GproteinDb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	137642920	158115	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4086893	158115	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	134157586	154163	0	None	-3	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3985509	154163	0	None	-3	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	90407037	157288	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4076902	157288	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90405670	164694	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	425	7	1	3	5.4	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217143	164694	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	425	7	1	3	5.4	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	118707082	113008	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	4	1	3	3.3	COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311196	113008	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	4	1	3	3.3	COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	925016	113030	16	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	289	3	1	2	3.7	Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311314	113030	16	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	289	3	1	2	3.7	Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137649416	157519	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4079893	157519	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	82051616	159457	1	None	12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	159457	1	None	12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	975397	113036	9	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	335	5	1	4	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC	10.1016/j.bmcl.2014.05.012
	CHEMBL3311324	113036	9	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	335	5	1	4	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC	10.1016/j.bmcl.2014.05.012
	137634844	156116	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4063239	156116	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137640323	156978	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4073013	156978	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	137653973	158684	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	354	6	2	3	4.3	Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O	10.1016/j.bmcl.2017.01.034
	CHEMBL4093067	158684	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	354	6	2	3	4.3	Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O	10.1016/j.bmcl.2017.01.034
	134133275	143643	0	None	-8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3899885	143643	0	None	-8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	85472225	162761	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	162761	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134133797	143568	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3899190	143568	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	85472621	162803	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4172392	162803	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	145955668	162425	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4166208	162425	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	134149615	148576	0	None	1	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148576	0	None	1	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	137640701	157089	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4074388	157089	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	137636217	156093	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4063013	156093	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	137642920	158115	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4086893	158115	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	90418476	162786	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4172136	162786	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	57521919	76277	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058532	76277	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4207911	76277	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	137636217	156093	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4063013	156093	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	134138099	147822	0	None	4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3932897	147822	0	None	4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	60195036	81721	0	None	-630	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL2163924	81721	0	None	-630	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	137632299	156467	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4067368	156467	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	90406631	164434	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	503	7	1	3	6.1	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4213709	164434	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	503	7	1	3	6.1	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137643228	158256	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	8	1	5	5.2	COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4088620	158256	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	8	1	5	5.2	COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	137647721	157830	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	157830	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	59455584	157041	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4073815	157041	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90406228	163702	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4204928	163702	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	561372	58827	65	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688452	58827	65	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	86343591	163703	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4204946	163703	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	134133275	143643	0	None	8	2	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3899885	143643	0	None	8	2	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	137643958	158279	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	505	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4088889	158279	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	505	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137657488	159680	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4104082	159680	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	90418753	162396	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165803	162396	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	73777111	149710	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	149710	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	25098573	2747	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	5587	2747	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	CHEMBL463785	2747	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	134141270	146810	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3924759	146810	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	90418849	162696	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	7	1	4	6.5	Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1021/acsmedchemlett.7b00233
	CHEMBL4170501	162696	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	7	1	4	6.5	Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1021/acsmedchemlett.7b00233
	8190724	113029	6	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	359	4	1	3	4.3	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311313	113029	6	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	359	4	1	3	4.3	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	258072	80088	25	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	275	3	1	2	3.4	Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL2131154	80088	25	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	275	3	1	2	3.4	Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	91824000	113028	8	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311312	113028	8	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1	10.1016/j.bmcl.2014.05.012
	137647721	157830	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	157830	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	57521919	76277	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058532	76277	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4207911	76277	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	54586011	61808	0	None	-14	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773257	61808	0	None	-14	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	137640701	157089	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4074388	157089	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134151903	153356	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3978465	153356	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	73777069	142669	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	142669	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	73777174	150454	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	150454	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	134136175	142680	0	None	1	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3892019	142680	0	None	1	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	643684	107515	63	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL3186422	107515	63	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	86343965	163811	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4206168	163811	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	90418650	157355	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4077787	157355	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	85470884	164004	2	None	2	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	164004	2	None	2	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134149615	148576	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148576	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	90406583	164661	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	416	7	1	4	4.9	N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4216721	164661	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	416	7	1	4	4.9	N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F	10.1016/j.bmcl.2018.02.013
	134144000	150209	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	150209	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134154415	152694	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	CHEMBL3972870	152694	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	137640328	156984	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	CHEMBL4073078	156984	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	134133675	143262	0	None	2	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896714	143262	0	None	2	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	1050	1902	94	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	11595431	1902	94	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	CHEMBL207881	1902	94	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	85471695	158669	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4092882	158669	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	137657736	159638	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4103573	159638	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	90405989	155960	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4061340	155960	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	137653883	158522	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	493	7	1	4	6.6	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F	10.1016/j.bmcl.2017.06.028
	CHEMBL4091291	158522	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	493	7	1	4	6.6	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F	10.1016/j.bmcl.2017.06.028
	11195	3882	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	3882	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	3882	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	87055315	165757	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246850	165757	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	145986046	165912	0	None	19	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250196	165912	0	None	19	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	142738582	184520	0	None	-42	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4847662	184520	0	None	-42	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	134157207	154211	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3985939	154211	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	134135468	144475	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	144475	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	134145700	148751	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3940429	148751	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134155067	151306	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3960738	151306	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137646995	157833	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	391	7	1	4	5.0	O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4083499	157833	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	391	7	1	4	5.0	O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1	10.1016/j.bmcl.2017.06.028
	137660451	159245	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4099026	159245	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134151115	152199	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968537	152199	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	90418653	137513	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL3754160	137513	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	86343594	163597	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4203544	163597	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	137641343	157057	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	157057	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134132142	144869	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	144869	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	134132142	144869	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3909872	144869	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57522038	3887	60	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	3887	60	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	3887	60	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	137635671	155991	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4061699	155991	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137632299	156467	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4067368	156467	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	137661886	159327	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4099943	159327	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	137657968	159592	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4103081	159592	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90418139	162581	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4168786	162581	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	90406219	164314	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	469	7	1	3	5.8	O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4212281	164314	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	469	7	1	3	5.8	O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	90406961	163782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4205879	163782	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	90406842	164706	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	427	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4217252	164706	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	427	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C	10.1016/j.bmcl.2018.02.013
