Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 137642920 | 164894 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4086893 | 164894 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134157586 | 160942 | 0 | None | -3 | 3 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 366 | 8 | 1 | 3 | 5.5 | O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3985509 | 160942 | 0 | None | -3 | 3 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 366 | 8 | 1 | 3 | 5.5 | O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90407037 | 164067 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 377 | 8 | 1 | 3 | 5.3 | CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4076902 | 164067 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 377 | 8 | 1 | 3 | 5.3 | CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90405670 | 171473 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 425 | 7 | 1 | 3 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4217143 | 171473 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 425 | 7 | 1 | 3 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 118707082 | 119785 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.3 | COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311196 | 119785 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 309 | 4 | 1 | 3 | 3.3 | COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 925016 | 119807 | 16 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 289 | 3 | 1 | 2 | 3.7 | Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311314 | 119807 | 16 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 289 | 3 | 1 | 2 | 3.7 | Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137649416 | 164298 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4079893 | 164298 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 82051616 | 166236 | 1 | None | 12 | 2 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4101323 | 166236 | 1 | None | 12 | 2 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2017.01.034 | ||
| 975397 | 119813 | 9 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 335 | 5 | 1 | 4 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311324 | 119813 | 9 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 335 | 5 | 1 | 4 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC | 10.1016/j.bmcl.2014.05.012 | ||
| 137634844 | 162895 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 412 | 9 | 1 | 3 | 6.1 | CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4063239 | 162895 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 412 | 9 | 1 | 3 | 6.1 | CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 137640323 | 163757 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 358 | 7 | 1 | 4 | 4.3 | O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4073013 | 163757 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 358 | 7 | 1 | 4 | 4.3 | O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137653973 | 165463 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 354 | 6 | 2 | 3 | 4.3 | Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4093067 | 165463 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 354 | 6 | 2 | 3 | 4.3 | Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O | 10.1016/j.bmcl.2017.01.034 | ||
| 134133275 | 150421 | 0 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3899885 | 150421 | 0 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 85472225 | 169540 | 0 | None | -2 | 3 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4171724 | 169540 | 0 | None | -2 | 3 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 134133797 | 150346 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 338 | 3 | 0 | 4 | 3.6 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3899190 | 150346 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 338 | 3 | 0 | 4 | 3.6 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 85472621 | 169582 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4172392 | 169582 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| 145955668 | 169204 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 415 | 7 | 1 | 4 | 6.0 | Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4166208 | 169204 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 415 | 7 | 1 | 4 | 6.0 | Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| 134149615 | 155355 | 0 | None | 1 | 3 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3939004 | 155355 | 0 | None | 1 | 3 | Mouse | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137640701 | 163868 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 427 | 9 | 1 | 4 | 6.2 | CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4074388 | 163868 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 427 | 9 | 1 | 4 | 6.2 | CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 137636217 | 162872 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4063013 | 162872 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 137642920 | 164894 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4086893 | 164894 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 390 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 90418476 | 169565 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 511 | 7 | 1 | 4 | 6.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4172136 | 169565 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 511 | 7 | 1 | 4 | 6.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 57521919 | 83052 | 0 | None | 23 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058532 | 83052 | 0 | None | 23 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL4207911 | 83052 | 0 | None | 23 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| 137636217 | 162872 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4063013 | 162872 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 425 | 8 | 1 | 4 | 6.1 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134138099 | 154600 | 0 | None | 4 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3932897 | 154600 | 0 | None | 4 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | ||
| 60195036 | 88496 | 0 | None | -630 | 2 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 481 | 12 | 2 | 5 | 5.1 | Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm3002026 | ||
| CHEMBL2163924 | 88496 | 0 | None | -630 | 2 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 481 | 12 | 2 | 5 | 5.1 | Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm3002026 | ||
| 137632299 | 163246 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 455 | 7 | 1 | 4 | 5.8 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4067368 | 163246 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 455 | 7 | 1 | 4 | 5.8 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90406631 | 171213 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 503 | 7 | 1 | 3 | 6.1 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4213709 | 171213 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 503 | 7 | 1 | 3 | 6.1 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 137643228 | 165035 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 457 | 8 | 1 | 5 | 5.2 | COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4088620 | 165035 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 457 | 8 | 1 | 5 | 5.2 | COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137647721 | 164609 | 0 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.5 | CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4083440 | 164609 | 0 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.5 | CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 59455584 | 163820 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 8 | 1 | 4 | 4.6 | CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4073815 | 163820 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 378 | 8 | 1 | 4 | 4.6 | CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90406228 | 170481 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 453 | 8 | 1 | 3 | 5.9 | CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4204928 | 170481 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 453 | 8 | 1 | 3 | 5.9 | CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| 561372 | 65601 | 65 | None | -20 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 256 | 6 | 1 | 2 | 3.3 | O=C(O)CCc1ccc(OCc2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1688452 | 65601 | 65 | None | -20 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 256 | 6 | 1 | 2 | 3.3 | O=C(O)CCc1ccc(OCc2ccccc2)cc1 | 10.1021/jm300215x | ||
| 86343591 | 170482 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 457 | 7 | 1 | 3 | 5.8 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4204946 | 170482 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 457 | 7 | 1 | 3 | 5.8 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134133275 | 150421 | 0 | None | 8 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3899885 | 150421 | 0 | None | 8 | 2 | Mouse | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137643958 | 165058 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 505 | 7 | 1 | 4 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4088889 | 165058 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 505 | 7 | 1 | 4 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137657488 | 166459 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 441 | 7 | 1 | 4 | 5.5 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4104082 | 166459 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 441 | 7 | 1 | 4 | 5.5 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90418753 | 169175 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 4 | 6.6 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4165803 | 169175 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 4 | 6.6 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 73777111 | 156489 | 0 | None | -1 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3947837 | 156489 | 0 | None | -1 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 25098573 | 9523 | 8 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 10.1021/jm800970b | ||
| 5587 | 9523 | 8 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 10.1021/jm800970b | ||
| CHEMBL463785 | 9523 | 8 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 10.1021/jm800970b | ||
| 134141270 | 153588 | 0 | None | -3 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 334 | 8 | 1 | 3 | 4.6 | CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3924759 | 153588 | 0 | None | -3 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 334 | 8 | 1 | 3 | 4.6 | CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90418849 | 169475 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 473 | 7 | 1 | 4 | 6.5 | Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4170501 | 169475 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 473 | 7 | 1 | 4 | 6.5 | Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O | 10.1021/acsmedchemlett.7b00233 | ||
| 8190724 | 119806 | 6 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 4.3 | Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311313 | 119806 | 6 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 359 | 4 | 1 | 3 | 4.3 | Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 258072 | 86863 | 25 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 275 | 3 | 1 | 2 | 3.4 | Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL2131154 | 86863 | 25 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 275 | 3 | 1 | 2 | 3.4 | Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 91824000 | 119805 | 8 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311312 | 119805 | 8 | None | - | 1 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137647721 | 164609 | 0 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.5 | CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4083440 | 164609 | 0 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.5 | CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 57521919 | 83052 | 0 | None | 23 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL2058532 | 83052 | 0 | None | 23 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL4207911 | 83052 | 0 | None | 23 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| 54586011 | 68582 | 0 | None | -14 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 324 | 6 | 1 | 2 | 4.3 | O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1773257 | 68582 | 0 | None | -14 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 324 | 6 | 1 | 2 | 4.3 | O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm300215x | ||
| 137640701 | 163868 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 427 | 9 | 1 | 4 | 6.2 | CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4074388 | 163868 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 427 | 9 | 1 | 4 | 6.2 | CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134151903 | 160135 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 438 | 6 | 1 | 6 | 4.2 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3978465 | 160135 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 438 | 6 | 1 | 6 | 4.2 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 73777069 | 149447 | 0 | None | -1 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3891920 | 149447 | 0 | None | -1 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 73777174 | 157233 | 0 | None | 2 | 2 | Mouse | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3954140 | 157233 | 0 | None | 2 | 2 | Mouse | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 134136175 | 149458 | 0 | None | 1 | 3 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3892019 | 149458 | 0 | None | 1 | 3 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 643684 | 114292 | 63 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 298 | 15 | 2 | 2 | 5.1 | CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| CHEMBL3186422 | 114292 | 63 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 298 | 15 | 2 | 2 | 5.1 | CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| 86343965 | 170590 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 443 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4206168 | 170590 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 443 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 90418650 | 164134 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4077787 | 164134 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 85470884 | 170783 | 2 | None | 2 | 5 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4208325 | 170783 | 2 | None | 2 | 5 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134149615 | 155355 | 0 | None | -1 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3939004 | 155355 | 0 | None | -1 | 3 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90406583 | 171440 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 416 | 7 | 1 | 4 | 4.9 | N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4216721 | 171440 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 416 | 7 | 1 | 4 | 4.9 | N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| 134144000 | 156988 | 0 | None | -1 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3952043 | 156988 | 0 | None | -1 | 2 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 134154415 | 159473 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 447 | 6 | 1 | 5 | 6.3 | Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3972870 | 159473 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 447 | 6 | 1 | 5 | 6.3 | Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 | 10.1021/acsmedchemlett.6b00394 | ||
| 137640328 | 163763 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4073078 | 163763 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F | 10.1016/j.bmcl.2017.06.028 | ||
| 134133675 | 150040 | 0 | None | 2 | 3 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 318 | 8 | 1 | 3 | 4.1 | CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3896714 | 150040 | 0 | None | 2 | 3 | Mouse | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 318 | 8 | 1 | 3 | 4.1 | CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 1050 | 8683 | 94 | None | -26 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1021/jm300215x | ||
| 11595431 | 8683 | 94 | None | -26 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1021/jm300215x | ||
| CHEMBL207881 | 8683 | 94 | None | -26 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1021/jm300215x | ||
| 85471695 | 165448 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4092882 | 165448 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137657736 | 166417 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 385 | 7 | 1 | 4 | 5.2 | Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4103573 | 166417 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 385 | 7 | 1 | 4 | 5.2 | Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 90405989 | 162739 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 383 | 7 | 1 | 3 | 5.3 | Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4061340 | 162739 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 383 | 7 | 1 | 3 | 5.3 | Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 137653883 | 165301 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 493 | 7 | 1 | 4 | 6.6 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4091291 | 165301 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 493 | 7 | 1 | 4 | 6.6 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F | 10.1016/j.bmcl.2017.06.028 | ||
| 11195 | 10654 | 0 | None | -1 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| 86280676 | 10654 | 0 | None | -1 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3941880 | 10654 | 0 | None | -1 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| 87055315 | 172536 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 349 | 8 | 2 | 3 | 4.7 | CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4246850 | 172536 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 349 | 8 | 2 | 3 | 4.7 | CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 | 10.1016/j.bmcl.2018.06.047 | ||
| 145986046 | 172691 | 0 | None | 19 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 437 | 10 | 1 | 6 | 4.3 | CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4250196 | 172691 | 0 | None | 19 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 437 | 10 | 1 | 6 | 4.3 | CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 142738582 | 191299 | 0 | None | -42 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 293 | 4 | 2 | 1 | 4.5 | Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1 | 10.1021/acs.jmedchem.1c00031 | ||
| CHEMBL4847662 | 191299 | 0 | None | -42 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 293 | 4 | 2 | 1 | 4.5 | Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1 | 10.1021/acs.jmedchem.1c00031 | ||
| 134157207 | 160990 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 386 | 7 | 1 | 3 | 5.3 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3985939 | 160990 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 386 | 7 | 1 | 3 | 5.3 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 134135468 | 151253 | 0 | None | -1 | 2 | Mouse | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 4.8 | O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3906716 | 151253 | 0 | None | -1 | 2 | Mouse | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 4.8 | O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| 134145700 | 155530 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 400 | 7 | 1 | 4 | 5.0 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3940429 | 155530 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 400 | 7 | 1 | 4 | 5.0 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 134155067 | 158085 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 401 | 7 | 1 | 5 | 4.4 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3960738 | 158085 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 401 | 7 | 1 | 5 | 4.4 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 137646995 | 164612 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 391 | 7 | 1 | 4 | 5.0 | O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4083499 | 164612 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 391 | 7 | 1 | 4 | 5.0 | O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137660451 | 166024 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 445 | 7 | 1 | 4 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4099026 | 166024 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 445 | 7 | 1 | 4 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 134151115 | 158978 | 0 | None | -4 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 336 | 6 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3968537 | 158978 | 0 | None | -4 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 336 | 6 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90418653 | 144291 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL3754160 | 144291 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| 86343594 | 170376 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 7 | 1 | 3 | 5.6 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4203544 | 170376 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 7 | 1 | 3 | 5.6 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 137641343 | 163836 | 0 | None | 117 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4074009 | 163836 | 0 | None | 117 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134132142 | 151647 | 0 | None | 13 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3909872 | 151647 | 0 | None | 13 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | ||
| 134132142 | 151647 | 0 | None | 13 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3909872 | 151647 | 0 | None | 13 | 2 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 57522038 | 10659 | 60 | None | 6 | 3 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| 6490 | 10659 | 60 | None | 6 | 3 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| CHEMBL2058533 | 10659 | 60 | None | 6 | 3 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| 137635671 | 162770 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4061699 | 162770 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137632299 | 163246 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 455 | 7 | 1 | 4 | 5.8 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4067368 | 163246 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 455 | 7 | 1 | 4 | 5.8 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137661886 | 166106 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 453 | 7 | 1 | 4 | 6.2 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4099943 | 166106 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 453 | 7 | 1 | 4 | 6.2 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 137657968 | 166371 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4103081 | 166371 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90418139 | 169360 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 443 | 7 | 1 | 4 | 5.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4168786 | 169360 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 443 | 7 | 1 | 4 | 5.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 90406219 | 171093 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 469 | 7 | 1 | 3 | 5.8 | O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4212281 | 171093 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 469 | 7 | 1 | 3 | 5.8 | O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| 90406961 | 170561 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 445 | 7 | 1 | 3 | 5.9 | OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4205879 | 170561 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 445 | 7 | 1 | 3 | 5.9 | OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| 90406842 | 171485 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 427 | 7 | 1 | 3 | 5.5 | Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4217252 | 171485 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 427 | 7 | 1 | 3 | 5.5 | Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| 85472222 | 169845 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 437 | 9 | 1 | 4 | 6.7 | CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4176414 | 169845 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 437 | 9 | 1 | 4 | 6.7 | CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 51349861 | 65603 | 0 | None | -77 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.1 | O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1688454 | 65603 | 0 | None | -77 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.1 | O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1 | 10.1021/jm300215x | ||
