Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| #Vendors | Reference ligand
| Fold selectivity | # Tested GPCRs | Species
| p-value (-log) | Activity Type
| Activity Relation
| Activity Value
| AssayType
| Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
|
54582892 | 61600 | 0 | None | 3 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 514 | 12 | 1 | 5 | 6.0 | O=C(NC1CC1)c1ccc(OCCCC2CC2CCCC2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
CHEMBL1771104 | 61600 | 0 | None | 3 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 514 | 12 | 1 | 5 | 6.0 | O=C(NC1CC1)c1ccc(OCCCC2CC2CCCC2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
89584034 | 158706 | 0 | None | 3 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 500 | 10 | 0 | 6 | 4.0 | COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4093284 | 158706 | 0 | None | 3 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 500 | 10 | 0 | 6 | 4.0 | COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
89584002 | 159716 | 0 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 472 | 8 | 0 | 5 | 4.4 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4104464 | 159716 | 0 | None | 1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 472 | 8 | 0 | 5 | 4.4 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
54587813 | 61595 | 0 | None | -1 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 458 | 8 | 1 | 5 | 4.5 | O=C(NC1CC1)c1ccc(OCCC2CC2C2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
CHEMBL1771098 | 61595 | 0 | None | -1 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 458 | 8 | 1 | 5 | 4.5 | O=C(NC1CC1)c1ccc(OCCC2CC2C2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
117678530 | 159145 | 0 | None | 2 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 466 | 9 | 0 | 5 | 4.3 | CCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4098051 | 159145 | 0 | None | 2 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 466 | 9 | 0 | 5 | 4.3 | CCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
89584002 | 159716 | 0 | None | -1 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 472 | 8 | 0 | 5 | 4.4 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4104464 | 159716 | 0 | None | -1 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 472 | 8 | 0 | 5 | 4.4 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
54587813 | 61595 | 0 | None | 1 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 458 | 8 | 1 | 5 | 4.5 | O=C(NC1CC1)c1ccc(OCCC2CC2C2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
CHEMBL1771098 | 61595 | 0 | None | 1 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 458 | 8 | 1 | 5 | 4.5 | O=C(NC1CC1)c1ccc(OCCC2CC2C2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
145949889 | 162818 | 0 | None | 229 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse GPR119 assessed as increase in cAMP levelAgonist activity at mouse GPR119 assessed as increase in cAMP level |
ChEMBL | 536 | 7 | 1 | 10 | 3.1 | COc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1C[C@@H]2COC[C@@H](C1)N2C(=O)OC1(C)CC1 | 10.1021/acsmedchemlett.8b00073 | |
CHEMBL4172551 | 162818 | 0 | None | 229 | 2 | Mouse | 9.4 | pEC50 | = | 9.4 | Functional | Agonist activity at mouse GPR119 assessed as increase in cAMP levelAgonist activity at mouse GPR119 assessed as increase in cAMP level |
ChEMBL | 536 | 7 | 1 | 10 | 3.1 | COc1c(Nc2ccc(S(C)(=O)=O)cc2F)ncnc1OC1C[C@@H]2COC[C@@H](C1)N2C(=O)OC1(C)CC1 | 10.1021/acsmedchemlett.8b00073 | |
53630410 | 1145 | 0 | None | 14 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 507 | 4 | 0 | 9 | 3.9 | O=C(N1CCC(CC1)Sc1ncnc2c1cnn2c1ccc(cc1F)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
5739 | 1145 | 0 | None | 14 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 507 | 4 | 0 | 9 | 3.9 | O=C(N1CCC(CC1)Sc1ncnc2c1cnn2c1ccc(cc1F)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
CHEMBL1773283 | 1145 | 0 | None | 14 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 507 | 4 | 0 | 9 | 3.9 | O=C(N1CCC(CC1)Sc1ncnc2c1cnn2c1ccc(cc1F)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
118720405 | 115884 | 0 | None | 15 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF methodAgonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method |
ChEMBL | 465 | 5 | 0 | 5 | 5.4 | CCOC(=O)[C@@]1(Cc2ccccc2)CCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 | 10.1016/j.bmcl.2014.10.010 | |
CHEMBL3354778 | 115884 | 0 | None | 15 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF methodAgonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method |