	85472222	163066	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	437	9	1	4	6.7	CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4176414	163066	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	437	9	1	4	6.7	CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	51349861	58829	0	None	-77	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL1688454	58829	0	None	-77	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	10466	166670	80	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	CHEMBL4281719	166670	80	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	134153222	152525	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3971461	152525	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	134134149	143375	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3897776	143375	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	134155480	151251	0	None	38	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3960231	151251	0	None	38	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137648785	157610	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4080995	157610	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137655521	158989	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	467	8	1	4	6.1	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4096332	158989	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	467	8	1	4	6.1	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	25109512	189764	0	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	CHEMBL515995	189764	0	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	137641343	157057	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	157057	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	90418782	163083	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4176642	163083	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	90407441	163714	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	417	7	1	3	6.0	Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4205035	163714	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	417	7	1	3	6.0	Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	54580132	61804	0	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	CHEMBL1773253	61804	0	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	7789	100685	88	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	300	16	2	2	5.3	CCCCCCC(O)CCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL292352	100685	88	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	300	16	2	2	5.3	CCCCCCC(O)CCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	86343595	164695	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217161	164695	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137646145	158024	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4085643	158024	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	57521809	76264	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058520	76264	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL4210970	76264	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	86294762	164115	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4209823	164115	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	134133355	143536	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3898962	143536	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137657488	159680	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4104082	159680	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	134146386	148907	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3941726	148907	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	46892131	144671	2	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	144671	2	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	134143163	145744	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3916564	145744	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	90406575	164354	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	455	8	1	4	5.4	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4212717	164354	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	455	8	1	4	5.4	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	134136175	142680	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3892019	142680	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	145983493	165504	0	None	371	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4240607	165504	0	None	371	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134146021	149064	0	None	-5	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3942922	149064	0	None	-5	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	134154330	152880	0	None	1	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3974501	152880	0	None	1	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	137638355	156829	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	156829	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134147174	149703	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3947787	149703	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	137649360	157386	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4078286	157386	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	90418662	158941	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4095819	158941	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	73777175	143909	0	None	1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	143909	0	None	1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	57521814	76269	0	None	10	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058525	76269	0	None	10	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	90418662	158941	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4095819	158941	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	85470884	164004	2	None	-2	5	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	164004	2	None	-2	5	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	57521808	76263	0	None	-3	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL2058519	76263	0	None	-3	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	57521809	76264	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058520	76264	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4210970	76264	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	90442468	164482	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	456	8	1	5	4.8	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4214224	164482	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	456	8	1	5	4.8	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134156096	151447	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3961950	151447	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137638355	156829	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	156829	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137642604	158517	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	158517	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137632403	156304	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4065447	156304	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	84481843	113035	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	5	1	3	4.2	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311322	113035	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	5	1	3	4.2	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	8190727	113038	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	347	3	1	4	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311326	113038	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	347	3	1	4	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	137632403	156304	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4065447	156304	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	134153562	152723	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	CHEMBL3973101	152723	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	87055315	165757	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120Agonist activity at human GPR120	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246850	165757	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120Agonist activity at human GPR120	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	73777156	152715	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	152715	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	137642604	158517	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	158517	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	90418651	162413	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4166012	162413	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	59455552	156041	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062462	156041	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134154417	152704	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3972973	152704	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	57521813	76268	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058524	76268	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	134134846	144239	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3904654	144239	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	54582149	61806	0	None	-33	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773255	61806	0	None	-33	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	134146958	149609	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3947070	149609	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73777085	153230	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	153230	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	90418650	157355	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4077787	157355	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	90418650	157355	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4077787	157355	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	57521913	76270	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058526	76270	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	134145750	149145	0	None	3	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3943430	149145	0	None	3	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134141029	147167	0	None	4	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3927879	147167	0	None	4	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	145984594	165933	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	436	9	1	6	4.2	CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250664	165933	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	436	9	1	6	4.2	CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1	10.1016/j.bmcl.2018.06.047
	134156455	154321	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3986721	154321	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	73777153	142823	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	142823	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	137645347	157802	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	7	1	2	6.2	Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4083233	157802	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	7	1	2	6.2	Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134147107	149876	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3949142	149876	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	25150014	3885	55	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	3952	3885	55	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	CHEMBL449588	3885	55	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	137646188	157605	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	CHEMBL4080936	157605	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	137660451	159245	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4099026	159245	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	57521915	76272	0	None	15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058528	76272	0	None	15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	11195	3882	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	3882	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	3882	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	134152545	153477	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3979588	153477	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	137636733	156204	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	CHEMBL4064298	156204	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	90442039	162909	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4173940	162909	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	57521916	76273	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058529	76273	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	25098573	2747	8	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	5587	2747	8	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	CHEMBL463785	2747	8	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	23136411	58832	0	None	-11	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688457	58832	0	None	-11	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	134143370	145803	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3916986	145803	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	145983824	165739	0	None	-6	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246334	165739	0	None	-6	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134129938	142440	0	None	263	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890089	142440	0	None	263	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134153298	152366	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3970166	152366	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	85472225	162761	0	None	2	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	162761	0	None	2	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134153546	152581	0	None	8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971857	152581	0	None	8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137636733	156204	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	CHEMBL4064298	156204	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	82051652	158598	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4092090	158598	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137654721	158739	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	CHEMBL4093589	158739	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	711134	113025	17	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311305	113025	17	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137646188	157605	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	CHEMBL4080936	157605	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	134155277	151325	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3961009	151325	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	1049	363	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	4618	363	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	5280934	363	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	CHEMBL8739	363	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	DB00132	363	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	90406335	163830	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4206369	163830	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F	10.1016/j.bmcl.2018.02.013