| 10466 | 173449 | 80 | None | 12 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 272 | 15 | 2 | 2 | 4.5 | O=C(O)CCCCCCCCCCCCCCCO | 10.1039/C7MD00130D | ||
| CHEMBL4281719 | 173449 | 80 | None | 12 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 272 | 15 | 2 | 2 | 4.5 | O=C(O)CCCCCCCCCCCCCCCO | 10.1039/C7MD00130D | ||
| 134153222 | 159304 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3971461 | 159304 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 134134149 | 150153 | 0 | None | -2 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3897776 | 150153 | 0 | None | -2 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134155480 | 158030 | 0 | None | 38 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3960231 | 158030 | 0 | None | 38 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 137648785 | 164389 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 427 | 7 | 1 | 4 | 5.2 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4080995 | 164389 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 427 | 7 | 1 | 4 | 5.2 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137655521 | 165768 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 467 | 8 | 1 | 4 | 6.1 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4096332 | 165768 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 467 | 8 | 1 | 4 | 6.1 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 25109512 | 196543 | 0 | None | 12 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 382 | 10 | 1 | 5 | 4.8 | O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1 | 10.1021/jm800970b | ||
| CHEMBL515995 | 196543 | 0 | None | 12 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 382 | 10 | 1 | 5 | 4.8 | O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1 | 10.1021/jm800970b | ||
| 137641343 | 163836 | 0 | None | 117 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4074009 | 163836 | 0 | None | 117 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 90418782 | 169862 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 513 | 7 | 1 | 4 | 6.6 | O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4176642 | 169862 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 513 | 7 | 1 | 4 | 6.6 | O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| 90407441 | 170493 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 417 | 7 | 1 | 3 | 6.0 | Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4205035 | 170493 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 417 | 7 | 1 | 3 | 6.0 | Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| 54580132 | 68578 | 0 | None | -3 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 334 | 6 | 1 | 2 | 4.0 | O=C(O)CCc1ccc(OCc2ccccc2Br)cc1 | 10.1021/jm300215x | ||
| CHEMBL1773253 | 68578 | 0 | None | -3 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 334 | 6 | 1 | 2 | 4.0 | O=C(O)CCc1ccc(OCc2ccccc2Br)cc1 | 10.1021/jm300215x | ||
| 7789 | 107461 | 88 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 300 | 16 | 2 | 2 | 5.3 | CCCCCCC(O)CCCCCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| CHEMBL292352 | 107461 | 88 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 300 | 16 | 2 | 2 | 5.3 | CCCCCCC(O)CCCCCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| 86343595 | 171474 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 7 | 1 | 3 | 5.6 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4217161 | 171474 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 461 | 7 | 1 | 3 | 5.6 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 137646145 | 164803 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 385 | 7 | 1 | 4 | 5.2 | Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4085643 | 164803 | 0 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 385 | 7 | 1 | 4 | 5.2 | Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 57521809 | 83039 | 0 | None | 13 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058520 | 83039 | 0 | None | 13 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL4210970 | 83039 | 0 | None | 13 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| 86294762 | 170894 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 477 | 7 | 1 | 3 | 6.2 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4209823 | 170894 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 477 | 7 | 1 | 3 | 6.2 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134133355 | 150314 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 413 | 6 | 1 | 5 | 4.2 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3898962 | 150314 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 413 | 6 | 1 | 5 | 4.2 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 137657488 | 166459 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 441 | 7 | 1 | 4 | 5.5 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4104082 | 166459 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 441 | 7 | 1 | 4 | 5.5 | Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 134146386 | 155686 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3941726 | 155686 | 0 | None | - | 1 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 46892131 | 151449 | 2 | None | -3 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3908362 | 151449 | 2 | None | -3 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 134143163 | 152522 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.7 | Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3916564 | 152522 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.7 | Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90406575 | 171133 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 455 | 8 | 1 | 4 | 5.4 | COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4212717 | 171133 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 455 | 8 | 1 | 4 | 5.4 | COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134136175 | 149458 | 0 | None | -1 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3892019 | 149458 | 0 | None | -1 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 145983493 | 172283 | 0 | None | 371 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 442 | 10 | 1 | 4 | 5.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4240607 | 172283 | 0 | None | 371 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 442 | 10 | 1 | 4 | 5.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 134146021 | 155843 | 0 | None | -5 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 392 | 7 | 1 | 3 | 5.3 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3942922 | 155843 | 0 | None | -5 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 392 | 7 | 1 | 3 | 5.3 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134154330 | 159659 | 0 | None | 1 | 2 | Mouse | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 340 | 7 | 1 | 3 | 4.5 | O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3974501 | 159659 | 0 | None | 1 | 2 | Mouse | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 340 | 7 | 1 | 3 | 4.5 | O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137638355 | 163608 | 0 | None | 97 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 318 | 6 | 1 | 2 | 4.6 | Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4071290 | 163608 | 0 | None | 97 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 318 | 6 | 1 | 2 | 4.6 | Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134147174 | 156482 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 370 | 6 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3947787 | 156482 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 370 | 6 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137649360 | 164165 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4078286 | 164165 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90418662 | 165720 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 395 | 8 | 1 | 4 | 5.6 | CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4095819 | 165720 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 395 | 8 | 1 | 4 | 5.6 | CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 73777175 | 150687 | 0 | None | 1 | 3 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3901994 | 150687 | 0 | None | 1 | 3 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 57521814 | 83044 | 0 | None | 10 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.0 | COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058525 | 83044 | 0 | None | 10 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.0 | COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| 90418662 | 165720 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 395 | 8 | 1 | 4 | 5.6 | CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4095819 | 165720 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 395 | 8 | 1 | 4 | 5.6 | CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 85470884 | 170783 | 2 | None | -2 | 5 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4208325 | 170783 | 2 | None | -2 | 5 | Mouse | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 57521808 | 83038 | 0 | None | -3 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| CHEMBL2058519 | 83038 | 0 | None | -3 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| 57521809 | 83039 | 0 | None | 13 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL2058520 | 83039 | 0 | None | 13 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL4210970 | 83039 | 0 | None | 13 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| 90442468 | 171261 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 4.8 | COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4214224 | 171261 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 4.8 | COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134156096 | 158226 | 0 | None | -5 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 400 | 8 | 1 | 3 | 6.2 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3961950 | 158226 | 0 | None | -5 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 400 | 8 | 1 | 3 | 6.2 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137638355 | 163608 | 0 | None | 97 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 318 | 6 | 1 | 2 | 4.6 | Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4071290 | 163608 | 0 | None | 97 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 318 | 6 | 1 | 2 | 4.6 | Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137642604 | 165296 | 0 | None | 41 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4091228 | 165296 | 0 | None | 41 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 137632403 | 163083 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 386 | 8 | 1 | 4 | 4.9 | COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4065447 | 163083 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 386 | 8 | 1 | 4 | 4.9 | COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 84481843 | 119812 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 333 | 5 | 1 | 3 | 4.2 | Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311322 | 119812 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 333 | 5 | 1 | 3 | 4.2 | Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 8190727 | 119815 | 5 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 347 | 3 | 1 | 4 | 3.6 | Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311326 | 119815 | 5 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 347 | 3 | 1 | 4 | 3.6 | Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137632403 | 163083 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 386 | 8 | 1 | 4 | 4.9 | COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4065447 | 163083 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 386 | 8 | 1 | 4 | 4.9 | COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 134153562 | 159502 | 0 | None | -2 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 394 | 7 | 1 | 3 | 4.9 | O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3973101 | 159502 | 0 | None | -2 | 3 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 394 | 7 | 1 | 3 | 4.9 | O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F | 10.1016/j.bmcl.2016.10.054 | ||
| 87055315 | 172536 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 349 | 8 | 2 | 3 | 4.7 | CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4246850 | 172536 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 349 | 8 | 2 | 3 | 4.7 | CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1 | 10.1016/j.bmcl.2018.06.047 | ||
| 73777156 | 159494 | 0 | None | -1 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3973034 | 159494 | 0 | None | -1 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| 137642604 | 165296 | 0 | None | 41 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4091228 | 165296 | 0 | None | 41 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 90418651 | 169192 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 469 | 8 | 1 | 4 | 6.6 | CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4166012 | 169192 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 469 | 8 | 1 | 4 | 6.6 | CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | ||
| 59455552 | 162820 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 384 | 7 | 1 | 4 | 4.7 | Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4062462 | 162820 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 384 | 7 | 1 | 4 | 4.7 | Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134154417 | 159483 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3972973 | 159483 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 57521813 | 83043 | 0 | None | -1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 400 | 7 | 1 | 2 | 6.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058524 | 83043 | 0 | None | -1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 400 | 7 | 1 | 2 | 6.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm300215x | ||
| 134134846 | 151017 | 0 | None | -1 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 337 | 3 | 0 | 3 | 4.2 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3904654 | 151017 | 0 | None | -1 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 337 | 3 | 0 | 3 | 4.2 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 54582149 | 68580 | 0 | None | -33 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 281 | 6 | 1 | 3 | 3.2 | N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| CHEMBL1773255 | 68580 | 0 | None | -33 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 281 | 6 | 1 | 3 | 3.2 | N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| 134146958 | 156388 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 388 | 6 | 1 | 3 | 5.1 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3947070 | 156388 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 388 | 6 | 1 | 3 | 5.1 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 73777085 | 160009 | 0 | None | -1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3977361 | 160009 | 0 | None | -1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| 90418650 | 164134 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4077787 | 164134 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| 90418650 | 164134 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4077787 | 164134 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 57521913 | 83045 | 0 | None | 2 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 376 | 9 | 1 | 3 | 5.3 | CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058526 | 83045 | 0 | None | 2 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 376 | 9 | 1 | 3 | 5.3 | CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| 134145750 | 155924 | 0 | None | 3 | 2 | Mouse | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 324 | 6 | 1 | 2 | 4.6 | O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3943430 | 155924 | 0 | None | 3 | 2 | Mouse | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 324 | 6 | 1 | 2 | 4.6 | O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134141029 | 153945 | 0 | None | 4 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 6 | 1 | 3 | 4.8 | O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3927879 | 153945 | 0 | None | 4 | 2 | Mouse | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 6 | 1 | 3 | 4.8 | O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 145984594 | 172712 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 436 | 9 | 1 | 6 | 4.2 | CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4250664 | 172712 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 436 | 9 | 1 | 6 | 4.2 | CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 134156455 | 161100 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 394 | 6 | 1 | 5 | 4.3 | Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3986721 | 161100 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 394 | 6 | 1 | 5 | 4.3 | Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | ||
| 73777153 | 149601 | 0 | None | -2 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3893026 | 149601 | 0 | None | -2 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 137645347 | 164581 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 394 | 7 | 1 | 2 | 6.2 | Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4083233 | 164581 | 0 | None | - | 1 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 394 | 7 | 1 | 2 | 6.2 | Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134147107 | 156655 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 417 | 3 | 1 | 3 | 5.5 | O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3949142 | 156655 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 417 | 3 | 1 | 3 | 5.5 | O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 25150014 | 10657 | 55 | None | -44 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 264 | 3 | 1 | 1 | 3.4 | OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C | 10.1021/jm300215x | ||
| 3952 | 10657 | 55 | None | -44 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 264 | 3 | 1 | 1 | 3.4 | OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C | 10.1021/jm300215x | ||
| CHEMBL449588 | 10657 | 55 | None | -44 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 264 | 3 | 1 | 1 | 3.4 | OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C | 10.1021/jm300215x | ||
| 137646188 | 164384 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 406 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4080936 | 164384 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 406 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 | 10.1016/j.bmcl.2017.01.034 | ||
| 137660451 | 166024 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 445 | 7 | 1 | 4 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4099026 | 166024 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 445 | 7 | 1 | 4 | 5.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 57521915 | 83047 | 0 | None | 15 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 378 | 8 | 1 | 3 | 5.7 | CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058528 | 83047 | 0 | None | 15 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 378 | 8 | 1 | 3 | 5.7 | CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| 11195 | 10654 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| 86280676 | 10654 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3941880 | 10654 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | ||
| 134152545 | 160256 | 0 | None | -3 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3979588 | 160256 | 0 | None | -3 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | ||
| 137636733 | 162983 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 348 | 6 | 1 | 2 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4064298 | 162983 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 348 | 6 | 1 | 2 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br | 10.1016/j.bmcl.2017.01.034 | ||
| 90442039 | 169688 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 509 | 7 | 1 | 4 | 7.1 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4173940 | 169688 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 509 | 7 | 1 | 4 | 7.1 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | ||
| 57521916 | 83048 | 0 | None | 2 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 366 | 7 | 1 | 2 | 5.6 | O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058529 | 83048 | 0 | None | 2 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 366 | 7 | 1 | 2 | 5.6 | O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| 25098573 | 9523 | 8 | None | 8 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 10.1021/jm300215x | ||
| 5587 | 9523 | 8 | None | 8 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 10.1021/jm300215x | ||
| CHEMBL463785 | 9523 | 8 | None | 8 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 10.1021/jm300215x | ||
| 23136411 | 65606 | 0 | None | -11 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1688457 | 65606 | 0 | None | -11 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1 | 10.1021/jm300215x | ||
| 134143370 | 152581 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 442 | 7 | 1 | 6 | 4.0 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3916986 | 152581 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 442 | 7 | 1 | 6 | 4.0 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| 145983824 | 172518 | 0 | None | -6 | 2 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 484 | 13 | 1 | 4 | 6.3 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4246334 | 172518 | 0 | None | -6 | 2 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 484 | 13 | 1 | 4 | 6.3 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 134129938 | 149218 | 0 | None | 263 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 414 | 6 | 1 | 4 | 5.0 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3890089 | 149218 | 0 | None | 263 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 414 | 6 | 1 | 4 | 5.0 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 134153298 | 159145 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 412 | 6 | 1 | 4 | 4.8 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3970166 | 159145 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 412 | 6 | 1 | 4 | 4.8 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 85472225 | 169540 | 0 | None | 2 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4171724 | 169540 | 0 | None | 2 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 134153546 | 159360 | 0 | None | 8 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3971857 | 159360 | 0 | None | 8 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 137636733 | 162983 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 348 | 6 | 1 | 2 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4064298 | 162983 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 348 | 6 | 1 | 2 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br | 10.1016/j.bmcl.2017.01.034 | ||
| 82051652 | 165377 | 1 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 284 | 6 | 1 | 2 | 3.9 | Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4092090 | 165377 | 1 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 284 | 6 | 1 | 2 | 3.9 | Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137654721 | 165518 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 328 | 8 | 1 | 3 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4093589 | 165518 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 328 | 8 | 1 | 3 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C | 10.1016/j.bmcl.2017.01.034 | ||
