Cl
CHEMBL232995 5ht2b_rat Rat No 7.2 EC50 = 59 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
383 8 1 6 2.8 CC(CC1=C2CCOC2=C(C3=C1OCC3)COCC(=O)OC4=CC=CC=C4)N
CHEMBL209254 5ht2b_human Human No 7.2 EC50 = 59 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
223 1 1 2 2.5 C1CN(C2C1CNC2)C3=CC(=CC=C3)Cl
CHEMBL197653 5ht2b_rat Rat Yes 8.2 EC50 = 6.1 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
209 2 2 5 0.5 CC(CN1C2=C(C(=O)C=CC2=CN1)F)N
CHEMBL197653 5ht2b_rat Rat Yes 8.2 EC50 = 6.1 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
209 2 2 5 0.5 CC(CN1C2=C(C(=O)C=CC2=CN1)F)N
CHEMBL391196 5ht2b_rat Rat No 8.2 EC50 = 6.2 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
314 2 2 4 1.3 CC(C(C1=C2CCOC2=C(C3=C1OCC3)Br)O)N
CHEMBL391196 5ht2b_rat Rat No 8.2 EC50 = 6.2 Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
314 2 2 4 1.3 CC(C(C1=C2CCOC2=C(C3=C1OCC3)Br)O)N
CHEMBL76307 5ht2b_human Human No 8.2 EC50 = 6.5 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
211 2 1 2 2.2 CC(CN1CCC2=C1C=C(C=C2)Cl)N
CHEMBL1770383 5ht2b_human Human No 7.2 EC50 = 60 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)Cl
CHEMBL1770383 5ht2b_human Human No 7.2 EC50 = 60 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
274 2 1 3 2.7 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)Cl
CHEMBL1643674 5ht2b_human Human No 6.2 EC50 = 602 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
231 2 2 4 0.9 CCNC1=C2CCNCCC2=NC3=CC=NN31
CHEMBL1643674 5ht2b_human Human No 6.2 EC50 = 602 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
231 2 2 4 0.9 CCNC1=C2CCNCCC2=NC3=CC=NN31
CHEMBL590580 5ht2b_human Human No 7.2 EC50 = 61 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 1.3 CC1=C2C(=CC=C1)N3CCNCCC3NC2=O
CHEMBL590580 5ht2b_human Human No 7.2 EC50 = 61 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 1.3 CC1=C2C(=CC=C1)N3CCNCCC3NC2=O
CHEMBL1770377 5ht2b_human Human No 6.2 EC50 = 610 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)F
CHEMBL1770377 5ht2b_human Human No 6.2 EC50 = 610 Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 4 2.2 C1CNCCC2=NC(=NC=C21)CC3=CC=C(C=C3)F
CHEMBL201897 5ht2b_human Human No 7.2 EC50 = 62 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=CN=C3)N
CHEMBL210802 5ht2b_human Human Yes 7.2 EC50 = 62 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL201897 5ht2b_human Human No 7.2 EC50 = 62 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 2 1.6 CC(CN1C=CC2=C1C3=C(C=C2)C=CN=C3)N
CHEMBL210802 5ht2b_human Human Yes 7.2 EC50 = 62 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
258 1 1 7 1.4 C1CN(C2C1CNC2)C3=NC=CC(=N3)C(F)(F)F
CHEMBL181787 5ht2b_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL181787 5ht2b_human Human No 7.2 EC50 = 63.1 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)Cl)OC
CHEMBL253810 5ht2b_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL253810 5ht2b_human Human No 6.2 EC50 = 631.0 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
210 1 1 1 3.1 CCC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL179378 5ht2b_human Human Yes 7.2 EC50 = 64 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
317 1 1 2 2.7 CC1CNCCC2=CC(=C(C=C12)I)OC
CHEMBL209714 5ht2b_human Human No 7.2 EC50 = 65 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
256 1 1 5 2.7 C1CN(C2C1CNC2)C3=CC=CC(=C3)C(F)(F)F
CHEMBL209714 5ht2b_human Human No 7.2 EC50 = 65 Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
256 1 1 5 2.7 C1CN(C2C1CNC2)C3=CC=CC(=C3)C(F)(F)F
CHEMBL494947 5ht2b_human Human Yes 7.2 EC50 = 65.3 Funct
Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control
305 4 1 5 2.0 C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
CHEMBL494947 5ht2b_human Human Yes 7.2 EC50 = 65.3 Funct
Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control
305 4 1 5 2.0 C1CN(CCN1)C2=CN=CC(=N2)OCC3=CC(=CC=C3)Cl
CHEMBL493152 5ht2b_human Human No 7.2 EC50 = 69 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
302 3 2 4 2.3 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3
CHEMBL493152 5ht2b_human Human No 7.2 EC50 = 69 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
302 3 2 4 2.3 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3
CHEMBL80366 5ht2b_human Human No 8.1 EC50 = 7.3 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
229 2 1 3 2.3 CC(CN1CCC2=CC(=C(C=C21)Cl)F)N
CHEMBL1643855 5ht2b_human Human No 6.2 EC50 = 706 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.5 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=N5
CHEMBL1643855 5ht2b_human Human No 6.2 EC50 = 706 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 6 1.5 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=N5
CHEMBL80862 5ht2b_human Human No 7.1 EC50 = 72 Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
236 4 1 3 2.4 CCSC1=CC2=C(CCN2CC(C)N)C=C1
CHEMBL1643859 5ht2b_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
390 3 2 6 1.0 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC6=C(C=C5)NC(=O)C6
CHEMBL1643859 5ht2b_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
390 3 2 6 1.0 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC6=C(C=C5)NC(=O)C6
CHEMBL194378 5ht2b_human Human Yes 7.1 EC50 = 74 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay
284 5 3 5 -1.6 CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O
CHEMBL194378 5ht2b_human Human Yes 7.1 EC50 = 74 Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay
284 5 3 5 -1.6 CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O
CHEMBL595553 5ht2b_human Human No 6.1 EC50 = 748 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL595553 5ht2b_human Human No 6.1 EC50 = 748 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
330 3 1 4 3.2 C1CC2=C(C1OC3=CC=CC=C3Cl)N=C(C=C2)N4CCNCC4
CHEMBL522349 5ht2b_human Human No 7.1 EC50 = 75 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
320 3 2 5 2.4 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3F
CHEMBL522349 5ht2b_human Human No 7.1 EC50 = 75 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
320 3 2 5 2.4 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NC3=CC=CC=C3F
CHEMBL30713 5ht2b_human Human Yes 7.1 EC50 = 75.8 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
174 2 2 1 2.0 CC(CC1=CNC2=CC=CC=C21)N
CHEMBL178366 5ht2b_human Human No 7.1 EC50 = 78 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=CC(=C(C=C12)Cl)Cl
CHEMBL361742 5ht2b_human Human Yes 6.1 EC50 = 780 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
191 1 1 2 2.1 CC1CNCCC2=C1C=C(C=C2)OC
CHEMBL360328 5ht2b_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL179337 5ht2b_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C(C=C(C=C12)Cl)Cl
CHEMBL178124 5ht2b_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL254215 5ht2b_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL360328 5ht2b_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL179337 5ht2b_human Human Yes 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
230 0 1 1 3.4 CC1CNCCC2=C(C=C(C=C12)Cl)Cl
CHEMBL178124 5ht2b_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL254215 5ht2b_human Human No 6.1 EC50 = 794.3 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 4 3.0 CC1CNCCC2=C1C=C(C=C2)C(F)(F)F
CHEMBL223468 5ht2b_human Human No 8.1 EC50 = 8 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C2=C(C=C1)C3CNCCN3C2=O)OC
CHEMBL223468 5ht2b_human Human No 8.1 EC50 = 8 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CCC1=C(C2=C(C=C1)C3CNCCN3C2=O)OC
CHEMBL199385 5ht2b_rat Rat Yes 8.1 EC50 = 8.6 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
177 2 2 4 -0.3 C1=CC2=CNN(C2=CC1=O)CCN
CHEMBL199385 5ht2b_rat Rat Yes 8.1 EC50 = 8.6 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
177 2 2 4 -0.3 C1=CC2=CNN(C2=CC1=O)CCN
CHEMBL200104 5ht2b_rat Rat Yes 8.1 EC50 = 8.9 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
205 2 2 4 0.5 CC1=C2C(=CNN2CC(C)N)C=CC1=O
CHEMBL200104 5ht2b_rat Rat Yes 8.1 EC50 = 8.9 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
205 2 2 4 0.5 CC1=C2C(=CNN2CC(C)N)C=CC1=O
CHEMBL492349 5ht2b_human Human No 6.1 EC50 = 802 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
351 4 2 4 2.9 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NCC3=CC=CC=C3Cl
CHEMBL492349 5ht2b_human Human No 6.1 EC50 = 802 Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
351 4 2 4 2.9 C1CNCCC2=C1C=CC(=C2)S(=O)(=O)NCC3=CC=CC=C3Cl
CHEMBL577691 5ht2b_human Human No 7.1 EC50 = 81 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC(=CC=C3)Cl
CHEMBL577691 5ht2b_human Human No 7.1 EC50 = 81 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC(=CC=C3)Cl
CHEMBL223628 5ht2b_human Human No 6.1 EC50 = 825 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CC(C)OC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL223628 5ht2b_human Human No 6.1 EC50 = 825 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.1 CC(C)OC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL2397913 5ht2b_human Human No 6.1 EC50 = 827 Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
246 1 1 3 1.2 CC1=C(C2=C(C=C1)C(=O)N3CCNCC3C2)OC
CHEMBL568692 5ht2b_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
295 3 1 3 1.7 C1CC1C2=CC=C(C=C2)CN3C(=O)C=C4CCNCCC4=N3