	134138318	148019	0	None	1	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3934450	148019	0	None	1	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	134144214	150358	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953203	150358	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	59455555	158716	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4093383	158716	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	73776979	143359	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3897637	143359	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	137654721	158739	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	CHEMBL4093589	158739	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	82051652	158598	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4092090	158598	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137657736	159638	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4103573	159638	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	145986262	165845	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	8	1	4	4.7	O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F	10.1016/j.bmcl.2018.06.047
	CHEMBL4248845	165845	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	8	1	4	4.7	O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F	10.1016/j.bmcl.2018.06.047
	134154473	152374	0	None	218	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3970238	152374	0	None	218	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134139171	146263	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3920591	146263	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	86343964	163620	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	421	7	1	3	5.5	Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4203774	163620	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	421	7	1	3	5.5	Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1	10.1016/j.bmcl.2018.02.013
	137647294	157952	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	8	1	4	6.9	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4084679	157952	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	8	1	4	6.9	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C	10.1016/j.bmcl.2017.06.028
	90407659	164233	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	440	7	1	4	5.1	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4211144	164233	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	440	7	1	4	5.1	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134157586	154163	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3985509	154163	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	137636575	155901	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4060663	155901	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134133675	143262	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896714	143262	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	90404813	164508	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	473	7	1	3	6.3	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	CHEMBL4214698	164508	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	473	7	1	3	6.3	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	57521812	76267	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL2058523	76267	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	137633536	156295	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	156295	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	134154330	152880	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3974501	152880	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134148110	149570	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3946820	149570	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134138802	147919	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	147919	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	46892131	144671	2	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	144671	2	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	137661388	159240	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4098969	159240	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	134133297	143779	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3900990	143779	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57521811	76266	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	CHEMBL2058522	76266	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	24825492	149542	0	None	-9	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL394666	149542	0	None	-9	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	85472227	162188	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162566	162188	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	134149615	148576	0	None	1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148576	0	None	1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	73777174	150454	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	150454	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	145960576	162152	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161929	162152	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134145195	150423	0	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	5	1	5	4.4	Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953859	150423	0	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	5	1	5	4.4	Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1	10.1016/j.bmcl.2016.10.054
	1052	2321	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	3323	2321	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	5280450	2321	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	CHEMBL267476	2321	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	DB14104	2321	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	900631	113037	17	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	3	1	4	3.2	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311325	113037	17	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	3	1	4	3.2	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	118707173	113039	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	331	6	1	3	3.8	C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311327	113039	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	331	6	1	3	3.8	C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	137633536	156295	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	156295	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	137661388	159240	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4098969	159240	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	1050	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	11595431	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	CHEMBL207881	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	825631	113026	15	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311306	113026	15	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1	10.1016/j.bmcl.2014.05.012
	841618	113033	18	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	3	1	2	4.1	Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311318	113033	18	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	3	1	2	4.1	Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	134141270	146810	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3924759	146810	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	134145412	149271	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3944507	149271	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	134147601	150028	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3950444	150028	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	1049	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	4618	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	5280934	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	CHEMBL8739	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	DB00132	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	134143899	150239	0	None	1	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3952316	150239	0	None	1	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	73777063	1154	39	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	1154	39	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	1154	39	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	134152336	153456	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3979448	153456	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	117886639	148450	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	148450	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	90417528	162172	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	9	1	4	7.2	CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162353	162172	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	9	1	4	7.2	CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	85472359	162129	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161536	162129	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	134148736	148554	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3938783	148554	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	134156096	151447	0	None	5	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3961950	151447	0	None	5	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137649360	157386	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4078286	157386	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	86343961	164287	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	435	7	1	3	5.8	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4211967	164287	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	435	7	1	3	5.8	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C	10.1016/j.bmcl.2018.02.013
	145985748	165643	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	444	9	1	4	5.4	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4243863	165643	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	444	9	1	4	5.4	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134156727	153634	0	None	-4	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	153634	0	None	-4	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	134151115	152199	0	None	4	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968537	152199	0	None	4	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	137631865	156334	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4065769	156334	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	1050	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	11595431	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	CHEMBL207881	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	73777065	147256	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3928591	147256	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	134146021	149064	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3942922	149064	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	73777135	150370	0	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	150370	0	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	137643339	158043	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	158043	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	90406970	164776	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4218078	164776	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134146720	149131	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3943315	149131	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	23136477	58830	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688455	58830	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4213909	58830	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	134132711	144938	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	144938	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	134145778	149347	0	None	13	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3945213	149347	0	None	13	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	137657972	159604	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	159604	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	23136477	58830	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL1688455	58830	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4213909	58830	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	118707084	113010	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	321	5	1	4	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311198	113010	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	321	5	1	4	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	8190712	113034	10	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	5	1	2	4.4	CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311319	113034	10	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	5	1	2	4.4	CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137643339	158043	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	158043	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	956298	113024	9	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	319	4	1	4	2.9	COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C	10.1016/j.bmcl.2014.05.012
	CHEMBL3311303	113024	9	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	319	4	1	4	2.9	COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C	10.1016/j.bmcl.2014.05.012
	137657972	159604	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	159604	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	134131874	144857	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3909773	144857	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	86281122	164326	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4212409	164326	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1	10.1016/j.bmcl.2018.02.013
	137660302	159438	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4101135	159438	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	137638176	156733	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	7	1	4	6.1	Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1016/j.bmcl.2017.06.028
	CHEMBL4070355	156733	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	7	1	4	6.1	Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1016/j.bmcl.2017.06.028
