GproteinDb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	57401968	69202	0	None	-	1	Human	10.0	pIC50	=	10	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	451	4	1	3	5.9	CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(NC(C)=O)c3ccccc34)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934121	69202	0	None	-	1	Human	10.0	pIC50	=	10	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	451	4	1	3	5.9	CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(NC(C)=O)c3ccccc34)ccc21	10.1016/j.bmcl.2011.10.125
	10410064	69204	0	None	-	1	Human	10.0	pIC50	=	10	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	423	3	2	2	5.4	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934123	69204	0	None	-	1	Human	10.0	pIC50	=	10	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	423	3	2	2	5.4	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	57394992	69208	0	None	501	2	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	457	3	2	2	6.1	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Cl)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934127	69208	0	None	501	2	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	457	3	2	2	6.1	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Cl)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	10457264	69211	0	None	1513	2	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	466	3	2	4	4.8	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934130	69211	0	None	1513	2	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	466	3	2	4	4.8	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	10091316	69197	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	382	2	2	2	4.8	O[C@@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2	10.1016/j.bmcl.2011.10.125
	CHEMBL1934116	69197	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	382	2	2	2	4.8	O[C@@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2	10.1016/j.bmcl.2011.10.125
	57391501	69207	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	441	3	2	2	5.6	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(F)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934126	69207	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	441	3	2	2	5.6	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(F)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	57396735	69209	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	501	3	2	2	6.2	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Br)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934128	69209	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	501	3	2	2	6.2	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(Br)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	10090198	69188	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	364	2	1	1	5.9	C1=CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934107	69188	1	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	364	2	1	1	5.9	C1=CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	10025150	69194	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	420	3	0	3	6.4	CCC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934113	69194	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	420	3	0	3	6.4	CCC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57401967	69200	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	467	4	2	4	4.9	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](NC(C)=O)[C@H]4O)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934119	69200	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	467	4	2	4	4.9	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](NC(C)=O)[C@H]4O)ccc21	10.1016/j.bmcl.2011.10.125
	30979231	69183	3	None	19	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	392	3	0	2	6.4	CCn1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934102	69183	3	None	19	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	392	3	0	2	6.4	CCn1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57403720	69184	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	406	4	0	2	6.4	CCn1c2ccccc2c2cc(CCN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934103	69184	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	406	4	0	2	6.4	CCn1c2ccccc2c2cc(CCN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57401969	69203	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	423	3	2	2	5.4	CC(=O)N[C@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934122	69203	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	423	3	2	2	5.4	CC(=O)N[C@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	57400179	69199	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	426	3	2	4	4.8	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@H]4O)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934118	69199	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	426	3	2	4	4.8	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@H]4O)ccc21	10.1016/j.bmcl.2011.10.125
	57396733	69185	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	420	5	0	2	6.8	CCn1c2ccccc2c2cc(CCCN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934104	69185	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	420	5	0	2	6.8	CCn1c2ccccc2c2cc(CCCN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57396734	69192	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	442	3	0	4	5.2	CS(=O)(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934111	69192	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	442	3	0	4	5.2	CS(=O)(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57400177	69196	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	410	3	1	3	5.8	CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(O)c3ccccc34)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934115	69196	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	410	3	1	3	5.8	CCn1c2ccccc2c2cc(CN3CCC4(CC3)CC(O)c3ccccc34)ccc21	10.1016/j.bmcl.2011.10.125
	57394991	69201	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	451	4	1	3	5.4	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4NC(C)=O)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934120	69201	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	451	4	1	3	5.4	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4NC(C)=O)ccc21	10.1016/j.bmcl.2011.10.125
	57403723	69205	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	426	3	2	4	4.8	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@@H]4O)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934124	69205	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	426	3	2	4	4.8	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3[C@H](O)[C@@H]4O)ccc21	10.1016/j.bmcl.2011.10.125