CHEMBL568692 5ht2b_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
295 3 1 3 1.7 C1CC1C2=CC=C(C=C2)CN3C(=O)C=C4CCNCCC4=N3
CHEMBL179337 5ht2b_human Human Yes 6.1 EC50 = 840 Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
230 0 1 1 3.4 CC1CNCCC2=C(C=C(C=C12)Cl)Cl
CHEMBL1643673 5ht2b_human Human No 6.1 EC50 = 842 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
245 2 1 4 1.0 CCN(C)C1=C2CCNCCC2=NC3=CC=NN31
CHEMBL1643673 5ht2b_human Human No 6.1 EC50 = 842 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
245 2 1 4 1.0 CCN(C)C1=C2CCNCCC2=NC3=CC=NN31
CHEMBL437314 5ht2b_rat Rat No 7.1 EC50 = 85 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL437314 5ht2b_rat Rat No 7.1 EC50 = 85 Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL220207 5ht2b_human Human No 7.1 EC50 = 87 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
234 1 1 3 0.8 CSC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL220207 5ht2b_human Human No 7.1 EC50 = 87 Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
234 1 1 3 0.8 CSC1=CC=CC2=C1C(=O)N3C2CNCC3
CHEMBL2397877 5ht2b_human Human No 8.1 EC50 = 9 Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
237 0 1 2 1.5 C1CN2C(CC3=C(C2=O)C=C(C=C3)Cl)CN1
CHEMBL202324 5ht2b_human Human No 7.0 EC50 = 91 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
265 5 1 2 2.8 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC=C
CHEMBL202324 5ht2b_human Human No 7.0 EC50 = 91 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
265 5 1 2 2.8 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC=C
CHEMBL584210 5ht2b_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3Cl
CHEMBL1643670 5ht2b_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
243 1 1 4 0.8 C1CN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL1643676 5ht2b_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5F
CHEMBL584210 5ht2b_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
290 2 1 3 1.5 C1CNCCC2=NN(C(=O)C=C21)CC3=CC=CC=C3Cl
CHEMBL1643670 5ht2b_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
243 1 1 4 0.8 C1CN(C1)C2=C3CCNCCC3=NC4=CC=NN42
CHEMBL1643676 5ht2b_human Human No 7.0 EC50 = 94 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 2.3 C1CNCCC2=NC3=CC=NN3C(=C21)N4CC(C4)OC5=CC=CC=C5F
CHEMBL360328 5ht2b_human Human Yes 6.0 EC50 = 943 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2b_human Human Yes 6.0 EC50 = 943 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2b_human Human Yes 6.0 EC50 = 943 Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL360328 5ht2b_human Human Yes 6.0 EC50 = 943 Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis
196 0 1 1 2.7 CC1CNCCC2=C1C=C(C=C2)Cl
CHEMBL380763 5ht2b_human Human No 7.0 EC50 = 97 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
315 5 1 2 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4
CHEMBL380763 5ht2b_human Human No 7.0 EC50 = 97 Funct
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
315 5 1 2 3.7 CC(CN1C=CC2=C1C3=C(C=C2)N=CC=C3)NCC4=CC=CC=C4
CHEMBL593545 5ht2b_human Human No 6.0 EC50 = 998 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL593545 5ht2b_human Human No 6.0 EC50 = 998 Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
344 3 1 4 3.6 C1CC(C2=C(C1)C=CC(=N2)N3CCNCC3)OC4=CC=CC=C4Cl
CHEMBL473185 5ht2b_human Human Yes 9.7 IC50 = 0.2 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
363 4 1 3 4.0 C1CN(CCC1CC2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL473185 5ht2b_human Human Yes 9.7 IC50 = 0.2 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
363 4 1 3 4.0 C1CN(CCC1CC2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL475407 5ht2b_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
367 4 1 4 3.1 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL475407 5ht2b_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
367 4 1 4 3.1 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL475245 5ht2b_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
345 4 1 2 3.9 C1CN(CCC1CC2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL475245 5ht2b_human Human No 9.4 IC50 = 0.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
345 4 1 2 3.9 C1CN(CCC1CC2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL472990 5ht2b_human Human No 9.2 IC50 = 0.6 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
385 4 1 5 3.2 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL472990 5ht2b_human Human No 9.2 IC50 = 0.6 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
385 4 1 5 3.2 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL473186 5ht2b_human Human Yes 9.2 IC50 = 0.7 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
281 2 1 4 4.0 CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N
CHEMBL473186 5ht2b_human Human Yes 9.2 IC50 = 0.7 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
281 2 1 4 4.0 CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N
CHEMBL474408 5ht2b_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
349 3 1 3 3.5 C1CN(CCC1C2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL474408 5ht2b_human Human No 9.0 IC50 = 1.1 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
349 3 1 3 3.5 C1CN(CCC1C2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL1201356 5ht2b_human Human Yes 8.8 IC50 = 1.5 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
339 4 3 3 2.3 CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
CHEMBL214554 5ht2b_human Human Yes 8.7 IC50 = 1.8 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
379 3 0 5 4.7 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=CC=CC=C5O2
CHEMBL214554 5ht2b_human Human Yes 8.8 IC50 = 1.8 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
379 3 0 5 4.7 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=CC=CC=C5O2
CHEMBL514934 5ht2b_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
418 4 1 4 4.5 C1CN(CCC1C2=NC3=CC=CC=C3N2)S(=O)(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL514934 5ht2b_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
418 4 1 4 4.5 C1CN(CCC1C2=NC3=CC=CC=C3N2)S(=O)(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL1113 5ht2b_human Human Yes 8.0 IC50 = 10 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL213329 5ht2b_human Human Yes 7.0 IC50 = 100 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
447 1 0 4 5.0 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=C(O2)C=CC(=C5)Br
CHEMBL1110 5ht2b_human Human Yes 7.0 IC50 = 100 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
294 2 1 2 1.6 CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
CHEMBL213329 5ht2b_human Human Yes 7.0 IC50 = 100 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
447 1 0 4 5.0 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=C(O2)C=CC(=C5)Br
CHEMBL1110 5ht2b_human Human Yes 7.0 IC50 = 100 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
294 2 1 2 1.6 CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
CHEMBL472416 5ht2b_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
396 3 0 2 4.8 CN1C2=CC=CC=C2N=C1C3CCN(CC3)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL3736252 5ht2b_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
434 11 0 5 5.9 COC1=C(C=C(C=C1)CCN(CCC2=CC=CC=C2)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3736149 5ht2b_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
478 13 0 6 6.2 COC1=C(C=C(C=C1)CCN(CCCC2=CC=CC=C2OC)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL472416 5ht2b_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
396 3 0 2 4.8 CN1C2=CC=CC=C2N=C1C3CCN(CC3)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL3736252 5ht2b_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
434 11 0 5 5.9 COC1=C(C=C(C=C1)CCN(CCC2=CC=CC=C2)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3736149 5ht2b_human Human No 5.0 IC50 = 10000 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
478 13 0 6 6.2 COC1=C(C=C(C=C1)CCN(CCCC2=CC=CC=C2OC)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL728 5ht2b_human Human Yes 7.0 IC50 = 102 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL3771331 5ht2b_human Human No 7.0 IC50 = 104 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
328 4 4 3 1.2 CCNC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL3771331 5ht2b_human Human No 7.0 IC50 = 104 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
328 4 4 3 1.2 CCNC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL3099899 5ht2b_human Human No 6.0 IC50 = 1040 Funct
Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor
494 7 1 5 5.0 COC1=C(C=C(C=C1)CNC(=O)C2=C(N=CC(=C2)C3=CC(=CC(=C3)Cl)Cl)C4=CN=CC=C4)OC
CHEMBL3770770 5ht2b_human Human Yes 6.0 IC50 = 1056 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
273 3 3 3 1.0 COC1=CC=CC(=C1)NC2=NC3(CCCC3)N=C(N2)N
CHEMBL1201216 5ht2b_human Human Yes 6.0 IC50 = 1056 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
325 4 0 4 2.4 CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
CHEMBL3770770 5ht2b_human Human Yes 6.0 IC50 = 1056 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
273 3 3 3 1.0 COC1=CC=CC(=C1)NC2=NC3(CCCC3)N=C(N2)N
CHEMBL1201216 5ht2b_human Human Yes 6.0 IC50 = 1056 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
325 4 0 4 2.4 CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4