	117873187	152344	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3969920	152344	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	87054900	148761	0	None	1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3940493	148761	0	None	1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	90418278	162379	16	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	162379	16	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	73777175	143909	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	143909	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	60195039	81793	0	None	-181	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164240	81793	0	None	-181	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	134134229	143255	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	143255	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134134229	143255	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896657	143255	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	86281125	164071	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4209308	164071	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	57522038	3887	60	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	3887	60	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	3887	60	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	117886649	152078	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3967504	152078	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	134142866	145642	0	None	2	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3915765	145642	0	None	2	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	57521914	76271	0	None	-6	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058527	76271	0	None	-6	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	60195125	3888	8	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	9149	3888	8	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	CHEMBL2164242	3888	8	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	73777135	150370	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	150370	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73776995	148742	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3940359	148742	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	24825509	87946	0	None	-29	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234057	87946	0	None	-29	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	134154953	151276	0	None	7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3960369	151276	0	None	7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	86343963	164744	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217669	164744	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134155950	151090	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959068	151090	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	145984009	165589	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	418	7	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4242595	165589	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	418	7	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1	10.1016/j.bmcl.2018.06.047
	134157207	154211	0	None	3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3985939	154211	0	None	3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57522038	3887	60	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	6490	3887	60	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	CHEMBL2058533	3887	60	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	134157563	154007	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3984072	154007	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	54584098	61805	5	None	-5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL1773254	61805	5	None	-5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	54583098	61809	0	None	-70	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1773258	61809	0	None	-70	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	134157563	154007	0	None	-1	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3984072	154007	0	None	-1	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	73777069	142669	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	142669	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	134138318	148019	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3934450	148019	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	134144000	150209	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	150209	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	86281123	163748	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	439	7	1	3	5.7	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4205429	163748	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	439	7	1	3	5.7	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	137646553	157914	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4084333	157914	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	118707083	113009	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	325	4	1	3	3.8	COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311197	113009	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	325	4	1	3	3.8	COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	743974	113027	70	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	113027	70	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137638995	156965	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	156965	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	23136401	159135	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	159135	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	145984445	165460	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	9	1	4	5.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4239572	165460	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	9	1	4	5.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134138281	147786	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3932664	147786	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	90417978	161984	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4159180	161984	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	73777153	142823	0	None	2	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	142823	0	None	2	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	57521918	76276	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058531	76276	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	54582150	61810	0	None	-22	2	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1773259	61810	0	None	-22	2	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	59455584	157041	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4073815	157041	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	137646553	157914	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4084333	157914	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134132951	144622	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3907996	144622	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	137638995	156965	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	156965	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	90407027	164194	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	437	7	1	3	6.3	Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4210752	164194	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	437	7	1	3	6.3	Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	54585039	61803	5	None	-17	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL1773252	61803	5	None	-17	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	134143899	150239	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3952316	150239	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	87054900	148761	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3940493	148761	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	90406418	164577	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	CHEMBL4215446	164577	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	134131620	142432	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890035	142432	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	23136401	159135	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	159135	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	90418513	162623	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169436	162623	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	23136363	58833	0	None	-14	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688458	58833	0	None	-14	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	134150245	152245	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968947	152245	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137643146	158064	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4086174	158064	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	73777085	153230	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	153230	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73776997	154280	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3986483	154280	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	23346507	88288	1	None	-30	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL234834	88288	1	None	-30	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	57521810	76265	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058521	76265	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	24825484	87991	0	None	-208	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234269	87991	0	None	-208	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	73777111	149710	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	149710	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	137642184	158502	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4091118	158502	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	134156727	153634	0	None	4	2	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	153634	0	None	4	2	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	137637576	156063	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	156063	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137658634	159403	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4100773	159403	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	137643146	158064	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4086174	158064	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	134144214	150358	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953203	150358	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	59455552	156041	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062462	156041	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134134229	143255	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	143255	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134134229	143255	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896657	143255	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	137637576	156063	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	156063	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137658634	159403	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4100773	159403	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	57522038	3887	60	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	3887	60	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	3887	60	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	137638911	156729	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	156729	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137656526	159753	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	159753	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	743974	113027	70	None	-3	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	113027	70	None	-3	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	46941175	61812	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL1773261	61812	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	46941175	61812	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773261	61812	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	3518281	113032	11	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	293	3	1	2	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311317	113032	11	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	293	3	1	2	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	137642184	158502	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4091118	158502	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	145985122	165908	0	None	17	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250132	165908	0	None	17	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134147174	149703	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3947787	149703	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	134145412	149271	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3944507	149271	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	73777156	152715	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	152715	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	134143163	145744	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3916564	145744	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	137638911	156729	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	156729	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	134134149	143375	0	None	2	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3897776	143375	0	None	2	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	137640328	156984	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	CHEMBL4073078	156984	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	117886639	148450	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	148450	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	118184919	162873	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4173280	162873	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	54586984	61807	0	None	-34	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773256	61807	0	None	-34	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	134139171	146263	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3920591	146263	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	137661886	159327	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4099943	159327	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	90418886	162920	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	423	9	1	4	6.1	CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4174122	162920	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	423	9	1	4	6.1	CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	137656526	159753	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	159753	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	145985686	165430	0	None	354	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4238809	165430	0	None	354	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	137648785	157610	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4080995	157610	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134153986	