Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
25174150 9117 0 None 64 2 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099326 9117 0 None 64 2 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
25191879 9126 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 599 18 2 5 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099335 9126 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 599 18 2 5 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O 10.1021/jm1001919
25191880 9123 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 587 18 2 6 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099332 9123 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 587 18 2 6 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192021 9114 0 None 223 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099323 9114 0 None 223 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192023 8531 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 625 18 2 7 7.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094346 8531 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 625 18 2 7 7.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192174 9122 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 586 18 2 5 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099331 9122 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 586 18 2 5 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
132379 111732 19 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111732 19 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
25192176 8532 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 626 18 2 8 7.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094347 8532 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 626 18 2 8 7.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192175 9125 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 588 18 2 7 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099334 9125 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 588 18 2 7 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192022 3355 7 None 21 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6158 3355 7 None 21 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
CHEMBL1098560 3355 7 None 21 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
23501721 9121 0 None 316 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099330 9121 0 None 316 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
25192325 9124 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 621 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099333 9124 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 621 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O 10.1021/jm1001919
25192326 9030 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 592 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1098550 9030 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 592 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192327 9128 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 624 18 2 6 8.2 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099337 9128 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 624 18 2 6 8.2 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192468 8534 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094349 8534 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O 10.1021/jm1001919
132379 111732 19 None - 1 Human 9.1 pIC50 = 9.1 Functional
Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111732 19 None - 1 Human 9.1 pIC50 = 9.1 Functional
Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
25192471 8533 0 None 15 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094348 8533 0 None 15 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
10319829 26118 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 26118 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10341135 29388 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 29388 0 None - 1 Human 7.0 pIC50 = 7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10047140 27607 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 27607 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
14946858 29161 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 29161 0 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
6444688 187320 35 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 187320 35 None - 1 Human 6.0 pIC50 = 6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
10071290 28100 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 28100 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
25192022 3355 7 None 21 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6158 3355 7 None 21 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
CHEMBL1098560 3355 7 None 21 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6444688 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00100a034
CHEMBL49302 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00100a034
10343923 27783 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 27783 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10477988 28143 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 28143 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10364772 28160 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 28160 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
25192471 8533 0 None 15 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094348 8533 0 None 15 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
6444688 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm960088k
CHEMBL49302 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm960088k
46888200 9127 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 637 18 3 4 9.1 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099336 9127 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 637 18 3 4 9.1 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O 10.1021/jm1001919
10341242 28153 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 28153 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
6450158 187174 20 None - 1 Human 6.9 pIC50 = 6.9 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 187174 20 None - 1 Human 6.9 pIC50 = 6.9 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
46888199 9120 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 696 18 2 8 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099329 9120 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 696 18 2 8 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
114999 3538 21 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
6156 3538 21 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
CHEMBL14823 3538 21 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
44382384 59542 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL171666 59542 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10092630 27821 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 27821 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10475503 28008 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 28008 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10023244 26162 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 26162 1 None - 1 Human 6.8 pIC50 = 6.8 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357534 26740 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 26740 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10406292 28396 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 28396 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9865985 28673 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 28673 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
10427789 27940 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 27940 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
23501721 9121 0 None 316 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099330 9121 0 None 316 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
9976757 28501 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 28501 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44382378 58869 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL168854 58869 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10474602 25979 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 25979 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
46888201 9129 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 654 19 2 7 8.2 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1 10.1021/jm1001919
CHEMBL1099338 9129 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 654 19 2 7 8.2 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1 10.1021/jm1001919
3368 1173 26 None -3 2 Mouse 7.5 pIC50 = 7.5 Functional
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 1173 26 None -3 2 Mouse 7.5 pIC50 = 7.5 Functional
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 1173 26 None -3 2 Mouse 7.5 pIC50 = 7.5 Functional
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
10001576 28381 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 28381 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10046878 28433 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 28433 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
46888196 9116 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 640 20 2 6 8.5 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1 10.1021/jm1001919
CHEMBL1099325 9116 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 640 20 2 6 8.5 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1 10.1021/jm1001919
44382275 59737 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL172457 59737 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
25192021 9114 0 None 223 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099323 9114 0 None 223 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
44382276 120316 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL352814 120316 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
9978895 118976 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL342416 118976 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10021742 9456 6 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9456 6 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
44356239 27842 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 361 8 0 2 4.9 CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1 10.1021/jm00100a034
CHEMBL137121 27842 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 361 8 0 2 4.9 CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1 10.1021/jm00100a034
46888197 9118 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099327 9118 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O 10.1021/jm1001919
46888198 9119 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 668 18 2 8 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099328 9119 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 668 18 2 8 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
9934323 100253 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL288758 100253 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
10091738 27803 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 27803 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
46888202 8535 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 656 18 2 6 8.4 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094350 8535 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 656 18 2 6 8.4 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
44382468 59088 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL169639 59088 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10430674 119338 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 119338 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
25174150 9117 0 None 64 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099326 9117 0 None 64 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
44357546 116753 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 116753 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
46888195 9115 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 616 18 2 4 8.7 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099324 9115 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 616 18 2 4 8.7 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O 10.1021/jm1001919
122023 50795 60 None 1 3 Human 7.1 pIC50 = 7.1 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
CHEMBL15766 50795 60 None 1 3 Human 7.1 pIC50 = 7.1 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
CHEMBL45460 50795 60 None 1 3 Human 7.1 pIC50 = 7.1 Functional
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
132379 111732 19 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111732 19 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
3368 1173 26 None 3 2 Human 8.0 pIC50 = 8.0 Functional
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 1173 26 None 3 2 Human 8.0 pIC50 = 8.0 Functional
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 1173 26 None 3 2 Human 8.0 pIC50 = 8.0 Functional
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
10022413 27658 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 27658 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10692884 188165 0 None - 0 Human 8.0 pKi = 8.0 Functional
Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs
ChEMBL 409 10 1 3 5.1 CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1 10.1021/jm980540v
CHEMBL49866 188165 0 None - 0 Human 8.0 pKi = 8.0 Functional
Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs
ChEMBL 409 10 1 3 5.1 CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1 10.1021/jm980540v
60490 207261 106 None -8 2 Human 8.2 pIC50 = 8.2 Functional
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
Drug Central 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O None
CHEMBL93 207261 106 None -8 2 Human 8.2 pIC50 = 8.2 Functional
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
Drug Central 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O None
71398 106439 44 None 3 14 Human 8.2 pIC50 = 8.2 Functional
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
Drug Central 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 None
CHEMBL313972 106439 44 None 3 14 Human 8.2 pIC50 = 8.2 Functional
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
Drug Central 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 None
6157 2934 20 None - 1 Human 5.8 pIC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6438358 2934 20 None - 1 Human 5.8 pIC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