ChEMBL | 465 | 5 | 0 | 5 | 5.4 | CCOC(=O)[C@@]1(Cc2ccccc2)CCc2cnc3c(-c4ccc(C(F)(F)F)cc4)cnn3c21 | 10.1016/j.bmcl.2014.10.010 | |
71573174 | 155913 | 0 | None | 1 | 2 | Mouse | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 454 | 8 | 0 | 5 | 4.2 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4060838 | 155913 | 0 | None | 1 | 2 | Mouse | 9.3 | pEC50 | = | 9.3 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 454 | 8 | 0 | 5 | 4.2 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
54582152 | 1040 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 507 | 4 | 1 | 9 | 2.4 | O=C(N1CCC(CC1)Oc1ncnc2c1[nH]c(=O)n2c1ccc(cc1F)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
5740 | 1040 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 507 | 4 | 1 | 9 | 2.4 | O=C(N1CCC(CC1)Oc1ncnc2c1[nH]c(=O)n2c1ccc(cc1F)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
CHEMBL1773292 | 1040 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 507 | 4 | 1 | 9 | 2.4 | O=C(N1CCC(CC1)Oc1ncnc2c1[nH]c(=O)n2c1ccc(cc1F)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
134136399 | 142889 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay |
ChEMBL | 523 | 7 | 1 | 10 | 3.6 | CC(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Oc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 | 10.1016/j.bmc.2016.10.030 | |
CHEMBL3893596 | 142889 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level measured after 60 mins by HTRF assay |
ChEMBL | 523 | 7 | 1 | 10 | 3.6 | CC(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(Oc1ncnc(Nc3ccc(S(C)(=O)=O)cc3F)c1[N+](=O)[O-])C2 | 10.1016/j.bmc.2016.10.030 | |
24939268 | 452 | 67 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 505 | 7 | 1 | 11 | 3.6 | O=N(=O)c1c(ncnc1N1CCC(CC1)c1onc(n1)C(C)C)Nc1ccc(cc1F)S(=O)(=O)C | 10.1016/j.bmcl.2011.03.007 | |
5653 | 452 | 67 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 505 | 7 | 1 | 11 | 3.6 | O=N(=O)c1c(ncnc1N1CCC(CC1)c1onc(n1)C(C)C)Nc1ccc(cc1F)S(=O)(=O)C | 10.1016/j.bmcl.2011.03.007 | |
CHEMBL461384 | 452 | 67 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 505 | 7 | 1 | 11 | 3.6 | O=N(=O)c1c(ncnc1N1CCC(CC1)c1onc(n1)C(C)C)Nc1ccc(cc1F)S(=O)(=O)C | 10.1016/j.bmcl.2011.03.007 | |
24939268 | 452 | 67 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationAgonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation |
ChEMBL | 505 | 7 | 1 | 11 | 3.6 | O=N(=O)c1c(ncnc1N1CCC(CC1)c1onc(n1)C(C)C)Nc1ccc(cc1F)S(=O)(=O)C | 10.1021/jm8006867 | |
5653 | 452 | 67 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationAgonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation |
ChEMBL | 505 | 7 | 1 | 11 | 3.6 | O=N(=O)c1c(ncnc1N1CCC(CC1)c1onc(n1)C(C)C)Nc1ccc(cc1F)S(=O)(=O)C | 10.1021/jm8006867 | |
CHEMBL461384 | 452 | 67 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentationAgonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation |
ChEMBL | 505 | 7 | 1 | 11 | 3.6 | O=N(=O)c1c(ncnc1N1CCC(CC1)c1onc(n1)C(C)C)Nc1ccc(cc1F)S(=O)(=O)C | 10.1021/jm8006867 | |
11397354 | 1053 | 2 | None | 23 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 474 | 4 | 0 | 9 | 3.5 | O=C(N1CCC(CC1)Oc1ncnc2c1onc2c1ccc(cc1)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
5741 | 1053 | 2 | None | 23 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 474 | 4 | 0 | 9 | 3.5 | O=C(N1CCC(CC1)Oc1ncnc2c1onc2c1ccc(cc1)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
CHEMBL1773293 | 1053 | 2 | None | 23 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 by melanophore assayAgonist activity at human GPR119 by melanophore assay |
ChEMBL | 474 | 4 | 0 | 9 | 3.5 | O=C(N1CCC(CC1)Oc1ncnc2c1onc2c1ccc(cc1)S(=O)(=O)C)OC(C)(C)C | 10.1016/j.bmcl.2011.03.007 | |
89584118 | 157298 | 0 | None | 2 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 482 | 10 | 0 | 6 | 3.9 | COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4077033 | 157298 | 0 | None | 2 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 482 | 10 | 0 | 6 | 3.9 | COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
122191633 | 123747 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human GPR119 expressed in CHO cells by cAMP assayAgonist activity at human GPR119 expressed in CHO cells by cAMP assay |
ChEMBL | 465 | 9 | 0 | 7 | 4.2 | CCS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(c3nc(C(C)C)no3)CC2)c(F)c1 | 10.1021/acsmedchemlett.5b00207 | |
CHEMBL3622182 | 123747 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human GPR119 expressed in CHO cells by cAMP assayAgonist activity at human GPR119 expressed in CHO cells by cAMP assay |
ChEMBL | 465 | 9 | 0 | 7 | 4.2 | CCS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(c3nc(C(C)C)no3)CC2)c(F)c1 | 10.1021/acsmedchemlett.5b00207 | |