152506	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971308	152506	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134153562	152723	0	None	2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	CHEMBL3973101	152723	0	None	2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	134140073	146321	0	None	1	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3921062	146321	0	None	1	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	134135468	144475	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	144475	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	57521702	76262	0	None	-11	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	CHEMBL2058518	76262	0	None	-11	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	137636575	155901	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4060663	155901	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137635671	155991	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4061699	155991	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	85471695	158669	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4092882	158669	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	85470884	164004	2	None	-7	5	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	164004	2	None	-7	5	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134155847	151102	0	None	63	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959144	151102	0	None	63	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134132711	144938	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	144938	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	137636167	155987	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	155987	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	134142450	145446	0	None	10	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3914253	145446	0	None	10	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	137660302	159438	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4101135	159438	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	90418333	162655	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169851	162655	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	57522038	3887	60	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	3887	60	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	3887	60	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	57839754	157816	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083325	157816	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	90407037	157288	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4076902	157288	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	3893	2287	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	4642	2287	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	5534	2287	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL108766	2287	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	DB03017	2287	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	59455555	158716	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4093383	158716	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134149615	148576	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	148576	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	90418278	162379	16	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	162379	16	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134155277	151325	0	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3961009	151325	0	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	134133992	143739	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3900705	143739	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134133297	143779	0	None	3	3	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3900990	143779	0	None	3	3	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	977153	51420	15	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	339	4	1	3	4.1	COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl	10.1016/j.bmcl.2014.05.012
	CHEMBL1581959	51420	15	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	339	4	1	3	4.1	COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl	10.1016/j.bmcl.2014.05.012
	137636167	155987	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	155987	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	57839754	157816	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083325	157816	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	743974	113027	70	None	-1	3	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	113027	70	None	-1	3	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	8190702	113031	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	4	1	3	3.6	CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311316	113031	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	4	1	3	3.6	CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	85470884	164004	2	None	2	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	164004	2	None	2	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137634829	156072	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062742	156072	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134154417	152704	0	None	2	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3972973	152704	0	None	2	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137631865	156334	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4065769	156334	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134145750	149145	0	None	-3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3943430	149145	0	None	-3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134142450	145446	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3914253	145446	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	134140073	146321	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3921062	146321	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	46892131	144671	2	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	144671	2	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	51350138	58849	0	None	-660	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL1688473	58849	0	None	-660	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	86343792	164681	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	475	7	1	3	6.3	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2018.02.013
	CHEMBL4216937	164681	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	475	7	1	3	6.3	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2018.02.013
	60195038	81792	0	None	-912	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164239	81792	0	None	-912	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	85472487	162477	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4167097	162477	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	51350272	58841	0	None	-107	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1688465	58841	0	None	-107	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	145985219	165464	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	420	9	1	4	5.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4239630	165464	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	420	9	1	4	5.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	90406893	164435	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	454	8	1	4	5.3	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4213710	164435	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	454	8	1	4	5.3	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134148736	148554	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3938783	148554	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	86281121	164012	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	451	7	1	3	6.4	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4208442	164012	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	451	7	1	3	6.4	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	134138802	147919	0	None	4	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	147919	0	None	4	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	137649416	157519	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4079893	157519	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	134150245	152245	0	None	6	3	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968947	152245	0	None	6	3	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137657968	159592	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4103081	159592	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90407263	163599	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4203559	163599	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	57521917	76275	0	None	-8	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058530	76275	0	None	-8	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	90418067	162331	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	9	1	5	5.6	CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4164722	162331	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	9	1	5	5.6	CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	86343790	163939	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	441	7	1	3	5.9	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl	10.1016/j.bmcl.2018.02.013
	CHEMBL4207603	163939	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	441	7	1	3	5.9	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl	10.1016/j.bmcl.2018.02.013
	145984796	165742	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	9	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246396	165742	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	9	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	90405989	155960	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4061340	155960	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	60195040	81794	0	None	-5248	2	Human	4.0	pEC50	=	4.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164241	81794	0	None	-5248	2	Human	4.0	pEC50	=	4.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	134132142	144869	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	144869	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	134132142	144869	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3909872	144869	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	145971522	163116	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4177287	163116	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	134142866	145642	0	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3915765	145642	0	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	57522038	3887	60	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	3887	60	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	3887	60	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	137634844	156116	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4063239	156116	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	23136363	58833	0	None	-14	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL1688458	58833	0	None	-14	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	134141029	147167	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3927879	147167	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	82051616	159457	1	None	12	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	159457	1	None	12	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	73777063	1154	39	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	1154	39	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	1154	39	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	85472618	162310	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4164509	162310	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	137640323	156978	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4073013	156978	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	5588	1861	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	9976563	1861	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	CHEMBL513978	1861	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	11531145	1862	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	19471906
	11531145	1862	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	20685848
	5589	1862	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	19471906
	5589	1862	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	20685848
	1054	2917	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	3400	2917	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	445639	2917	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	CHEMBL8659	2917	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	1052	2321	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	3323	2321	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	5280450	2321	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	CHEMBL267476	2321	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	DB14104	2321	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	11195	3882	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	86280676	3882	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	CHEMBL3941880	3882	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	11195	3882	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	86280676	3882	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	CHEMBL3941880	3882	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	73777063	1154	39	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	8418	1154	39	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	CHEMBL3919973	1154	39	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	1054	2917	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	3400	2917	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	445639	2917	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	CHEMBL8659	2917	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	1049	363	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	4618	363	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	5280934	363	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	CHEMBL8739	363	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	DB00132	363	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	11005	2694	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	2806	2694	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	CHEMBL111077	2694	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	DB08231	2694	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	1050	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	1050	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	11595431	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	11595431	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	CHEMBL207881	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	CHEMBL207881	1902	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	1049	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	4618	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	5280934	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	CHEMBL8739	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	DB00132	363	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	1052	2321	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	3323	2321	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	5280450	2321	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	CHEMBL267476	2321	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	DB14104	2321	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	25098573	2747	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110