CHEMBL422420 2934 20 None - 1 Human 5.8 pIC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
114999 3538 21 None - 1 Human 6.1 pIC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
6156 3538 21 None - 1 Human 6.1 pIC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
CHEMBL14823 3538 21 None - 1 Human 6.1 pIC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
3368 1173 26 None 3 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
9867257 1173 26 None 3 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
CHEMBL51770 1173 26 None 3 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
25192022 3355 7 None 21 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
6158 3355 7 None 21 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
CHEMBL1098560 3355 7 None 21 2 Human 8.1 pIC50 = 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
177941 1588 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
2948 1588 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
CHEMBL329123 1588 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
DB12850 1588 50 None - 1 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
6154 634 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
6154 634 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
9956189 634 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
9956189 634 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
6155 1176 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
9823886 1176 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
CHEMBL301829 1176 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
DB13053 1176 0 None 1318 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
44379678 164922 0 None - 0 Human 10.0 pIC50 = 10 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 527 14 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL422388 164922 0 None - 0 Human 10.0 pIC50 = 10 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 527 14 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
44379453 58085 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 513 13 1 6 4.9 CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167350 58085 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 513 13 1 6 4.9 CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
15817161 58135 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 499 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167804 58135 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 499 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
9865985 28673 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 28673 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
114999 3538 21 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
6156 3538 21 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
CHEMBL14823 3538 21 None - 1 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
204058 163459 8 None - 1 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm960088k
CHEMBL419948 163459 8 None - 1 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm960088k
196905 111631 8 None - 0 Human 8.8 pIC50 = 8.8 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm960088k
CHEMBL328492 111631 8 None - 0 Human 8.8 pIC50 = 8.8 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm960088k
2487 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
5280492 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
CHEMBL65061 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
DB12961 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
6444688 187320 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49302 187320 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
2487 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
5280492 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
CHEMBL65061 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
DB12961 2368 36 None 31 2 Human 8.7 pIC50 = 8.7 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
11799000 17168 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
CHEMBL125611 17168 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
10385899 27407 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL136805 27407 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
9999755 26572 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136094 26572 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
44357534 26740 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 26740 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10071290 28100 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 28100 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
196905 111631 8 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL328492 111631 8 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
11756030 58760 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL168658 58760 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
14946858 29161 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 29161 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10407251 119081 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL342688 119081 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
15666577 9201 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL110402 9201 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 10.1021/jm00095a011
15666579 5627 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 10.1021/jm00095a011
CHEMBL107760 5627 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 10.1021/jm00095a011
15666578 7904 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 10.1021/jm00095a011
CHEMBL109015 7904 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 10.1021/jm00095a011
15666603 8138 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109176 8138 1 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
15666621 9242 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 406 12 1 2 7.2 O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL110707 9242 0 None - 0 Human 6.0 pIC50 = 6 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 406 12 1 2 7.2 O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1 10.1021/jm00095a011
44315785 14651 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205307 14651 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL80541 14651 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
11741184 28162 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
CHEMBL137342 28162 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
15666575 5188 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCCc1csc(CCc2ccccc2)c1 10.1021/jm00095a011
CHEMBL106055 5188 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCCc1csc(CCc2ccccc2)c1 10.1021/jm00095a011
15666597 109638 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.9 O=C(O)CCCCCCc1csc(Cc2ccccc2)c1 10.1021/jm00095a011
CHEMBL322290 109638 1 None - 0 Human 5.0 pIC50 = 5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.9 O=C(O)CCCCCCc1csc(Cc2ccccc2)c1 10.1021/jm00095a011
135531245 205264 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL78966 205264 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
10046878 28433 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 28433 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
135503765 205213 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1 10.1021/jm00041a021
CHEMBL78605 205213 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1 10.1021/jm00041a021
15666618 9254 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.7 CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL110767 9254 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.7 CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
10024190 25973 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL135431 25973 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10052488 59051 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.2 CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169446 59051 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.2 CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10069417 164908 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL422282 164908 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
18373405 31697 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL140539 31697 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
9985159 59126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 555 14 1 8 6.4 CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169835 59126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 555 14 1 8 6.4 CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44385218 59671 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/S0960-894X(97)00134-0
CHEMBL172201 59671 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/S0960-894X(97)00134-0
44385131 129499 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL367291 129499 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
6444688 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL49302 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00046a017
18963028 14622 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205053 14622 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47716 14622 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
10343923 27783 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 27783 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
135401173 104779 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O 10.1021/jm00041a021
CHEMBL310870 104779 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O 10.1021/jm00041a021
6444688 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00070a015
CHEMBL49302 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00070a015
10053662 59660 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 565 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
CHEMBL172168 59660 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 565 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
44337707 109742 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL322985 109742 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
9980059 28359 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1 10.1021/jm00101a008
CHEMBL137480 28359 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1 10.1021/jm00101a008
44385159 61351 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1 10.1016/S0960-894X(97)00134-0
CHEMBL176747 61351 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1 10.1016/S0960-894X(97)00134-0
6444688 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49302 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
10091738 27803 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 27803 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
6444688 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49302 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
6444688 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00172a020
CHEMBL49302 187320 35 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00172a020
6435820 165016 6 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
CHEMBL422598 165016 6 None - 1 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
204058 163459 8 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL419948 163459 8 None - 1 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
9805394 57583 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL166699 57583 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10385899 27407 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL136805 27407 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
10474602 25979 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 25979 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10069416 28385 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137497 28385 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10341135 29388 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 29388 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44381856 168556 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 1 7 6.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O 10.1021/jm00006a002
CHEMBL435665 168556 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 1 7 6.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O 10.1021/jm00006a002
9930128 60418 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.1 COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL175073 60418 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.1 COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
11726048 27598 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136953 27598 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10071290 28100 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 28100 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10318241 28348 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137472 28348 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10250881 25070 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 408 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134698 25070 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 408 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10390056 116549 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 472 10 2 4 5.9 O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL336303 116549 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 472 10 2 4 5.9 O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10451768 27896 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137168 27896 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
15666613 9243 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1 10.1021/jm00095a011
CHEMBL110708 9243 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1 10.1021/jm00095a011
44385199 59643 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 375 7 2 3 4.6 COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL172091 59643 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 375 7 2 3 4.6 COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
20704716 184725 0 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
CHEMBL485054 184725 0 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
11549986 156207 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1542 48 11 26 1.8 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1 10.1021/jm050383h
CHEMBL406432 156207 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1542 48 11 26 1.8 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1 10.1021/jm050383h