	23572819	69195	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	410	3	1	3	5.3	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4O)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934114	69195	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	410	3	1	3	5.3	CCn1c2ccccc2c2cc(CN3CCC4(CC3)c3ccccc3CC4O)ccc21	10.1016/j.bmcl.2011.10.125
	57400176	69191	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	422	2	0	4	6.0	COC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934110	69191	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	422	2	0	4	6.0	COC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	10455647	69190	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	435	2	0	3	5.9	CN(C)C(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934109	69190	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	435	2	0	3	5.9	CN(C)C(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	10046992	69193	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	407	2	1	3	5.3	NC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934112	69193	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	407	2	1	3	5.3	NC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57403721	69186	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	406	2	0	2	6.0	CCn1c2ccccc2c2cc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934105	69186	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	406	2	0	2	6.0	CCn1c2ccccc2c2cc(C(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57401966	69187	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	421	2	1	2	6.4	CCn1c2ccccc2c2cc(NC(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934106	69187	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	421	2	1	2	6.4	CCn1c2ccccc2c2cc(NC(=O)N3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57391502	69210	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	491	3	2	2	6.5	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(C(F)(F)F)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934129	69210	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	491	3	2	2	6.5	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccc(C(F)(F)F)cc5c4c3)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	57403722	69189	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	406	2	0	3	6.0	CC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934108	69189	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	406	2	0	3	6.0	CC(=O)n1c2ccccc2c2cc(CN3CCC4(C=Cc5ccccc54)CC3)ccc21	10.1016/j.bmcl.2011.10.125
	57400180	69206	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	439	3	3	3	4.4	CC(=O)N[C@H]1c2ccccc2C2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)[C@@H]1O	10.1016/j.bmcl.2011.10.125
	CHEMBL1934125	69206	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	439	3	3	3	4.4	CC(=O)N[C@H]1c2ccccc2C2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)[C@@H]1O	10.1016/j.bmcl.2011.10.125
	57400178	69198	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	382	2	2	2	4.8	O[C@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2	10.1016/j.bmcl.2011.10.125
	CHEMBL1934117	69198	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assayAntagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay	ChEMBL	382	2	2	2	4.8	O[C@H]1Cc2ccccc2C12CCN(Cc1ccc3[nH]c4ccccc4c3c1)CC2	10.1016/j.bmcl.2011.10.125
	7757	1060	0	None	-	1	Human	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	466	5	2	4	5.7	CCCN[C@@H]1CC2(c3c1cccc3)CCN(CC2)Cc1ccc2c(c1)c1ccccc1n2C(=O)N	22123324
	86277835	1060	0	None	-	1	Human	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	466	5	2	4	5.7	CCCN[C@@H]1CC2(c3c1cccc3)CCN(CC2)Cc1ccc2c(c1)c1ccccc1n2C(=O)N	22123324
	11238212	507	0	None	-	1	Human	5.9	pIC50	None	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	551	8	2	6	5.9	Brc1ccc(c(c1)OC(F)(F)F)CCN[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	15677346
	1304	507	0	None	-	1	Human	5.9	pIC50	None	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	551	8	2	6	5.9	Brc1ccc(c(c1)OC(F)(F)F)CCN[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	15677346
	101600353	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	101600353	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11459838
	1301	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	1301	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11459838
	134824567	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	134824567	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11459838
	16207764	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	16207764	2435	0	None	-	1	Human	6.7	pIC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11459838
	1307	524	0	None	1	2	Human	7.3	pIC50	None	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12009900
	1290	256	0	None	-15	2	Human	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12009900
	1298	2449	0	None	-	1	Human	8.7	pIC50	None	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	16167454	2449	0	None	-	1	Human	8.7	pIC50	None	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	91898993	2449	0	None	-	1	Human	8.7	pIC50	None	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	1297	3054	0	None	-1	2	Human	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11404457
	1297	3054	0	None	-1	2	Human	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11459838

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	9806086	64876	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	502	10	3	5	5.7	COc1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)ccc1C(=O)NCCCN1CCCCC1	10.1016/j.bmcl.2004.07.077
	CHEMBL182554	64876	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	502	10	3	5	5.7	COc1cc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)ccc1C(=O)NCCCN1CCCCC1	10.1016/j.bmcl.2004.07.077
	10436090	65874	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	501	10	4	5	5.7	COc1cc(NC(=O)Nc2cccc(Nc3ccccc3)c2)ccc1C(=O)NCCCN1CCCCC1	10.1016/j.bmcl.2004.07.077
	CHEMBL184438	65874	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	501	10	4	5	5.7	COc1cc(NC(=O)Nc2cccc(Nc3ccccc3)c2)ccc1C(=O)NCCCN1CCCCC1	10.1016/j.bmcl.2004.07.077
	44395076	66661	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	549	10	3	5	5.7	O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc(C(=O)NCCN2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2004.07.077
	CHEMBL186894	66661	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	549	10	3	5	5.7	O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc(C(=O)NCCN2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2004.07.077