| 711134 | 119802 | 17 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 291 | 4 | 1 | 3 | 3.1 | COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311305 | 119802 | 17 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 291 | 4 | 1 | 3 | 3.1 | COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137646188 | 164384 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 406 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4080936 | 164384 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 406 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12 | 10.1016/j.bmcl.2017.01.034 | ||
| 134155277 | 158104 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3961009 | 158104 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| 1049 | 7151 | 75 | None | -1 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm800970b | ||
| 4618 | 7151 | 75 | None | -1 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm800970b | ||
| 5280934 | 7151 | 75 | None | -1 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm800970b | ||
| CHEMBL8739 | 7151 | 75 | None | -1 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm800970b | ||
| DB00132 | 7151 | 75 | None | -1 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm800970b | ||
| 90406335 | 170609 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 457 | 7 | 1 | 3 | 5.8 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4206369 | 170609 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 457 | 7 | 1 | 3 | 5.8 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F | 10.1016/j.bmcl.2018.02.013 | ||
| 134138318 | 154798 | 0 | None | 1 | 3 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 378 | 9 | 1 | 4 | 5.4 | COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3934450 | 154798 | 0 | None | 1 | 3 | Mouse | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 378 | 9 | 1 | 4 | 5.4 | COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134144214 | 157137 | 0 | None | 2 | 3 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 384 | 8 | 1 | 3 | 5.7 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3953203 | 157137 | 0 | None | 2 | 3 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 384 | 8 | 1 | 3 | 5.7 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 59455555 | 165495 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4093383 | 165495 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 73776979 | 150137 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 419 | 5 | 1 | 3 | 5.9 | O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3897637 | 150137 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 419 | 5 | 1 | 3 | 5.9 | O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 137654721 | 165518 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 328 | 8 | 1 | 3 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4093589 | 165518 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 328 | 8 | 1 | 3 | 4.4 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C | 10.1016/j.bmcl.2017.01.034 | ||
| 82051652 | 165377 | 1 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 284 | 6 | 1 | 2 | 3.9 | Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4092090 | 165377 | 1 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 284 | 6 | 1 | 2 | 3.9 | Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137657736 | 166417 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 385 | 7 | 1 | 4 | 5.2 | Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4103573 | 166417 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 385 | 7 | 1 | 4 | 5.2 | Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 145986262 | 172624 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 428 | 8 | 1 | 4 | 4.7 | O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4248845 | 172624 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 428 | 8 | 1 | 4 | 4.7 | O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F | 10.1016/j.bmcl.2018.06.047 | ||
| 134154473 | 159153 | 0 | None | 218 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3970238 | 159153 | 0 | None | 218 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 134139171 | 153041 | 0 | None | 2 | 3 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 350 | 6 | 1 | 3 | 5.4 | Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3920591 | 153041 | 0 | None | 2 | 3 | Mouse | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 350 | 6 | 1 | 3 | 5.4 | Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 86343964 | 170399 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 421 | 7 | 1 | 3 | 5.5 | Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4203774 | 170399 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 421 | 7 | 1 | 3 | 5.5 | Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| 137647294 | 164731 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 461 | 8 | 1 | 4 | 6.9 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4084679 | 164731 | 0 | None | - | 1 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 461 | 8 | 1 | 4 | 6.9 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 90407659 | 171012 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 440 | 7 | 1 | 4 | 5.1 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4211144 | 171012 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 440 | 7 | 1 | 4 | 5.1 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134157586 | 160942 | 0 | None | 3 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 366 | 8 | 1 | 3 | 5.5 | O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3985509 | 160942 | 0 | None | 3 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 366 | 8 | 1 | 3 | 5.5 | O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137636575 | 162680 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 479 | 7 | 1 | 4 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4060663 | 162680 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 479 | 7 | 1 | 4 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 134133675 | 150040 | 0 | None | -2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 318 | 8 | 1 | 3 | 4.1 | CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3896714 | 150040 | 0 | None | -2 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 318 | 8 | 1 | 3 | 4.1 | CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90404813 | 171287 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 473 | 7 | 1 | 3 | 6.3 | CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4214698 | 171287 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 473 | 7 | 1 | 3 | 6.3 | CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O | 10.1016/j.bmcl.2018.02.013 | ||
| 57521812 | 83042 | 0 | None | 2 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 410 | 7 | 1 | 2 | 5.7 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058523 | 83042 | 0 | None | 2 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 410 | 7 | 1 | 2 | 5.7 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1 | 10.1021/jm300215x | ||
| 137633536 | 163074 | 0 | None | -4 | 6 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4065397 | 163074 | 0 | None | -4 | 6 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | ||
| 134154330 | 159659 | 0 | None | -1 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 340 | 7 | 1 | 3 | 4.5 | O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3974501 | 159659 | 0 | None | -1 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 340 | 7 | 1 | 3 | 4.5 | O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134148110 | 156349 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3946820 | 156349 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 134138802 | 154697 | 0 | None | -4 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3933619 | 154697 | 0 | None | -4 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| 46892131 | 151449 | 2 | None | -3 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3908362 | 151449 | 2 | None | -3 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 137661388 | 166019 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4098969 | 166019 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C | 10.1016/j.bmcl.2017.01.034 | ||
| 134133297 | 150557 | 0 | None | -3 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 372 | 7 | 1 | 3 | 4.9 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3900990 | 150557 | 0 | None | -3 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 372 | 7 | 1 | 3 | 4.9 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 57521811 | 83041 | 0 | None | 1 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 366 | 7 | 1 | 2 | 5.6 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058522 | 83041 | 0 | None | 1 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 366 | 7 | 1 | 2 | 5.6 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1 | 10.1021/jm300215x | ||
| 24825492 | 156321 | 0 | None | -9 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 333 | 6 | 2 | 2 | 4.1 | O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1 | 10.1021/jm300215x | ||
| CHEMBL394666 | 156321 | 0 | None | -9 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 333 | 6 | 2 | 2 | 4.1 | O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1 | 10.1021/jm300215x | ||
| 85472227 | 168967 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 519 | 7 | 1 | 4 | 6.8 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4162566 | 168967 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 519 | 7 | 1 | 4 | 6.8 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 134149615 | 155355 | 0 | None | 1 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3939004 | 155355 | 0 | None | 1 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| 73777174 | 157233 | 0 | None | -2 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3954140 | 157233 | 0 | None | -2 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 145960576 | 168931 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 527 | 8 | 1 | 5 | 6.6 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4161929 | 168931 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 527 | 8 | 1 | 5 | 6.6 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 134145195 | 157202 | 0 | None | - | 1 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 392 | 5 | 1 | 5 | 4.4 | Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3953859 | 157202 | 0 | None | - | 1 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 392 | 5 | 1 | 5 | 4.4 | Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 1052 | 9101 | 85 | None | 3 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 10.1016/j.bmcl.2014.05.012 | ||
| 3323 | 9101 | 85 | None | 3 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 10.1016/j.bmcl.2014.05.012 | ||
| 5280450 | 9101 | 85 | None | 3 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL267476 | 9101 | 85 | None | 3 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 10.1016/j.bmcl.2014.05.012 | ||
| DB14104 | 9101 | 85 | None | 3 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 10.1016/j.bmcl.2014.05.012 | ||
| 900631 | 119814 | 17 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 333 | 3 | 1 | 4 | 3.2 | Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311325 | 119814 | 17 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 333 | 3 | 1 | 4 | 3.2 | Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 118707173 | 119816 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 331 | 6 | 1 | 3 | 3.8 | C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311327 | 119816 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 331 | 6 | 1 | 3 | 3.8 | C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137633536 | 163074 | 0 | None | -4 | 6 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4065397 | 163074 | 0 | None | -4 | 6 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | ||
| 137661388 | 166019 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4098969 | 166019 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C | 10.1016/j.bmcl.2017.01.034 | ||
| 1050 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1016/j.bmcl.2020.127650 | ||
| 11595431 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1016/j.bmcl.2020.127650 | ||
| CHEMBL207881 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1016/j.bmcl.2020.127650 | ||
| 825631 | 119803 | 15 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 291 | 4 | 1 | 3 | 3.1 | COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311306 | 119803 | 15 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 291 | 4 | 1 | 3 | 3.1 | COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 841618 | 119810 | 18 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 309 | 3 | 1 | 2 | 4.1 | Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311318 | 119810 | 18 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 309 | 3 | 1 | 2 | 4.1 | Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 134141270 | 153588 | 0 | None | 3 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 334 | 8 | 1 | 3 | 4.6 | CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3924759 | 153588 | 0 | None | 3 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 334 | 8 | 1 | 3 | 4.6 | CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134145412 | 156050 | 0 | None | 2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 330 | 8 | 1 | 3 | 4.3 | O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3944507 | 156050 | 0 | None | 2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 330 | 8 | 1 | 3 | 4.3 | O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134147601 | 156807 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3950444 | 156807 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 1049 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm300215x | ||
| 4618 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm300215x | ||
| 5280934 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm300215x | ||
| CHEMBL8739 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm300215x | ||
| DB00132 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 10.1021/jm300215x | ||
| 134143899 | 157018 | 0 | None | 1 | 3 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 350 | 5 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3952316 | 157018 | 0 | None | 1 | 3 | Mouse | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 350 | 5 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 73777063 | 7937 | 39 | None | 1 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | ||
| 8418 | 7937 | 39 | None | 1 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3919973 | 7937 | 39 | None | 1 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | ||
| 134152336 | 160235 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 408 | 5 | 1 | 5 | 4.2 | Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3979448 | 160235 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 408 | 5 | 1 | 5 | 4.2 | Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | ||
| 117886639 | 155229 | 0 | None | -1 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3937916 | 155229 | 0 | None | -1 | 2 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | ||
| 90417528 | 168951 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 513 | 9 | 1 | 4 | 7.2 | CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4162353 | 168951 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 513 | 9 | 1 | 4 | 7.2 | CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 85472359 | 168908 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 471 | 8 | 1 | 4 | 6.3 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4161536 | 168908 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 471 | 8 | 1 | 4 | 6.3 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 134148736 | 155333 | 0 | None | 2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 383 | 8 | 1 | 4 | 5.4 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3938783 | 155333 | 0 | None | 2 | 2 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 383 | 8 | 1 | 4 | 5.4 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134156096 | 158226 | 0 | None | 5 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 400 | 8 | 1 | 3 | 6.2 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3961950 | 158226 | 0 | None | 5 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 400 | 8 | 1 | 3 | 6.2 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137649360 | 164165 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4078286 | 164165 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 86343961 | 171066 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 435 | 7 | 1 | 3 | 5.8 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4211967 | 171066 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 435 | 7 | 1 | 3 | 5.8 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| 145985748 | 172422 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 444 | 9 | 1 | 4 | 5.4 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4243863 | 172422 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 444 | 9 | 1 | 4 | 5.4 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 134156727 | 160413 | 0 | None | -4 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3980898 | 160413 | 0 | None | -4 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| 134151115 | 158978 | 0 | None | 4 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 336 | 6 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3968537 | 158978 | 0 | None | 4 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 336 | 6 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137631865 | 163113 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4065769 | 163113 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 1050 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1016/j.bmcl.2018.06.047 | ||
| 11595431 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL207881 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1016/j.bmcl.2018.06.047 | ||
| 73777065 | 154034 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3928591 | 154034 | 0 | None | - | 1 | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 134146021 | 155843 | 0 | None | 5 | 2 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 392 | 7 | 1 | 3 | 5.3 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3942922 | 155843 | 0 | None | 5 | 2 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 392 | 7 | 1 | 3 | 5.3 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 73777135 | 157149 | 0 | None | -5 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3953289 | 157149 | 0 | None | -5 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| 137643339 | 164822 | 0 | None | 26 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4085843 | 164822 | 0 | None | 26 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 90406970 | 171555 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 477 | 7 | 1 | 3 | 6.2 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4218078 | 171555 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 477 | 7 | 1 | 3 | 6.2 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134146720 | 155910 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 443 | 7 | 1 | 6 | 5.6 | COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3943315 | 155910 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 443 | 7 | 1 | 6 | 5.6 | COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 23136477 | 65604 | 3 | None | 15 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1688455 | 65604 | 3 | None | 15 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL4213909 | 65604 | 3 | None | 15 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| 134132711 | 151716 | 0 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3910333 | 151716 | 0 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 134145778 | 156126 | 0 | None | 13 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 355 | 3 | 0 | 3 | 4.3 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3945213 | 156126 | 0 | None | 13 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 355 | 3 | 0 | 3 | 4.3 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 137657972 | 166383 | 0 | None | 40 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 376 | 8 | 1 | 3 | 5.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4103243 | 166383 | 0 | None | 40 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 376 | 8 | 1 | 3 | 5.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 23136477 | 65604 | 3 | None | 15 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL1688455 | 65604 | 3 | None | 15 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL4213909 | 65604 | 3 | None | 15 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 332 | 7 | 1 | 2 | 5.0 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1 | 10.1016/j.bmc.2017.10.040 | ||
| 118707084 | 119787 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 3.1 | COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311198 | 119787 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 3.1 | COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 8190712 | 119811 | 10 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 317 | 5 | 1 | 2 | 4.4 | CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311319 | 119811 | 10 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 317 | 5 | 1 | 2 | 4.4 | CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137643339 | 164822 | 0 | None | 26 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4085843 | 164822 | 0 | None | 26 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 956298 | 119801 | 9 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311303 | 119801 | 9 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C | 10.1016/j.bmcl.2014.05.012 | ||
| 137657972 | 166383 | 0 | None | 40 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 376 | 8 | 1 | 3 | 5.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4103243 | 166383 | 0 | None | 40 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 376 | 8 | 1 | 3 | 5.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134131874 | 151635 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 404 | 6 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3909773 | 151635 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 404 | 6 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 86281122 | 171105 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 453 | 8 | 1 | 3 | 5.9 | CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4212409 | 171105 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 453 | 8 | 1 | 3 | 5.9 | CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| 137660302 | 166217 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 413 | 8 | 1 | 4 | 5.8 | CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4101135 | 166217 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 413 | 8 | 1 | 4 | 5.8 | CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 137638176 | 163512 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 457 | 7 | 1 | 4 | 6.1 | Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4070355 | 163512 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 457 | 7 | 1 | 4 | 6.1 | Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O | 10.1016/j.bmcl.2017.06.028 | ||
| 117873187 | 159123 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3969920 | 159123 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 87054900 | 155540 | 0 | None | 1 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3940493 | 155540 | 0 | None | 1 | 2 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90418278 | 169158 | 16 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4165366 | 169158 | 16 | None | 1 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 73777175 | 150687 | 0 | None | -1 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3901994 | 150687 | 0 | None | -1 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 60195039 | 88568 | 0 | None | -181 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 377 | 8 | 2 | 2 | 5.7 | CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| CHEMBL2164240 | 88568 | 0 | None | -181 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 377 | 8 | 2 | 2 | 5.7 | CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| 134134229 | 150033 | 0 | None | 1 | 3 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3896657 | 150033 | 0 | None | 1 | 3 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | ||