44386172 165790 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 397 6 2 5 4.2 COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL424779 165790 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 397 6 2 5 4.2 COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
11726048 27598 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136953 27598 1 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
44359651 119183 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL343124 119183 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
6441619 206782 18 None - 1 Human 4.8 pIC50 = 4.8 Binding
Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 206782 18 None - 1 Human 4.8 pIC50 = 4.8 Binding
Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
15718079 101437 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL297501 101437 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
10430674 119338 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 119338 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
10315808 26949 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 9 1 3 5.3 O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL136433 26949 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 9 1 3 5.3 O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10248148 115995 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335525 115995 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
15839736 14640 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL1205143 14640 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL58534 14640 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
44385258 60368 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 7 2 3 5.1 CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL174638 60368 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 7 2 3 5.1 CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
6444688 187320 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
CHEMBL49302 187320 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
10022413 27658 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 27658 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10343923 27783 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 27783 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10341242 28153 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 28153 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
6444688 187320 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 187320 35 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
9805394 57583 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL166699 57583 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
18963032 101092 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL294987 101092 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
114999 3538 21 None - 1 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
6156 3538 21 None - 1 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
CHEMBL14823 3538 21 None - 1 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
10477988 28143 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 28143 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357546 116753 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 116753 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
178581 140254 2 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C
ChEMBL 413 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1 10.1021/jm050383h
CHEMBL380555 140254 2 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C
ChEMBL 413 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1 10.1021/jm050383h
15666615 9177 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 372 11 1 2 6.4 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1 10.1021/jm00095a011
CHEMBL110243 9177 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 372 11 1 2 6.4 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1 10.1021/jm00095a011
10386030 119271 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 395 9 1 3 6.1 O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL343710 119271 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 395 9 1 3 6.1 O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1 10.1021/jm00101a008
44379592 57158 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 387 10 3 4 4.7 [N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1 10.1016/s0960-894x(00)00103-7
CHEMBL164721 57158 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 387 10 3 4 4.7 [N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1 10.1016/s0960-894x(00)00103-7
44379573 58100 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL167465 58100 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
10021622 28600 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 10 1 3 5.7 O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137676 28600 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 10 1 3 5.7 O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10430946 115492 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335142 115492 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O 10.1021/jm00101a007
15718082 187173 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL49209 187173 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O 10.1021/jm00064a006
195214 183839 19 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 454 16 2 4 6.2 CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL48068 183839 19 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 454 16 2 4 6.2 CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1021/jm00064a006
443292 5025 17 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 299 3 2 5 3.6 CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1 10.1021/jm00045a011
CHEMBL105139 5025 17 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 299 3 2 5 3.6 CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1 10.1021/jm00045a011
9934500 165601 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL424290 165601 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
10319829 26118 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 26118 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10387303 27600 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136955 27600 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
15839732 45687 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15299 45687 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
44404447 168758 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 2973 97 22 50 0.7 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL437275 168758 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 2973 97 22 50 0.7 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
10007005 120793 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.1 C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC 10.1021/jm00006a002
CHEMBL355503 120793 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.1 C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC 10.1021/jm00006a002
10474602 25979 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 25979 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9999718 25066 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134697 25066 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10046386 28575 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137654 28575 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O 10.1021/jm00101a007
10482767 168612 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 553 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
CHEMBL436047 168612 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 553 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
44384958 59879 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL172974 59879 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1 10.1016/S0960-894X(97)00134-0
135507252 205597 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 438 13 3 5 5.0 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
CHEMBL81503 205597 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 438 13 3 5 5.0 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
10483151 59571 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 571 14 1 8 7.1 CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL171780 59571 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 571 14 1 8 7.1 CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
18373300 119325 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
CHEMBL344176 119325 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
10406292 28396 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 28396 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
204055 208311 8 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 208311 8 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
6444688 187320 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 187320 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
6444688 187320 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
CHEMBL49302 187320 35 None - 1 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
10023244 26162 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 26162 1 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
9999755 26572 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136094 26572 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
10091738 27803 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 27803 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10475503 28008 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 28008 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10406292 28396 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 28396 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9976757 28501 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 28501 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10362331 28725 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
CHEMBL137801 28725 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
10451768 27896 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137168 27896 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
10387480 28012 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137248 28012 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
10407251 119081 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL342688 119081 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
10024190 25973 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL135431 25973 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10362331 28725 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
CHEMBL137801 28725 4 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
44403823 161945 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL415548 161945 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
129065 107545 29 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 377 4 3 6 3.2 Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C 10.1021/jm00045a011
CHEMBL318809 107545 29 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 377 4 3 6 3.2 Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C 10.1021/jm00045a011
18963030 14623 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205054 14623 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47725 14623 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
15666588 96876 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
CHEMBL265563 96876 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
15666614 111303 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1 10.1021/jm00095a011
CHEMBL326650 111303 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1 10.1021/jm00095a011
9841175 14649 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 14649 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 14649 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
114999 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
6156 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
CHEMBL14823 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
44213761 120733 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 346 9 3 3 3.7 O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL354872 120733 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 346 9 3 3 3.7 O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
114999 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
6156 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
CHEMBL14823 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
10387303 27600 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136955 27600 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10427789 27940 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 27940 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10455429 28962 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 431 8 1 3 6.6 CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL138018 28962 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 431 8 1 3 6.6 CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10430678 168409 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1 10.1021/jm00101a007
CHEMBL434810 168409 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1 10.1021/jm00101a007
10314767 28542 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 333 7 1 3 4.7 O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137633 28542 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 333 7 1 3 4.7 O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10407131 161956 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
CHEMBL415687 161956 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
114999 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
6156 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
CHEMBL14823 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
15666630 8089 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 362 11 1 3 6.0 Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1 10.1021/jm00095a011
CHEMBL109129 8089 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 362 11 1 3 6.0 Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1 10.1021/jm00095a011
15666582 110686 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 360 12 1 3 5.5 COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1 10.1021/jm00095a011
CHEMBL326000 110686 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 360 12 1 3 5.5 COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1 10.1021/jm00095a011
44317392 205247 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 511 13 2 7 4.8 CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
