Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
10099401 100739 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL295895 100739 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10120470 174887 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45770 174887 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293169 182571 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 551 14 0 5 5.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47953 182571 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 551 14 0 5 5.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293020 179651 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 11 0 5 4.6 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47500 179651 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 11 0 5 4.6 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71224515 139901 0 None - 1 Human 7.0 pEC50 = 7 Functional
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3809148 139901 0 None - 1 Human 7.0 pEC50 = 7 Functional
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
44293287 186748 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49308 186748 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
44293019 162117 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 464 11 0 3 5.6 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL417003 162117 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 464 11 0 3 5.6 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
53322111 57068 0 None -125 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
CHEMBL1651721 57068 0 None -125 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
10164519 187266 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49624 187266 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292938 178387 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47059 178387 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292917 171106 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 519 13 0 3 5.7 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL44663 171106 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 519 13 0 3 5.7 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292891 187142 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49540 187142 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
10120470 174887 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.042
CHEMBL45770 174887 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.042
10030777 167622 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL433263 167622 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293324 101122 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 12 0 5 4.6 CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL298686 101122 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 12 0 5 4.6 CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293289 98506 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL279759 98506 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292945 162212 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 15 2 4 4.8 CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O 10.1016/j.bmcl.2004.01.042
CHEMBL417173 162212 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 15 2 4 4.8 CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O 10.1016/j.bmcl.2004.01.042
10461880 188184 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 645 13 3 4 5.4 CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC 10.1016/j.bmcl.2004.01.042
CHEMBL50556 188184 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 645 13 3 4 5.4 CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC 10.1016/j.bmcl.2004.01.042
71234037 110651 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 531 9 2 7 3.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263689 110651 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 531 9 2 7 3.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
10142987 101314 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL300022 101314 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44292731 183098 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 550 14 1 4 5.1 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48030 183098 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 550 14 1 4 5.1 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10142987 101314 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.042
CHEMBL300022 101314 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.042
44292995 187873 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 468 11 0 5 4.2 CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL50278 187873 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 468 11 0 5 4.2 CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71233908 110648 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 515 8 2 6 3.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263683 110648 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 515 8 2 6 3.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
10030777 167622 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL433263 167622 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10164519 187266 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49624 187266 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293289 98506 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL279759 98506 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293018 178999 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3ccc(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL47420 178999 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3ccc(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44292938 178387 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47059 178387 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10165009 178443 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 521 15 1 4 5.8 CCCCOC(=O)N(CC(=O)NCC1CC1)Cc1ccc(-c2ccccc2CN(CCCC)C(C)=O)cc1 10.1016/j.bmcl.2004.01.042
CHEMBL47120 178443 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 521 15 1 4 5.8 CCCCOC(=O)N(CC(=O)NCC1CC1)Cc1ccc(-c2ccccc2CN(CCCC)C(C)=O)cc1 10.1016/j.bmcl.2004.01.042
44255904 57086 0 None -79 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651828 57086 0 None -79 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
10185204 176020 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 13 0 5 5.0 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45976 176020 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 13 0 5 5.0 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
2837084 70795 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Effective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorEffective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 308 1 1 2 4.1 CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL195534 70795 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Effective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorEffective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 308 1 1 2 4.1 CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