CHEMBL621 5ht2b_human Human Yes 7.0 IC50 = 107 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL621 5ht2b_human Human Yes 7.0 IC50 = 107 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL30008 5ht2b_human Human Yes 6.0 IC50 = 1088 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL30008 5ht2b_human Human Yes 6.0 IC50 = 1088 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL42 5ht2b_human Human Yes 8.0 IC50 = 11 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL3286557 5ht2b_human Human No 7.0 IC50 = 110 Funct
Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)
304 3 2 6 2.6 CNC1=NC(=NC2=C1CCNCC2)C(C3=CC=CC=C3)(F)F
CHEMBL1358628 5ht2b_human Human Yes 7.0 IC50 = 110 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 5ht2b_human Human Yes 7.0 IC50 = 110 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 5ht2b_human Human Yes 7.0 IC50 = 110 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL3286557 5ht2b_human Human No 7.0 IC50 = 110 Funct
Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)
304 3 2 6 2.6 CNC1=NC(=NC2=C1CCNCC2)C(C3=CC=CC=C3)(F)F
CHEMBL473235 5ht2b_human Human No 6.0 IC50 = 1100 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
432 5 1 4 5.0 C1CN(CCC1CC2=NC3=CC=CC=C3N2)S(=O)(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL514967 5ht2b_human Human No 6.0 IC50 = 1100 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
388 3 1 2 5.8 C1CCC(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL473235 5ht2b_human Human No 6.0 IC50 = 1100 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
432 5 1 4 5.0 C1CN(CCC1CC2=NC3=CC=CC=C3N2)S(=O)(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL514967 5ht2b_human Human No 6.0 IC50 = 1100 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
388 3 1 2 5.8 C1CCC(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL502620 5ht2b_human Human Yes 6.0 IC50 = 1106 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
812 10 4 16 3.8 CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O
CHEMBL502620 5ht2b_human Human Yes 6.0 IC50 = 1106 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
812 10 4 16 3.8 CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O
CHEMBL657 5ht2b_human Human Yes 6.0 IC50 = 1118 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
255 6 0 2 3.3 CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
CHEMBL657 5ht2b_human Human Yes 6.0 IC50 = 1118 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
255 6 0 2 3.3 CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
CHEMBL558 5ht2b_human Human Yes 5.9 IC50 = 1138 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
179 3 1 2 2.1 CC1=C(C(=CC=C1)C)OCC(C)N
CHEMBL558 5ht2b_human Human Yes 5.9 IC50 = 1138 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
179 3 1 2 2.1 CC1=C(C(=CC=C1)C)OCC(C)N
CHEMBL461571 5ht2b_human Human No 5.9 IC50 = 1140 Funct
Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor
532 8 1 8 7.1 CC1=C(C2=C(N1CC3=CC(=CC=C3)OC(C)C(=O)O)C=C(C=C2)OC(F)(F)F)C(=O)C4=CC=C(C=C4)Cl
CHEMBL461571 5ht2b_human Human No 5.9 IC50 = 1140 Funct
Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor
532 8 1 8 7.1 CC1=C(C2=C(N1CC3=CC(=CC=C3)OC(C)C(=O)O)C=C(C=C2)OC(F)(F)F)C(=O)C4=CC=C(C=C4)Cl
CHEMBL384255 5ht2b_human Human No 6.9 IC50 = 115 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
394 3 0 5 5.1 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)C
CHEMBL384255 5ht2b_human Human No 6.9 IC50 = 115 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
394 3 0 5 5.1 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)C
CHEMBL282575 5ht2b_human Human Yes 4.9 IC50 = 11565 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
376 3 1 3 4.5 CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5
CHEMBL104 5ht2b_human Human Yes 4.9 IC50 = 11604 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL104 5ht2b_human Human Yes 4.9 IC50 = 11604 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL1091206 5ht2b_human Human No 6.9 IC50 = 118 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
345 3 0 5 2.7 CSC1=NN2C3=C(CCC3)C=NC2=C1S(=O)(=O)C4=CC=CC=C4
CHEMBL1091206 5ht2b_human Human No 6.9 IC50 = 118 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
345 3 0 5 2.7 CSC1=NN2C3=C(CCC3)C=NC2=C1S(=O)(=O)C4=CC=CC=C4
CHEMBL472415 5ht2b_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 1 3 4.1 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=NC=C(C=C4)C5=CC=CC=C5
CHEMBL296419 5ht2b_human Human Yes 7.9 IC50 = 12 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL472415 5ht2b_human Human No 7.9 IC50 = 12 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 1 3 4.1 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=NC=C(C=C4)C5=CC=CC=C5
CHEMBL472986 5ht2b_human Human No 6.9 IC50 = 120 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
383 3 1 4 3.2 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=NC=CC=N5
CHEMBL578170 5ht2b_human Human No 6.9 IC50 = 120 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
367 5 2 5 4.0 CC1=CC=C(C=C1)C(=O)NC2CCC(CC2)NC3=NC=C(C(=N3)N(C)C)C
CHEMBL472986 5ht2b_human Human No 6.9 IC50 = 120 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
383 3 1 4 3.2 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=NC=CC=N5
CHEMBL578170 5ht2b_human Human No 6.9 IC50 = 120 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
367 5 2 5 4.0 CC1=CC=C(C=C1)C(=O)NC2CCC(CC2)NC3=NC=C(C(=N3)N(C)C)C
CHEMBL445809 5ht2b_human Human Yes 5.9 IC50 = 1200 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
381 3 1 2 4.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL472789 5ht2b_human Human No 5.9 IC50 = 1200 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
412 4 1 3 4.8 COC1=C(C=CC(=C1)C2=CC=CC=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL445809 5ht2b_human Human Yes 5.9 IC50 = 1200 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
381 3 1 2 4.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL472789 5ht2b_human Human No 5.9 IC50 = 1200 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
412 4 1 3 4.8 COC1=C(C=CC(=C1)C2=CC=CC=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL474839 5ht2b_human Human No 4.9 IC50 = 12000 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
389 3 1 3 4.2 C1CCN(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL474839 5ht2b_human Human No 4.9 IC50 = 12000 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
389 3 1 3 4.2 C1CCN(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL1922537 5ht2b_human Human No 4.9 IC50 = 12400 Funct
Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins
272 2 1 3 2.1 CCC=C1CC2CNC3=C(C=CC=C3OC)C(=O)N2C1
CHEMBL1922537 5ht2b_human Human No 4.9 IC50 = 12400 Funct
Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins
272 2 1 3 2.1 CCC=C1CC2CNC3=C(C=CC=C3OC)C(=O)N2C1
CHEMBL3735261 5ht2b_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
538 15 0 8 6.2 COC1=C(C=C(C=C1)CCN(CCCC2=CC(=C(C(=C2)OC)OC)OC)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3735911 5ht2b_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
478 13 0 6 6.2 COC1=C(C=C(C=C1)CCN(CCCC2=CC(=CC=C2)OC)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3735261 5ht2b_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
538 15 0 8 6.2 COC1=C(C=C(C=C1)CCN(CCCC2=CC(=C(C(=C2)OC)OC)OC)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3735911 5ht2b_human Human No 5.9 IC50 = 1258.9 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
478 13 0 6 6.2 COC1=C(C=C(C=C1)CCN(CCCC2=CC(=CC=C2)OC)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3735643 5ht2b_human Human No 4.9 IC50 = 12589.3 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
524 14 0 8 5.7 COC1=C(C=C(C=C1)CCN(CCCC2=CC(=C(C(=C2)OC)OC)OC)CC3=CC4=C(C=C3)OCO4)OC
CHEMBL3735643 5ht2b_human Human No 4.9 IC50 = 12589.3 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
524 14 0 8 5.7 COC1=C(C=C(C=C1)CCN(CCCC2=CC(=C(C(=C2)OC)OC)OC)CC3=CC4=C(C=C3)OCO4)OC
CHEMBL71 5ht2b_human Human Yes 6.9 IC50 = 126 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
319 4 0 3 5.2 CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
CHEMBL1092241 5ht2b_human Human No 6.9 IC50 = 127 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
373 3 0 5 3.6 CC1=C2CCCCC2=NC3=C(C(=NN13)SC)S(=O)(=O)C4=CC=CC=C4
CHEMBL1092241 5ht2b_human Human No 6.9 IC50 = 127 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
373 3 0 5 3.6 CC1=C2CCCCC2=NC3=C(C(=NN13)SC)S(=O)(=O)C4=CC=CC=C4
CHEMBL377562 5ht2b_human Human Yes 5.9 IC50 = 1281 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
442 2 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Br)C5=C(O2)C(=CC=C5)OC
CHEMBL377562 5ht2b_human Human Yes 5.9 IC50 = 1281 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
442 2 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Br)C5=C(O2)C(=CC=C5)OC
CHEMBL479 5ht2b_human Human Yes 6.9 IC50 = 129 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL2110371 5ht2b_human Human Yes 7.9 IC50 = 13 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
338 1 1 2 4.0 CC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC=CC4=C3C=CC=N4)Cl