| 134134229 | 150033 | 0 | None | 1 | 3 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3896657 | 150033 | 0 | None | 1 | 3 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 86281125 | 170850 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 445 | 7 | 1 | 3 | 5.9 | OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4209308 | 170850 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 445 | 7 | 1 | 3 | 5.9 | OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 57522038 | 10659 | 60 | None | -6 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| 6490 | 10659 | 60 | None | -6 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| CHEMBL2058533 | 10659 | 60 | None | -6 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| 117886649 | 158857 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 391 | 4 | 1 | 3 | 5.4 | OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3967504 | 158857 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 391 | 4 | 1 | 3 | 5.4 | OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 134142866 | 152420 | 0 | None | 2 | 3 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3915765 | 152420 | 0 | None | 2 | 3 | Mouse | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 57521914 | 83046 | 0 | None | -6 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 416 | 8 | 1 | 3 | 5.8 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058527 | 83046 | 0 | None | -6 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 416 | 8 | 1 | 3 | 5.8 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1 | 10.1021/jm300215x | ||
| 60195125 | 10660 | 8 | None | -1096 | 3 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | 499 | 12 | 2 | 5 | 5.2 | OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C | 10.1021/jm3002026 | ||
| 9149 | 10660 | 8 | None | -1096 | 3 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | 499 | 12 | 2 | 5 | 5.2 | OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C | 10.1021/jm3002026 | ||
| CHEMBL2164242 | 10660 | 8 | None | -1096 | 3 | Human | 4.4 | pEC50 | = | 4.4 | Functional | ChEMBL | 499 | 12 | 2 | 5 | 5.2 | OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C | 10.1021/jm3002026 | ||
| 73777135 | 157149 | 0 | None | 5 | 2 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3953289 | 157149 | 0 | None | 5 | 2 | Mouse | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| 73776995 | 155521 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3940359 | 155521 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 24825509 | 94721 | 0 | None | -29 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL234057 | 94721 | 0 | None | -29 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1 | 10.1021/jm300215x | ||
| 134154953 | 158055 | 0 | None | 7 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3960369 | 158055 | 0 | None | 7 | 2 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 86343963 | 171523 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 443 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4217669 | 171523 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 443 | 7 | 1 | 3 | 5.5 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134155950 | 157869 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 430 | 6 | 1 | 4 | 4.6 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3959068 | 157869 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 430 | 6 | 1 | 4 | 4.6 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| 145984009 | 172368 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 418 | 7 | 1 | 4 | 4.7 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4242595 | 172368 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 418 | 7 | 1 | 4 | 4.7 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 134157207 | 160990 | 0 | None | 3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 386 | 7 | 1 | 3 | 5.3 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3985939 | 160990 | 0 | None | 3 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 386 | 7 | 1 | 3 | 5.3 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 57522038 | 10659 | 60 | None | -6 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/acsmedchemlett.6b00025 | ||
| 6490 | 10659 | 60 | None | -6 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/acsmedchemlett.6b00025 | ||
| CHEMBL2058533 | 10659 | 60 | None | -6 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/acsmedchemlett.6b00025 | ||
| 134157563 | 160786 | 0 | None | 1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 365 | 6 | 1 | 4 | 5.0 | O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3984072 | 160786 | 0 | None | 1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 365 | 6 | 1 | 4 | 5.0 | O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| 54584098 | 68579 | 5 | None | -5 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 334 | 6 | 1 | 2 | 4.0 | O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1773254 | 68579 | 5 | None | -5 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 334 | 6 | 1 | 2 | 4.0 | O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1 | 10.1021/jm300215x | ||
| 54583098 | 68583 | 0 | None | -70 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 331 | 7 | 2 | 2 | 5.0 | O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1773258 | 68583 | 0 | None | -70 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 331 | 7 | 2 | 2 | 5.0 | O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1 | 10.1021/jm300215x | ||
| 134157563 | 160786 | 0 | None | -1 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 365 | 6 | 1 | 4 | 5.0 | O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3984072 | 160786 | 0 | None | -1 | 2 | Mouse | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 365 | 6 | 1 | 4 | 5.0 | O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| 73777069 | 149447 | 0 | None | 1 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3891920 | 149447 | 0 | None | 1 | 2 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 134138318 | 154798 | 0 | None | -1 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 378 | 9 | 1 | 4 | 5.4 | COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3934450 | 154798 | 0 | None | -1 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 378 | 9 | 1 | 4 | 5.4 | COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134144000 | 156988 | 0 | None | 1 | 2 | Mouse | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3952043 | 156988 | 0 | None | 1 | 2 | Mouse | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 86281123 | 170527 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 439 | 7 | 1 | 3 | 5.7 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4205429 | 170527 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 439 | 7 | 1 | 3 | 5.7 | Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2018.02.013 | ||
| 137646553 | 164693 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 362 | 6 | 1 | 2 | 4.7 | Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4084333 | 164693 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 362 | 6 | 1 | 2 | 4.7 | Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 118707083 | 119786 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 3.8 | COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311197 | 119786 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 325 | 4 | 1 | 3 | 3.8 | COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 743974 | 119804 | 70 | None | 1 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311308 | 119804 | 70 | None | 1 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137638995 | 163744 | 0 | None | 16 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4072885 | 163744 | 0 | None | 16 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 23136401 | 165914 | 0 | None | 7 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.4 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4097919 | 165914 | 0 | None | 7 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.4 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 145984445 | 172239 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 456 | 9 | 1 | 4 | 5.3 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4239572 | 172239 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 456 | 9 | 1 | 4 | 5.3 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 134138281 | 154564 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 410 | 7 | 1 | 6 | 3.9 | COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3932664 | 154564 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 410 | 7 | 1 | 6 | 3.9 | COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 90417978 | 168763 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4159180 | 168763 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 73777153 | 149601 | 0 | None | 2 | 3 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3893026 | 149601 | 0 | None | 2 | 3 | Mouse | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 57521918 | 83051 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 380 | 7 | 1 | 2 | 5.9 | Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058531 | 83051 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 380 | 7 | 1 | 2 | 5.9 | Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1 | 10.1021/jm300215x | ||
| 54582150 | 68584 | 0 | None | -22 | 2 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | 331 | 7 | 2 | 2 | 5.0 | O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1773259 | 68584 | 0 | None | -22 | 2 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | 331 | 7 | 2 | 2 | 5.0 | O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| 59455584 | 163820 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 378 | 8 | 1 | 4 | 4.6 | CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4073815 | 163820 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 378 | 8 | 1 | 4 | 4.6 | CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137646553 | 164693 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 362 | 6 | 1 | 2 | 4.7 | Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4084333 | 164693 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 362 | 6 | 1 | 2 | 4.7 | Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134132951 | 151400 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 454 | 8 | 1 | 7 | 3.9 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3907996 | 151400 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 454 | 8 | 1 | 7 | 3.9 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 137638995 | 163744 | 0 | None | 16 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4072885 | 163744 | 0 | None | 16 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 90407027 | 170973 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 437 | 7 | 1 | 3 | 6.3 | Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4210752 | 170973 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 437 | 7 | 1 | 3 | 6.3 | Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| 54585039 | 68577 | 5 | None | -17 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 334 | 6 | 1 | 2 | 4.0 | O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1773252 | 68577 | 5 | None | -17 | 2 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 334 | 6 | 1 | 2 | 4.0 | O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1 | 10.1021/jm300215x | ||
| 134143899 | 157018 | 0 | None | -1 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 350 | 5 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3952316 | 157018 | 0 | None | -1 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 350 | 5 | 1 | 3 | 5.0 | O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 87054900 | 155540 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3940493 | 155540 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90406418 | 171356 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 457 | 7 | 1 | 3 | 5.8 | CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4215446 | 171356 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 457 | 7 | 1 | 3 | 5.8 | CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O | 10.1016/j.bmcl.2018.02.013 | ||
| 134131620 | 149210 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 4.5 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3890035 | 149210 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 4.5 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | ||
| 23136401 | 165914 | 0 | None | 7 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.4 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4097919 | 165914 | 0 | None | 7 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.4 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 90418513 | 169402 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 429 | 8 | 1 | 4 | 6.2 | CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4169436 | 169402 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 429 | 8 | 1 | 4 | 6.2 | CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 23136363 | 65607 | 0 | None | -14 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.1 | O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1688458 | 65607 | 0 | None | -14 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.1 | O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 | 10.1021/jm300215x | ||
| 134150245 | 159024 | 0 | None | -6 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 5.1 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3968947 | 159024 | 0 | None | -6 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 5.1 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137643146 | 164843 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 455 | 8 | 1 | 4 | 5.8 | CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4086174 | 164843 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 455 | 8 | 1 | 4 | 5.8 | CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 73777085 | 160009 | 0 | None | 1 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3977361 | 160009 | 0 | None | 1 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | ||
| 73776997 | 161059 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 407 | 4 | 1 | 4 | 4.5 | O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3986483 | 161059 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 407 | 4 | 1 | 4 | 4.5 | O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 | 10.1021/acsmedchemlett.6b00360 | ||
| 23346507 | 95063 | 1 | None | -30 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 255 | 6 | 2 | 2 | 3.3 | O=C(O)CCc1ccc(NCc2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL234834 | 95063 | 1 | None | -30 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 255 | 6 | 2 | 2 | 3.3 | O=C(O)CCc1ccc(NCc2ccccc2)cc1 | 10.1021/jm300215x | ||
| 57521810 | 83040 | 0 | None | 1 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058521 | 83040 | 0 | None | 1 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 350 | 7 | 1 | 2 | 5.1 | O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1 | 10.1021/jm300215x | ||
| 24825484 | 94766 | 0 | None | -208 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 331 | 7 | 2 | 2 | 5.0 | O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL234269 | 94766 | 0 | None | -208 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 331 | 7 | 2 | 2 | 5.0 | O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm300215x | ||
| 73777111 | 156489 | 0 | None | 1 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3947837 | 156489 | 0 | None | 1 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | ||
| 137642184 | 165281 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 386 | 8 | 2 | 4 | 4.4 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4091118 | 165281 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 386 | 8 | 2 | 4 | 4.4 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134156727 | 160413 | 0 | None | 4 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3980898 | 160413 | 0 | None | 4 | 2 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | ||
| 137637576 | 162842 | 0 | None | 63 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 298 | 6 | 1 | 2 | 4.2 | Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4062640 | 162842 | 0 | None | 63 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 298 | 6 | 1 | 2 | 4.2 | Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137658634 | 166182 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4100773 | 166182 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137643146 | 164843 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 455 | 8 | 1 | 4 | 5.8 | CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4086174 | 164843 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 455 | 8 | 1 | 4 | 5.8 | CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 134144214 | 157137 | 0 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 384 | 8 | 1 | 3 | 5.7 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3953203 | 157137 | 0 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 384 | 8 | 1 | 3 | 5.7 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 59455552 | 162820 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 384 | 7 | 1 | 4 | 4.7 | Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4062462 | 162820 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 384 | 7 | 1 | 4 | 4.7 | Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134134229 | 150033 | 0 | None | -1 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3896657 | 150033 | 0 | None | -1 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | ||
| 134134229 | 150033 | 0 | None | -1 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3896657 | 150033 | 0 | None | -1 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137637576 | 162842 | 0 | None | 63 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 298 | 6 | 1 | 2 | 4.2 | Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4062640 | 162842 | 0 | None | 63 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 298 | 6 | 1 | 2 | 4.2 | Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 137658634 | 166182 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4100773 | 166182 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 342 | 8 | 1 | 3 | 4.7 | Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 57522038 | 10659 | 60 | None | -6 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmc.2017.10.040 | ||
| 6490 | 10659 | 60 | None | -6 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL2058533 | 10659 | 60 | None | -6 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmc.2017.10.040 | ||
| 137638911 | 163508 | 0 | None | 32 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4070298 | 163508 | 0 | None | 32 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 137656526 | 166532 | 0 | None | 2 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 356 | 7 | 1 | 3 | 4.9 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4105013 | 166532 | 0 | None | 2 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 356 | 7 | 1 | 3 | 4.9 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 743974 | 119804 | 70 | None | -3 | 3 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311308 | 119804 | 70 | None | -3 | 3 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 46941175 | 68586 | 26 | None | -331 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 345 | 7 | 2 | 2 | 5.3 | Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm3002026 | ||
| CHEMBL1773261 | 68586 | 26 | None | -331 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 345 | 7 | 2 | 2 | 5.3 | Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm3002026 | ||
| 46941175 | 68586 | 26 | None | -331 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 345 | 7 | 2 | 2 | 5.3 | Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| CHEMBL1773261 | 68586 | 26 | None | -331 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 345 | 7 | 2 | 2 | 5.3 | Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| 3518281 | 119809 | 11 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 293 | 3 | 1 | 2 | 3.6 | Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311317 | 119809 | 11 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 293 | 3 | 1 | 2 | 3.6 | Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1 | 10.1016/j.bmcl.2014.05.012 | ||
| 137642184 | 165281 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 386 | 8 | 2 | 4 | 4.4 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4091118 | 165281 | 0 | None | - | 1 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 386 | 8 | 2 | 4 | 4.4 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 145985122 | 172687 | 0 | None | 17 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 456 | 11 | 1 | 4 | 5.5 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4250132 | 172687 | 0 | None | 17 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 456 | 11 | 1 | 4 | 5.5 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 134147174 | 156482 | 0 | None | 2 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 370 | 6 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3947787 | 156482 | 0 | None | 2 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 370 | 6 | 1 | 3 | 5.7 | O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134145412 | 156050 | 0 | None | -2 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 330 | 8 | 1 | 3 | 4.3 | O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3944507 | 156050 | 0 | None | -2 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 330 | 8 | 1 | 3 | 4.3 | O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 73777156 | 159494 | 0 | None | 1 | 3 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3973034 | 159494 | 0 | None | 1 | 3 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| 134143163 | 152522 | 0 | None | 2 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.7 | Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3916564 | 152522 | 0 | None | 2 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 362 | 8 | 1 | 3 | 5.7 | Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137638911 | 163508 | 0 | None | 32 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4070298 | 163508 | 0 | None | 32 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.5 | Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 134134149 | 150153 | 0 | None | 2 | 3 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3897776 | 150153 | 0 | None | 2 | 3 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.4 | O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137640328 | 163763 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4073078 | 163763 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F | 10.1016/j.bmcl.2017.06.028 | ||
| 117886639 | 155229 | 0 | None | 1 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3937916 | 155229 | 0 | None | 1 | 2 | Mouse | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | ||
| 118184919 | 169652 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 468 | 7 | 1 | 5 | 5.6 | N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4173280 | 169652 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 468 | 7 | 1 | 5 | 5.6 | N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 54586984 | 68581 | 0 | None | -34 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 323 | 6 | 2 | 2 | 4.3 | O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm300215x | ||
| CHEMBL1773256 | 68581 | 0 | None | -34 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 323 | 6 | 2 | 2 | 4.3 | O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm300215x | ||