CHEMBL78859 205247 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 511 13 2 7 4.8 CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
2487 2368 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
5280492 2368 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
CHEMBL65061 2368 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
DB12961 2368 36 None 31 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
114999 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
6156 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
CHEMBL14823 3538 21 None - 1 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
10053028 59006 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 540 13 2 8 5.9 CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169120 59006 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 540 13 2 8 5.9 CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
6441619 206782 18 None - 1 Human 5.5 pIC50 = 5.5 Binding
Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 206782 18 None - 1 Human 5.5 pIC50 = 5.5 Binding
Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
18963062 14782 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1206683 14782 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL295799 14782 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
15666601 6146 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.7 O=C(O)CCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL108094 6146 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.7 O=C(O)CCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
15839733 45636 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15295 45636 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
44296838 194840 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself
ChEMBL 334 14 2 2 5.4 CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O 10.1016/S0960-894X(01)80795-2
CHEMBL53967 194840 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself
ChEMBL 334 14 2 2 5.4 CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O 10.1016/S0960-894X(01)80795-2
15839729 206888 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
CHEMBL15559 206888 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
CHEMBL90788 206888 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
15839729 206888 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15559 206888 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL90788 206888 1 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
9955657 206655 15 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 455 13 2 5 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1 10.1021/jm960088k
CHEMBL89326 206655 15 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 455 13 2 5 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1 10.1021/jm960088k
9893718 206501 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL292768 206501 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL88337 206501 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
9893718 206501 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL292768 206501 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL88337 206501 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10046878 28433 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 28433 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
9976757 28501 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 28501 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10430674 119338 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 119338 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
9912012 162204 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL416277 162204 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
10364772 28160 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 28160 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
204055 208311 8 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 208311 8 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135543808 205584 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 480 11 3 6 4.9 CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
CHEMBL81401 205584 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 480 11 3 6 4.9 CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
132379 111732 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm9506985
CHEMBL328712 111732 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm9506985
132379 111732 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111732 19 None - 1 Human 8.3 pIC50 = 8.3 Binding
Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
10292143 116597 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL336665 116597 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL48667 116597 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10292143 116597 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL336665 116597 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL48667 116597 1 None - 1 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
10090758 59000 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 373 9 2 3 3.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL169055 59000 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 373 9 2 3 3.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
10047140 27607 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 27607 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10001576 28381 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 28381 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
9999718 25066 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134697 25066 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
14946858 29161 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 29161 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10068808 27710 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 387 8 1 5 4.9 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137030 27710 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 387 8 1 5 4.9 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
18373405 31697 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL140539 31697 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
18373357 116793 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL337790 116793 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
44359651 119183 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL343124 119183 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
10021742 9456 6 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9456 6 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
10248148 115995 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335525 115995 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
44270188 51386 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15817 51386 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
18963059 14624 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205055 14624 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47726 14624 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
204055 208311 8 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 208311 8 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
60490 207261 106 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
ChEMBL 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O 10.1021/jm950725r
CHEMBL93 207261 106 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
ChEMBL 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O 10.1021/jm950725r
114999 3538 21 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
6156 3538 21 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
CHEMBL14823 3538 21 None - 1 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
9934323 100253 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL288758 100253 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
10170399 14822 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL1207275 14822 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL384950 14822 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
10415107 14898 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
CHEMBL1207951 14898 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
CHEMBL462734 14898 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
10022413 27658 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 27658 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10170399 14822 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL1207275 14822 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL384950 14822 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
15666610 7905 1 None - 0 Human 5.4 pIC50 = 5.4 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109016 7905 1 None - 0 Human 5.4 pIC50 = 5.4 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
44385160 61352 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL176748 61352 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1 10.1016/S0960-894X(97)00134-0
19427041 14643 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL1205171 14643 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL60881 14643 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10023244 26162 1 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 26162 1 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10047140 27607 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 27607 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10475503 28008 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 28008 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10318241 28348 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137472 28348 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10001576 28381 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 28381 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10436331 120544 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 2 7 5.0 CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL354553 120544 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 2 7 5.0 CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
15237280 58101 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 511 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167474 58101 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 511 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
3368 1173 26 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 1173 26 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 1173 26 None - 0 Human 8.3 pIC50 = 8.3 Binding
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
135543742 205388 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1 10.1021/jm00041a021
CHEMBL79991 205388 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1 10.1021/jm00041a021
44348541 16820 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 323 7 1 2 3.0 CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1 10.1021/jm9506985
CHEMBL124717 16820 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 323 7 1 2 3.0 CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1 10.1021/jm9506985
44357534 26740 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 26740 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10341135 29388 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 29388 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10427789 27940 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 27940 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10363959 28513 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137594 28513 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10387480 28012 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137248 28012 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
11725988 27986 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 359 8 1 5 4.2 c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL137234 27986 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 359 8 1 5 4.2 c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1 10.1021/jm00101a007
10340408 118565 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1 10.1021/jm00101a008
CHEMBL341565 118565 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1 10.1021/jm00101a008
18373300 119325 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
CHEMBL344176 119325 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
15666581 5648 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.2 O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1 10.1021/jm00095a011
CHEMBL107781 5648 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.2 O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1 10.1021/jm00095a011
10391552 120322 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL352863 120322 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135507183 205642 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
CHEMBL81817 205642 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
44403823 161945 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL415548 161945 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
135507225 104221 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 424 12 3 5 4.6 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
CHEMBL309883 104221 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 424 12 3 5 4.6 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
10247237 28487 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 8 1 3 5.2 CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137570 28487 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 8 1 3 5.2 CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10032156 59017 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 647 16 1 8 8.6 CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169246 59017 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 647 16 1 8 8.6 CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
9906324 14619 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205046 14619 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL46820 14619 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
9906324 14619 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL1205046 14619 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL46820 14619 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
9865985 28673 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 28673 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
9978895 118976 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL342416 118976 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