CHEMBL1403281 5ht2b_human Human Yes 7.9 IC50 = 13 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL2110371 5ht2b_human Human Yes 7.9 IC50 = 13 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
338 1 1 2 4.0 CC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC=CC4=C3C=CC=N4)Cl
CHEMBL2323581 5ht2b_human Human No 7.9 IC50 = 13 Funct
Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method
314 3 0 3 2.4 CN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)C(OC)OC
CHEMBL1403281 5ht2b_human Human Yes 7.9 IC50 = 13 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL568400 5ht2b_human Human No 6.9 IC50 = 130 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
422 5 2 5 4.9 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC(=C(C=C3)Cl)Cl)N(C)C
CHEMBL568400 5ht2b_human Human No 6.9 IC50 = 130 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
422 5 2 5 4.9 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC(=C(C=C3)Cl)Cl)N(C)C
CHEMBL1123 5ht2b_human Human Yes 5.9 IC50 = 1301 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL1123 5ht2b_human Human Yes 5.9 IC50 = 1301 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
309 8 0 3 5.5 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2
CHEMBL408 5ht2b_human Human Yes 5.9 IC50 = 1312 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
442 5 2 6 5.1 CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O
CHEMBL385346 5ht2b_human Human Yes 6.9 IC50 = 133 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
396 2 0 4 5.1 CC(C)N1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=CC=CC=C5O2
CHEMBL385346 5ht2b_human Human Yes 6.9 IC50 = 133 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
396 2 0 4 5.1 CC(C)N1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=CC=CC=C5O2
CHEMBL1108 5ht2b_human Human Yes 5.9 IC50 = 1342 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL1108 5ht2b_human Human Yes 5.9 IC50 = 1342 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL3815112 5ht2b_human Human No 6.9 IC50 = 135 Funct
Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay
466 12 0 6 6.3 COC1=C(C=C(C=C1)CCN(CCCC2=CC=CC=C2F)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3815112 5ht2b_human Human No 6.9 IC50 = 135 Funct
Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay
466 12 0 6 6.3 COC1=C(C=C(C=C1)CCN(CCCC2=CC=CC=C2F)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL445 5ht2b_human Human Yes 6.9 IC50 = 136 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL954 5ht2b_human Human Yes 5.9 IC50 = 1363 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
406 9 0 2 7.2 CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
CHEMBL1405 5ht2b_human Human Yes 4.9 IC50 = 13630 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
270 0 1 2 3.1 CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O
CHEMBL1405 5ht2b_human Human Yes 4.9 IC50 = 13630 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
270 0 1 2 3.1 CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O
CHEMBL475245 5ht2b_human Human No 7.9 IC50 = 14 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
345 4 1 2 3.9 C1CN(CCC1CC2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL475245 5ht2b_human Human No 7.9 IC50 = 14 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
345 4 1 2 3.9 C1CN(CCC1CC2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL1333512 5ht2b_human Human Yes 6.9 IC50 = 142 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
260 4 2 2 5.0 C1=CC=C(C=C1)NC2=CC=C(C=C2)NC3=CC=CC=C3
CHEMBL1333512 5ht2b_human Human Yes 6.9 IC50 = 142 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
260 4 2 2 5.0 C1=CC=C(C=C1)NC2=CC=C(C=C2)NC3=CC=CC=C3
CHEMBL378541 5ht2b_human Human Yes 5.8 IC50 = 1470 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
398 2 0 5 4.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=C(O2)C(=CC=C5)OC
CHEMBL378541 5ht2b_human Human Yes 5.8 IC50 = 1470 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
398 2 0 5 4.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=C(O2)C(=CC=C5)OC
CHEMBL379734 5ht2b_human Human Yes 7.8 IC50 = 15 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
362 3 0 5 3.5 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2
CHEMBL472985 5ht2b_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 1 3 3.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=N5
CHEMBL379734 5ht2b_human Human Yes 7.8 IC50 = 15 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
362 3 0 5 3.5 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2
CHEMBL472985 5ht2b_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 1 3 3.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=N5
CHEMBL473391 5ht2b_human Human Yes 6.8 IC50 = 150 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
353 3 1 2 4.1 C1C(CN1C(=O)C2=CC=C(C=C2)C3=CC=CC=C3)C4=NC5=CC=CC=C5N4
CHEMBL182150 5ht2b_human Human Yes 6.8 IC50 = 150 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
425 5 2 7 4.8 CN(C)C1=NC(=NC2=CC=CC=C21)NC3CCC(CC3)NC(=O)C4=CC(=C(C=C4)F)F
CHEMBL473391 5ht2b_human Human Yes 6.8 IC50 = 150 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
353 3 1 2 4.1 C1C(CN1C(=O)C2=CC=C(C=C2)C3=CC=CC=C3)C4=NC5=CC=CC=C5N4
CHEMBL182150 5ht2b_human Human Yes 6.8 IC50 = 150 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
425 5 2 7 4.8 CN(C)C1=NC(=NC2=CC=CC=C21)NC3CCC(CC3)NC(=O)C4=CC(=C(C=C4)F)F
CHEMBL472589 5ht2b_human Human Yes 5.8 IC50 = 1500 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 0 3 5.1 C1CN(CCC1C2=NC3=CC=CC=C3O2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL1935601 5ht2b_human Human No 5.8 IC50 = 1500 Funct
Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor
401 2 1 6 2.9 C1CC2(COC1)C3=C(CCN2)C4=C(O3)C=C(C=C4)S(=O)(=O)C5=CC=CC(=C5)F
CHEMBL276393 5ht2b_human Human Yes 5.8 IC50 = 1500 Funct
Inhibition of 5HT2BInhibition of 5HT2B
449 8 1 8 3.7 CN1C2=C(C=CC(=C2)NC(=O)COC3=CC=C(C=C3)C(F)(F)F)N=C1N(C)CCN(C)C
CHEMBL472589 5ht2b_human Human Yes 5.8 IC50 = 1500 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 0 3 5.1 C1CN(CCC1C2=NC3=CC=CC=C3O2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL1935601 5ht2b_human Human No 5.8 IC50 = 1500 Funct
Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor
401 2 1 6 2.9 C1CC2(COC1)C3=C(CCN2)C4=C(O3)C=C(C=C4)S(=O)(=O)C5=CC=CC(=C5)F
CHEMBL276393 5ht2b_human Human Yes 5.8 IC50 = 1500 Funct
Inhibition of 5HT2BInhibition of 5HT2B
449 8 1 8 3.7 CN1C2=C(C=CC(=C2)NC(=O)COC3=CC=C(C=C3)C(F)(F)F)N=C1N(C)CCN(C)C
CHEMBL1909048 5ht2b_human Human Yes 5.8 IC50 = 1508 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
314 3 0 1 4.7 C1CN(CCC1CC2=CC=CC=C2)C(=O)C3=CC=CC=C3Cl
CHEMBL1909048 5ht2b_human Human Yes 5.8 IC50 = 1508 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
314 3 0 1 4.7 C1CN(CCC1CC2=CC=CC=C2)C(=O)C3=CC=CC=C3Cl
CHEMBL357995 5ht2b_human Human Yes 5.8 IC50 = 1523 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
380 9 2 4 4.7 CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)OC(=O)C3=CC=CC=C3
CHEMBL357995 5ht2b_human Human Yes 5.8 IC50 = 1523 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
380 9 2 4 4.7 CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)OC(=O)C3=CC=CC=C3
CHEMBL1909051 5ht2b_human Human Yes 5.8 IC50 = 1549 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
347 3 0 4 5.0 C1CN(CCC1CC2=CC=CC=C2)C(=O)C3=CC=CC=C3C(F)(F)F
CHEMBL383860 5ht2b_human Human No 7.8 IC50 = 16 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
425 4 0 5 4.6 C1CN(CCC12N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2)CCC6=CC=CC=C6
CHEMBL383860 5ht2b_human Human No 7.8 IC50 = 16 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
425 4 0 5 4.6 C1CN(CCC12N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2)CCC6=CC=CC=C6
CHEMBL2022867 5ht2b_human Human Yes 5.8 IC50 = 1600 Funct
Inhibition of 5HT2BInhibition of 5HT2B
271 2 0 2 3.8 C1=CC=C(C=C1)N2C=C(C=N2)C3=CC=NC4=CC=CC=C34
CHEMBL2022867 5ht2b_human Human Yes 5.8 IC50 = 1600 Funct
Inhibition of 5HT2BInhibition of 5HT2B
271 2 0 2 3.8 C1=CC=C(C=C1)N2C=C(C=N2)C3=CC=NC4=CC=CC=C34
CHEMBL473214 5ht2b_human Human No 4.8 IC50 = 16000 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
465 4 1 6 6.0 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=C(C=C5)OC(F)(F)F
CHEMBL473214 5ht2b_human Human No 4.8 IC50 = 16000 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
465 4 1 6 6.0 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=C(C=C5)OC(F)(F)F
CHEMBL1091919 5ht2b_human Human No 6.8 IC50 = 161 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
373 3 0 5 3.6 CC1=NC2=C(C(=NN2C3=C1CCCC3)SC)S(=O)(=O)C4=CC=CC=C4
CHEMBL1091919 5ht2b_human Human No 6.8 IC50 = 161 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
373 3 0 5 3.6 CC1=NC2=C(C(=NN2C3=C1CCCC3)SC)S(=O)(=O)C4=CC=CC=C4
CHEMBL6966 5ht2b_human Human Yes 6.8 IC50 = 165 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
455 13 0 6 3.8 CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
CHEMBL567791 5ht2b_human Human No 6.8 IC50 = 170 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
388 5 2 5 4.3 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)Cl)N(C)C
CHEMBL567791 5ht2b_human Human No 6.8 IC50 = 170 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
388 5 2 5 4.3 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)Cl)N(C)C