| 134139171 | 153041 | 0 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 350 | 6 | 1 | 3 | 5.4 | Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3920591 | 153041 | 0 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 350 | 6 | 1 | 3 | 5.4 | Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137661886 | 166106 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 453 | 7 | 1 | 4 | 6.2 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4099943 | 166106 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 453 | 7 | 1 | 4 | 6.2 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 90418886 | 169699 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 423 | 9 | 1 | 4 | 6.1 | CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4174122 | 169699 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 423 | 9 | 1 | 4 | 6.1 | CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 137656526 | 166532 | 0 | None | 2 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 356 | 7 | 1 | 3 | 4.9 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4105013 | 166532 | 0 | None | 2 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 356 | 7 | 1 | 3 | 4.9 | O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 145985686 | 172209 | 0 | None | 354 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 4.2 | COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4238809 | 172209 | 0 | None | 354 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 4.2 | COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1 | 10.1016/j.bmcl.2018.06.047 | ||
| 137648785 | 164389 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 427 | 7 | 1 | 4 | 5.2 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4080995 | 164389 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 427 | 7 | 1 | 4 | 5.2 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 134153986 | 159285 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3971308 | 159285 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 134153562 | 159502 | 0 | None | 2 | 3 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 394 | 7 | 1 | 3 | 4.9 | O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3973101 | 159502 | 0 | None | 2 | 3 | Mouse | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 394 | 7 | 1 | 3 | 4.9 | O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F | 10.1016/j.bmcl.2016.10.054 | ||
| 134140073 | 153099 | 0 | None | 1 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.4 | CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3921062 | 153099 | 0 | None | 1 | 2 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.4 | CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 134135468 | 151253 | 0 | None | 1 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 4.8 | O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3906716 | 151253 | 0 | None | 1 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 389 | 4 | 1 | 3 | 4.8 | O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| 57521702 | 83037 | 0 | None | -11 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058518 | 83037 | 0 | None | -11 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1 | 10.1021/jm300215x | ||
| 137636575 | 162680 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 479 | 7 | 1 | 4 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4060663 | 162680 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 479 | 7 | 1 | 4 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 137635671 | 162770 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4061699 | 162770 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1 | 10.1016/j.bmcl.2017.06.028 | ||
| 85471695 | 165448 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4092882 | 165448 | 0 | None | - | 1 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 85470884 | 170783 | 2 | None | -7 | 5 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4208325 | 170783 | 2 | None | -7 | 5 | Rat | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134155847 | 157881 | 0 | None | 63 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 418 | 5 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3959144 | 157881 | 0 | None | 63 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 418 | 5 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 134132711 | 151716 | 0 | None | -1 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3910333 | 151716 | 0 | None | -1 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 137636167 | 162766 | 0 | None | 2 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4061630 | 162766 | 0 | None | 2 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O | 10.1016/j.bmcl.2017.01.034 | ||
| 134142450 | 152224 | 0 | None | 10 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.7 | CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3914253 | 152224 | 0 | None | 10 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.7 | CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137660302 | 166217 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 413 | 8 | 1 | 4 | 5.8 | CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4101135 | 166217 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 413 | 8 | 1 | 4 | 5.8 | CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 90418333 | 169434 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 473 | 8 | 1 | 5 | 5.7 | COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4169851 | 169434 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 473 | 8 | 1 | 5 | 5.7 | COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 57522038 | 10659 | 60 | None | -6 | 3 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmc.2017.10.040 | ||
| 6490 | 10659 | 60 | None | -6 | 3 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmc.2017.10.040 | ||
| CHEMBL2058533 | 10659 | 60 | None | -6 | 3 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmc.2017.10.040 | ||
| 57839754 | 164595 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 270 | 6 | 1 | 2 | 3.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4083325 | 164595 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 270 | 6 | 1 | 2 | 3.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 90407037 | 164067 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 377 | 8 | 1 | 3 | 5.3 | CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4076902 | 164067 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 377 | 8 | 1 | 3 | 5.3 | CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 3893 | 9067 | 98 | None | -10 | 4 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 200 | 10 | 1 | 1 | 4.0 | CCCCCCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| 4642 | 9067 | 98 | None | -10 | 4 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 200 | 10 | 1 | 1 | 4.0 | CCCCCCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| 5534 | 9067 | 98 | None | -10 | 4 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 200 | 10 | 1 | 1 | 4.0 | CCCCCCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| CHEMBL108766 | 9067 | 98 | None | -10 | 4 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 200 | 10 | 1 | 1 | 4.0 | CCCCCCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| DB03017 | 9067 | 98 | None | -10 | 4 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 200 | 10 | 1 | 1 | 4.0 | CCCCCCCCCCCC(=O)O | 10.1039/C7MD00130D | ||
| 59455555 | 165495 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4093383 | 165495 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134149615 | 155355 | 0 | None | -1 | 3 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3939004 | 155355 | 0 | None | -1 | 3 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 370 | 5 | 1 | 3 | 4.6 | O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1016/j.bmcl.2016.10.054 | ||
| 90418278 | 169158 | 16 | None | -1 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4165366 | 169158 | 16 | None | -1 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | ||
| 134155277 | 158104 | 0 | None | 3 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3961009 | 158104 | 0 | None | 3 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 388 | 7 | 1 | 3 | 5.5 | Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl | 10.1016/j.bmcl.2016.10.054 | ||
| 134133992 | 150517 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| CHEMBL3900705 | 150517 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | ||
| 134133297 | 150557 | 0 | None | 3 | 3 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 372 | 7 | 1 | 3 | 4.9 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3900990 | 150557 | 0 | None | 3 | 3 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 372 | 7 | 1 | 3 | 4.9 | Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 977153 | 58194 | 15 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 4.1 | COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL1581959 | 58194 | 15 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 339 | 4 | 1 | 3 | 4.1 | COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl | 10.1016/j.bmcl.2014.05.012 | ||
| 137636167 | 162766 | 0 | None | 2 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4061630 | 162766 | 0 | None | 2 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 370 | 7 | 1 | 3 | 5.2 | Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O | 10.1016/j.bmcl.2017.01.034 | ||
| 57839754 | 164595 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 270 | 6 | 1 | 2 | 3.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4083325 | 164595 | 1 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 270 | 6 | 1 | 2 | 3.6 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 743974 | 119804 | 70 | None | -1 | 3 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311308 | 119804 | 70 | None | -1 | 3 | Rat | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 8190702 | 119808 | 2 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 317 | 4 | 1 | 3 | 3.6 | CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| CHEMBL3311316 | 119808 | 2 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 317 | 4 | 1 | 3 | 3.6 | CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | ||
| 85470884 | 170783 | 2 | None | 2 | 5 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4208325 | 170783 | 2 | None | 2 | 5 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | ||
| 137634829 | 162851 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4062742 | 162851 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134154417 | 159483 | 0 | None | 2 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3972973 | 159483 | 0 | None | 2 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137631865 | 163113 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4065769 | 163113 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 5.5 | Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 134145750 | 155924 | 0 | None | -3 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 324 | 6 | 1 | 2 | 4.6 | O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3943430 | 155924 | 0 | None | -3 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 324 | 6 | 1 | 2 | 4.6 | O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134142450 | 152224 | 0 | None | -10 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.7 | CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3914253 | 152224 | 0 | None | -10 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.7 | CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 134140073 | 153099 | 0 | None | -1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.4 | CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3921062 | 153099 | 0 | None | -1 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 382 | 5 | 1 | 3 | 5.4 | CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 46892131 | 151449 | 2 | None | 3 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| CHEMBL3908362 | 151449 | 2 | None | 3 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | ||
| 51350138 | 65623 | 0 | None | -660 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 378 | 7 | 1 | 2 | 5.7 | Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| CHEMBL1688473 | 65623 | 0 | None | -660 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 378 | 7 | 1 | 2 | 5.7 | Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| 86343792 | 171460 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 475 | 7 | 1 | 3 | 6.3 | O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4216937 | 171460 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 475 | 7 | 1 | 3 | 6.3 | O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2018.02.013 | ||
| 60195038 | 88567 | 0 | None | -912 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 363 | 7 | 2 | 2 | 5.4 | Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| CHEMBL2164239 | 88567 | 0 | None | -912 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 363 | 7 | 2 | 2 | 5.4 | Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| 85472487 | 169256 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4167097 | 169256 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| 51350272 | 65615 | 0 | None | -107 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| CHEMBL1688465 | 65615 | 0 | None | -107 | 2 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 346 | 7 | 1 | 2 | 5.3 | Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1 | 10.1021/jm300215x | ||
| 145985219 | 172243 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 420 | 9 | 1 | 4 | 5.0 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4239630 | 172243 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 420 | 9 | 1 | 4 | 5.0 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 90406893 | 171214 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 454 | 8 | 1 | 4 | 5.3 | CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4213710 | 171214 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 454 | 8 | 1 | 4 | 5.3 | CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1 | 10.1016/j.bmcl.2018.02.013 | ||
| 134148736 | 155333 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 383 | 8 | 1 | 4 | 5.4 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3938783 | 155333 | 0 | None | -2 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 383 | 8 | 1 | 4 | 5.4 | O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 86281121 | 170791 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 451 | 7 | 1 | 3 | 6.4 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4208442 | 170791 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 451 | 7 | 1 | 3 | 6.4 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2018.02.013 | ||
| 134138802 | 154697 | 0 | None | 4 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3933619 | 154697 | 0 | None | 4 | 2 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | ||
| 137649416 | 164298 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4079893 | 164298 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 338 | 6 | 1 | 2 | 4.6 | Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134150245 | 159024 | 0 | None | 6 | 3 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 5.1 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3968947 | 159024 | 0 | None | 6 | 3 | Mouse | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 374 | 7 | 1 | 3 | 5.1 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 137657968 | 166371 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4103081 | 166371 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 394 | 8 | 1 | 3 | 6.2 | CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1016/j.bmcl.2017.06.028 | ||
| 90407263 | 170378 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4203559 | 170378 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F | 10.1016/j.bmcl.2018.02.013 | ||
| 57521917 | 83050 | 0 | None | -8 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 366 | 7 | 1 | 2 | 5.6 | O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| CHEMBL2058530 | 83050 | 0 | None | -8 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 366 | 7 | 1 | 2 | 5.6 | O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1 | 10.1021/jm300215x | ||
| 90418067 | 169110 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 425 | 9 | 1 | 5 | 5.6 | CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4164722 | 169110 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 425 | 9 | 1 | 5 | 5.6 | CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | ||
| 86343790 | 170718 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 441 | 7 | 1 | 3 | 5.9 | O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl | 10.1016/j.bmcl.2018.02.013 | ||
| CHEMBL4207603 | 170718 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 441 | 7 | 1 | 3 | 5.9 | O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl | 10.1016/j.bmcl.2018.02.013 | ||
| 145984796 | 172521 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 428 | 9 | 1 | 4 | 4.7 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| CHEMBL4246396 | 172521 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 428 | 9 | 1 | 4 | 4.7 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1 | 10.1016/j.bmcl.2018.06.047 | ||
| 90405989 | 162739 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 383 | 7 | 1 | 3 | 5.3 | Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| CHEMBL4061340 | 162739 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 383 | 7 | 1 | 3 | 5.3 | Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C | 10.1016/j.bmcl.2017.06.028 | ||
| 60195040 | 88569 | 0 | None | -5248 | 2 | Human | 4.0 | pEC50 | = | 4.0 | Functional | ChEMBL | 377 | 7 | 2 | 2 | 5.7 | Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| CHEMBL2164241 | 88569 | 0 | None | -5248 | 2 | Human | 4.0 | pEC50 | = | 4.0 | Functional | ChEMBL | 377 | 7 | 2 | 2 | 5.7 | Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/jm3002026 | ||
| 134132142 | 151647 | 0 | None | -13 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3909872 | 151647 | 0 | None | -13 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | ||
| 134132142 | 151647 | 0 | None | -13 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3909872 | 151647 | 0 | None | -13 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1016/j.bmcl.2016.10.054 | ||
| 145971522 | 169895 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4177287 | 169895 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | ||
| 134142866 | 152420 | 0 | None | -2 | 3 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3915765 | 152420 | 0 | None | -2 | 3 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 358 | 7 | 1 | 3 | 4.6 | O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1 | 10.1016/j.bmcl.2016.10.054 | ||
| 57522038 | 10659 | 60 | None | -6 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| 6490 | 10659 | 60 | None | -6 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| CHEMBL2058533 | 10659 | 60 | None | -6 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1021/jm300215x | ||
| 137634844 | 162895 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 412 | 9 | 1 | 3 | 6.1 | CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4063239 | 162895 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5.0 | Functional | ChEMBL | 412 | 9 | 1 | 3 | 6.1 | CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F | 10.1016/j.bmcl.2017.01.034 | ||
| 23136363 | 65607 | 0 | None | -14 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.1 | O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL1688458 | 65607 | 0 | None | -14 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 348 | 8 | 1 | 3 | 5.1 | O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 134141029 | 153945 | 0 | None | -4 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 6 | 1 | 3 | 4.8 | O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| CHEMBL3927879 | 153945 | 0 | None | -4 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 352 | 6 | 1 | 3 | 4.8 | O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1 | 10.1016/j.bmcl.2016.10.054 | ||
| 82051616 | 166236 | 1 | None | 12 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4101323 | 166236 | 1 | None | 12 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 304 | 6 | 1 | 2 | 4.2 | Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2017.01.034 | ||
| 73777063 | 7937 | 39 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | ||
| 8418 | 7937 | 39 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | ||
| CHEMBL3919973 | 7937 | 39 | None | -1 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | ||
| 85472618 | 169089 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 491 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| CHEMBL4164509 | 169089 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 491 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F | 10.1021/acsmedchemlett.7b00233 | ||
| 137640323 | 163757 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 358 | 7 | 1 | 4 | 4.3 | O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| CHEMBL4073013 | 163757 | 0 | None | - | 1 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 358 | 7 | 1 | 4 | 4.3 | O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1 | 10.1016/j.bmcl.2017.01.034 | ||
| 5588 | 8642 | 0 | None | - | 1 | Human | 5.0 | pA2 | = | 5.0 | Functional | Guide to Pharmacology | 372 | 9 | 3 | 3 | 6.1 | C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C | 19471906 | ||
| 9976563 | 8642 | 0 | None | - | 1 | Human | 5.0 | pA2 | = | 5.0 | Functional | Guide to Pharmacology | 372 | 9 | 3 | 3 | 6.1 | C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C | 19471906 | ||
| CHEMBL513978 | 8642 | 0 | None | - | 1 | Human | 5.0 | pA2 | = | 5.0 | Functional | Guide to Pharmacology | 372 | 9 | 3 | 3 | 6.1 | C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C | 19471906 | ||
| 11531145 | 8643 | 0 | None | - | 1 | Human | 5.0 | pA2 | = | 5.0 | Functional | Guide to Pharmacology | 386 | 10 | 2 | 3 | 6.4 | COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O | 19471906 | ||
| 11531145 | 8643 | 0 | None | - | 1 | Human | 5.0 | pA2 | = | 5.0 | Functional | Guide to Pharmacology | 386 | 10 | 2 | 3 | 6.4 | COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O | 20685848 | ||
| 5589 | 8643 | 0 | None | - | 1 | Human | 5.0 | pA2 | = | 5.0 | Functional | Guide to Pharmacology | 386 | 10 | 2 | 3 | 6.4 | COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O | 19471906 | ||
| 5589 | 8643 | 0 | None | - | 1 | Human | 5.0 | pA2 | = | 5.0 | Functional | Guide to Pharmacology | 386 | 10 | 2 | 3 | 6.4 | COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O | 20685848 | ||
| 1054 | 9691 | 85 | None | -1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | None | ||
| 3400 | 9691 | 85 | None | -1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | None | ||
| 445639 | 9691 | 85 | None | -1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | None | ||
| CHEMBL8659 | 9691 | 85 | None | -1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | None | ||
| 1052 | 9101 | 85 | None | 3 | 4 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | None | ||
| 3323 | 9101 | 85 | None | 3 | 4 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | None | ||
| 5280450 | 9101 | 85 | None | 3 | 4 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | None | ||
| CHEMBL267476 | 9101 | 85 | None | 3 | 4 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | None | ||
| DB14104 | 9101 | 85 | None | 3 | 4 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | None | ||
| 11195 | 10654 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | Guide to Pharmacology | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 27570890 | ||
| 86280676 | 10654 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | Guide to Pharmacology | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 27570890 | ||
| CHEMBL3941880 | 10654 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | Guide to Pharmacology | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 27570890 | ||
| 11195 | 10654 | 0 | None | -1 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 27570890 | ||
| 86280676 | 10654 | 0 | None | -1 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 27570890 | ||
| CHEMBL3941880 | 10654 | 0 | None | -1 | 2 | Mouse | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 27570890 | ||
| 73777063 | 7937 | 39 | None | -1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 24997608 | ||
| 8418 | 7937 | 39 | None | -1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 24997608 | ||
| CHEMBL3919973 | 7937 | 39 | None | -1 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 24997608 | ||
| 1054 | 9691 | 85 | None | -1 | 5 | Human | 4.7 | pEC50 | = | 4.7 | Functional | Guide to Pharmacology | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | 22282525 | ||
| 3400 | 9691 | 85 | None | -1 | 5 | Human | 4.7 | pEC50 | = | 4.7 | Functional | Guide to Pharmacology | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | 22282525 | ||