71573174 | 155913 | 0 | None | -1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 454 | 8 | 0 | 5 | 4.2 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4060838 | 155913 | 0 | None | -1 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 454 | 8 | 0 | 5 | 4.2 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1)N1CCC1 | 10.1016/j.bmcl.2017.01.091 | |
89584012 | 157543 | 0 | None | 8 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 488 | 8 | 1 | 6 | 3.3 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CC(O)C1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4080222 | 157543 | 0 | None | 8 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at human GPR119 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 488 | 8 | 1 | 6 | 3.3 | O=C(Cc1ccc(OCC[C@@H]2C[C@@H]2C2CCN(c3ncc(Cl)cn3)CC2)cc1F)N1CC(O)C1 | 10.1016/j.bmcl.2017.01.091 | |
89584034 | 158706 | 0 | None | -3 | 2 | Mouse | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 500 | 10 | 0 | 6 | 4.0 | COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
CHEMBL4093284 | 158706 | 0 | None | -3 | 2 | Mouse | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 500 | 10 | 0 | 6 | 4.0 | COCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3cc(F)c(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 | |
54582892 | 61600 | 0 | None | -3 | 2 | Mouse | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 514 | 12 | 1 | 5 | 6.0 | O=C(NC1CC1)c1ccc(OCCCC2CC2CCCC2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
CHEMBL1771104 | 61600 | 0 | None | -3 | 2 | Mouse | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay |
ChEMBL | 514 | 12 | 1 | 5 | 6.0 | O=C(NC1CC1)c1ccc(OCCCC2CC2CCCC2CCN(c3ncc(Cl)cn3)CC2)cc1F | 10.1016/j.bmcl.2010.12.086 | |
117678530 | 159145 | 0 | None | -2 | 2 | Mouse | 9.1 | pEC50 | = | 9.1 | Functional | Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assayAgonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase in intracellular cAMP level after 60 mins by HTRF assay |
ChEMBL | 466 | 9 | 0 | 5 | 4.3 | CCc1cnc(N2CCC([C@H]3C[C@H]3CCOc3ccc(CC(=O)N4CCC4)c(F)c3)CC2)nc1 | 10.1016/j.bmcl.2017.01.091 |
Showing 1 to 50 of 4,098 entries
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
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Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Assay information
| Chemical information
| |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity
| Common name
| GPCRdb ID | #Vendors
| Reference ligand | Fold selectivity | # Tested GPCRs
| Species | p-value (-log)
| Activity Type
| Activity Relation
| Activity Value
| Assay Type
| Assay Description
| Source | Mol weight | Rot Bonds | H don | H acc | LogP
| Smiles
| DOI |
155568284 | 176110 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 440 | 3 | 0 | 7 | 3.8 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(C(F)(F)F)cc3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
CHEMBL4591642 | 176110 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 440 | 3 | 0 | 7 | 3.8 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(C(F)(F)F)cc3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
57468373 | 114670 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 453 | 6 | 0 | 7 | 3.2 | CCc1ccc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
CHEMBL3338170 | 114670 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 453 | 6 | 0 | 7 | 3.2 | CCc1ccc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
25204244 | 114664 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 448 | 5 | 0 | 7 | 3.0 | CC(C)OC(=O)N1CCCC(Oc2ccn(-c3ccc(S(C)(=O)=O)cc3)c(=O)c2)CC1 | 10.1021/jm501175v | ||
CHEMBL3338164 | 114664 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 448 | 5 | 0 | 7 | 3.0 | CC(C)OC(=O)N1CCCC(Oc2ccn(-c3ccc(S(C)(=O)=O)cc3)c(=O)c2)CC1 | 10.1021/jm501175v | ||
57468459 | 114676 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 415 | 6 | 0 | 7 | 3.5 | CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(C#N)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
CHEMBL3338176 | 114676 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 415 | 6 | 0 | 7 | 3.5 | CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(C#N)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
155536150 | 172138 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 474 | 3 | 0 | 7 | 4.5 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(C(F)(F)F)cc3Cl)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
CHEMBL4473081 | 172138 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 474 | 3 | 0 | 7 | 4.5 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(C(F)(F)F)cc3Cl)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