71234065 110649 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 537 8 3 6 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCc3cccc(C(N)=O)c3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263685 110649 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 537 8 3 6 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCc3cccc(C(N)=O)c3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
44293203 183676 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 183676 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71450781 83921 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FSH receptor by aromatase-based assayAgonist activity at human FSH receptor by aromatase-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216804 83921 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FSH receptor by aromatase-based assayAgonist activity at human FSH receptor by aromatase-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
44580873 192719 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FSH receptorAgonist activity at human recombinant FSH receptor
ChEMBL 561 9 2 5 5.1 COc1ccc(C2SC(CC(=O)NCCC3=CCc4ccccc43)C(=O)N2c2ccc(C(N)=O)c(Cl)c2)cc1 10.1016/j.ejmech.2007.07.017
CHEMBL524348 192719 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FSH receptorAgonist activity at human recombinant FSH receptor
ChEMBL 561 9 2 5 5.1 COc1ccc(C2SC(CC(=O)NCCC3=CCc4ccccc43)C(=O)N2c2ccc(C(N)=O)c(Cl)c2)cc1 10.1016/j.ejmech.2007.07.017
44293299 174951 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)cc(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45782 174951 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)cc(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71224679 110653 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 559 7 4 8 3.4 Cc1ccccc1N1CCN(c2ccc(C(=O)N[C@@H]3CCC[C@@H](O)[C@H]3O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263692 110653 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 559 7 4 8 3.4 Cc1ccccc1N1CCN(c2ccc(C(=O)N[C@@H]3CCC[C@@H](O)[C@H]3O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
44293203 183676 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 183676 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292920 100821 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL296449 100821 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293189 187245 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49608 187245 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10099401 100739 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL295895 100739 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293203 183676 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 183676 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71450781 83921 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FSH receptor by cAMP-based assayAgonist activity at human FSH receptor by cAMP-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216804 83921 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FSH receptor by cAMP-based assayAgonist activity at human FSH receptor by cAMP-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
71234040 110650 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 516 9 2 6 4.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCC3CCOC3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263687 110650 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 516 9 2 6 4.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCC3CCOC3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
71234266 110652 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263691 110652 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
44293189 187245 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49608 187245 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293172 176370 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 14 0 4 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL46216 176370 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 14 0 4 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292698 181685 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 14 0 5 5.3 CCCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL47838 181685 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 14 0 5 5.3 CCCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293300 167555 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 454 10 0 5 3.8 CCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL432883 167555 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 454 10 0 5 3.8 CCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71233981 110647 0 None - 1 Human 4.0 pEC50 = 4 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263667 110647 0 None - 1 Human 4.0 pEC50 = 4 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
11260332 68337 0 None 51 2 Human 8.0 pIC50 = 8 Functional
In vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68337 0 None 51 2 Human 8.0 pIC50 = 8 Functional
In vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53324743 57084 0 None -18 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651826 57084 0 None -18 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11190706 134754 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 475 5 0 2 7.8 CC(=O)N1c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL372649 134754 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 475 5 0 2 7.8 CC(=O)N1c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53324742 57083 0 None -26 2 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651825 57083 0 None -26 2 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11352881 165699 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1ccccc1C1(C)CC(C)(C)N(C(C)=O)c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 10.1021/jm049676l
CHEMBL426824 165699 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1ccccc1C1(C)CC(C)(C)N(C(C)=O)c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 10.1021/jm049676l
11442786 70746 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 470 6 1 3 5.5 COc1ccc(CCNC(=O)c2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
CHEMBL195321 70746 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 470 6 1 3 5.5 COc1ccc(CCNC(=O)c2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
11156384 123538 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 504 4 2 3 7.2 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(O)cc2)CC1(C)C 10.1021/jm049676l
CHEMBL363164 123538 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 504 4 2 3 7.2 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(O)cc2)CC1(C)C 10.1021/jm049676l
11306348 70778 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL195469 70778 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11258158 122609 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 402 3 1 3 5.4 CC(=O)N1c2ccc(NC(=O)c3ccco3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL361167 122609 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 402 3 1 3 5.4 CC(=O)N1c2ccc(NC(=O)c3ccco3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11260332 68337 0 None 51 2 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68337 0 None 51 2 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11431176 133444 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 462 5 1 3 5.5 CC(=O)N1c2ccc(NS(=O)(=O)Cc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL371595 133444 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 462 5 1 3 5.5 CC(=O)N1c2ccc(NS(=O)(=O)Cc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11203161 68982 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1cc(NC(=O)c2ccc(-c3ccccc3)cc2)cc2c1N(C(C)=O)C(C)(C)CC2(C)c1ccccc1 10.1021/jm049676l