| 445639 | 9691 | 85 | None | -1 | 5 | Human | 4.7 | pEC50 | = | 4.7 | Functional | Guide to Pharmacology | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | 22282525 | ||
| CHEMBL8659 | 9691 | 85 | None | -1 | 5 | Human | 4.7 | pEC50 | = | 4.7 | Functional | Guide to Pharmacology | 282 | 15 | 1 | 1 | 6.1 | CCCCCCCC/C=C\CCCCCCCC(=O)O | 22282525 | ||
| 1049 | 7151 | 75 | None | -4 | 3 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 18320172 | ||
| 4618 | 7151 | 75 | None | -4 | 3 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 18320172 | ||
| 5280934 | 7151 | 75 | None | -4 | 3 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 18320172 | ||
| CHEMBL8739 | 7151 | 75 | None | -4 | 3 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 18320172 | ||
| DB00132 | 7151 | 75 | None | -4 | 3 | Rat | 5.1 | pEC50 | = | 5.1 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 18320172 | ||
| 11005 | 9471 | 107 | None | 1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | Guide to Pharmacology | 228 | 12 | 1 | 1 | 4.8 | CCCCCCCCCCCCCC(=O)O | 22282525 | ||
| 2806 | 9471 | 107 | None | 1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | Guide to Pharmacology | 228 | 12 | 1 | 1 | 4.8 | CCCCCCCCCCCCCC(=O)O | 22282525 | ||
| CHEMBL111077 | 9471 | 107 | None | 1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | Guide to Pharmacology | 228 | 12 | 1 | 1 | 4.8 | CCCCCCCCCCCCCC(=O)O | 22282525 | ||
| DB08231 | 9471 | 107 | None | 1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | Guide to Pharmacology | 228 | 12 | 1 | 1 | 4.8 | CCCCCCCCCCCCCC(=O)O | 22282525 | ||
| 1050 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 16702987 | ||
| 1050 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 18827341 | ||
| 11595431 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 16702987 | ||
| 11595431 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 18827341 | ||
| CHEMBL207881 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 16702987 | ||
| CHEMBL207881 | 8683 | 94 | None | -26 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 18827341 | ||
| 1049 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 22519963 | ||
| 4618 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 22519963 | ||
| 5280934 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 22519963 | ||
| CHEMBL8739 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 22519963 | ||
| DB00132 | 7151 | 75 | None | -1 | 3 | Human | 5.5 | pEC50 | = | 5.5 | Functional | Guide to Pharmacology | 278 | 13 | 1 | 1 | 5.7 | CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O | 22519963 | ||
| 1052 | 9101 | 85 | None | 3 | 4 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 16702987 | ||
| 3323 | 9101 | 85 | None | 3 | 4 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 16702987 | ||
| 5280450 | 9101 | 85 | None | 3 | 4 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 16702987 | ||
| CHEMBL267476 | 9101 | 85 | None | 3 | 4 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 16702987 | ||
| DB14104 | 9101 | 85 | None | 3 | 4 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 280 | 14 | 1 | 1 | 5.9 | CCCCC/C=C\C/C=C\CCCCCCCC(=O)O | 16702987 | ||
| 25098573 | 9523 | 8 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 19007110 | ||
| 5587 | 9523 | 8 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 19007110 | ||
| CHEMBL463785 | 9523 | 8 | None | 8 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 376 | 10 | 1 | 4 | 4.7 | OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1 | 19007110 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 134154473 | 159153 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 370 | 6 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3970238 | 159153 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 370 | 6 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 73776979 | 150137 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 419 | 5 | 1 | 3 | 5.9 | O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3897637 | 150137 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 419 | 5 | 1 | 3 | 5.9 | O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 137638318 | 163513 | 0 | None | - | 1 | Mouse | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4070359 | 163513 | 0 | None | - | 1 | Mouse | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL5266523 | 200264 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 484 | 10 | 2 | 8 | 3.7 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5269688 | 200384 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 486 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5278791 | 200775 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 486 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5283726 | 201006 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 4.3 | Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 127031569 | 145962 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 264 | 4 | 1 | 1 | 3.3 | O=C(O)CCc1ccc(C#CCc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3787580 | 145962 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 264 | 4 | 1 | 1 | 3.3 | O=C(O)CCc1ccc(C#CCc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| 145971522 | 169895 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4177287 | 169895 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| 134129938 | 149218 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 5.0 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3890089 | 149218 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 5.0 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 156011529 | 184176 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 6.2 | CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4638249 | 184176 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 6.2 | CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1 | 10.1016/j.bmc.2019.115263 | |||
| 134132142 | 151647 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3909872 | 151647 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | |||
| 73777175 | 150687 | 0 | None | - | 0 | Mouse | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3901994 | 150687 | 0 | None | - | 0 | Mouse | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 85472621 | 169582 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4172392 | 169582 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| 66562488 | 97146 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 336 | 4 | 1 | 1 | 4.3 | O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F | 10.1021/ml4000673 | |||
| CHEMBL2386364 | 97146 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 336 | 4 | 1 | 1 | 4.3 | O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F | 10.1021/ml4000673 | |||
| CHEMBL5274344 | 200589 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 492 | 6 | 2 | 7 | 4.9 | Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5286838 | 201138 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 362 | 3 | 0 | 4 | 3.6 | C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.0c01002 | |||
| 73777153 | 149601 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3893026 | 149601 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5276740 | 200692 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 417 | 6 | 2 | 8 | 4.3 | Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5281423 | 200890 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.0 | Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5288340 | 201196 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 482 | 9 | 2 | 8 | 3.9 | COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 137640163 | 163627 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 372 | 5 | 1 | 5 | 4.4 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4071523 | 163627 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 372 | 5 | 1 | 5 | 4.4 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL5284985 | 201053 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 389 | 5 | 2 | 8 | 3.5 | Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1 | 10.1021/acsmedchemlett.2c00160 | |||
| 11195 | 10654 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| 86280676 | 10654 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3941880 | 10654 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL5275980 | 200660 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 462 | 7 | 1 | 3 | 6.9 | OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F | 10.1021/acs.jmedchem.0c01002 | |||
| 134153222 | 159304 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3971461 | 159304 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL5286544 | 201129 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 457 | 5 | 2 | 8 | 4.8 | Cc1c(Cl)cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 11195 | 10654 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| 86280676 | 10654 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3941880 | 10654 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| 145955668 | 169204 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 415 | 7 | 1 | 4 | 6.0 | Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4166208 | 169204 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 415 | 7 | 1 | 4 | 6.0 | Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| 162644046 | 188589 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 361 | 4 | 2 | 5 | 3.0 | Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4778107 | 188589 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 361 | 4 | 2 | 5 | 3.0 | Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| 134146720 | 155910 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 443 | 7 | 1 | 6 | 5.6 | COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3943315 | 155910 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 443 | 7 | 1 | 6 | 5.6 | COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 134146958 | 156388 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 5.1 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3947070 | 156388 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 5.1 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 134147601 | 156807 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3950444 | 156807 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 90418139 | 169360 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 5.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4168786 | 169360 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 5.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL5272492 | 200506 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 403 | 6 | 2 | 8 | 3.8 | CCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12 | 10.1021/acsmedchemlett.2c00160 | |||
| 90418650 | 164134 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4077787 | 164134 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 401 | 7 | 1 | 4 | 5.7 | Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| 134132711 | 151716 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3910333 | 151716 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 73345869 | 97137 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 321 | 5 | 1 | 2 | 3.7 | N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386355 | 97137 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 321 | 5 | 1 | 2 | 3.7 | N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| CHEMBL5281020 | 200875 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.0 | Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3F)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 134133992 | 150517 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3900705 | 150517 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 73777135 | 157149 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3953289 | 157149 | 0 | None | - | 0 | Mouse | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| 73777175 | 150687 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3901994 | 150687 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 357 | 3 | 1 | 2 | 4.9 | O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5287358 | 201160 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.1 | COc1ccccc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5288405 | 201202 | 0 | None | - | 0 | Human | 4.9 | pEC50 | = | 4.9 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.1 | COc1cccc(CCNc2nc(N)nc(COc3cc(C)cc(N4CCCC4=O)c3)n2)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 90418653 | 144291 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL3754160 | 144291 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 469 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C | 10.1021/acsmedchemlett.7b00233 | |||
| 90418278 | 169158 | 16 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4165366 | 169158 | 16 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL5283217 | 200970 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 449 | 6 | 2 | 8 | 3.7 | Cc1ccc(Nc2nc(N)nc(COc3cc(C#N)cc(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5277986 | 200740 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 438 | 6 | 2 | 7 | 4.2 | Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3C)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 25150014 | 10657 | 55 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 264 | 3 | 1 | 1 | 3.4 | OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C | 10.1021/ml4000673 | |||
| 3952 | 10657 | 55 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 264 | 3 | 1 | 1 | 3.4 | OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C | 10.1021/ml4000673 | |||
| CHEMBL449588 | 10657 | 55 | None | - | 1 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 264 | 3 | 1 | 1 | 3.4 | OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C | 10.1021/ml4000673 | |||
| CHEMBL5266881 | 200279 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 458 | 6 | 2 | 7 | 4.5 | Cc1ccc(Nc2nc(N)nc(COc3cc(Cl)cc(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5290885 | 201296 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 423 | 5 | 2 | 8 | 4.2 | Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 134151903 | 160135 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 438 | 6 | 1 | 6 | 4.2 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3978465 | 160135 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 438 | 6 | 1 | 6 | 4.2 | COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 134133797 | 150346 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 338 | 3 | 0 | 4 | 3.6 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3899190 | 150346 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 338 | 3 | 0 | 4 | 3.6 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 162674347 | 189900 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4794951 | 189900 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 90418651 | 169192 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 469 | 8 | 1 | 4 | 6.6 | CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4166012 | 169192 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 469 | 8 | 1 | 4 | 6.6 | CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL5289099 | 201239 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 425 | 6 | 2 | 8 | 4.1 | Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C(F)F)cc(=O)oc4c3)n2)cc1 | 10.1021/acsmedchemlett.2c00160 | |||
| 57522038 | 10659 | 60 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmcl.2020.127650 | |||
| 6490 | 10659 | 60 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL2058533 | 10659 | 60 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 364 | 7 | 1 | 2 | 5.4 | OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C | 10.1016/j.bmcl.2020.127650 | |||
| 66562385 | 97143 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 282 | 3 | 1 | 1 | 3.6 | Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386361 | 97143 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 282 | 3 | 1 | 1 | 3.6 | Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| 134134229 | 150033 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3896657 | 150033 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | |||
| 134138802 | 154697 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3933619 | 154697 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| 134145071 | 156946 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3951664 | 156946 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL5275980 | 200660 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 462 | 7 | 1 | 3 | 6.9 | OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F | 10.1021/acs.jmedchem.0c01002 | |||
| CHEMBL5278703 | 200769 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 438 | 6 | 2 | 7 | 4.3 | Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 134152545 | 160256 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3979588 | 160256 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| 134154975 | 158179 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 4.0 | O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3961620 | 158179 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 362 | 5 | 1 | 4 | 4.0 | O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| 90418513 | 169402 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 429 | 8 | 1 | 4 | 6.2 | CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4169436 | 169402 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 429 | 8 | 1 | 4 | 6.2 | CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| 134155950 | 157869 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 4.6 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3959068 | 157869 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 430 | 6 | 1 | 4 | 4.6 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| 134155847 | 157881 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 418 | 5 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3959144 | 157881 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 418 | 5 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 134155480 | 158030 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3960231 | 158030 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 137654131 | 165793 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 416 | 5 | 1 | 4 | 5.3 | COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4096579 | 165793 | 0 | None | - | 0 | Mouse | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 416 | 5 | 1 | 4 | 5.3 | COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| 134143370 | 152581 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 442 | 7 | 1 | 6 | 4.0 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3916986 | 152581 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 442 | 7 | 1 | 6 | 4.0 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL5290651 | 201285 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 432 | 8 | 2 | 7 | 3.4 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 127031003 | 145922 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 232 | 3 | 1 | 1 | 2.8 | C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3787072 | 145922 | 0 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 232 | 3 | 1 | 1 | 2.8 | C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| 8452407 | 187165 | 6 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 293 | 4 | 2 | 5 | 2.0 | Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4751828 | 187165 | 6 | None | - | 0 | Human | 4.8 | pEC50 | = | 4.8 | Binding | ChEMBL | 293 | 4 | 2 | 5 | 2.0 | Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | 10.1016/j.bmcl.2020.127650 | |||
| 78426052 | 184871 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 489 | 7 | 1 | 4 | 6.4 | Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4647832 | 184871 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 489 | 7 | 1 | 4 | 6.4 | Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL5286962 | 201145 | 0 | None | - | 0 | Human | 4.7 | pEC50 | = | 4.7 | Binding | ChEMBL | 438 | 6 | 2 | 7 | 4.2 | Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 90418782 | 169862 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 513 | 7 | 1 | 4 | 6.6 | O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4176642 | 169862 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 513 | 7 | 1 | 4 | 6.6 | O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| 73777153 | 149601 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3893026 | 149601 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 355 | 3 | 1 | 2 | 5.2 | O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 66562288 | 145787 | 0 | None | - | 0 | Human | 4.7 | pEC50 | = | 4.7 | Binding | ChEMBL | 246 | 3 | 1 | 1 | 3.2 | C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3785637 | 145787 | 0 | None | - | 0 | Human | 4.7 | pEC50 | = | 4.7 | Binding | ChEMBL | 246 | 3 | 1 | 1 | 3.2 | C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL5285139 | 201059 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 486 | 8 | 2 | 7 | 4.4 | Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)ccc3Cl)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 137633489 | 163379 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 4.0 | N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4068825 | 163379 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 4.0 | N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 | 10.1021/acs.jmedchem.7b00210 | |||
| 134148110 | 156349 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3946820 | 156349 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 134134229 | 150033 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3896657 | 150033 | 0 | None | - | 0 | Mouse | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 368 | 5 | 1 | 3 | 5.2 | O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1 | 10.1021/acsmedchemlett.6b00360 | |||
| 90418753 | 169175 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 6.6 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4165803 | 169175 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 463 | 8 | 1 | 4 | 6.6 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| 73776997 | 161059 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 407 | 4 | 1 | 4 | 4.5 | O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3986483 | 161059 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 407 | 4 | 1 | 4 | 4.5 | O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1 | 10.1021/acsmedchemlett.6b00360 | |||
| 16777240 | 186558 | 2 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 330 | 3 | 2 | 3 | 3.4 | Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4744629 | 186558 | 2 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 330 | 3 | 2 | 3 | 3.4 | Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL5278789 | 200774 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 508 | 7 | 2 | 8 | 4.8 | Cc1ccc(Nc2nc(N)nc(COc3cc(OC(F)(F)F)cc(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 156016724 | 184496 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.5 | O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 | 10.1016/j.ejmech.2018.04.061 | |||
| CHEMBL4642294 | 184496 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.5 | O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 | 10.1016/j.ejmech.2018.04.061 | |||
| 156016724 | 184496 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.5 | O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4642294 | 184496 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 5.5 | O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2 | 10.1016/j.bmc.2019.115263 | |||
| 73777111 | 156489 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3947837 | 156489 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 134153546 | 159360 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3971857 | 159360 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.4 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 137633536 | 163074 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | |||
| CHEMBL4065397 | 163074 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | |||