6450158 187174 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49210 187174 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
6450158 187174 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 187174 20 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
135516891 157516 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 384 10 3 6 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL407983 157516 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 384 10 3 6 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
18963040 14868 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL1207571 14868 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL416259 14868 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10364772 28160 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 28160 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10092630 27821 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 27821 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
132425 6865 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL108415 6865 5 None - 0 Human 7.2 pIC50 = 7.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
11799000 17168 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
CHEMBL125611 17168 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
10319829 26118 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 26118 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10363959 28513 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137594 28513 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
15666631 8087 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.0 O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109128 8087 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.0 O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1 10.1021/jm00095a011
44379572 120300 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 540 10 2 4 5.3 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL352717 120300 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 540 10 2 4 5.3 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1 10.1016/s0960-894x(00)00103-7
9849151 59096 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169683 59096 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
15839731 49451 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15648 49451 0 None - 1 Human 7.2 pIC50 = 7.2 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
10339300 130225 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL367943 130225 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
10341242 28153 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 28153 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
10477988 28143 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 28143 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357546 116753 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 116753 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
9911868 18034 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined
ChEMBL 455 11 1 7 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1 10.1016/S0960-894X(97)00025-5
CHEMBL126463 18034 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined
ChEMBL 455 11 1 7 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1 10.1016/S0960-894X(97)00025-5
15666586 108567 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
CHEMBL320258 108567 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
44379573 58100 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL167465 58100 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
10019853 28536 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 335 8 1 3 4.9 O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137625 28536 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 335 8 1 3 4.9 O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10337448 28107 1 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 342 8 0 3 5.9 N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137307 28107 1 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 342 8 0 3 5.9 N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9841175 14649 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 14649 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 14649 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
44315539 14797 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1206776 14797 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL305933 14797 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
135430350 168054 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
CHEMBL432363 168054 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
10021742 9456 6 None - 1 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9456 6 None - 1 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
10349070 130888 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 630 16 2 7 7.9 CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL368540 130888 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 630 16 2 7 7.9 CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10481412 59785 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL172628 59785 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44384957 166238 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 389 7 2 4 4.3 COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL426773 166238 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 389 7 2 4 4.3 COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
44403368 161327 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 2750 92 21 47 -1.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL412510 161327 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 2750 92 21 47 -1.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
3368 1173 26 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
9867257 1173 26 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
CHEMBL51770 1173 26 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
9958915 58123 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167669 58123 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
10741106 117802 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 426 9 0 4 4.7 CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21 10.1021/jm950699x
CHEMBL340180 117802 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 426 9 0 4 4.7 CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21 10.1021/jm950699x
15666623 167796 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL430520 167796 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
9841175 14649 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 14649 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 14649 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
11740566 119447 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 381 8 1 3 5.7 CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL345047 119447 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 381 8 1 3 5.7 CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
9934500 165601 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL424290 165601 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
44315583 14648 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205289 14648 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL76530 14648 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
9976891 28167 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1 10.1021/jm00101a007
CHEMBL137346 28167 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1 10.1021/jm00101a007
135543741 205596 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.7 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1 10.1021/jm00041a021
CHEMBL81489 205596 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.7 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1 10.1021/jm00041a021
44385920 61382 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O 10.1016/S0960-894X(97)00134-0
CHEMBL176974 61382 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O 10.1016/S0960-894X(97)00134-0
15718085 101345 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL296869 101345 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
135507273 205295 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
CHEMBL79233 205295 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
122023 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL15766 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL45460 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
4534 191902 94 None - 0 Human 7.1 pIC50 = 7.1 Binding
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
ChEMBL 302 5 4 4 3.6 CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 10.1021/jm00085a019
CHEMBL52 191902 94 None - 0 Human 7.1 pIC50 = 7.1 Binding
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
ChEMBL 302 5 4 4 3.6 CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 10.1021/jm00085a019
122023 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL15766 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL45460 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
122023 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL15766 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL45460 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
122023 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
CHEMBL15766 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
CHEMBL45460 50795 60 None - 1 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
135500104 163773 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
CHEMBL420576 163773 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
10347709 59102 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 557 13 2 8 6.6 CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169722 59102 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 557 13 2 8 6.6 CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135457469 105640 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL312483 105640 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
10092630 27821 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 27821 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10737187 15519 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 359 8 0 2 4.5 CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 10.1021/jm9506985
CHEMBL121748 15519 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 359 8 0 2 4.5 CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 10.1021/jm9506985
18373357 116793 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL337790 116793 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
44386171 61374 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 377 5 2 2 5.4 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl 10.1016/S0960-894X(97)00134-0
CHEMBL176903 61374 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 377 5 2 2 5.4 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl 10.1016/S0960-894X(97)00134-0
10052575 58954 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 525 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL168944 58954 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 525 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44385966 60426 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 4.8 COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL175128 60426 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 4.8 COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
25114442 3061 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
5817 3061 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
CHEMBL3286797 3061 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
DB12024 3061 56 None - 1 Human 5.0 pIC50 = 5.0 Binding
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
192617 100752 22 None - 1 Human 10.4 pKi = 10.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292782 100752 22 None - 1 Human 10.4 pKi = 10.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 100752 22 None - 1 Human 10.4 pKi = 10.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292782 100752 22 None - 1 Human 10.4 pKi = 10.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
19600933 202800 0 None - 1 Human 10.1 pKi = 10.1 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL62265 202800 0 None - 1 Human 10.1 pKi = 10.1 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
10745838 118062 0 None - 1 Human 10.0 pKi = 10.0 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL340460 118062 0 None - 1 Human 10.0 pKi = 10.0 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
2487 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
5280492 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
CHEMBL65061 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
DB12961 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
2487 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
5280492 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
CHEMBL65061 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
DB12961 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
2487 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
5280492 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
CHEMBL65061 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
DB12961 2368 36 None 31 2 Human 9.9 pKi = 9.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
132379 111732 19 None - 1 Human 9.9 pKi = 9.9 Binding
Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111732 19 None - 1 Human 9.9 pKi = 9.9 Binding
Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
10120811 96452 0 None - 1 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL262231 96452 0 None - 1 Human 9.9 pKi = 9.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00046a017
CHEMBL292782 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00046a017
192617 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL292782 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
192617 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292782 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292782 100752 22 None - 1 Human 9.3 pKi = 9.3 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
10745838 118062 0 None - 1 Human 9.2 pKi = 9.2 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL340460 118062 0 None - 1 Human 9.2 pKi = 9.2 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
6441619 206782 18 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 206782 18 None - 1 Human 9.1 pKi = 9.1 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