CHEMBL472985 5ht2b_human Human No 5.8 IC50 = 1700 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
382 3 1 3 3.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=N5
CHEMBL472985 5ht2b_human Human No 5.8 IC50 = 1700 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
382 3 1 3 3.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=N5
CHEMBL215380 5ht2b_human Human Yes 6.8 IC50 = 175 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
478 3 0 7 5.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)OC(F)F)C5=C(O2)C=CC(=C5)Br
CHEMBL215380 5ht2b_human Human Yes 6.8 IC50 = 175 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
478 3 0 7 5.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)OC(F)F)C5=C(O2)C=CC(=C5)Br
CHEMBL212506 5ht2b_human Human Yes 6.8 IC50 = 179 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
470 4 0 5 5.3 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)OC)C5=C(O2)C=CC(=C5)Br
CHEMBL212506 5ht2b_human Human Yes 6.8 IC50 = 179 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
470 4 0 5 5.3 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)OC)C5=C(O2)C=CC(=C5)Br
CHEMBL3770512 5ht2b_human Human No 7.7 IC50 = 18.1 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
343 6 3 4 2.3 CCCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL3770512 5ht2b_human Human No 7.7 IC50 = 18.1 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
343 6 3 4 2.3 CCCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL388590 5ht2b_human Human Yes 5.7 IC50 = 1804 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
424 3 1 3 5.7 CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br
CHEMBL388590 5ht2b_human Human Yes 5.7 IC50 = 1804 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
424 3 1 3 5.7 CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br
CHEMBL549 5ht2b_human Human Yes 5.7 IC50 = 1839 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
324 5 0 4 3.2 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL549 5ht2b_human Human Yes 5.7 IC50 = 1839 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
324 5 0 4 3.2 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL1630578 5ht2b_human Human Yes 4.7 IC50 = 18507 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
625 6 0 8 5.9 CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
CHEMBL1630578 5ht2b_human Human Yes 4.7 IC50 = 18507 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
625 6 0 8 5.9 CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
CHEMBL398440 5ht2b_human Human Yes 5.7 IC50 = 1856 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
157 0 1 1 2.0 CC1=CC(=CC(=C1Cl)C)O
CHEMBL398440 5ht2b_human Human Yes 5.7 IC50 = 1856 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
157 0 1 1 2.0 CC1=CC(=CC(=C1Cl)C)O
CHEMBL1909050 5ht2b_human Human Yes 5.7 IC50 = 1860 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
293 3 0 1 4.4 CC1=CC=CC=C1C(=O)N2CCC(CC2)CC3=CC=CC=C3
CHEMBL1909050 5ht2b_human Human Yes 5.7 IC50 = 1860 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
293 3 0 1 4.4 CC1=CC=CC=C1C(=O)N2CCC(CC2)CC3=CC=CC=C3
CHEMBL378357 5ht2b_human Human Yes 6.7 IC50 = 188 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
440 2 0 4 5.2 CC(C)N1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4)C5=C(O2)C=CC(=C5)Br
CHEMBL378357 5ht2b_human Human Yes 6.7 IC50 = 188 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
440 2 0 4 5.2 CC(C)N1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4)C5=C(O2)C=CC(=C5)Br
CHEMBL473186 5ht2b_human Human Yes 7.7 IC50 = 19 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
281 2 1 4 4.0 CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N
CHEMBL473186 5ht2b_human Human Yes 7.7 IC50 = 19 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
281 2 1 4 4.0 CC(C)C1=NC(=NC(=C1)C2=CC=C(C3=CC=CC=C32)F)N
CHEMBL216228 5ht2b_human Human Yes 5.7 IC50 = 1900 Funct
Inhibition of 5HT2BInhibition of 5HT2B
397 5 1 5 4.4 CC1=NC(=NC2=C1C=C(C=C2)NC(=O)COC3=CC=C(C=C3)Cl)N4CCCC4
CHEMBL216228 5ht2b_human Human Yes 5.7 IC50 = 1900 Funct
Inhibition of 5HT2BInhibition of 5HT2B
397 5 1 5 4.4 CC1=NC(=NC2=C1C=C(C=C2)NC(=O)COC3=CC=C(C=C3)Cl)N4CCCC4
CHEMBL475406 5ht2b_human Human No 8.6 IC50 = 2.3 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
396 4 1 2 5.3 C1CN(CCC1CC2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL475406 5ht2b_human Human No 8.6 IC50 = 2.3 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
396 4 1 2 5.3 C1CN(CCC1CC2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL445809 5ht2b_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
381 3 1 2 4.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL474404 5ht2b_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
331 3 1 2 3.4 C1CN(CCC1C2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL445809 5ht2b_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
381 3 1 2 4.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL474404 5ht2b_human Human Yes 8.6 IC50 = 2.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
331 3 1 2 3.4 C1CN(CCC1C2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL515422 5ht2b_human Human No 8.6 IC50 = 2.5 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
383 3 1 4 3.2 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CN=C(N=C4)C5=CC=CC=C5
CHEMBL515422 5ht2b_human Human No 8.6 IC50 = 2.5 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
383 3 1 4 3.2 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CN=C(N=C4)C5=CC=CC=C5
CHEMBL35226 5ht2b_human Human No 6.7 IC50 = 200 Funct
Ability to displace [3H]5-HT from 5-hydroxytryptamine 2B receptorAbility to displace [3H]5-HT from 5-hydroxytryptamine 2B receptor
339 5 1 4 4.5 CCCN1CCC(CC1)COC2=NC3=CC=CC=C3C4=C2CCCN4
CHEMBL83668 5ht2b_human Human Yes 5.7 IC50 = 2007 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
307 3 0 2 5.5 CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2
CHEMBL83668 5ht2b_human Human Yes 5.7 IC50 = 2007 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
307 3 0 2 5.5 CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2
CHEMBL365882 5ht2b_human Human No 6.7 IC50 = 201 Funct
Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor
459 5 1 5 5.0 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=C(C(=CC=C3)Cl)Cl)N4CCN(CC4)C
CHEMBL9514 5ht2b_human Human Yes 4.7 IC50 = 20180 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
301 4 2 5 2.8 COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3
CHEMBL9514 5ht2b_human Human Yes 4.7 IC50 = 20180 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
301 4 2 5 2.8 COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3
CHEMBL54 5ht2b_human Human Yes 5.7 IC50 = 2050 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL83 5ht2b_human Human Yes 5.7 IC50 = 2084 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL83 5ht2b_human Human Yes 5.7 IC50 = 2084 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL862 5ht2b_human Human Yes 5.7 IC50 = 2098 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
246 2 2 1 2.0 C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
CHEMBL862 5ht2b_human Human Yes 5.7 IC50 = 2098 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
246 2 2 1 2.0 C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
CHEMBL384160 5ht2b_human Human No 7.7 IC50 = 21 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
377 3 0 5 4.0 CC(C)CN1CCC2(CC1)N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2
CHEMBL384160 5ht2b_human Human No 7.7 IC50 = 21 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
377 3 0 5 4.0 CC(C)CN1CCC2(CC1)N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2
CHEMBL473187 5ht2b_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
398 3 2 3 3.3 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(NC4=O)C5=CC=CC=C5
CHEMBL473187 5ht2b_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
398 3 2 3 3.3 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(NC4=O)C5=CC=CC=C5
CHEMBL2323579 5ht2b_human Human No 7.7 IC50 = 22 Funct
Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method
440 6 1 4 2.7 CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CN(C4=CC=CC2=C34)C)N(C1)C
CHEMBL3634745 5ht2b_human Human No 6.7 IC50 = 220 Funct
Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b
422 5 1 4 4.9 C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=C(C=C3)C4=C(NC(=O)C=C4)C5=CC=C(C=C5)F
CHEMBL3634745 5ht2b_human Human No 6.7 IC50 = 220 Funct
Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b
422 5 1 4 4.9 C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=C(C=C3)C4=C(NC(=O)C=C4)C5=CC=C(C=C5)F
CHEMBL85 5ht2b_human Human Yes 7.6 IC50 = 23 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL85 5ht2b_human Human Yes 7.6 IC50 = 23 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL474840 5ht2b_human Human No 5.6 IC50 = 2300 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
390 3 1 4 3.0 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)N5CCOCC5
CHEMBL474840 5ht2b_human Human No 5.6 IC50 = 2300 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
390 3 1 4 3.0 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)N5CCOCC5