| 134145778 | 156126 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 355 | 3 | 0 | 3 | 4.3 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3945213 | 156126 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 355 | 3 | 0 | 3 | 4.3 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 134156727 | 160413 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3980898 | 160413 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| 137650498 | 164101 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 4.3 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4077353 | 164101 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 4.3 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 134134846 | 151017 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 337 | 3 | 0 | 3 | 4.2 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3904654 | 151017 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 337 | 3 | 0 | 3 | 4.2 | O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 137641818 | 164986 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 373 | 6 | 1 | 5 | 4.1 | COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4087992 | 164986 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 373 | 6 | 1 | 5 | 4.1 | COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 73777085 | 160009 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3977361 | 160009 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5285104 | 201058 | 0 | None | - | 0 | Human | 4.6 | pEC50 | = | 4.6 | Binding | ChEMBL | 486 | 8 | 2 | 7 | 4.4 | Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)cc3Cl)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 137651638 | 164000 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.8 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4076190 | 164000 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.8 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 137646368 | 164807 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 358 | 5 | 1 | 5 | 3.8 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4085695 | 164807 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 358 | 5 | 1 | 5 | 3.8 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 134154953 | 158055 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3960369 | 158055 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 66562289 | 145797 | 0 | None | - | 0 | Human | 4.6 | pEC50 | = | 4.6 | Binding | ChEMBL | 246 | 3 | 1 | 1 | 3.2 | C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3785764 | 145797 | 0 | None | - | 0 | Human | 4.6 | pEC50 | = | 4.6 | Binding | ChEMBL | 246 | 3 | 1 | 1 | 3.2 | C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| 134153067 | 159035 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3969073 | 159035 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 78425909 | 184453 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 1 | 3 | 6.1 | O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4641735 | 184453 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 1 | 3 | 6.1 | O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2 | 10.1016/j.bmc.2019.115263 | |||
| 117873187 | 159123 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3969920 | 159123 | 0 | None | - | 0 | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 73777156 | 159494 | 0 | None | - | 0 | Mouse | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3973034 | 159494 | 0 | None | - | 0 | Mouse | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5267225 | 200292 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 436 | 8 | 2 | 7 | 3.3 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(F)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 837245 | 17371 | 46 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 315 | 3 | 1 | 2 | 3.8 | Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL1170012 | 17371 | 46 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 315 | 3 | 1 | 2 | 3.8 | Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 73356514 | 97150 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 404 | 8 | 1 | 4 | 2.8 | CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386368 | 97150 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 404 | 8 | 1 | 4 | 2.8 | CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| 73345870 | 97151 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 404 | 8 | 1 | 4 | 2.8 | CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386369 | 97151 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 404 | 8 | 1 | 4 | 2.8 | CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| 73354950 | 97153 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 418 | 9 | 1 | 4 | 3.2 | CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386370 | 97153 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 418 | 9 | 1 | 4 | 3.2 | CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| 73348895 | 97154 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 418 | 9 | 1 | 4 | 3.2 | CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386371 | 97154 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 418 | 9 | 1 | 4 | 3.2 | CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| CHEMBL5268800 | 200358 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 452 | 8 | 2 | 7 | 3.8 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3Cl)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 73777111 | 156489 | 0 | None | - | 0 | Mouse | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3947837 | 156489 | 0 | None | - | 0 | Mouse | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 373 | 3 | 1 | 2 | 5.1 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5289929 | 201264 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 458 | 6 | 2 | 7 | 4.5 | Cc1ccc(Nc2nc(N)nc(COc3ccc(Cl)c(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 156635006 | 186319 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 400 | 4 | 2 | 4 | 4.0 | Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4741544 | 186319 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 400 | 4 | 2 | 4 | 4.0 | Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| 117886639 | 155229 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3937916 | 155229 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5269158 | 200372 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 454 | 7 | 2 | 8 | 3.9 | COc1ccc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc1N1CCCC1=O | 10.1021/acsmedchemlett.2c00160 | |||
| 66562392 | 97147 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 336 | 3 | 1 | 1 | 4.6 | O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F | 10.1021/ml4000673 | |||
| CHEMBL2386365 | 97147 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 336 | 3 | 1 | 1 | 4.6 | O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F | 10.1021/ml4000673 | |||
| 134138281 | 154564 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 410 | 7 | 1 | 6 | 3.9 | COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3932664 | 154564 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 410 | 7 | 1 | 6 | 3.9 | COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 134138802 | 154697 | 0 | None | - | 0 | Mouse | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3933619 | 154697 | 0 | None | - | 0 | Mouse | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 383 | 4 | 1 | 3 | 4.7 | O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| 134153986 | 159285 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3971308 | 159285 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 396 | 4 | 1 | 3 | 4.8 | O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 117886649 | 158857 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 391 | 4 | 1 | 3 | 5.4 | OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3967504 | 158857 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 391 | 4 | 1 | 3 | 5.4 | OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5287009 | 201150 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 418 | 8 | 2 | 7 | 3.1 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 118184919 | 169652 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.6 | N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4173280 | 169652 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.6 | N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| 127030344 | 145923 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 242 | 3 | 1 | 1 | 3.2 | O=C(O)CCc1ccc(C#CC2CCCC2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3787110 | 145923 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 242 | 3 | 1 | 1 | 3.2 | O=C(O)CCc1ccc(C#CC2CCCC2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| 127031002 | 145865 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 232 | 3 | 1 | 1 | 2.8 | C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3786526 | 145865 | 0 | None | - | 0 | Human | 4.5 | pEC50 | = | 4.5 | Binding | ChEMBL | 232 | 3 | 1 | 1 | 2.8 | C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/acs.jmedchem.5b01962 | |||
| 134132142 | 151647 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3909872 | 151647 | 0 | None | - | 0 | Mouse | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 402 | 7 | 1 | 3 | 5.8 | Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O | 10.1021/acsmedchemlett.6b00360 | |||
| 1050 | 8683 | 94 | None | - | 2 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1021/acs.jmedchem.0c01002 | |||
| 11595431 | 8683 | 94 | None | - | 2 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1021/acs.jmedchem.0c01002 | |||
| CHEMBL207881 | 8683 | 94 | None | - | 2 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 347 | 8 | 2 | 3 | 5.1 | OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1 | 10.1021/acs.jmedchem.0c01002 | |||
| 674995 | 149782 | 14 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 343 | 5 | 1 | 3 | 4.4 | O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3894632 | 149782 | 14 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 343 | 5 | 1 | 3 | 4.4 | O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| 162672256 | 189651 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 346 | 4 | 2 | 4 | 3.1 | COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4791789 | 189651 | 0 | None | - | 0 | Human | 5.5 | pEC50 | = | 5.5 | Binding | ChEMBL | 346 | 4 | 2 | 4 | 3.1 | COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL5278642 | 200767 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 443 | 5 | 2 | 8 | 4.5 | Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(Cl)c(Cl)c4)n3)ccc12 | 10.1021/acsmedchemlett.2c00160 | |||
| 137648938 | 164191 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 382 | 4 | 1 | 3 | 5.5 | Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4078553 | 164191 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 382 | 4 | 1 | 3 | 5.5 | Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| 73777156 | 159494 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3973034 | 159494 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 396 | 4 | 1 | 4 | 4.7 | N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5283269 | 200975 | 0 | None | - | 0 | Human | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 502 | 9 | 2 | 8 | 4.0 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3OC(F)(F)F)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 71655293 | 97136 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 3.3 | N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386354 | 97136 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 3.3 | N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| 71655227 | 97144 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 282 | 3 | 1 | 1 | 3.6 | Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386362 | 97144 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 282 | 3 | 1 | 1 | 3.6 | Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| 134147107 | 156655 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 5.5 | O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3949142 | 156655 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 5.5 | O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 156635004 | 186491 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 344 | 4 | 2 | 3 | 3.7 | CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4743951 | 186491 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 344 | 4 | 2 | 3 | 3.7 | CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 162674533 | 190244 | 0 | None | - | 0 | Human | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 372 | 3 | 2 | 3 | 4.4 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4799103 | 190244 | 0 | None | - | 0 | Human | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 372 | 3 | 2 | 3 | 4.4 | CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 134144000 | 156988 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3952043 | 156988 | 0 | None | - | 0 | Mouse | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 134132711 | 151716 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3910333 | 151716 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 372 | 3 | 0 | 4 | 4.2 | O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL5273939 | 200566 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(C)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 137660172 | 165892 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4097652 | 165892 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O | 10.1021/acs.jmedchem.7b00210 | |||
| 117886639 | 155229 | 0 | None | - | 0 | Mouse | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3937916 | 155229 | 0 | None | - | 0 | Mouse | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 391 | 3 | 1 | 3 | 5.3 | CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1 | 10.1021/acsmedchemlett.6b00360 | |||
| 127033352 | 145798 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 272 | 8 | 1 | 1 | 4.4 | CCCCCCCC#Cc1ccc(CCC(=O)O)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3785789 | 145798 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 272 | 8 | 1 | 1 | 4.4 | CCCCCCCC#Cc1ccc(CCC(=O)O)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| 137658977 | 165883 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 4.3 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4097537 | 165883 | 0 | None | - | 0 | Mouse | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 4.3 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 137649363 | 164175 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4078374 | 164175 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 134146386 | 155686 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3941726 | 155686 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 384 | 5 | 1 | 3 | 5.0 | O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| 73777174 | 157233 | 0 | None | - | 0 | Mouse | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3954140 | 157233 | 0 | None | - | 0 | Mouse | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 90442039 | 169688 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 509 | 7 | 1 | 4 | 7.1 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4173940 | 169688 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 509 | 7 | 1 | 4 | 7.1 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F | 10.1021/acsmedchemlett.7b00233 | |||
| 134132951 | 151400 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 454 | 8 | 1 | 7 | 3.9 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3907996 | 151400 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 454 | 8 | 1 | 7 | 3.9 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 137652399 | 164274 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4079621 | 164274 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O | 10.1021/acs.jmedchem.7b00210 | |||
| 46892131 | 151449 | 2 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3908362 | 151449 | 2 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 134138099 | 154600 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3932897 | 154600 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 369 | 3 | 0 | 3 | 4.6 | Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL5289774 | 201259 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 375 | 5 | 2 | 8 | 3.2 | Cc1ccc(Nc2nc(N)nc(COc3ccc4ccc(=O)oc4c3)n2)cc1 | 10.1021/acsmedchemlett.2c00160 | |||
| 73507535 | 184243 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 5.5 | O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4639009 | 184243 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 5.5 | O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1 | 10.1016/j.bmc.2019.115263 | |||
| 73777065 | 154034 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3928591 | 154034 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 137642248 | 164932 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4087308 | 164932 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1 | 10.1021/acs.jmedchem.7b00210 | |||
| 137643731 | 165165 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 361 | 5 | 1 | 4 | 4.2 | O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4089919 | 165165 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 361 | 5 | 1 | 4 | 4.2 | O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| 137658977 | 165883 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 4.3 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4097537 | 165883 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 385 | 5 | 1 | 5 | 4.3 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 73777069 | 149447 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3891920 | 149447 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| 11195 | 10654 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| 86280676 | 10654 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3941880 | 10654 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 356 | 3 | 0 | 4 | 3.7 | Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2 | 10.1021/acs.jmedchem.6b00685 | |||
| 67072752 | 93304 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 289 | 4 | 1 | 2 | 3.2 | N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 | 10.1021/jm301470a | |||
| CHEMBL2315528 | 93304 | 0 | None | - | 1 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 289 | 4 | 1 | 2 | 3.2 | N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 | 10.1021/jm301470a | |||
| 127033353 | 145929 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 278 | 5 | 1 | 1 | 3.7 | O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3787151 | 145929 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 278 | 5 | 1 | 1 | 3.7 | O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| 73777135 | 157149 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3953289 | 157149 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 412 | 4 | 1 | 4 | 5.4 | N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| 137632610 | 163125 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 4.0 | N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4065890 | 163125 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 4.0 | N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 743974 | 119804 | 70 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3311308 | 119804 | 70 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| 162673626 | 189972 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 350 | 3 | 2 | 3 | 3.7 | Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4795755 | 189972 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 350 | 3 | 2 | 3 | 3.7 | Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| 134144000 | 156988 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3952043 | 156988 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 431 | 8 | 1 | 6 | 4.0 | COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL5286838 | 201138 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 362 | 3 | 0 | 4 | 3.6 | C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.0c01002 | |||
| 134154415 | 159473 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 447 | 6 | 1 | 5 | 6.3 | Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3972870 | 159473 | 0 | None | - | 0 | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 447 | 6 | 1 | 5 | 6.3 | Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1 | 10.1021/acsmedchemlett.6b00394 | |||
| 118679768 | 184399 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 390 | 9 | 1 | 2 | 6.4 | O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 | 10.1016/j.ejmech.2018.04.061 | |||
| CHEMBL4641038 | 184399 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 390 | 9 | 1 | 2 | 6.4 | O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 | 10.1016/j.ejmech.2018.04.061 | |||
| 118679768 | 184399 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 390 | 9 | 1 | 2 | 6.4 | O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4641038 | 184399 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 390 | 9 | 1 | 2 | 6.4 | O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 | 10.1016/j.bmc.2019.115263 | |||
| 118679768 | 184399 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 390 | 9 | 1 | 2 | 6.4 | O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 | 10.1021/acs.jmedchem.0c01002 | |||
| CHEMBL4641038 | 184399 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 390 | 9 | 1 | 2 | 6.4 | O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1 | 10.1021/acs.jmedchem.0c01002 | |||
| CHEMBL5272316 | 200495 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 364 | 8 | 1 | 2 | 5.8 | Cc1ccc(C2=C(COc3ccc(CCCC(=O)O)cc3)CCCC2)cc1 | 10.1021/acs.jmedchem.0c01002 | |||
| CHEMBL5285896 | 201101 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 404 | 8 | 1 | 2 | 6.4 | O=C(O)CCCc1ccc(OCC2=C(c3ccc4c(c3)CCCC4)CCCC2)cc1 | 10.1021/acs.jmedchem.0c01002 | |||
| CHEMBL5268182 | 200329 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.4 | Cc1cc(OCc2nc(N)nc(NCCc3cc(F)ccc3F)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 46908122 | 158349 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.8 | O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3963275 | 158349 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 334 | 3 | 0 | 4 | 3.8 | O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 162676836 | 190282 | 0 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | ChEMBL | 332 | 3 | 3 | 4 | 2.8 | Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4799668 | 190282 | 0 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | ChEMBL | 332 | 3 | 3 | 4 | 2.8 | Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| 90418476 | 169565 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 511 | 7 | 1 | 4 | 6.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4172136 | 169565 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 511 | 7 | 1 | 4 | 6.7 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| 137645249 | 164390 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 403 | 5 | 1 | 5 | 4.4 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4080998 | 164390 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 403 | 5 | 1 | 5 | 4.4 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| 137648938 | 164191 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 382 | 4 | 1 | 3 | 5.5 | Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4078553 | 164191 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 382 | 4 | 1 | 3 | 5.5 | Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| 156635003 | 187715 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 394 | 3 | 2 | 3 | 3.9 | Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4758125 | 187715 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 394 | 3 | 2 | 3 | 3.9 | Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| 137657813 | 166553 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 400 | 4 | 1 | 3 | 5.6 | Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4105241 | 166553 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 400 | 4 | 1 | 3 | 5.6 | Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| 134147328 | 156828 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 394 | 4 | 0 | 4 | 4.4 | N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3950610 | 156828 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 394 | 4 | 0 | 4 | 4.4 | N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 162649435 | 186819 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 288 | 6 | 1 | 2 | 3.7 | Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4747554 | 186819 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 288 | 6 | 1 | 2 | 3.7 | Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 73777085 | 160009 | 0 | None | - | 0 | Mouse | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3977361 | 160009 | 0 | None | - | 0 | Mouse | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 351 | 4 | 1 | 3 | 4.6 | COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5283683 | 201004 | 0 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | ChEMBL | 482 | 9 | 2 | 8 | 3.8 | COc1ccc(Cl)cc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1 | 10.1021/acsmedchemlett.2c00160 | |||