6441619 206782 18 None - 1 Human 9.1 pKi = 9.1 Binding
Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960088k
CHEMBL90214 206782 18 None - 1 Human 9.1 pKi = 9.1 Binding
Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960088k
9850643 207686 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 554 19 2 6 6.4 CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm00046a017
CHEMBL95453 207686 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 554 19 2 6 6.4 CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm00046a017
15658147 9584 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
CHEMBL112487 9584 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
CHEMBL112520 9584 0 None - 1 Human 9.0 pKi = 9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
9850974 206267 0 None - 1 Human 9.0 pKi = 9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 568 20 2 6 6.8 CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm960088k
CHEMBL86900 206267 0 None - 1 Human 9.0 pKi = 9 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 568 20 2 6 6.8 CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm960088k
15658147 9584 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL112487 9584 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL112520 9584 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
10120811 96452 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL262231 96452 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
19600933 202800 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL62265 202800 0 None - 1 Human 9.0 pKi = 9.0 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
9893718 206501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL292768 206501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL88337 206501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10529082 18818 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 489 10 1 5 6.4 COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL127913 18818 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 489 10 1 5 6.4 COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
9893718 206501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292768 206501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL88337 206501 0 None - 1 Human 8.9 pKi = 8.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
204058 163459 8 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm00046a017
CHEMBL419948 163459 8 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm00046a017
10529241 18512 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 493 9 1 4 7.1 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1 10.1021/jm960248s
CHEMBL127376 18512 0 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 493 9 1 4 7.1 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1 10.1021/jm960248s
10648186 18167 1 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 473 10 1 4 6.8 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1 10.1021/jm960248s
CHEMBL126976 18167 1 None - 1 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 473 10 1 4 6.8 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1 10.1021/jm960248s
11798848 16532 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 477 9 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1 10.1021/jm960248s
CHEMBL123722 16532 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 477 9 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1 10.1021/jm960248s
9958441 116834 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 517 12 1 5 7.2 COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL337995 116834 0 None - 1 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 517 12 1 5 7.2 COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
2487 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
5280492 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
CHEMBL65061 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
DB12961 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
2487 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
5280492 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
CHEMBL65061 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
DB12961 2368 36 None 31 2 Human 8.7 pKi = 8.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
18963032 101092 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL294987 101092 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
44340787 14581 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1204561 14581 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL326397 14581 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15839729 206888 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15559 206888 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL90788 206888 1 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
10046307 14796 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1206771 14796 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL305560 14796 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15658110 14574 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113528 14574 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1204495 14574 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658157 14575 0 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL114454 14575 0 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL1204496 14575 0 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
10037501 184724 4 None - 1 Human 4.0 pKi = 4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 245 1 1 5 0.5 CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N 10.1021/np50100a005
CHEMBL485053 184724 4 None - 1 Human 4.0 pKi = 4 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 245 1 1 5 0.5 CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N 10.1021/np50100a005
18963059 14624 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205055 14624 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47726 14624 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
14977959 9487 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 506 15 2 5 6.0 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112018 9487 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 506 15 2 5 6.0 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
18963030 14623 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205054 14623 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47725 14623 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
21765776 163691 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL420488 163691 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
14977907 9550 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 483 18 2 5 6.8 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL112310 9550 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 483 18 2 5 6.8 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
14977965 111349 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 524 15 2 5 6.2 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL326909 111349 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 524 15 2 5 6.2 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
11798329 18505 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 463 8 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1 10.1021/jm960248s
CHEMBL127341 18505 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 463 8 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1 10.1021/jm960248s
11800543 19391 0 None - 1 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129272 19391 0 None - 1 Human 7.9 pKi = 7.9 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
122023 50795 60 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL15766 50795 60 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL45460 50795 60 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
23257866 9466 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL111908 9466 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
10021742 9456 6 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9456 6 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
14977963 9643 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 574 15 2 5 7.1 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112737 9643 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 574 15 2 5 7.1 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
9829619 100753 0 None - 1 Human 7.9 pKi = 7.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292783 100753 0 None - 1 Human 7.9 pKi = 7.9 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
9977200 29376 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL138370 29376 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL60617 29376 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10292143 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL336665 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL48667 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10292143 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL336665 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL48667 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10292143 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL336665 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL48667 116597 1 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
18963040 14868 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1207571 14868 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL416259 14868 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15658122 9764 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 453 12 2 4 6.0 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113514 9764 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 453 12 2 4 6.0 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658098 169316 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 383 13 2 3 6.3 CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL441647 169316 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 383 13 2 3 6.3 CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1 10.1021/jm00074a012
14977952 109037 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 676 19 2 7 7.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL321261 109037 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 676 19 2 7 7.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977946 110580 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 531 18 2 6 6.2 CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL325423 110580 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 531 18 2 6 6.2 CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
44270188 51386 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15817 51386 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
9984593 9637 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 533 17 2 5 7.3 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1 10.1021/jm00046a017
CHEMBL112707 9637 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 533 17 2 5 7.3 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1 10.1021/jm00046a017
15839733 45636 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15295 45636 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
14977913 9261 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 5.7 COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL110797 9261 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 5.7 COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977924 110947 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL326192 110947 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10812265 58147 0 None - 1 Human 7.8 pKi = 7.8 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167923 58147 0 None - 1 Human 7.8 pKi = 7.8 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10475982 161824 0 None -15 2 Human 4.8 pKi = 4.8 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL414462 161824 0 None -15 2 Human 4.8 pKi = 4.8 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
21765774 9701 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL113146 9701 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
14977898 10090 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 519 15 3 6 5.3 COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL115437 10090 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 519 15 3 6 5.3 COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977924 110947 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL326192 110947 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
10405361 14645 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205188 14645 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL62051 14645 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15839732 45687 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15299 45687 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
44382468 59088 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL169639 59088 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44341107 9460 0 None - 1 Human 4.7 pKi = 4.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 277 4 1 3 3.2 Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1 10.1021/jm00074a014
CHEMBL111872 9460 0 None - 1 Human 4.7 pKi = 4.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 277 4 1 3 3.2 Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1 10.1021/jm00074a014
23257889 9502 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 535 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112088 9502 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 535 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
132379 111732 19 None - 1 Human 8.7 pKi = 8.7 Binding
Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111732 19 None - 1 Human 8.7 pKi = 8.7 Binding
Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
132379 111732 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00070a015
CHEMBL328712 111732 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00070a015
132379 111732 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00046a017
CHEMBL328712 111732 19 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00046a017
10694814 16570 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 449 12 1 5 5.9 COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL123862 16570 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 449 12 1 5 5.9 COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
2487 2368 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