CHEMBL415 5ht2b_human Human Yes 6.6 IC50 = 239 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL415 5ht2b_human Human Yes 6.6 IC50 = 239 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL584554 5ht2b_human Human No 5.6 IC50 = 2470 Funct
Inhibition of 5HT2B receptorInhibition of 5HT2B receptor
429 4 2 2 3.8 CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C(=O)NC5=CC=CC=C5
CHEMBL584554 5ht2b_human Human No 5.6 IC50 = 2470 Funct
Inhibition of 5HT2B receptorInhibition of 5HT2B receptor
429 4 2 2 3.8 CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C(=O)NC5=CC=CC=C5
CHEMBL3601563 5ht2b_human Human No 6.6 IC50 = 250 Funct
Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)
340 3 0 3 4.8 COC1=C(C2=C(C=C1)C(=NC=C2)C3CCC4=C3C=C(C=C4)Cl)OC
CHEMBL3601563 5ht2b_human Human No 6.6 IC50 = 250 Funct
Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)
340 3 0 3 4.8 COC1=C(C2=C(C=C1)C(=NC=C2)C3CCC4=C3C=C(C=C4)Cl)OC
CHEMBL1381098 5ht2b_human Human Yes 4.6 IC50 = 25158 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
185 1 0 2 4.3 C1=CC=C2C(=C1)C=CC=C2N=C=S
CHEMBL1381098 5ht2b_human Human Yes 4.6 IC50 = 25158 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
185 1 0 2 4.3 C1=CC=C2C(=C1)C=CC=C2N=C=S
CHEMBL376978 5ht2b_human Human No 7.6 IC50 = 26 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
397 3 0 6 4.8 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)F
CHEMBL376978 5ht2b_human Human No 7.6 IC50 = 26 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
397 3 0 6 4.8 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)F
CHEMBL219916 5ht2b_human Human Yes 5.6 IC50 = 2600 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL1368005 5ht2b_human Human Yes 5.6 IC50 = 2600 Funct
Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)
394 8 1 4 3.6 CC1=CC2=CC=CC=C2N1CCNC(=O)C=CC3=CC(=C(C(=C3)OC)OC)OC
CHEMBL219916 5ht2b_human Human Yes 5.6 IC50 = 2600 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL1368005 5ht2b_human Human Yes 5.6 IC50 = 2600 Funct
Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)
394 8 1 4 3.6 CC1=CC2=CC=CC=C2N1CCNC(=O)C=CC3=CC(=C(C(=C3)OC)OC)OC
CHEMBL3770106 5ht2b_human Human Yes 7.6 IC50 = 27.3 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
329 5 3 4 1.8 CCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL3770106 5ht2b_human Human Yes 7.6 IC50 = 27.3 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
329 5 3 4 1.8 CCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL513994 5ht2b_human Human Yes 6.6 IC50 = 270 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
402 4 1 7 4.7 C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N
CHEMBL513994 5ht2b_human Human Yes 6.6 IC50 = 270 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
402 4 1 7 4.7 C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N
CHEMBL594717 5ht2b_human Human No 7.6 IC50 = 28 Funct
Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT
355 4 1 5 3.2 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)C)C=C2
CHEMBL594717 5ht2b_human Human No 7.6 IC50 = 28 Funct
Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT
355 4 1 5 3.2 CC1CNCCN1C2=NC3=C(CCC3OCC4=C(C=CC(=C4)F)C)C=C2
CHEMBL215461 5ht2b_human Human Yes 6.6 IC50 = 280 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
368 1 0 4 4.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=CC=CC=C5O2
CHEMBL1411080 5ht2b_human Human Yes 6.6 IC50 = 280 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
287 3 3 3 1.6 COC1=CC=CC(=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL215461 5ht2b_human Human Yes 6.6 IC50 = 280 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
368 1 0 4 4.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=CC=CC=C5O2
CHEMBL1411080 5ht2b_human Human Yes 6.6 IC50 = 280 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
287 3 3 3 1.6 COC1=CC=CC(=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL470432 5ht2b_human Human No 6.6 IC50 = 281.8 Funct
Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL470432 5ht2b_human Human No 6.6 IC50 = 281.8 Funct
Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor
343 5 0 4 5.2 CCCN1CCC(CC1)COC2=NC3=C(C(=CS3)C)N4C2=CC=C4
CHEMBL3770981 5ht2b_human Human No 6.6 IC50 = 284.5 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
357 6 2 4 2.4 CCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N(C)C
CHEMBL3770981 5ht2b_human Human No 6.6 IC50 = 284.5 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
357 6 2 4 2.4 CCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N(C)C
CHEMBL213005 5ht2b_human Human Yes 7.5 IC50 = 29 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
458 3 0 5 5.4 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)Br
CHEMBL213005 5ht2b_human Human Yes 7.5 IC50 = 29 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
458 3 0 5 5.4 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)Br
CHEMBL60889 5ht2b_human Human Yes 6.5 IC50 = 295.9 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
422 7 2 6 2.8 CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N
CHEMBL60889 5ht2b_human Human Yes 6.5 IC50 = 295.9 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
422 7 2 6 2.8 CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N
CHEMBL475778 5ht2b_human Human No 8.5 IC50 = 3.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
412 4 1 3 4.8 COC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL475778 5ht2b_human Human No 8.5 IC50 = 3.4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
412 4 1 3 4.8 COC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL513994 5ht2b_human Human Yes 8.5 IC50 = 3.5 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
402 4 1 7 4.7 C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N
CHEMBL513994 5ht2b_human Human Yes 8.5 IC50 = 3.5 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
402 4 1 7 4.7 C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N
CHEMBL212656 5ht2b_human Human Yes 7.5 IC50 = 30 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
430 1 0 5 4.5 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)Br
CHEMBL472990 5ht2b_human Human No 7.5 IC50 = 30 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
385 4 1 5 3.2 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL212656 5ht2b_human Human Yes 7.5 IC50 = 30 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
430 1 0 5 4.5 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)Br
CHEMBL472990 5ht2b_human Human No 7.5 IC50 = 30 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
385 4 1 5 3.2 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL475406 5ht2b_human Human No 6.5 IC50 = 300 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
396 4 1 2 5.3 C1CN(CCC1CC2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL565551 5ht2b_human Human No 6.5 IC50 = 300 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
371 5 2 6 3.7 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)F
CHEMBL577912 5ht2b_human Human No 6.5 IC50 = 300 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
388 5 2 5 4.3 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL475406 5ht2b_human Human No 6.5 IC50 = 300 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
396 4 1 2 5.3 C1CN(CCC1CC2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CC=CC=C5
CHEMBL565551 5ht2b_human Human No 6.5 IC50 = 300 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
371 5 2 6 3.7 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)F
CHEMBL577912 5ht2b_human Human No 6.5 IC50 = 300 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
388 5 2 5 4.3 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)Cl
CHEMBL1651095 5ht2b_human Human Yes 4.5 IC50 = 30000 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay
223 1 2 4 1.6 CC1C(NC(=C2C=CC=CC2=O)S1)CO
CHEMBL1221 5ht2b_human Human Yes 5.5 IC50 = 3020 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL1221 5ht2b_human Human Yes 5.5 IC50 = 3020 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
398 6 0 2 6.1 C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL514967 5ht2b_human Human No 7.5 IC50 = 31 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
388 3 1 2 5.8 C1CCC(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL567993 5ht2b_human Human No 7.5 IC50 = 31 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
367 5 2 5 4.0 CC1=CC=CC(=C1)C(=O)NC2CCC(CC2)NC3=NC=C(C(=N3)N(C)C)C
CHEMBL514967 5ht2b_human Human No 7.5 IC50 = 31 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
388 3 1 2 5.8 C1CCC(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL567993 5ht2b_human Human No 7.5 IC50 = 31 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
367 5 2 5 4.0 CC1=CC=CC(=C1)C(=O)NC2CCC(CC2)NC3=NC=C(C(=N3)N(C)C)C
CHEMBL566075 5ht2b_human Human No 5.5 IC50 = 3100 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
503 6 2 11 5.6 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
CHEMBL566075 5ht2b_human Human No 5.5 IC50 = 3100 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
503 6 2 11 5.6 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
CHEMBL305660 5ht2b_human Human Yes 6.5 IC50 = 312.6 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL411 5ht2b_human Human Yes 5.5 IC50 = 3140 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL311469 5ht2b_human Human Yes 5.5 IC50 = 3170 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