57468382 | 114672 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 456 | 6 | 0 | 9 | 2.1 | COc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
CHEMBL3338172 | 114672 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 456 | 6 | 0 | 9 | 2.1 | COc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
57550101 | 114684 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 493 | 7 | 0 | 9 | 2.9 | CCCc1cnc(N2CCC(Oc3cc(=O)n(-c4ccc(S(C)(=O)=O)cc4)cc3C#N)CC2)nc1 | 10.1021/jm501175v | ||
CHEMBL3338187 | 114684 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 493 | 7 | 0 | 9 | 2.9 | CCCc1cnc(N2CCC(Oc3cc(=O)n(-c4ccc(S(C)(=O)=O)cc4)cc3C#N)CC2)nc1 | 10.1021/jm501175v | ||
53477049 | 114687 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 546 | 5 | 0 | 8 | 3.9 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)c(F)c1 | 10.1021/jm501175v | ||
CHEMBL3338190 | 114687 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 546 | 5 | 0 | 8 | 3.9 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)c(F)c1 | 10.1021/jm501175v | ||
155528272 | 171315 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 474 | 3 | 0 | 7 | 4.5 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(Cl)c(C(F)(F)F)c3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
CHEMBL4461083 | 171315 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 474 | 3 | 0 | 7 | 4.5 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(Cl)c(C(F)(F)F)c3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
155525761 | 171022 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 459 | 2 | 0 | 6 | 3.6 | CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(Cl)c(C(F)(F)F)c3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
CHEMBL4456666 | 171022 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 459 | 2 | 0 | 6 | 3.6 | CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(Cl)c(C(F)(F)F)c3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
155528891 | 171371 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 453 | 3 | 0 | 8 | 1.5 | CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3F)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
CHEMBL4461803 | 171371 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 453 | 3 | 0 | 8 | 1.5 | CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3F)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
162663470 | 181953 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at rat GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assayAgonist activity at rat GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay |
ChEMBL | 519 | 6 | 1 | 10 | 3.2 | CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCC[C@H](O)C6=O)ccc54)ncn3)CC2)n1 | 10.1016/j.bmc.2021.116034 | ||
CHEMBL4779950 | 181953 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at rat GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assayAgonist activity at rat GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay |
ChEMBL | 519 | 6 | 1 | 10 | 3.2 | CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCC[C@H](O)C6=O)ccc54)ncn3)CC2)n1 | 10.1016/j.bmc.2021.116034 | ||
53477048 | 114686 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 528 | 5 | 0 | 8 | 3.8 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)cc1 | 10.1021/jm501175v | ||
CHEMBL3338189 | 114686 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 528 | 5 | 0 | 8 | 3.8 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)cc1 | 10.1021/jm501175v | ||
53390936 | 114690 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 512 | 5 | 0 | 8 | 3.5 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(Cl)cn4)CC3)cc2=O)cc1F | 10.1021/jm501175v | ||
CHEMBL3338193 | 114690 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 512 | 5 | 0 | 8 | 3.5 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(Cl)cn4)CC3)cc2=O)cc1F | 10.1021/jm501175v | ||
155530371 | 171563 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 425 | 2 | 0 | 6 | 3.0 | CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(C(F)(F)F)cc3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
CHEMBL4464713 | 171563 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 425 | 2 | 0 | 6 | 3.0 | CC(C)(C)OC(=O)N1CCN(C(=O)c2cn(-c3ccc(C(F)(F)F)cc3)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
155523981 | 170906 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 468 | 4 | 0 | 9 | 2.4 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3F)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