5280492 2368 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
CHEMBL65061 2368 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
DB12961 2368 36 None 31 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
10182429 58139 0 None - 1 Human 7.7 pKi = 7.7 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 428 10 2 5 5.7 CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167850 58139 0 None - 1 Human 7.7 pKi = 7.7 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 428 10 2 5 5.7 CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
11800543 19391 0 None - 1 Human 7.7 pKi = 7.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129272 19391 0 None - 1 Human 7.7 pKi = 7.7 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
18963040 14868 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1207571 14868 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL416259 14868 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
18963040 14868 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL1207571 14868 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL416259 14868 0 None - 1 Human 7.7 pKi = 7.7 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
114999 3538 21 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
6156 3538 21 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
CHEMBL14823 3538 21 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
44341141 9434 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 667 18 1 7 6.9 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL111723 9434 0 None - 1 Human 6.7 pKi = 6.7 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 667 18 1 7 6.9 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
23257891 9705 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 551 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL113167 9705 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 551 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10325873 9519 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL112169 9519 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
44382378 58869 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL168854 58869 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44341318 9549 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 349 8 2 4 3.5 Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1 10.1021/jm00074a014
CHEMBL112309 9549 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 349 8 2 4 3.5 Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1 10.1021/jm00074a014
23257882 110415 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 564 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL324478 110415 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 564 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10745069 30096 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 542 13 2 4 7.9 CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC 10.1021/jm00022a006
CHEMBL138954 30096 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 542 13 2 4 7.9 CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC 10.1021/jm00022a006
177941 1588 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
2948 1588 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
CHEMBL329123 1588 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
DB12850 1588 50 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
9906324 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL1205046 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL46820 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
9906324 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205046 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL46820 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
9906324 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL1205046 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL46820 14619 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
14977920 9479 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL111969 9479 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O 10.1021/jm00074a013
44341073 10128 0 None - 1 Human 4.6 pKi = 4.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 307 5 1 4 3.2 COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1 10.1021/jm00074a014
CHEMBL115679 10128 0 None - 1 Human 4.6 pKi = 4.6 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 307 5 1 4 3.2 COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1 10.1021/jm00074a014
10324028 10028 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 509 15 2 6 5.6 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL115040 10028 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 509 15 2 6 5.6 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
44302963 14641 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205145 14641 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL58794 14641 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9826485 106364 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00070a015
CHEMBL313923 106364 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00070a015
114999 3538 21 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
6156 3538 21 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
CHEMBL14823 3538 21 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
15658099 163333 0 None - 1 Human 5.6 pKi = 5.6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 385 14 2 3 6.2 CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL419036 163333 0 None - 1 Human 5.6 pKi = 5.6 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 385 14 2 3 6.2 CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1 10.1021/jm00074a012
9826485 106364 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL313923 106364 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
14977927 10256 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 652 18 2 7 7.7 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL116101 10256 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 652 18 2 7 7.7 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
15658155 14572 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL113288 14572 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL1204493 14572 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
10179915 58107 0 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167520 58107 0 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
44302965 198954 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 551 14 1 7 6.5 CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2 10.1021/jm990504b
CHEMBL58495 198954 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 551 14 1 7 6.5 CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2 10.1021/jm990504b
192624 168491 2 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 394 10 2 5 5.1 CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL435273 168491 2 None - 1 Human 8.5 pKi = 8.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 394 10 2 5 5.1 CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
9912012 162204 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL416277 162204 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
9906324 14619 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL1205046 14619 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL46820 14619 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
6157 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
6438358 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
CHEMBL422420 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
44302966 96499 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 484 13 2 6 4.9 CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO 10.1021/jm990504b
CHEMBL262530 96499 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 484 13 2 6 4.9 CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO 10.1021/jm990504b
10554820 30279 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 556 13 2 5 7.5 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139115 30279 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 556 13 2 5 7.5 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
44302963 14641 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205145 14641 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL58794 14641 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9845585 58156 0 None - 1 Human 7.5 pKi = 7.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL168011 58156 0 None - 1 Human 7.5 pKi = 7.5 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
44382275 59737 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL172457 59737 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44382384 59542 0 None - 1 Human 5.5 pKi = 5.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL171666 59542 0 None - 1 Human 5.5 pKi = 5.5 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
14977911 9599 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 499 18 2 5 6.0 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL112544 9599 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 499 18 2 5 6.0 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O 10.1021/jm00074a013
14977931 9656 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 520 16 2 6 7.0 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112808 9656 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 520 16 2 6 7.0 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10021742 9456 6 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/jm00074a014
CHEMBL111825 9456 6 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/jm00074a014
14977957 9520 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 490 15 2 5 7.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112176 9520 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 490 15 2 5 7.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
14977933 9890 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 552 16 2 7 5.7 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL114290 9890 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 552 16 2 7 5.7 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10507666 30918 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 592 13 2 6 7.1 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139799 30918 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 592 13 2 6 7.1 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
9807782 19428 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129463 19428 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
6444688 187320 35 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00074a014
CHEMBL49302 187320 35 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00074a014
23257894 9655 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 521 16 1 5 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112804 9655 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 521 16 1 5 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10342316 58151 0 None - 1 Human 7.4 pKi = 7.4 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167972 58151 0 None - 1 Human 7.4 pKi = 7.4 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10363485 59103 0 None -29 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL169743 59103 0 None -29 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
9800998 99368 2 None -32 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL282524 99368 2 None -32 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
9829619 100753 0 None - 1 Human 7.4 pKi = 7.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292783 100753 0 None - 1 Human 7.4 pKi = 7.4 Binding
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
44382463 59224 0 None -9 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL170226 59224 0 None -9 2 Human 4.4 pKi = 4.4 Binding
In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
6157 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
6438358 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
CHEMBL422420 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
6157 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
6438358 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
CHEMBL422420 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
9807782 19428 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129463 19428 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
9893718 206501 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292768 206501 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL88337 206501 0 None - 1 Human 8.4 pKi = 8.4 Binding
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
3083459 120388 1 None - 1 Human 8.3 pKi = 8.3 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL353378 120388 1 None - 1 Human 8.3 pKi = 8.3 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
6439436 9554 2 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112338 9554 2 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
6439436 9554 2 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL112338 9554 2 None - 1 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
10292143 116597 1 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL336665 116597 1 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL48667 116597 1 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10050724 10124 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 477 13 2 5 5.7 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1 10.1021/jm00046a017
CHEMBL115658 10124 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 477 13 2 5 5.7 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1 10.1021/jm00046a017
15839731 49451 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15648 49451 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
9872540 30441 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 560 13 2 5 8.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139254 30441 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 560 13 2 5 8.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O 10.1021/jm00022a006
14977894 110607 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 471 17 3 5 5.6 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O 10.1021/jm00074a013
CHEMBL325615 110607 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 471 17 3 5 5.6 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O 10.1021/jm00074a013
14977961 9510 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 558 15 2 5 8.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112135 9510 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 558 15 2 5 8.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