| 2843133 | 154425 | 51 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 307 | 6 | 1 | 2 | 4.0 | CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3931570 | 154425 | 51 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 307 | 6 | 1 | 2 | 4.0 | CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 | 10.1021/acs.jmedchem.6b00685 | |||
| 73777063 | 7937 | 39 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | |||
| 8418 | 7937 | 39 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3919973 | 7937 | 39 | None | - | 0 | Mouse | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | |||
| 137657813 | 166553 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 400 | 4 | 1 | 3 | 5.6 | Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4105241 | 166553 | 0 | None | - | 0 | Mouse | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 400 | 4 | 1 | 3 | 5.6 | Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL5278391 | 200758 | 0 | None | - | 0 | Human | 4.3 | pEC50 | = | 4.3 | Binding | ChEMBL | 486 | 8 | 2 | 7 | 4.4 | Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5273250 | 200533 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 437 | 6 | 2 | 8 | 4.4 | CCc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 134141650 | 153477 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| CHEMBL3923955 | 153477 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 380 | 3 | 0 | 4 | 4.2 | N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1 | 10.1021/acs.jmedchem.6b00685 | |||
| 66562390 | 97140 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 268 | 3 | 1 | 1 | 3.2 | O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386358 | 97140 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 268 | 3 | 1 | 1 | 3.2 | O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1 | 10.1021/ml4000673 | |||
| 162645828 | 186442 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 4.2 | O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4743323 | 186442 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 4.2 | O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 73776995 | 155521 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3940359 | 155521 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 419 | 4 | 1 | 3 | 5.7 | CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5278718 | 200771 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 424 | 6 | 2 | 7 | 3.9 | Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 90118275 | 184159 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 377 | 9 | 1 | 4 | 4.8 | O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4637969 | 184159 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 377 | 9 | 1 | 4 | 4.8 | O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1 | 10.1016/j.bmc.2019.115263 | |||
| 156021563 | 184804 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 6.2 | COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4646784 | 184804 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 6.2 | COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1 | 10.1016/j.bmc.2019.115263 | |||
| 134155067 | 158085 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 401 | 7 | 1 | 5 | 4.4 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3960738 | 158085 | 0 | None | - | 0 | Human | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 401 | 7 | 1 | 5 | 4.4 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 134156727 | 160413 | 0 | None | - | 0 | Mouse | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3980898 | 160413 | 0 | None | - | 0 | Mouse | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 4.1 | CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL5286838 | 201138 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 362 | 3 | 0 | 4 | 3.6 | C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1 | 10.1021/acs.jmedchem.0c01002 | |||
| CHEMBL5268316 | 200338 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 438 | 6 | 2 | 7 | 4.2 | Cc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5268389 | 200342 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 423 | 5 | 2 | 8 | 4.2 | Cc1cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)ccc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5287642 | 201167 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 454 | 7 | 2 | 8 | 3.9 | COc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 137651358 | 163922 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 375 | 5 | 1 | 4 | 4.6 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4075162 | 163922 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 375 | 5 | 1 | 4 | 4.6 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL5278836 | 200778 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 452 | 8 | 2 | 7 | 3.8 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 162656082 | 187481 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 299 | 6 | 1 | 3 | 3.3 | N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4755578 | 187481 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 299 | 6 | 1 | 3 | 3.3 | N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 90405673 | 184789 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 489 | 7 | 1 | 3 | 6.0 | OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4646553 | 184789 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 489 | 7 | 1 | 3 | 6.0 | OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1 | 10.1016/j.bmc.2019.115263 | |||
| 90417978 | 168763 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4159180 | 168763 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| 137645249 | 164390 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 403 | 5 | 1 | 5 | 4.4 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4080998 | 164390 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 403 | 5 | 1 | 5 | 4.4 | COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| 743974 | 119804 | 70 | None | - | 0 | Mouse | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | |||
| CHEMBL3311308 | 119804 | 70 | None | - | 0 | Mouse | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 3.4 | COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1 | 10.1016/j.bmcl.2014.05.012 | |||
| 81762207 | 189526 | 1 | None | - | 0 | Human | 4.2 | pEC50 | = | 4.2 | Binding | ChEMBL | 266 | 3 | 2 | 3 | 2.2 | Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4790052 | 189526 | 1 | None | - | 0 | Human | 4.2 | pEC50 | = | 4.2 | Binding | ChEMBL | 266 | 3 | 2 | 3 | 2.2 | Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL5266170 | 200249 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 480 | 6 | 2 | 7 | 5.2 | Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)cc(C(C)(C)C)c3)n2)cc1Cl | 10.1021/acsmedchemlett.2c00160 | |||
| 137649555 | 164109 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4077507 | 164109 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 357 | 5 | 1 | 4 | 4.4 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 137656733 | 166363 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 383 | 4 | 1 | 4 | 4.9 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4102951 | 166363 | 0 | None | - | 0 | Mouse | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 383 | 4 | 1 | 4 | 4.9 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| 66562388 | 97149 | 0 | None | - | 0 | Human | 4.2 | pEC50 | = | 4.2 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 2.8 | CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386367 | 97149 | 0 | None | - | 0 | Human | 4.2 | pEC50 | = | 4.2 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 2.8 | CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1 | 10.1021/ml4000673 | |||
| 73777063 | 7937 | 39 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | |||
| 8418 | 7937 | 39 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3919973 | 7937 | 39 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 405 | 4 | 1 | 3 | 5.5 | OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F | 10.1021/acsmedchemlett.6b00360 | |||
| 85470884 | 170783 | 2 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | |||
| CHEMBL4208325 | 170783 | 2 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 459 | 7 | 1 | 3 | 6.0 | O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1 | 10.1016/j.bmcl.2018.02.013 | |||
| 137637713 | 162635 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 369 | 4 | 1 | 4 | 4.6 | Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4060171 | 162635 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 369 | 4 | 1 | 4 | 4.6 | Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 134133355 | 150314 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 413 | 6 | 1 | 5 | 4.2 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3898962 | 150314 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 413 | 6 | 1 | 5 | 4.2 | COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 137633536 | 163074 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | |||
| CHEMBL4065397 | 163074 | 0 | None | - | 0 | Mouse | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 368 | 7 | 1 | 3 | 4.6 | COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C | 10.1016/j.bmcl.2017.01.034 | |||
| 73777069 | 149447 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3891920 | 149447 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 389 | 4 | 1 | 3 | 5.0 | O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5266730 | 200269 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 486 | 8 | 2 | 7 | 4.4 | Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)cc(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 85472618 | 169089 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 491 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4164509 | 169089 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 491 | 7 | 1 | 4 | 6.7 | Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| 156016929 | 184504 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 540 | 7 | 1 | 7 | 5.3 | COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1 | 10.1016/j.bmc.2019.115263 | |||
| CHEMBL4642324 | 184504 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 540 | 7 | 1 | 7 | 5.3 | COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1 | 10.1016/j.bmc.2019.115263 | |||
| 137659366 | 166210 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.1 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4101071 | 166210 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.1 | Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 137638317 | 163501 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 387 | 6 | 1 | 5 | 4.4 | COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4070273 | 163501 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 387 | 6 | 1 | 5 | 4.4 | COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL5267671 | 200314 | 0 | None | - | 0 | Human | 4.1 | pEC50 | = | 4.1 | Binding | ChEMBL | 446 | 8 | 2 | 7 | 3.7 | Cc1cc(OCc2nc(N)nc(NCCc3c(C)cccc3C)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 137638318 | 163513 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4070359 | 163513 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 402 | 4 | 1 | 5 | 4.4 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1 | 10.1021/acs.jmedchem.7b00210 | |||
| 127031001 | 145911 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 242 | 3 | 1 | 1 | 3.4 | CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3786972 | 145911 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 242 | 3 | 1 | 1 | 3.4 | CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| 137651153 | 163983 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.7 | CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4076004 | 163983 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.7 | CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 67072752 | 93304 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 289 | 4 | 1 | 2 | 3.2 | N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 | 10.1021/ml4000673 | |||
| CHEMBL2315528 | 93304 | 0 | None | - | 1 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 289 | 4 | 1 | 2 | 3.2 | N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1 | 10.1021/ml4000673 | |||
| 137654131 | 165793 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 416 | 5 | 1 | 4 | 5.3 | COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4096579 | 165793 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 416 | 5 | 1 | 4 | 5.3 | COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12 | 10.1021/acs.jmedchem.7b00210 | |||
| 134131620 | 149210 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 4.5 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3890035 | 149210 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 4.5 | COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 66562286 | 97141 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 268 | 3 | 1 | 1 | 3.2 | O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F | 10.1021/ml4000673 | |||
| CHEMBL2386359 | 97141 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 268 | 3 | 1 | 1 | 3.2 | O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F | 10.1021/ml4000673 | |||
| 134153298 | 159145 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 412 | 6 | 1 | 4 | 4.8 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3970166 | 159145 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 412 | 6 | 1 | 4 | 4.8 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 134131874 | 151635 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 404 | 6 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3909773 | 151635 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 404 | 6 | 1 | 3 | 5.6 | O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL5289306 | 201243 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 4.1 | Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5267354 | 200302 | 0 | None | - | 0 | Human | 4.1 | pEC50 | = | 4.1 | Binding | ChEMBL | 503 | 9 | 2 | 9 | 3.0 | Cc1cc(OCc2nc(N)nc(NCCc3ccccc3N3CCOCC3)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 85472227 | 168967 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 519 | 7 | 1 | 4 | 6.8 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4162566 | 168967 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 519 | 7 | 1 | 4 | 6.8 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| 66562389 | 97142 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 286 | 3 | 1 | 1 | 3.4 | O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F | 10.1021/ml4000673 | |||
| CHEMBL2386360 | 97142 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 286 | 3 | 1 | 1 | 3.4 | O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F | 10.1021/ml4000673 | |||
| 134156455 | 161100 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 394 | 6 | 1 | 5 | 4.3 | Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3986721 | 161100 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 394 | 6 | 1 | 5 | 4.3 | Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | |||
| 137637713 | 162635 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 369 | 4 | 1 | 4 | 4.6 | Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4060171 | 162635 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 369 | 4 | 1 | 4 | 4.6 | Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12 | 10.1021/acs.jmedchem.7b00210 | |||
| 25149901 | 193465 | 1 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 250 | 3 | 1 | 1 | 3.1 | O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 | 10.1021/ml4000673 | |||
| CHEMBL488384 | 193465 | 1 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 250 | 3 | 1 | 1 | 3.1 | O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 | 10.1021/ml4000673 | |||
| 25149901 | 193465 | 1 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 250 | 3 | 1 | 1 | 3.1 | O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL488384 | 193465 | 1 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 250 | 3 | 1 | 1 | 3.1 | O=C(O)CCc1ccc(C#Cc2ccccc2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| 85472225 | 169540 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4171724 | 169540 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.5 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| 16775835 | 186942 | 2 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 316 | 3 | 2 | 3 | 3.1 | Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4748982 | 186942 | 2 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 316 | 3 | 2 | 3 | 3.1 | Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| 134152336 | 160235 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 408 | 5 | 1 | 5 | 4.2 | Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3979448 | 160235 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 408 | 5 | 1 | 5 | 4.2 | Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2 | 10.1021/acsmedchemlett.6b00394 | |||
| 16770747 | 188950 | 2 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 334 | 3 | 2 | 3 | 3.2 | Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4782622 | 188950 | 2 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 334 | 3 | 2 | 3 | 3.2 | Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F | 10.1016/j.bmcl.2020.127650 | |||
| 134145700 | 155530 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 400 | 7 | 1 | 4 | 5.0 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| CHEMBL3940429 | 155530 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 400 | 7 | 1 | 4 | 5.0 | COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F | 10.1021/acsmedchemlett.6b00394 | |||
| 137656733 | 166363 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 383 | 4 | 1 | 4 | 4.9 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4102951 | 166363 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 383 | 4 | 1 | 4 | 4.9 | Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL5275546 | 200640 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.4 | Cc1cc(OCc2nc(N)nc(NCCc3c(F)cccc3F)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| CHEMBL5282108 | 200924 | 0 | None | - | 0 | Human | 5.1 | pEC50 | = | 5.1 | Binding | ChEMBL | 486 | 8 | 2 | 7 | 4.4 | Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3Cl)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 90418333 | 169434 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 473 | 8 | 1 | 5 | 5.7 | COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4169851 | 169434 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 473 | 8 | 1 | 5 | 5.7 | COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| 71655226 | 97139 | 0 | None | - | 0 | Human | 4.0 | pEC50 | = | 4.0 | Binding | ChEMBL | 251 | 3 | 1 | 2 | 2.5 | O=C(O)CCc1ccc(C#Cc2ccccc2)nc1 | 10.1021/ml4000673 | |||
| CHEMBL2386357 | 97139 | 0 | None | - | 0 | Human | 4.0 | pEC50 | = | 4.0 | Binding | ChEMBL | 251 | 3 | 1 | 2 | 2.5 | O=C(O)CCc1ccc(C#Cc2ccccc2)nc1 | 10.1021/ml4000673 | |||
| 73777174 | 157233 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3954140 | 157233 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 356 | 3 | 1 | 3 | 4.4 | O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL5285725 | 201090 | 0 | None | - | 0 | Human | 4.0 | pEC50 | = | 4.0 | Binding | ChEMBL | 446 | 8 | 2 | 7 | 3.7 | Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)cc3C)n2)cc(N2CCCC2=O)c1 | 10.1021/acsmedchemlett.2c00160 | |||
| 6483 | 10658 | 54 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 3.3 | N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O | 10.1021/ml4000673 | |||
| 66553168 | 10658 | 54 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 3.3 | N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O | 10.1021/ml4000673 | |||
| CHEMBL2386353 | 10658 | 54 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 307 | 4 | 1 | 2 | 3.3 | N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O | 10.1021/ml4000673 | |||
| 66562386 | 97145 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 307 | 3 | 1 | 2 | 3.4 | Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| CHEMBL2386363 | 97145 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 307 | 3 | 1 | 2 | 3.4 | Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1 | 10.1021/ml4000673 | |||
| 127033020 | 145854 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 256 | 3 | 1 | 1 | 3.6 | O=C(O)CCc1ccc(C#CC2CCCCC2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| CHEMBL3786418 | 145854 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 256 | 3 | 1 | 1 | 3.6 | O=C(O)CCc1ccc(C#CC2CCCCC2)cc1 | 10.1021/acs.jmedchem.5b01962 | |||
| 162652317 | 187100 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 304 | 7 | 1 | 3 | 3.4 | COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4751137 | 187100 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 304 | 7 | 1 | 3 | 3.4 | COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 162672935 | 189981 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 332 | 7 | 1 | 4 | 3.2 | COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| CHEMBL4795858 | 189981 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 332 | 7 | 1 | 4 | 3.2 | COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1 | 10.1016/j.bmcl.2020.127650 | |||
| 85472359 | 168908 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 6.3 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4161536 | 168908 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 471 | 8 | 1 | 4 | 6.3 | CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1 | 10.1021/acsmedchemlett.7b00233 | |||
| 85472487 | 169256 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4167097 | 169256 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 477 | 7 | 1 | 4 | 6.4 | O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F | 10.1021/acsmedchemlett.7b00233 | |||
| 145960576 | 168931 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 527 | 8 | 1 | 5 | 6.6 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| CHEMBL4161929 | 168931 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 527 | 8 | 1 | 5 | 6.6 | O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1 | 10.1021/acsmedchemlett.7b00233 | |||
| 137637243 | 162668 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 4.1 | O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| CHEMBL4060517 | 162668 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 343 | 5 | 1 | 4 | 4.1 | O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1 | 10.1021/acs.jmedchem.7b00210 | |||
| 134135468 | 151253 | 0 | None | - | 0 | Mouse | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 389 | 4 | 1 | 3 | 4.8 | O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| CHEMBL3906716 | 151253 | 0 | None | - | 0 | Mouse | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 389 | 4 | 1 | 3 | 4.8 | O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1 | 10.1021/acsmedchemlett.6b00360 | |||
| 233085 | 119800 | 48 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 | 10.1016/j.bmcl.2014.05.012 | |||
| CHEMBL3311302 | 119800 | 48 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 | 10.1016/j.bmcl.2014.05.012 | |||
| 233085 | 119800 | 48 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 | 10.1016/j.bmcl.2014.05.012 | |||
| CHEMBL3311302 | 119800 | 48 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 | 10.1016/j.bmcl.2014.05.012 | |||
| 233085 | 119800 | 48 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 | 10.1016/j.bmcl.2014.05.012 | |||
| CHEMBL3311302 | 119800 | 48 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 | 10.1016/j.bmcl.2014.05.012 | |||