CHEMBL4454792 | 170906 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assayAgonist activity at recombinant human GPR119 expressed in HEK293 cells after 24 hrs by steady-glo luciferase assay |
ChEMBL | 468 | 4 | 0 | 9 | 2.4 | CC(C)(C)OC(=O)N1CCC(OC(=O)c2cn(-c3ccc(S(C)(=O)=O)cc3F)nn2)CC1 | 10.1016/j.bmcl.2019.126707 | ||
25204713 | 114668 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 468 | 5 | 0 | 7 | 3.3 | CS(=O)(=O)c1ccc(-n2ccc(OC3CCN(C(=O)Oc4ccccc4)CC3)cc2=O)cc1 | 10.1021/jm501175v | ||
CHEMBL3338168 | 114668 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 468 | 5 | 0 | 7 | 3.3 | CS(=O)(=O)c1ccc(-n2ccc(OC3CCN(C(=O)Oc4ccccc4)CC3)cc2=O)cc1 | 10.1021/jm501175v | ||
25138357 | 114665 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 434 | 5 | 0 | 7 | 2.6 | CC(C)OC(=O)N1CCC(Oc2ccn(-c3ccc(S(C)(=O)=O)cc3)c(=O)c2)CC1 | 10.1021/jm501175v | ||
CHEMBL3338165 | 114665 | 0 | None | - | 0 | Human | 6.9 | pEC50 | = | 6.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 434 | 5 | 0 | 7 | 2.6 | CC(C)OC(=O)N1CCC(Oc2ccn(-c3ccc(S(C)(=O)=O)cc3)c(=O)c2)CC1 | 10.1021/jm501175v | ||
53477157 | 114691 | 14 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 512 | 5 | 0 | 8 | 3.5 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(Cl)cn4)CC3)cc2=O)c(F)c1 | 10.1021/jm501175v | ||
CHEMBL3338194 | 114691 | 14 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 512 | 5 | 0 | 8 | 3.5 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(Cl)cn4)CC3)cc2=O)c(F)c1 | 10.1021/jm501175v | ||
162656652 | 180838 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assayAgonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay |
ChEMBL | 490 | 7 | 1 | 8 | 3.4 | CC(C)SC(=O)N1CCC(Oc2cc(N3CCc4cc([S+]([O-])CCO)ccc43)ncn2)CC1 | 10.1016/j.bmc.2021.116034 | ||
CHEMBL4757058 | 180838 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assayAgonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay |
ChEMBL | 490 | 7 | 1 | 8 | 3.4 | CC(C)SC(=O)N1CCC(Oc2cc(N3CCc4cc([S+]([O-])CCO)ccc43)ncn2)CC1 | 10.1016/j.bmc.2021.116034 | ||
68230201 | 122287 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | Agonist activity at human GPR119 by serum shift assayAgonist activity at human GPR119 by serum shift assay |
ChEMBL | 402 | 4 | 0 | 7 | 3.5 | CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(C#N)cn3)CC2)CC1 | 10.1016/j.bmcl.2015.04.102 | ||
CHEMBL3598092 | 122287 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | Agonist activity at human GPR119 by serum shift assayAgonist activity at human GPR119 by serum shift assay |
ChEMBL | 402 | 4 | 0 | 7 | 3.5 | CC(C)(C)OC(=O)N1CCC(O[C@H]2CC[C@H](Oc3cnc(C#N)cn3)CC2)CC1 | 10.1016/j.bmcl.2015.04.102 | ||
67607375 | 83672 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemiluminescence analysisAgonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemiluminescence analysis |
ChEMBL | 448 | 6 | 0 | 10 | 2.6 | CC1(OC(=O)N2CCC(n3ncc(COc4ccc(-n5cnnn5)cc4)c3C#N)CC2)CC1 | 10.1021/ml300296q | ||
CHEMBL2204983 | 83672 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemiluminescence analysisAgonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemiluminescence analysis |
ChEMBL | 448 | 6 | 0 | 10 | 2.6 | CC1(OC(=O)N2CCC(n3ncc(COc4ccc(-n5cnnn5)cc4)c3C#N)CC2)CC1 | 10.1021/ml300296q | ||
162675131 | 183404 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assayAgonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay |
ChEMBL | 505 | 6 | 0 | 10 | 3.1 | CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCOCC6=O)ccc54)ncn3)CC2)n1 | 10.1016/j.bmc.2021.116034 | ||
CHEMBL4798241 | 183404 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assayAgonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay |
ChEMBL | 505 | 6 | 0 | 10 | 3.1 | CC(C)c1noc(N2CCC(Oc3cc(N4CCc5cc(N6CCOCC6=O)ccc54)ncn3)CC2)n1 | 10.1016/j.bmc.2021.116034 | ||
25204038 | 114674 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 468 | 7 | 0 | 8 | 3.0 | CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
CHEMBL3338174 | 114674 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 468 | 7 | 0 | 8 | 3.0 | CCCc1cnc(N2CCC(Oc3ccn(-c4ccc(S(C)(=O)=O)cc4)c(=O)c3)CC2)nc1 | 10.1021/jm501175v | ||
53477155 | 114688 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 546 | 5 | 0 | 8 | 3.9 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)cc1F | 10.1021/jm501175v | ||
CHEMBL3338191 | 114688 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | Agonist activity at human GPR119Agonist activity at human GPR119 |
ChEMBL | 546 | 5 | 0 | 8 | 3.9 | CS(=O)(=O)c1ccc(-n2cc(Cl)c(OC3CCN(c4ncc(C(F)(F)F)cn4)CC3)cc2=O)cc1F | 10.1021/jm501175v |
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