	10388797	71415	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	444	5	2	5	4.3	Cc1cc(N2CCNCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	CHEMBL196667	71415	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	444	5	2	5	4.3	Cc1cc(N2CCNCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	11512135	69965	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	460	8	1	5	4.9	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	CHEMBL194408	69965	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	460	8	1	5	4.9	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	10027853	71518	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	474	6	2	6	4.4	Cc1cc(N2CCC(N)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL197026	71518	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	474	6	2	6	4.4	Cc1cc(N2CCC(N)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	11599973	193228	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]MCH from human MCHR2 expressed in CHO cellsDisplacement of [125I]MCH from human MCHR2 expressed in CHO cells	ChEMBL	600	8	2	4	6.5	O=C(CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)NC(c1ccc(F)cc1)c1c[nH]c(=O)c(Cl)c1	10.1016/j.bmcl.2009.05.067
	CHEMBL540930	193228	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]MCH from human MCHR2 expressed in CHO cellsDisplacement of [125I]MCH from human MCHR2 expressed in CHO cells	ChEMBL	600	8	2	4	6.5	O=C(CC1CCN(Cc2ccn(-c3ccc(C(F)(F)F)cc3)c2)CC1)NC(c1ccc(F)cc1)c1c[nH]c(=O)c(Cl)c1	10.1016/j.bmcl.2009.05.067
	11548234	70852	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	528	7	1	6	5.5	Cc1cc(N2CCC(N3CCCC3)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL195635	70852	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	528	7	1	6	5.5	Cc1cc(N2CCC(N3CCCC3)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	11201645	71527	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	445	7	2	5	4.5	Cc1cc(N(C)CCO)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL197050	71527	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	445	7	2	5	4.5	Cc1cc(N(C)CCO)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	44403765	135337	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	446	8	2	5	4.5	CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1	10.1021/jm050103y
	CHEMBL373084	135337	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	446	8	2	5	4.5	CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1	10.1021/jm050103y
	10005009	165823	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	472	6	2	6	4.0	Cc1cc(N2CC3CC2CN3)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL427540	165823	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	472	6	2	6	4.0	Cc1cc(N2CC3CC2CN3)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	9955811	65840	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	458	8	3	4	5.3	CCN1CCCC1CNC(=O)c1ccc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1	10.1016/j.bmcl.2004.07.077
	CHEMBL184292	65840	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligandBinding affinity against human Melanin-concentrating hormone receptor 2 stably transfected CHO cells was determined using [125I]MCH as radioligand	ChEMBL	458	8	3	4	5.3	CCN1CCCC1CNC(=O)c1ccc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1	10.1016/j.bmcl.2004.07.077
	11583744	71380	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	476	10	2	6	4.8	Cc1cc(NCCCN(C)C)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL196581	71380	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	476	10	2	6	4.8	Cc1cc(NCCCN(C)C)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	11648240	71117	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	458	8	2	5	5.1	Cc1cc(NCCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	CHEMBL196196	71117	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	458	8	2	5	5.1	Cc1cc(NCCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
	11539632	70217	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	CHEMBL194837	70217	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayDisplacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
	10173787	82026	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R2Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R2	ChEMBL	453	7	2	3	6.8	CCCc1cc(NC2CCC2)c2cc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)ccc2n1	10.1016/j.bmcl.2006.08.008
	CHEMBL217480	82026	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R2Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R2	ChEMBL	453	7	2	3	6.8	CCCc1cc(NC2CCC2)c2cc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)ccc2n1	10.1016/j.bmcl.2006.08.008
	45273336	194089	0	None	-46	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopiperazine-1-sulfonic acid from human MCH2RDisplacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopiperazine-1-sulfonic acid from human MCH2R	ChEMBL	2419	58	33	31	-3.5	CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCC(N)=O)CN[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O	10.1016/j.bmcl.2009.03.102
	91934329	194089	0	None	-46	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopiperazine-1-sulfonic acid from human MCH2RDisplacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopiperazine-1-sulfonic acid from human MCH2R	ChEMBL	2419	58	33	31	-3.5	CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCC(N)=O)CN[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O	10.1016/j.bmcl.2009.03.102
	CHEMBL557629	194089	0	None	-46	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopiperazine-1-sulfonic acid from human MCH2RDisplacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopiperazine-1-sulfonic acid from human MCH2R	ChEMBL	2419	58	33	31	-3.5	CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCC(N)=O)CN[C@@H](Cc2ccc(O)cc2)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O	10.1016/j.bmcl.2009.03.102
	10457264	69211	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-(1'-((9-ethyl-9H-carbazol-3-yl)methyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetamide from human MCHR2 expressed in HEK293 cells after 2 hrsDisplacement of [3H]N-(1'-((9-ethyl-9H-carbazol-3-yl)methyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetamide from human MCHR2 expressed in HEK293 cells after 2 hrs	ChEMBL	466	3	2	4	4.8	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125
	CHEMBL1934130	69211	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-(1'-((9-ethyl-9H-carbazol-3-yl)methyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetamide from human MCHR2 expressed in HEK293 cells after 2 hrsDisplacement of [3H]N-(1'-((9-ethyl-9H-carbazol-3-yl)methyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetamide from human MCHR2 expressed in HEK293 cells after 2 hrs	ChEMBL	466	3	2	4	4.8	CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c3ccccc3n4C(N)=O)CC2)c2ccccc21	10.1016/j.bmcl.2011.10.125

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Ligand source activities (1 row/activity)