6450158 187174 20 None - 1 Human 7.4 pKi = 7.4 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49210 187174 20 None - 1 Human 7.4 pKi = 7.4 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
14977916 111325 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL326779 111325 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O 10.1021/jm00074a013
10405361 14645 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205188 14645 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL62051 14645 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9977200 29376 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL138370 29376 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL60617 29376 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
21765772 110610 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL325637 110610 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
10793277 31085 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 576 13 2 5 7.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139969 31085 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 576 13 2 5 7.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O 10.1021/jm00022a006
6450158 187174 20 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 187174 20 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
15658112 63174 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1788228 63174 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1789864 63174 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658139 14576 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL115826 14576 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL1204497 14576 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
18963028 14622 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205053 14622 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47716 14622 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
44382276 120316 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL352814 120316 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10371282 110613 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 595 18 2 7 6.0 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL325643 110613 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 595 18 2 7 6.0 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
20704716 184725 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
CHEMBL485054 184725 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
10159791 58008 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167261 58008 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10046307 14796 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1206771 14796 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL305560 14796 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
19427041 14643 0 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL1205171 14643 0 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL60881 14643 0 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
15658149 14571 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL111811 14571 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL1204492 14571 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
15658119 9811 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 437 12 2 4 7.0 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113792 9811 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 437 12 2 4 7.0 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
14977948 9592 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 660 19 2 7 8.2 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112510 9592 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 660 19 2 7 8.2 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
9845587 165629 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL424361 165629 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10670634 57676 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 437 11 2 6 5.1 CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL166862 57676 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 437 11 2 6 5.1 CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
122023 50795 60 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL15766 50795 60 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL45460 50795 60 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
10600128 58110 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 462 10 2 5 6.1 CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167580 58110 0 None - 1 Human 7.2 pKi = 7.2 Binding
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 462 10 2 5 6.1 CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
6435820 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
CHEMBL422598 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
6435820 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL422598 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
6435820 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960088k
CHEMBL422598 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960088k
6435820 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL422598 165016 6 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
6444688 187320 35 None - 1 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49302 187320 35 None - 1 Human 8.1 pKi = 8.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
6852392 17270 4 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 361 14 3 4 4.0 CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1 10.1021/jm00074a012
CHEMBL1256923 17270 4 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 361 14 3 4 4.0 CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1 10.1021/jm00074a012
14977943 114962 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 592 17 3 7 6.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL334267 114962 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 592 17 3 7 6.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977939 96717 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 505 16 1 5 7.4 COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL264197 96717 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 505 16 1 5 7.4 COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
15839736 14640 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL1205143 14640 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL58534 14640 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
122023 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL15766 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL45460 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
122023 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL15766 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL45460 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
122023 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL15766 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL45460 50795 60 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
14977955 9576 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 548 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112455 9576 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 548 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10257351 110642 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 19 2 6 7.2 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL325773 110642 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 19 2 6 7.2 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
9959228 10075 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL115362 10075 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
9959228 10075 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL115362 10075 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
18963062 14782 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1206683 14782 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL295799 14782 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
10346127 9678 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 507 14 2 6 5.7 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL112972 9678 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 507 14 2 6 5.7 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
15658097 9735 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 401 14 3 4 5.2 CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL113351 9735 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 401 14 3 4 5.2 CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1 10.1021/jm00074a012
44341265 10405 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 263 4 2 2 3.2 Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1 10.1021/jm00074a014
CHEMBL116278 10405 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 263 4 2 2 3.2 Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1 10.1021/jm00074a014
15658135 14573 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL113401 14573 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL1204494 14573 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
None 216197 0 3H-LTB4 3 2 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 336 14 3 3 4.2 CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 216200 0 3H-LTB4 -6 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC(=O)C=CC=CCC=CCCCC(=O)O None
None 216202 0 3H-LTB4 1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC=CCC=CC=CC(=O)CCCC(=O)O None
None 216203 0 3H-LTB4 -1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 216206 0 3H-LTB4 1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 302 12 1 1 5.7 CCCCCC=CCC=CCC=CCC#CCCCC(=O)O None
None 216199 0 3H-LTB4 -57 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O None
None 216203 0 3H-LTB4 -1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 216204 0 3H-LTB4 -10 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 15 2 2 5.2 C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO None
None 216205 0 3H-LTB4 -10 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CC=CC(CC=CCCCC(=O)O)O None
None 216208 0 3H-LTB4 -4365 4 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 473 7 2 3 7.9 CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O None
None 216213 0 3H-LTB4 1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 332 13 0 3 5.3 CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)OC None
132191096 216207 0 3H-LTB4 -1 2 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 352 14 4 4 3.1 CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O None
None 216209 0 3H-LTB4 4 2 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 625 25 7 8 2.8 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N None
None 216211 0 3H-LTB4 2 2 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 439 18 4 5 4.3 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N None
None 216201 0 3H-LTB4 218 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 361 14 3 4 4.0 CCCCCC=CCC(C=CC1=NC(=CC=C1)CC(CCCCO)O)O None
None 216198 0 3H-LTB4 2 2 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 334 13 3 3 3.9 CCC=CCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 216210 0 3H-LTB4 2 2 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 496 20 5 6 3.4 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N None
None 216212 0 3H-LTB4 1 2 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 568 23 6 7 3.7 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)NC(=O)CCC(C(=O)O)N None
2855 4132 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3322 4132 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717 4132 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
CHEMBL603 4132 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
DB00549 4132 104 3H-LTB4 -147 6 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3325 3904 0 None - 1 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 14 3 4 4.0 CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O 10513580
6449854 3904 0 None - 1 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 361 14 3 4 4.0 CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O 10513580
3351 2402 0 None - 1 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1659282
35025716 2402 0 None - 1 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1659282
3405 11 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
5283156 11 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
CHEMBL1435825 11 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
177941 1588 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
2948 1588 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
CHEMBL329123 1588 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
DB12850 1588 50 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
114999 3538 21 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
6156 3538 21 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
CHEMBL14823 3538 21 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
3399 41 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
5280745 41 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
CHEMBL1593789 41 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
6155 1176 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
9823886 1176 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
CHEMBL301829 1176 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
DB13053 1176 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
6157 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6438358 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
CHEMBL422420 2934 20 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6154 634 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
6154 634 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
9956189 634 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
9956189 634 0 None - 1 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
2487 2368 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
5280492 2368 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
CHEMBL65061 2368 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
DB12961 2368 36 None 31 2 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
2855 4132 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3322 4132 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717 4132 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
CHEMBL603 4132 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
DB00549 4132 104 None -147 6 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None