	5587	2747	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110
	CHEMBL463785	2747	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		134154473	152374	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3970238	152374	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		73776979	143359	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3897637	143359	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		137638318	156734	0	None	-	1	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4070359	156734	0	None	-	1	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
		CHEMBL5266523	193485	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	484	10	2	8	3.7	Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5269688	193605	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5278791	193996	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5283726	194227	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.3	Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		127031569	139184	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
		CHEMBL3787580	139184	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
		145971522	163116	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
		CHEMBL4177287	163116	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
		134129938	142440	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3890089	142440	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		156011529	177397	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	420	7	1	3	6.2	CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1	10.1016/j.bmc.2019.115263
		CHEMBL4638249	177397	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	420	7	1	3	6.2	CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1	10.1016/j.bmc.2019.115263
		134132142	144869	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
		CHEMBL3909872	144869	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
		73777175	143909	0	None	-	0	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3901994	143909	0	None	-	0	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
		85472621	162803	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
		CHEMBL4172392	162803	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
		66562488	90371	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
		CHEMBL2386364	90371	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
		CHEMBL5274344	193810	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	492	6	2	7	4.9	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5286838	194359	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulation	ChEMBL	362	3	0	4	3.6	C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.0c01002
		73777153	142823	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3893026	142823	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL5276740	193913	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	417	6	2	8	4.3	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		CHEMBL5281423	194111	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	442	6	2	7	4.0	Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5288340	194417	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	482	9	2	8	3.9	COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1	10.1021/acsmedchemlett.2c00160
		137640163	156848	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4071523	156848	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
		CHEMBL5284985	194274	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	389	5	2	8	3.5	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
		11195	3882	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		86280676	3882	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		CHEMBL3941880	3882	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		CHEMBL5275980	193881	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assay	ChEMBL	462	7	1	3	6.9	OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F	10.1021/acs.jmedchem.0c01002
		134153222	152525	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3971461	152525	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL5286544	194350	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	457	5	2	8	4.8	Cc1c(Cl)cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		11195	3882	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		86280676	3882	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		CHEMBL3941880	3882	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		145955668	162425	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
		CHEMBL4166208	162425	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
		162644046	181810	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	361	4	2	5	3.0	Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4778107	181810	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	361	4	2	5	3.0	Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		134146720	149131	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3943315	149131	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		134146958	149609	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3947070	149609	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		134147601	150028	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3950444	150028	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		90418139	162581	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL4168786	162581	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL5272492	193727	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	403	6	2	8	3.8	CCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		90418650	157355	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
		CHEMBL4077787	157355	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
		134132711	144938	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3910333	144938	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
		73345869	90362	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		CHEMBL2386355	90362	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		CHEMBL5281020	194096	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	442	6	2	7	4.0	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3F)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		134133992	143739	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3900705	143739	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		73777135	150370	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		CHEMBL3953289	150370	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		73777175	143909	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3901994	143909	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL5287358	194381	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	448	9	2	8	3.1	COc1ccccc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1	10.1021/acsmedchemlett.2c00160
		CHEMBL5288405	194423	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	448	9	2	8	3.1	COc1cccc(CCNc2nc(N)nc(COc3cc(C)cc(N4CCCC4=O)c3)n2)c1	10.1021/acsmedchemlett.2c00160
		90418653	137513	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
		CHEMBL3754160	137513	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
		90418278	162379	16	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL4165366	162379	16	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL5283217	194191	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	449	6	2	8	3.7	Cc1ccc(Nc2nc(N)nc(COc3cc(C#N)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5277986	193961	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3C)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		25150014	3885	55	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
		3952	3885	55	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
		CHEMBL449588	3885	55	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
		CHEMBL5266881	193500	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	458	6	2	7	4.5	Cc1ccc(Nc2nc(N)nc(COc3cc(Cl)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5290885	194517	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	423	5	2	8	4.2	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		134151903	153356	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3978465	153356	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
		134133797	143568	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3899190	143568	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
		162674347	183121	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4794951	183121	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2020.127650
		90418651	162413	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
		CHEMBL4166012	162413	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
		CHEMBL5289099	194460	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	425	6	2	8	4.1	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C(F)F)cc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
		57522038	3887	60	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
		6490	3887	60	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
		CHEMBL2058533	3887	60	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
		66562385	90368	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		CHEMBL2386361	90368	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		134134229	143255	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
		CHEMBL3896657	143255	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
		134138802	147919	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
		CHEMBL3933619	147919	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
		134145071	150167	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3951664	150167	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL5275980	193881	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulation	ChEMBL	462	7	1	3	6.9	OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F	10.1021/acs.jmedchem.0c01002
		CHEMBL5278703	193990	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.3	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		134152545	153477	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
		CHEMBL3979588	153477	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
		134154975	151400	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	362	5	1	4	4.0	O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
		CHEMBL3961620	151400	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	362	5	1	4	4.0	O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
		90418513	162623	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
		CHEMBL4169436	162623	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
		134155950	151090	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
		CHEMBL3959068	151090	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
		134155847	151102	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3959144	151102	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		134155480	151251	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3960231	151251	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		137654131	159014	0	None	-	0	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		CHEMBL4096579	159014	0	None	-	0	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		134143370	145803	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
		CHEMBL3916986	145803	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
		CHEMBL5290651	194506	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	432	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		127031003	139144	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		CHEMBL3787072	139144	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		8452407	180386	6	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	293	4	2	5	2.0	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-]	10.1016/j.bmcl.2020.127650
		CHEMBL4751828	180386	6	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	293	4	2	5	2.0	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-]	10.1016/j.bmcl.2020.127650
		78426052	178092	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	4	6.4	Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1	10.1016/j.bmc.2019.115263
		CHEMBL4647832	178092	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	4	6.4	Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1	10.1016/j.bmc.2019.115263
		CHEMBL5286962	194366	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		90418782	163083	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
		CHEMBL4176642	163083	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
		73777153	142823	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3893026	142823	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
		66562288	139009	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		CHEMBL3785637	139009	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		CHEMBL5285139	194280	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)ccc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		137633489	156600	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
		CHEMBL4068825	156600	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
		134148110	149570	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3946820	149570	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		134134229	143255	0	None	-	0	Mouse	7.7	pEC50	=	7.7	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
		CHEMBL3896657	143255	0	None	-	0	Mouse	7.7	pEC50	=	7.7	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
		90418753	162396	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
		CHEMBL4165803	162396	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
		73776997	154280	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
		CHEMBL3986483	154280	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
		16777240	179779	2	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	330	3	2	3	3.4	Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4744629	179779	2	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	330	3	2	3	3.4	Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL5278789	193995	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	508	7	2	8	4.8	Cc1ccc(Nc2nc(N)nc(COc3cc(OC(F)(F)F)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		156016724	177717	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assayAgonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assay	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.ejmech.2018.04.061
		CHEMBL4642294	177717	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assayAgonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assay	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.ejmech.2018.04.061
		156016724	177717	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.bmc.2019.115263
		CHEMBL4642294	177717	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.bmc.2019.115263