223 1 1 1 3.3 CC(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C2
CHEMBL311469 5ht2b_human Human Yes 5.5 IC50 = 3170 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
223 1 1 1 3.3 CC(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C2
CHEMBL212755 5ht2b_human Human No 7.5 IC50 = 32 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
414 3 0 5 5.3 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)Cl
CHEMBL475407 5ht2b_human Human No 7.5 IC50 = 32 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
367 4 1 4 3.1 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL212755 5ht2b_human Human No 7.5 IC50 = 32 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
414 3 0 5 5.3 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C=CC(=C5)Cl
CHEMBL475407 5ht2b_human Human No 7.5 IC50 = 32 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
367 4 1 4 3.1 C1CN(CCC1C2=NC=CN2)S(=O)(=O)C3=CC=C(C=C3)C4=CC=CC=C4
CHEMBL577904 5ht2b_human Human No 6.5 IC50 = 320 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
403 6 2 7 4.0 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=C(C=C3)F)F
CHEMBL577904 5ht2b_human Human No 6.5 IC50 = 320 Funct
Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor
403 6 2 7 4.0 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=C(C=C3)F)F
CHEMBL475778 5ht2b_human Human No 5.5 IC50 = 3200 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
412 4 1 3 4.8 COC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL475778 5ht2b_human Human No 5.5 IC50 = 3200 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
412 4 1 3 4.8 COC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL3813726 5ht2b_human Human No 6.5 IC50 = 326 Funct
Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay
526 12 0 5 6.9 COC1=C(C=C(C=C1)CCN(CCCC2=CC=CC=C2Br)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL3813726 5ht2b_human Human No 6.5 IC50 = 326 Funct
Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay
526 12 0 5 6.9 COC1=C(C=C(C=C1)CCN(CCCC2=CC=CC=C2Br)CCC3=CC4=C(C=C3)OCO4)OC
CHEMBL175543 5ht2b_human Human Yes 5.5 IC50 = 3260 Funct
Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay
463 5 4 7 2.0 CNC(=O)C12CC1C(C(C2O)O)N3C=NC4=C(N=C(N=C43)Cl)NCC5=CC(=CC=C5)Cl
CHEMBL582877 5ht2b_human Human Yes 6.5 IC50 = 327.6 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
296 2 3 2 1.3 CC1(N=C(NC(=N1)NC2=CC(=CC=C2)Br)N)C
CHEMBL582877 5ht2b_human Human Yes 6.5 IC50 = 327.6 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
296 2 3 2 1.3 CC1(N=C(NC(=N1)NC2=CC(=CC=C2)Br)N)C
CHEMBL1909065 5ht2b_human Human No 7.5 IC50 = 33 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL3770342 5ht2b_human Human No 7.5 IC50 = 33.4 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
336 2 3 2 2.3 C1CCC2(CC1)N=C(NC(=N2)NC3=CC(=CC=C3)Br)N
CHEMBL3770342 5ht2b_human Human No 7.5 IC50 = 33.4 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
336 2 3 2 2.3 C1CCC2(CC1)N=C(NC(=N2)NC3=CC(=CC=C3)Br)N
CHEMBL21731 5ht2b_human Human Yes 6.5 IC50 = 336 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL900 5ht2b_human Human Yes 5.5 IC50 = 3391 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL900 5ht2b_human Human Yes 5.5 IC50 = 3391 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
269 6 0 2 3.8 CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C
CHEMBL809 5ht2b_human Human Yes 5.5 IC50 = 3393.5 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL809 5ht2b_human Human Yes 5.5 IC50 = 3393.5 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
306 2 1 1 4.8 CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
CHEMBL472791 5ht2b_human Human No 6.5 IC50 = 340 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 1 3 3.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CN=CC=C5
CHEMBL472791 5ht2b_human Human No 6.5 IC50 = 340 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
382 3 1 3 3.8 C1CN(CCC1C2=NC3=CC=CC=C3N2)C(=O)C4=CC=C(C=C4)C5=CN=CC=C5
CHEMBL964 5ht2b_human Human Yes 4.5 IC50 = 34547 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
297 7 0 4 3.9 CCN(CC)C(=S)SSC(=S)N(CC)CC
CHEMBL964 5ht2b_human Human Yes 4.5 IC50 = 34547 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
297 7 0 4 3.9 CCN(CC)C(=S)SSC(=S)N(CC)CC
CHEMBL564 5ht2b_human Human Yes 6.5 IC50 = 347 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
284 4 0 3 4.5 CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31
CHEMBL184717 5ht2b_human Human No 6.5 IC50 = 349 Funct
Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor
425 5 1 5 4.3 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=CC=C(C=C3)Cl)N4CCN(CC4)C
CHEMBL474408 5ht2b_human Human No 7.5 IC50 = 35 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
349 3 1 3 3.5 C1CN(CCC1C2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL3343672 5ht2b_human Human No 7.5 IC50 = 35 Funct
Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism
307 1 2 2 2.2 C1CC2(C3=CC=CC=C3C4=C2C=C(C=C4)C(=O)N=C(N)N)OC1
CHEMBL474408 5ht2b_human Human No 7.5 IC50 = 35 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin
349 3 1 3 3.5 C1CN(CCC1C2=NC=CN2)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)F
CHEMBL3343672 5ht2b_human Human No 7.5 IC50 = 35 Funct
Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism
307 1 2 2 2.2 C1CC2(C3=CC=CC=C3C4=C2C=C(C=C4)C(=O)N=C(N)N)OC1
CHEMBL3770342 5ht2b_human Human No 7.5 IC50 = 35.4 Funct
Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay
336 2 3 2 2.3 C1CCC2(CC1)N=C(NC(=N2)NC3=CC(=CC=C3)Br)N
CHEMBL3770351 5ht2b_human Human No 7.5 IC50 = 35.8 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
327 5 3 3 2.1 CCCC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL3770351 5ht2b_human Human No 7.5 IC50 = 35.8 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
327 5 3 3 2.1 CCCC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL215024 5ht2b_human Human Yes 6.5 IC50 = 350 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
444 3 0 4 5.8 C1CN(CCC12N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=CC=CC=C5O2)CC6=CC=CC=C6
CHEMBL215024 5ht2b_human Human Yes 6.5 IC50 = 350 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
444 3 0 4 5.8 C1CN(CCC12N3C(CC(=N3)C4=CC=C(C=C4)Cl)C5=CC=CC=C5O2)CC6=CC=CC=C6
CHEMBL81 5ht2b_human Human Yes 6.5 IC50 = 355 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL81 5ht2b_human Human Yes 6.5 IC50 = 355 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL38 5ht2b_human Human Yes 6.5 IC50 = 358 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
300 5 1 2 6.3 CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
CHEMBL1626 5ht2b_human Human Yes 7.4 IC50 = 36 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL3092753 5ht2b_human Human No 7.4 IC50 = 36.4 Funct
Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis
251 1 2 1 2.7 C1C2=CC=CC=C2C3=C1C=C(C=C3)C(=O)N=C(N)N
CHEMBL98350 5ht2b_human Human Yes 4.4 IC50 = 36707 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
307 2 0 4 3.1 C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
CHEMBL98350 5ht2b_human Human Yes 4.4 IC50 = 36707 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
307 2 0 4 3.1 C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
CHEMBL707 5ht2b_human Human Yes 6.4 IC50 = 368 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL2323580 5ht2b_human Human No 7.4 IC50 = 37 Funct
Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method
369 5 1 3 2.0 CN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)C(=O)NCCCN(C)C
CHEMBL3287218 5ht2b_human Human Yes 5.4 IC50 = 3700 Funct
Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)
513 4 0 6 4.4 CC1=NC=NC(=C1)C2=CC3=C(C=C2)C(CC3)N4CC5(C4)CCN(CC5)C(=O)CC6=CN7C=C(SC7=N6)C
CHEMBL3287218 5ht2b_human Human Yes 5.4 IC50 = 3700 Funct
Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)
513 4 0 6 4.4 CC1=NC=NC(=C1)C2=CC3=C(C=C2)C(CC3)N4CC5(C4)CCN(CC5)C(=O)CC6=CN7C=C(SC7=N6)C
CHEMBL648 5ht2b_human Human Yes 6.4 IC50 = 373 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL648 5ht2b_human Human Yes 6.4 IC50 = 373 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
266 3 0 2 3.6 CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
CHEMBL3736207 5ht2b_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
478 13 0 6 6.2 COC1=CC=C(C=C1)CCCN(CCC2=CC3=C(C=C2)OCO3)CCC4=CC(=C(C=C4)OC)OC
CHEMBL3736207 5ht2b_human Human No 5.4 IC50 = 3981.1 Funct
Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay
478 13 0 6 6.2 COC1=CC=C(C=C1)CCCN(CCC2=CC3=C(C=C2)OCO3)CCC4=CC(=C(C=C4)OC)OC
CHEMBL472789 5ht2b_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
412 4 1 3 4.8 COC1=C(C=CC(=C1)C2=CC=CC=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL472789 5ht2b_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
412 4 1 3 4.8 COC1=C(C=CC(=C1)C2=CC=CC=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL119443 5ht2b_human Human Yes 8.4 IC50 = 4.1 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
325 3 3 3 1.8 CC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
CHEMBL119443 5ht2b_human Human Yes 8.4 IC50 = 4.1 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