CHEMBL192868 68982 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1cc(NC(=O)c2ccc(-c3ccccc3)cc2)cc2c1N(C(C)=O)C(C)(C)CC2(C)c1ccccc1 10.1021/jm049676l
11224637 62834 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 446 3 1 2 6.4 CC(=O)N1c2ccc(NC(=O)c3ccc(Cl)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL178980 62834 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 446 3 1 2 6.4 CC(=O)N1c2ccc(NC(=O)c3ccc(Cl)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53326035 57085 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 742 16 1 9 8.0 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2[C@@](C)(c2ccc(OCc3cn(CCOCCOCCN=[N+]=[N-])nn3)cc2)CC1(C)C 10.1021/ml100229v
CHEMBL1651827 57085 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 742 16 1 9 8.0 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2[C@@](C)(c2ccc(OCc3cn(CCOCCOCCN=[N+]=[N-])nn3)cc2)CC1(C)C 10.1021/ml100229v
53318154 57069 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 542 6 1 3 7.5 C#CCOc1ccc([C@@]2(C)CC(C)(C)N(C(C)=O)c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)cc32)cc1 10.1021/ml100229v
CHEMBL1651722 57069 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 542 6 1 3 7.5 C#CCOc1ccc([C@@]2(C)CC(C)(C)N(C(C)=O)c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)cc32)cc1 10.1021/ml100229v
11260332 68337 0 None 51 2 Human 8.4 pIC50 = 8.4 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68337 0 None 51 2 Human 8.4 pIC50 = 8.4 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11396885 122570 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 5 1 2 6.7 CCCc1ccc(C(=O)Nc2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
CHEMBL360981 122570 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 5 1 2 6.7 CCCc1ccc(C(=O)Nc2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
11283470 168109 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2cc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL436481 168109 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2cc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11375523 70751 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(C)cc2)CC1(C)C 10.1021/jm049676l
CHEMBL195347 70751 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(C)cc2)CC1(C)C 10.1021/jm049676l
11443213 68664 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 489 4 0 3 7.4 CC(=O)N1c2ccc(OC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192334 68664 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 489 4 0 3 7.4 CC(=O)N1c2ccc(OC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11260332 68337 0 None -51 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell lineIn vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell line
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68337 0 None -51 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell lineIn vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell line
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11407702 134720 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 427 3 2 2 6.2 CC(=O)N1c2ccc(NC(=O)Nc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL372506 134720 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 427 3 2 2 6.2 CC(=O)N1c2ccc(NC(=O)Nc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11190814 123104 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 480 3 1 2 6.8 CC(=O)N1c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL361847 123104 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 480 3 1 2 6.8 CC(=O)N1c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11373573 63032 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 422 4 1 3 5.3 CC(=O)N1c2ccc(NC(=O)COC(C)(C)C)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL179505 63032 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 422 4 1 3 5.3 CC(=O)N1c2ccc(NC(=O)COC(C)(C)C)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11283209 126363 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3cccc(-c4ccccc4)c3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL365545 126363 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3cccc(-c4ccccc4)c3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53320758 57082 0 None -21 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651824 57082 0 None -21 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11224817 70280 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 4 1 2 7.4 CC(=O)N1c2ccc(NCc3ccc(C(C)(C)C)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL194996 70280 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 4 1 2 7.4 CC(=O)N1c2ccc(NCc3ccc(C(C)(C)C)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL2369814 207947 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
14557576 88945 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369794 88945 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
3172428 48145 4 None -158 2 Human 5.3 pPotency = 5.3 Functional
PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]
ChEMBL 459 7 3 8 1.6 NC(=O)c1nsc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc3c(c2)OCO3)c1N nan
CHEMBL1555290 48145 4 None -158 2 Human 5.3 pPotency = 5.3 Functional
PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]
ChEMBL 459 7 3 8 1.6 NC(=O)c1nsc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc3c(c2)OCO3)c1N nan


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
71457922 83920 0 None - 0 Human 9.0 pEC50 = 9 Binding
Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor
ChEMBL 653 10 2 6 5.8 COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216803 83920 0 None - 0 Human 9.0 pEC50 = 9 Binding
Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor
ChEMBL 653 10 2 6 5.8 COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC 10.1016/j.bmc.2012.03.069
71233981 110647 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3263667 110647 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
71234266 110652 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3263691 110652 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
71224515 139901 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3809148 139901 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
132072838 181415 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 565 4 2 6 5.1 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)CCc3c([nH]c4ccccc34)[C@H](OCc3ccc(Br)cc3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL4780505 181415 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 565 4 2 6 5.1 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)CCc3c([nH]c4ccccc34)[C@H](OCc3ccc(Br)cc3)C[C@@H]21 10.1016/j.bmc.2020.115546
1158 1666 0 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8188681