		73777111	149710	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3947837	149710	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		134153546	152581	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3971857	152581	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		137633536	156295	0	None	-	0	Rat	6.6	pEC50	=	6.6	Binding	Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
		CHEMBL4065397	156295	0	None	-	0	Rat	6.6	pEC50	=	6.6	Binding	Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
		134145778	149347	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3945213	149347	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
		134156727	153634	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
		CHEMBL3980898	153634	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
		137650498	157322	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4077353	157322	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
		134134846	144239	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3904654	144239	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
		137641818	158207	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4087992	158207	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		73777085	153230	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		CHEMBL3977361	153230	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		CHEMBL5285104	194279	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)cc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		137651638	157221	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4076190	157221	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		137646368	158028	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4085695	158028	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
		134154953	151276	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3960369	151276	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
		66562289	139019	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		CHEMBL3785764	139019	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		134153067	152256	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3969073	152256	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
		78425909	177674	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	398	8	1	3	6.1	O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2	10.1016/j.bmc.2019.115263
		CHEMBL4641735	177674	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	398	8	1	3	6.1	O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2	10.1016/j.bmc.2019.115263
		117873187	152344	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3969920	152344	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		73777156	152715	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
		CHEMBL3973034	152715	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
		CHEMBL5267225	193513	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	436	8	2	7	3.3	Cc1cc(OCc2nc(N)nc(NCCc3cccc(F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		837245	10599	46	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL1170012	10599	46	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		73356514	90375	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		CHEMBL2386368	90375	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		73345870	90376	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		CHEMBL2386369	90376	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		73354950	90378	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		CHEMBL2386370	90378	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		73348895	90379	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		CHEMBL2386371	90379	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		CHEMBL5268800	193579	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	452	8	2	7	3.8	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		73777111	149710	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3947837	149710	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL5289929	194485	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	458	6	2	7	4.5	Cc1ccc(Nc2nc(N)nc(COc3ccc(Cl)c(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		156635006	179540	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	400	4	2	4	4.0	Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4741544	179540	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	400	4	2	4	4.0	Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		117886639	148450	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
		CHEMBL3937916	148450	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
		CHEMBL5269158	193593	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	7	2	8	3.9	COc1ccc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc1N1CCCC1=O	10.1021/acsmedchemlett.2c00160
		66562392	90372	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
		CHEMBL2386365	90372	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
		134138281	147786	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3932664	147786	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
		134138802	147919	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
		CHEMBL3933619	147919	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
		134153986	152506	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3971308	152506	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		117886649	152078	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3967504	152078	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL5287009	194371	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	418	8	2	7	3.1	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		118184919	162873	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
		CHEMBL4173280	162873	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
		127030344	139145	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
		CHEMBL3787110	139145	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
		127031002	139087	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		CHEMBL3786526	139087	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
		134132142	144869	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
		CHEMBL3909872	144869	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
		1050	1902	94	None	-	2	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
		11595431	1902	94	None	-	2	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
		CHEMBL207881	1902	94	None	-	2	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
		674995	143004	14	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
		CHEMBL3894632	143004	14	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
		162672256	182872	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	346	4	2	4	3.1	COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4791789	182872	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	346	4	2	4	3.1	COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL5278642	193988	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	443	5	2	8	4.5	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(Cl)c(Cl)c4)n3)ccc12	10.1021/acsmedchemlett.2c00160
		137648938	157412	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4078553	157412	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		73777156	152715	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
		CHEMBL3973034	152715	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
		CHEMBL5283269	194196	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	502	9	2	8	4.0	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3OC(F)(F)F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		71655293	90361	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		CHEMBL2386354	90361	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		71655227	90369	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		CHEMBL2386362	90369	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		134147107	149876	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3949142	149876	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
		156635004	179712	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	344	4	2	3	3.7	CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4743951	179712	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	344	4	2	3	3.7	CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		162674533	183465	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4799103	183465	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
		134144000	150209	0	None	-	0	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3952043	150209	0	None	-	0	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		134132711	144938	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3910333	144938	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL5273939	193787	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(C)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		137660172	159113	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
		CHEMBL4097652	159113	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
		117886639	148450	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
		CHEMBL3937916	148450	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
		127033352	139020	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
		CHEMBL3785789	139020	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
		137658977	159104	0	None	-	0	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4097537	159104	0	None	-	0	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		137649363	157396	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	4	5.0	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4078374	157396	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	4	5.0	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		134146386	148907	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3941726	148907	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		73777174	150454	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3954140	150454	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
		90442039	162909	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
		CHEMBL4173940	162909	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
		134132951	144622	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3907996	144622	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
		137652399	157495	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
		CHEMBL4079621	157495	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
		46892131	144671	2	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3908362	144671	2	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
		134138099	147822	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
		CHEMBL3932897	147822	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
		CHEMBL5289774	194480	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	375	5	2	8	3.2	Cc1ccc(Nc2nc(N)nc(COc3ccc4ccc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
		73507535	177464	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	391	6	1	3	5.5	O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1	10.1016/j.bmc.2019.115263
		CHEMBL4639009	177464	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	391	6	1	3	5.5	O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1	10.1016/j.bmc.2019.115263
		73777065	147256	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3928591	147256	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		137642248	158153	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
		CHEMBL4087308	158153	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
		137643731	158386	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4089919	158386	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
		137658977	159104	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4097537	159104	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		73777069	142669	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3891920	142669	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		11195	3882	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		86280676	3882	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		CHEMBL3941880	3882	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
		67072752	86529	0	None	-	1	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
		CHEMBL2315528	86529	0	None	-	1	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
		127033353	139151	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
		CHEMBL3787151	139151	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
		73777135	150370	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		CHEMBL3953289	150370	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		137632610	156346	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4065890	156346	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		743974	113027	70	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1021/acs.jmedchem.6b00685
		CHEMBL3311308	113027	70	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1021/acs.jmedchem.6b00685
		162673626	183193	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4795755	183193	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		134144000	150209	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3952043	150209	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL5286838	194359	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assay	ChEMBL	362	3	0	4	3.6	C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.0c01002
		134154415	152694	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
		CHEMBL3972870	152694	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
		118679768	177620	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assayAgonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.ejmech.2018.04.061
		CHEMBL4641038	177620	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assayAgonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.ejmech.2018.04.061
		118679768	177620	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.bmc.2019.115263
		CHEMBL4641038	177620	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.bmc.2019.115263
		118679768	177620	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
		CHEMBL4641038	177620	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
		CHEMBL5272316	193716	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	364	8	1	2	5.8	Cc1ccc(C2=C(COc3ccc(CCCC(=O)O)cc3)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
		CHEMBL5285896	194322	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	404	8	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc4c(c3)CCCC4)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
		CHEMBL5268182	193550	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(F)ccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		46908122	151570	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	334	3	0	4	3.8	O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3963275	151570	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	334	3	0	4	3.8	O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