325 3 3 3 1.8 CC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
CHEMBL185376 5ht2b_human Human No 6.4 IC50 = 400 Funct
Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor
417 6 2 7 5.4 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=CC=C(C=C3)C(F)(F)F)NC(C)C
CHEMBL841 5ht2b_human Human Yes 5.4 IC50 = 4105 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
477 7 1 3 5.0 CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL841 5ht2b_human Human Yes 5.4 IC50 = 4105 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
477 7 1 3 5.0 CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL1091207 5ht2b_human Human No 6.4 IC50 = 411 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
359 3 0 5 3.2 CSC1=NN2C3=C(CCCC3)C=NC2=C1S(=O)(=O)C4=CC=CC=C4
CHEMBL1091207 5ht2b_human Human No 6.4 IC50 = 411 Funct
Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry
359 3 0 5 3.2 CSC1=NN2C3=C(CCCC3)C=NC2=C1S(=O)(=O)C4=CC=CC=C4
CHEMBL215883 5ht2b_human Human Yes 7.4 IC50 = 42 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
348 2 0 5 3.0 CCN1CCC2(CC1)N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2
CHEMBL215883 5ht2b_human Human Yes 7.4 IC50 = 42 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
348 2 0 5 3.0 CCN1CCC2(CC1)N3C(CC(=N3)C4=CC=NC=C4)C5=CC=CC=C5O2
CHEMBL1224034 5ht2b_human Human No 7.4 IC50 = 42.7 Funct
Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay
336 1 1 4 3.4 C1CCC(CC1)NC(=O)N2C3C(CO2)CSC4=C3C=C(C=C4)F
CHEMBL1224034 5ht2b_human Human No 7.4 IC50 = 42.7 Funct
Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay
336 1 1 4 3.4 C1CCC(CC1)NC(=O)N2C3C(CO2)CSC4=C3C=C(C=C4)F
CHEMBL384745 5ht2b_human Human Yes 6.4 IC50 = 426 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
412 1 0 4 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Br)C5=CC=CC=C5O2
CHEMBL384745 5ht2b_human Human Yes 6.4 IC50 = 426 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
412 1 0 4 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)Br)C5=CC=CC=C5O2
CHEMBL215404 5ht2b_human Human Yes 6.4 IC50 = 427 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
478 3 0 7 5.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4OC(F)F)C5=C(O2)C=CC(=C5)Br
CHEMBL215404 5ht2b_human Human Yes 6.4 IC50 = 427 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
478 3 0 7 5.3 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4OC(F)F)C5=C(O2)C=CC(=C5)Br
CHEMBL1172 5ht2b_human Human Yes 7.4 IC50 = 43 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL1172 5ht2b_human Human Yes 7.4 IC50 = 43 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
311 0 1 2 4.5 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
CHEMBL2392349 5ht2b_human Human No 7.4 IC50 = 43 Funct
Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor
444 8 0 4 4.9 COC1=CC=CC=C1N2CCN(CC2)CCCCCN3CC4=C(C3=O)C5=CC=CC=C5C=C4
CHEMBL2426677 5ht2b_human Human No 5.4 IC50 = 4300 Funct
Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)
469 5 0 5 3.6 COC1=CC=C(C=C1)CC(=O)N2CCC3(CC2)CN(C3)C4CCC5=C4C=CC(=C5)C6=NC=CC=N6
CHEMBL2426677 5ht2b_human Human No 5.4 IC50 = 4300 Funct
Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)
469 5 0 5 3.6 COC1=CC=C(C=C1)CC(=O)N2CCC3(CC2)CN(C3)C4CCC5=C4C=CC(=C5)C6=NC=CC=N6
CHEMBL364863 5ht2b_human Human No 6.4 IC50 = 442 Funct
Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor
458 5 1 8 4.6 CC1=CC(=NC2=C1C=C(C=C2)NC(=O)COC3=CC=C(C=C3)C(F)(F)F)N4CCN(CC4)C
CHEMBL214594 5ht2b_human Human Yes 7.3 IC50 = 46 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
381 2 0 6 3.8 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C(=CC=C5)OC
CHEMBL214594 5ht2b_human Human Yes 7.3 IC50 = 46 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
381 2 0 6 3.8 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)F)C5=C(O2)C(=CC=C5)OC
CHEMBL1262 5ht2b_human Human Yes 5.3 IC50 = 4606.4 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
429 6 0 3 6.1 C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
CHEMBL2170062 5ht2b_human Human Yes 5.3 IC50 = 4700 Funct
Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor
337 5 0 4 3.5 CC1=CC(=NN1C2=CC3=CC=CC=C3C=C2)OCCN4CCOCC4
CHEMBL474839 5ht2b_human Human No 7.3 IC50 = 48 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
389 3 1 3 4.2 C1CCN(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL474839 5ht2b_human Human No 7.3 IC50 = 48 Funct
Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay
389 3 1 3 4.2 C1CCN(CC1)C2=CC=C(C=C2)C(=O)N3CCC(CC3)C4=NC5=CC=CC=C5N4
CHEMBL1670 5ht2b_human Human Yes 5.3 IC50 = 4832 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
320 3 0 0 6.2 C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
CHEMBL3771373 5ht2b_human Human Yes 6.3 IC50 = 485.9 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
271 2 3 2 2.0 CC1=CC=C(C=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL3771373 5ht2b_human Human Yes 6.3 IC50 = 485.9 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
271 2 3 2 2.0 CC1=CC=C(C=C1)NC2=NC3(CCCCC3)N=C(N2)N
CHEMBL1909072 5ht2b_human Human Yes 7.3 IC50 = 49 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL3770185 5ht2b_human Human No 7.3 IC50 = 49.4 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
343 6 3 4 2.2 CCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)NC
CHEMBL3770185 5ht2b_human Human No 7.3 IC50 = 49.4 Funct
Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay
343 6 3 4 2.2 CCOC(=O)C1=CC(=CC=C1)NC2=NC3(CCCCC3)N=C(N2)NC
CHEMBL212228 5ht2b_human Human Yes 7.3 IC50 = 50 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
333 1 0 4 3.7 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4)C5=CC=CC=C5O2
CHEMBL212228 5ht2b_human Human Yes 7.3 IC50 = 50 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
333 1 0 4 3.7 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4)C5=CC=CC=C5O2
CHEMBL213006 5ht2b_human Human Yes 6.3 IC50 = 500 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
396 3 0 4 5.2 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4Cl)C5=CC=CC=C5O2
CHEMBL213006 5ht2b_human Human Yes 6.3 IC50 = 500 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
396 3 0 4 5.2 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4Cl)C5=CC=CC=C5O2
CHEMBL214184 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
454 3 0 4 5.7 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)C)C5=C(O2)C=CC(=C5)Br
CHEMBL215991 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
402 1 0 5 3.8 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CO4)C5=C(O2)C=CC(=C5)Br
CHEMBL214802 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
462 1 0 4 5.7 CN1CCC2(CC1)N3C(CC(=N3)C4=CC5=CC=CC=C5C=C4)C6=C(O2)C=CC(=C6)Br
CHEMBL213332 5ht2b_human Human No 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
279 1 0 4 2.9 CC1(N2C(CC(=N2)C3=CC=NC=C3)C4=CC=CC=C4O1)C
CHEMBL215386 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
442 2 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)OC)C5=C(O2)C=CC(=C5)Br
CHEMBL378540 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
442 2 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4OC)C5=C(O2)C=CC(=C5)Br
CHEMBL384270 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
418 1 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CS4)C5=C(O2)C=CC(=C5)Br
CHEMBL425260 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
472 3 0 6 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC(=C(C=C4)OC)OC)C5=C(O2)C=CC(=C5)Br
CHEMBL214184 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
454 3 0 4 5.7 CCCN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)C)C5=C(O2)C=CC(=C5)Br
CHEMBL215991 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
402 1 0 5 3.8 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CO4)C5=C(O2)C=CC(=C5)Br
CHEMBL214802 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
462 1 0 4 5.7 CN1CCC2(CC1)N3C(CC(=N3)C4=CC5=CC=CC=C5C=C4)C6=C(O2)C=CC(=C6)Br
CHEMBL213332 5ht2b_human Human No 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
279 1 0 4 2.9 CC1(N2C(CC(=N2)C3=CC=NC=C3)C4=CC=CC=C4O1)C
CHEMBL215386 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
442 2 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=C(C=C4)OC)C5=C(O2)C=CC(=C5)Br
CHEMBL378540 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
442 2 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CC=C4OC)C5=C(O2)C=CC(=C5)Br
CHEMBL384270 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
418 1 0 5 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC=CS4)C5=C(O2)C=CC(=C5)Br
CHEMBL425260 5ht2b_human Human Yes 5.3 IC50 = 5000 Funct
Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release
472 3 0 6 4.4 CN1CCC2(CC1)N3C(CC(=N3)C4=CC(=C(C=C4)OC)OC)C5=C(O2)C=CC(=C5)Br
CHEMBL1668584 5ht2b_human Human Yes 5.3 IC50 = 5130 Funct
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor
316 3 1 5 2.8 CC1=CC(=NC2=C(C(=NN12)NC)S(=O)(=O)C3=CC=CC=C3)C
CHEMBL1668584 5ht2b_human Human Yes 5.3 IC50 = 5130 Funct
Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor
316 3 1 5 2.8 CC1=CC(=NC2=C(C(=NN12)NC)S(=O)(=O)C3=CC=CC=C3)C
CHEMBL395110 5ht2b_human Human Yes 6.3 IC50 = 514 Funct
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL395110 5ht2b_human Human Yes 6.3 IC50 = 514 Funct
DRUGMA