		162676836	183503	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	3	3	4	2.8	Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4799668	183503	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	3	3	4	2.8	Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		90418476	162786	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL4172136	162786	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		137645249	157611	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		CHEMBL4080998	157611	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		137648938	157412	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4078553	157412	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		156635003	180936	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4758125	180936	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		137657813	159774	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4105241	159774	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		134147328	150049	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3950610	150049	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
		162649435	180040	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4747554	180040	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		73777085	153230	0	None	-	0	Mouse	5.3	pEC50	=	5.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		CHEMBL3977361	153230	0	None	-	0	Mouse	5.3	pEC50	=	5.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
		CHEMBL5283683	194225	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	482	9	2	8	3.8	COc1ccc(Cl)cc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1	10.1021/acsmedchemlett.2c00160
		2843133	147647	51	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
		CHEMBL3931570	147647	51	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
		73777063	1154	39	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
		8418	1154	39	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
		CHEMBL3919973	1154	39	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
		137657813	159774	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4105241	159774	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL5278391	193979	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5273250	193754	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	437	6	2	8	4.4	CCc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		134141650	146699	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
		CHEMBL3923955	146699	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
		66562390	90365	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
		CHEMBL2386358	90365	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
		162645828	179663	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4743323	179663	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
		73776995	148742	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3940359	148742	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL5278718	193992	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	424	6	2	7	3.9	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		90118275	177380	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	377	9	1	4	4.8	O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1	10.1016/j.bmc.2019.115263
		CHEMBL4637969	177380	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	377	9	1	4	4.8	O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1	10.1016/j.bmc.2019.115263
		156021563	178025	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.bmc.2019.115263
		CHEMBL4646784	178025	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.bmc.2019.115263
		134155067	151306	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3960738	151306	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		134156727	153634	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
		CHEMBL3980898	153634	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
		CHEMBL5286838	194359	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulation	ChEMBL	362	3	0	4	3.6	C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.0c01002
		CHEMBL5268316	193559	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5268389	193563	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	423	5	2	8	4.2	Cc1cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)ccc1Cl	10.1021/acsmedchemlett.2c00160
		CHEMBL5287642	194388	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	7	2	8	3.9	COc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		137651358	157143	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4075162	157143	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL5278836	193999	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	452	8	2	7	3.8	Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		162656082	180702	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4755578	180702	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		90405673	178010	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	3	6.0	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmc.2019.115263
		CHEMBL4646553	178010	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	3	6.0	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmc.2019.115263
		90417978	161984	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL4159180	161984	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		137645249	157611	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		CHEMBL4080998	157611	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		743974	113027	70	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
		CHEMBL3311308	113027	70	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
		81762207	182747	1	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	266	3	2	3	2.2	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F	10.1016/j.bmcl.2020.127650
		CHEMBL4790052	182747	1	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	266	3	2	3	2.2	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F	10.1016/j.bmcl.2020.127650
		CHEMBL5266170	193470	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	480	6	2	7	5.2	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)cc(C(C)(C)C)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
		137649555	157330	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4077507	157330	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		137656733	159584	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4102951	159584	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		66562388	90374	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		CHEMBL2386367	90374	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
		73777063	1154	39	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
		8418	1154	39	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
		CHEMBL3919973	1154	39	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
		85470884	164004	2	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
		CHEMBL4208325	164004	2	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
		137637713	155856	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4060171	155856	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		134133355	143536	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3898962	143536	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		137633536	156295	0	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
		CHEMBL4065397	156295	0	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
		73777069	142669	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3891920	142669	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL5266730	193490	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)cc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		85472618	162310	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
		CHEMBL4164509	162310	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
		156016929	177725	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
		CHEMBL4642324	177725	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
		137659366	159431	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4101071	159431	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
		137638317	156722	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
		CHEMBL4070273	156722	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
		CHEMBL5267671	193535	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	446	8	2	7	3.7	Cc1cc(OCc2nc(N)nc(NCCc3c(C)cccc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		137638318	156734	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4070359	156734	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
		127031001	139133	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
		CHEMBL3786972	139133	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
		137651153	157204	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4076004	157204	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		67072752	86529	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
		CHEMBL2315528	86529	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
		137654131	159014	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		CHEMBL4096579	159014	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
		134131620	142432	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3890035	142432	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		66562286	90366	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
		CHEMBL2386359	90366	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
		134153298	152366	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3970166	152366	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		134131874	144857	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL3909773	144857	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
		CHEMBL5289306	194464	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5267354	193523	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	503	9	2	9	3.0	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3N3CCOCC3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		85472227	162188	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL4162566	162188	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
		66562389	90367	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
		CHEMBL2386360	90367	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
		134156455	154321	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
		CHEMBL3986721	154321	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
		137637713	155856	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		CHEMBL4060171	155856	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
		25149901	186686	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
		CHEMBL488384	186686	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
		25149901	186686	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
		CHEMBL488384	186686	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
		85472225	162761	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL4171724	162761	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		16775835	180163	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	316	3	2	3	3.1	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4748982	180163	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	316	3	2	3	3.1	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		134152336	153456	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
		CHEMBL3979448	153456	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
		16770747	182171	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	334	3	2	3	3.2	Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		CHEMBL4782622	182171	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	334	3	2	3	3.2	Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
		134145700	148751	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		CHEMBL3940429	148751	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
		137656733	159584	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4102951	159584	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL5275546	193861	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3c(F)cccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		CHEMBL5282108	194145	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		90418333	162655	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
		CHEMBL4169851	162655	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
		71655226	90364	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
		CHEMBL2386357	90364	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
		73777174	150454	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL3954140	150454	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
		CHEMBL5285725	194311	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	446	8	2	7	3.7	Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)cc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
		6483	3886	54	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		66553168	3886	54	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		CHEMBL2386353	3886	54	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
		66562386	90370	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		CHEMBL2386363	90370	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
		127033020	139076	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
		CHEMBL3786418	139076	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
		162652317	180321	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4751137	180321	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		162672935	183202	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	7	1	4	3.2	COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		CHEMBL4795858	183202	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	7	1	4	3.2	COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
		85472359	162129	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
		CHEMBL4161536	162129	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
		85472487	162477	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
		CHEMBL4167097	162477	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
		145960576	162152	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		CHEMBL4161929	162152	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
		137637243	155889	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
		CHEMBL4060517	155889	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
		134135468	144475	0	None	-	0	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
		CHEMBL3906716	144475	0	None	-	0	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
		233085	113023	48	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
		CHEMBL3311302	113023	48	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
		233085	113023	48	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
		CHEMBL3311302	113023	48	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
		233085	113023	48	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
		CHEMBL3311302	113023	48	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012

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Main reference

Ligand source activities (1 row/activity)